Incidental Mutation 'R5892:Zfp110'
ID 457242
Institutional Source Beutler Lab
Gene Symbol Zfp110
Ensembl Gene ENSMUSG00000058638
Gene Name zinc finger protein 110
Synonyms Nrif1, 2900024E01Rik, NRIF
MMRRC Submission 044093-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.698) question?
Stock # R5892 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 12568688-12584504 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 12582405 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 351 (T351I)
Ref Sequence ENSEMBL: ENSMUSP00000132060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004614] [ENSMUST00000168247]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000004614
AA Change: T351I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000004614
Gene: ENSMUSG00000058638
AA Change: T351I

DomainStartEndE-ValueType
KRAB 18 78 1.38e-26 SMART
SCAN 158 269 1.48e-39 SMART
KRAB 284 351 2.94e-12 SMART
low complexity region 424 438 N/A INTRINSIC
ZnF_C2H2 688 710 1.43e-1 SMART
ZnF_C2H2 716 738 2.24e-3 SMART
ZnF_C2H2 744 766 2.27e-4 SMART
ZnF_C2H2 772 794 6.32e-3 SMART
ZnF_C2H2 800 822 2.75e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137718
Predicted Effect probably benign
Transcript: ENSMUST00000168247
AA Change: T351I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000132060
Gene: ENSMUSG00000058638
AA Change: T351I

DomainStartEndE-ValueType
KRAB 18 78 1.38e-26 SMART
SCAN 158 269 1.48e-39 SMART
KRAB 284 351 2.94e-12 SMART
low complexity region 424 438 N/A INTRINSIC
ZnF_C2H2 688 710 1.43e-1 SMART
ZnF_C2H2 716 738 2.24e-3 SMART
ZnF_C2H2 744 766 2.27e-4 SMART
ZnF_C2H2 772 794 6.32e-3 SMART
ZnF_C2H2 800 822 2.75e-3 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.6%
Validation Efficiency 98% (56/57)
MGI Phenotype PHENOTYPE: Homozygous mutants on a C57BL/6 background die at embryonic day 12. On a strain 129 background, mutants are viable and fertile, but males are more docile and testis weight is greatly reduced. On an F2 background, 20% of homozygous pups die neonatally. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930524J08Rik G T 5: 100,127,124 (GRCm39) probably benign Het
Abcb11 C T 2: 69,091,844 (GRCm39) A893T probably damaging Het
Adtrp A T 13: 41,981,682 (GRCm39) N30K probably benign Het
Alms1 T A 6: 85,597,885 (GRCm39) S904T probably damaging Het
Cep170 T A 1: 176,582,953 (GRCm39) probably null Het
Cntnap3 A G 13: 64,946,994 (GRCm39) V145A probably damaging Het
Dclre1a T C 19: 56,535,572 (GRCm39) E4G probably benign Het
Depdc1a G C 3: 159,232,306 (GRCm39) A686P probably damaging Het
Dnah7b T C 1: 46,376,753 (GRCm39) probably null Het
Enox1 A G 14: 77,723,457 (GRCm39) probably benign Het
Fam107b A G 2: 3,779,601 (GRCm39) E268G probably damaging Het
Fer1l6 A G 15: 58,435,917 (GRCm39) S437G probably benign Het
Flnb C A 14: 7,907,183 (GRCm38) T1252K probably damaging Het
Fubp1 A G 3: 151,923,951 (GRCm39) probably benign Het
Gm20402 G A 3: 52,176,370 (GRCm39) A50T probably benign Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Gzmk C T 13: 113,310,456 (GRCm39) probably null Het
Ino80 A T 2: 119,270,028 (GRCm39) probably benign Het
Ints8 T C 4: 11,223,813 (GRCm39) T677A probably damaging Het
Kat6a A G 8: 23,428,305 (GRCm39) E1220G probably damaging Het
Lrfn5 A G 12: 61,890,204 (GRCm39) T498A probably damaging Het
Lrp2 T A 2: 69,273,120 (GRCm39) T4043S probably benign Het
Malrd1 A G 2: 15,619,078 (GRCm39) N314S probably benign Het
Mfsd1 A G 3: 67,497,162 (GRCm39) probably null Het
Muc1 C T 3: 89,138,300 (GRCm39) P381S probably benign Het
Myh2 A T 11: 67,076,002 (GRCm39) K730* probably null Het
Nat3 T A 8: 68,000,590 (GRCm39) N156K probably benign Het
Nelfe T C 17: 35,073,645 (GRCm39) probably benign Het
Nlrp1a A T 11: 70,990,471 (GRCm39) L927Q probably damaging Het
P4ha2 A G 11: 54,011,014 (GRCm39) Y343C probably damaging Het
Pclo A T 5: 14,571,185 (GRCm39) Q190L probably damaging Het
Pde8a A G 7: 80,945,439 (GRCm39) N183S probably damaging Het
Plekha2 C T 8: 25,542,381 (GRCm39) V278I probably benign Het
Plekha6 G C 1: 133,200,045 (GRCm39) R208P possibly damaging Het
Plxnb1 T C 9: 108,940,775 (GRCm39) L1550P probably damaging Het
Ppox C T 1: 171,105,034 (GRCm39) V385I probably damaging Het
Prdm16 T C 4: 154,407,716 (GRCm39) D1170G possibly damaging Het
Prmt5 A T 14: 54,747,368 (GRCm39) S470T probably damaging Het
Robo2 T A 16: 73,692,668 (GRCm39) probably benign Het
Siglecg G A 7: 43,061,628 (GRCm39) probably benign Het
Slc30a5 T C 13: 100,949,810 (GRCm39) N367S probably damaging Het
Tex29 C T 8: 11,904,288 (GRCm39) probably benign Het
Tmem117 T A 15: 94,536,020 (GRCm39) V18E probably damaging Het
Tmtc2 C T 10: 105,249,366 (GRCm39) M122I probably benign Het
Tpr T A 1: 150,283,151 (GRCm39) N287K probably benign Het
Unc93b1 A T 19: 3,993,632 (GRCm39) D358V probably damaging Het
Vrk2 A T 11: 26,484,372 (GRCm39) probably benign Het
Wdr24 A T 17: 26,046,960 (GRCm39) Q671L probably benign Het
Zfp963 T C 8: 70,196,027 (GRCm39) D142G probably benign Het
Other mutations in Zfp110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00705:Zfp110 APN 7 12,583,086 (GRCm39) missense probably benign 0.38
IGL01094:Zfp110 APN 7 12,583,723 (GRCm39) missense probably damaging 1.00
IGL01576:Zfp110 APN 7 12,583,598 (GRCm39) missense probably damaging 1.00
IGL01859:Zfp110 APN 7 12,583,467 (GRCm39) missense possibly damaging 0.86
IGL02003:Zfp110 APN 7 12,583,832 (GRCm39) nonsense probably null
R0122:Zfp110 UTSW 7 12,582,524 (GRCm39) missense possibly damaging 0.51
R0357:Zfp110 UTSW 7 12,570,302 (GRCm39) missense probably damaging 0.98
R0383:Zfp110 UTSW 7 12,583,187 (GRCm39) missense probably benign 0.00
R0725:Zfp110 UTSW 7 12,570,290 (GRCm39) missense possibly damaging 0.52
R0926:Zfp110 UTSW 7 12,583,808 (GRCm39) nonsense probably null
R1146:Zfp110 UTSW 7 12,580,721 (GRCm39) critical splice acceptor site probably null
R1146:Zfp110 UTSW 7 12,580,721 (GRCm39) critical splice acceptor site probably null
R1472:Zfp110 UTSW 7 12,582,468 (GRCm39) missense possibly damaging 0.85
R1663:Zfp110 UTSW 7 12,582,569 (GRCm39) missense probably benign 0.08
R1975:Zfp110 UTSW 7 12,582,429 (GRCm39) missense probably benign 0.00
R2046:Zfp110 UTSW 7 12,583,349 (GRCm39) missense probably benign 0.00
R2296:Zfp110 UTSW 7 12,583,467 (GRCm39) missense probably damaging 0.97
R2341:Zfp110 UTSW 7 12,583,113 (GRCm39) missense probably benign 0.04
R4332:Zfp110 UTSW 7 12,578,498 (GRCm39) nonsense probably null
R5955:Zfp110 UTSW 7 12,582,672 (GRCm39) missense possibly damaging 0.85
R6083:Zfp110 UTSW 7 12,578,602 (GRCm39) missense possibly damaging 0.95
R6115:Zfp110 UTSW 7 12,583,701 (GRCm39) missense probably damaging 0.98
R7187:Zfp110 UTSW 7 12,583,753 (GRCm39) nonsense probably null
R7455:Zfp110 UTSW 7 12,581,984 (GRCm39) missense probably benign
R7570:Zfp110 UTSW 7 12,583,267 (GRCm39) missense possibly damaging 0.94
R7727:Zfp110 UTSW 7 12,582,922 (GRCm39) missense possibly damaging 0.91
R7895:Zfp110 UTSW 7 12,571,020 (GRCm39) missense possibly damaging 0.86
R8179:Zfp110 UTSW 7 12,578,498 (GRCm39) nonsense probably null
R8703:Zfp110 UTSW 7 12,582,888 (GRCm39) missense probably benign
R9207:Zfp110 UTSW 7 12,582,485 (GRCm39) missense probably benign 0.33
R9794:Zfp110 UTSW 7 12,578,521 (GRCm39) missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- AAAGCTCCTGGTTTTGCTGC -3'
(R):5'- CCCTGGCTTTTGTGACGACTAG -3'

Sequencing Primer
(F):5'- TTGTCACTCCCTAGACGGAAG -3'
(R):5'- ACGACTAGTTTGGTCTTGAGAC -3'
Posted On 2017-02-15