Incidental Mutation 'R5893:Vmn2r1'
ID |
457284 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r1
|
Ensembl Gene |
ENSMUSG00000027824 |
Gene Name |
vomeronasal 2, receptor 1 |
Synonyms |
V2r83, EG56544 |
MMRRC Submission |
044094-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.133)
|
Stock # |
R5893 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
63988968-64016905 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 63993974 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Tyrosine
at position 107
(N107Y)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000029406
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029406]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000029406
AA Change: N107Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000029406 Gene: ENSMUSG00000027824 AA Change: N107Y
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
86 |
504 |
6e-92 |
PFAM |
Pfam:NCD3G
|
546 |
599 |
2.4e-17 |
PFAM |
Pfam:7tm_3
|
632 |
866 |
4.1e-48 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.4%
|
Validation Efficiency |
95% (73/77) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 68 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
AAdacl4fm3 |
C |
T |
4: 144,429,766 (GRCm39) |
V408I |
probably benign |
Het |
Ablim1 |
T |
A |
19: 57,204,285 (GRCm39) |
R35S |
probably benign |
Het |
Acacb |
A |
T |
5: 114,367,912 (GRCm39) |
I1637F |
probably benign |
Het |
Adamts18 |
A |
T |
8: 114,499,709 (GRCm39) |
C402S |
probably damaging |
Het |
Adra2b |
T |
A |
2: 127,206,402 (GRCm39) |
D306E |
probably benign |
Het |
Ammecr1l |
C |
T |
18: 31,911,973 (GRCm39) |
T263I |
probably damaging |
Het |
Antxr1 |
T |
C |
6: 87,114,241 (GRCm39) |
I509V |
probably benign |
Het |
Bahcc1 |
A |
G |
11: 120,176,256 (GRCm39) |
E1967G |
probably damaging |
Het |
Brap |
T |
A |
5: 121,817,405 (GRCm39) |
Y337* |
probably null |
Het |
Brca2 |
T |
C |
5: 150,492,603 (GRCm39) |
V3206A |
probably benign |
Het |
Cacna1e |
A |
T |
1: 154,313,069 (GRCm39) |
F1486I |
probably damaging |
Het |
Cbx4 |
A |
G |
11: 118,973,016 (GRCm39) |
Y120H |
probably damaging |
Het |
Ccar2 |
T |
A |
14: 70,388,800 (GRCm39) |
Q137L |
probably benign |
Het |
Ceacam12 |
A |
G |
7: 17,803,299 (GRCm39) |
D235G |
probably damaging |
Het |
Celsr1 |
A |
G |
15: 85,788,215 (GRCm39) |
V2679A |
probably benign |
Het |
Champ1 |
C |
T |
8: 13,928,777 (GRCm39) |
P312S |
probably benign |
Het |
Chst5 |
A |
G |
8: 112,616,828 (GRCm39) |
L264S |
probably damaging |
Het |
Cip2a |
A |
G |
16: 48,817,863 (GRCm39) |
S78G |
probably benign |
Het |
Colec10 |
T |
A |
15: 54,274,185 (GRCm39) |
F4L |
probably benign |
Het |
Cyp2a4 |
G |
A |
7: 26,008,353 (GRCm39) |
G165D |
probably damaging |
Het |
Cyp2c29 |
G |
C |
19: 39,318,833 (GRCm39) |
A438P |
possibly damaging |
Het |
Dlat |
A |
G |
9: 50,555,439 (GRCm39) |
|
probably benign |
Het |
Dmxl2 |
A |
G |
9: 54,294,704 (GRCm39) |
V2457A |
possibly damaging |
Het |
Dnah7a |
A |
G |
1: 53,496,944 (GRCm39) |
M3104T |
possibly damaging |
Het |
Dock8 |
C |
T |
19: 25,099,811 (GRCm39) |
H645Y |
probably damaging |
Het |
Ehbp1l1 |
T |
C |
19: 5,768,459 (GRCm39) |
E948G |
probably benign |
Het |
Eps8l2 |
C |
T |
7: 140,937,537 (GRCm39) |
R384C |
probably damaging |
Het |
Fam174a |
A |
T |
1: 95,252,884 (GRCm39) |
N162I |
probably damaging |
Het |
Fbp2 |
T |
A |
13: 62,984,916 (GRCm39) |
N335I |
probably benign |
Het |
Foxred2 |
C |
A |
15: 77,831,344 (GRCm39) |
G490C |
probably damaging |
Het |
Fyttd1 |
T |
G |
16: 32,719,283 (GRCm39) |
D200E |
probably damaging |
Het |
Gdf15 |
A |
T |
8: 71,082,473 (GRCm39) |
V211E |
possibly damaging |
Het |
Gm6214 |
A |
G |
3: 140,545,107 (GRCm39) |
|
noncoding transcript |
Het |
Havcr2 |
A |
G |
11: 46,347,143 (GRCm39) |
Y40C |
probably damaging |
Het |
Htra1 |
T |
G |
7: 130,563,321 (GRCm39) |
V184G |
probably damaging |
Het |
Hydin |
A |
T |
8: 111,217,308 (GRCm39) |
I1399F |
probably benign |
Het |
Igtp |
T |
C |
11: 58,097,474 (GRCm39) |
L215P |
probably damaging |
Het |
Kctd1 |
T |
C |
18: 15,102,745 (GRCm39) |
E812G |
possibly damaging |
Het |
Lap3 |
T |
C |
5: 45,668,621 (GRCm39) |
|
probably benign |
Het |
Lgalsl2 |
A |
T |
7: 5,362,623 (GRCm39) |
T85S |
probably benign |
Het |
Lrp1b |
C |
A |
2: 40,491,599 (GRCm39) |
A223S |
probably damaging |
Het |
Mtnr1b |
A |
T |
9: 15,774,540 (GRCm39) |
V173E |
probably damaging |
Het |
Nat10 |
A |
C |
2: 103,552,184 (GRCm39) |
|
probably benign |
Het |
Ndfip2 |
T |
A |
14: 105,532,291 (GRCm39) |
V229E |
probably damaging |
Het |
Nefh |
G |
A |
11: 4,891,323 (GRCm39) |
T432M |
probably damaging |
Het |
Nfe2l3 |
A |
G |
6: 51,434,832 (GRCm39) |
Y464C |
probably damaging |
Het |
Nrip1 |
C |
A |
16: 76,090,841 (GRCm39) |
A239S |
probably damaging |
Het |
Olfml2b |
A |
G |
1: 170,490,042 (GRCm39) |
S221G |
probably benign |
Het |
Orc4 |
G |
T |
2: 48,795,559 (GRCm39) |
S389* |
probably null |
Het |
P4hb |
A |
G |
11: 120,462,476 (GRCm39) |
S77P |
probably damaging |
Het |
Pcyt2 |
T |
C |
11: 120,508,623 (GRCm39) |
|
probably null |
Het |
Plagl1 |
T |
C |
10: 13,003,938 (GRCm39) |
|
probably benign |
Het |
Poglut1 |
C |
T |
16: 38,349,957 (GRCm39) |
R272Q |
probably damaging |
Het |
Pramel26 |
T |
A |
4: 143,537,038 (GRCm39) |
Y431F |
probably damaging |
Het |
Rdh5 |
T |
C |
10: 128,750,090 (GRCm39) |
|
probably null |
Het |
Rogdi |
A |
T |
16: 4,831,258 (GRCm39) |
L3* |
probably null |
Het |
Skap1 |
T |
C |
11: 96,472,224 (GRCm39) |
*166Q |
probably null |
Het |
Slc38a4 |
A |
G |
15: 96,897,432 (GRCm39) |
I461T |
probably benign |
Het |
Snx31 |
A |
C |
15: 36,523,601 (GRCm39) |
I360M |
probably damaging |
Het |
Spata22 |
A |
T |
11: 73,227,073 (GRCm39) |
K96* |
probably null |
Het |
Strn3 |
A |
T |
12: 51,690,006 (GRCm39) |
|
probably null |
Het |
Trip12 |
A |
C |
1: 84,736,884 (GRCm39) |
|
probably benign |
Het |
Uggt1 |
A |
T |
1: 36,266,709 (GRCm39) |
|
probably null |
Het |
Upk3a |
A |
C |
15: 84,903,538 (GRCm39) |
D79A |
probably damaging |
Het |
Uts2r |
A |
T |
11: 121,052,105 (GRCm39) |
Y323F |
probably benign |
Het |
Vps13c |
A |
T |
9: 67,810,121 (GRCm39) |
|
probably null |
Het |
Wnt7b |
A |
G |
15: 85,465,575 (GRCm39) |
|
probably benign |
Het |
Zfp410 |
T |
A |
12: 84,384,385 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Vmn2r1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00233:Vmn2r1
|
APN |
3 |
64,012,389 (GRCm39) |
nonsense |
probably null |
|
IGL00335:Vmn2r1
|
APN |
3 |
64,012,809 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL01509:Vmn2r1
|
APN |
3 |
64,010,466 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01641:Vmn2r1
|
APN |
3 |
64,011,924 (GRCm39) |
missense |
probably benign |
0.19 |
IGL01656:Vmn2r1
|
APN |
3 |
63,989,274 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL01927:Vmn2r1
|
APN |
3 |
63,989,105 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02093:Vmn2r1
|
APN |
3 |
64,012,130 (GRCm39) |
missense |
probably benign |
|
IGL02146:Vmn2r1
|
APN |
3 |
64,012,104 (GRCm39) |
missense |
probably benign |
0.39 |
IGL02186:Vmn2r1
|
APN |
3 |
63,989,138 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02320:Vmn2r1
|
APN |
3 |
63,989,180 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL02423:Vmn2r1
|
APN |
3 |
63,997,665 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02709:Vmn2r1
|
APN |
3 |
64,012,355 (GRCm39) |
missense |
probably benign |
0.24 |
R0034:Vmn2r1
|
UTSW |
3 |
63,997,435 (GRCm39) |
missense |
probably damaging |
1.00 |
R0064:Vmn2r1
|
UTSW |
3 |
64,012,209 (GRCm39) |
missense |
possibly damaging |
0.76 |
R0152:Vmn2r1
|
UTSW |
3 |
63,989,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0305:Vmn2r1
|
UTSW |
3 |
63,997,087 (GRCm39) |
missense |
probably damaging |
1.00 |
R0314:Vmn2r1
|
UTSW |
3 |
63,993,980 (GRCm39) |
missense |
probably damaging |
1.00 |
R0317:Vmn2r1
|
UTSW |
3 |
63,989,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0465:Vmn2r1
|
UTSW |
3 |
63,989,180 (GRCm39) |
missense |
possibly damaging |
0.61 |
R1144:Vmn2r1
|
UTSW |
3 |
63,997,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R1163:Vmn2r1
|
UTSW |
3 |
63,994,046 (GRCm39) |
missense |
probably benign |
0.03 |
R1448:Vmn2r1
|
UTSW |
3 |
64,008,734 (GRCm39) |
missense |
probably damaging |
1.00 |
R1491:Vmn2r1
|
UTSW |
3 |
63,997,034 (GRCm39) |
missense |
probably damaging |
1.00 |
R1543:Vmn2r1
|
UTSW |
3 |
63,996,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R1611:Vmn2r1
|
UTSW |
3 |
64,011,958 (GRCm39) |
nonsense |
probably null |
|
R1676:Vmn2r1
|
UTSW |
3 |
63,997,603 (GRCm39) |
nonsense |
probably null |
|
R1727:Vmn2r1
|
UTSW |
3 |
63,989,163 (GRCm39) |
missense |
probably benign |
|
R1851:Vmn2r1
|
UTSW |
3 |
64,008,926 (GRCm39) |
missense |
probably benign |
0.32 |
R3080:Vmn2r1
|
UTSW |
3 |
63,997,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R3790:Vmn2r1
|
UTSW |
3 |
63,994,185 (GRCm39) |
critical splice donor site |
probably null |
|
R4111:Vmn2r1
|
UTSW |
3 |
63,997,176 (GRCm39) |
missense |
probably benign |
0.23 |
R4689:Vmn2r1
|
UTSW |
3 |
64,012,074 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4747:Vmn2r1
|
UTSW |
3 |
63,989,267 (GRCm39) |
missense |
probably benign |
0.00 |
R4970:Vmn2r1
|
UTSW |
3 |
63,997,544 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5033:Vmn2r1
|
UTSW |
3 |
64,012,501 (GRCm39) |
missense |
probably damaging |
1.00 |
R5086:Vmn2r1
|
UTSW |
3 |
63,997,418 (GRCm39) |
missense |
probably benign |
0.00 |
R5112:Vmn2r1
|
UTSW |
3 |
63,997,544 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5385:Vmn2r1
|
UTSW |
3 |
64,008,819 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5629:Vmn2r1
|
UTSW |
3 |
64,012,538 (GRCm39) |
missense |
possibly damaging |
0.87 |
R5762:Vmn2r1
|
UTSW |
3 |
63,997,474 (GRCm39) |
missense |
probably benign |
0.24 |
R5867:Vmn2r1
|
UTSW |
3 |
64,011,990 (GRCm39) |
missense |
probably benign |
|
R6037:Vmn2r1
|
UTSW |
3 |
63,989,150 (GRCm39) |
missense |
probably benign |
0.00 |
R6037:Vmn2r1
|
UTSW |
3 |
63,989,150 (GRCm39) |
missense |
probably benign |
0.00 |
R6290:Vmn2r1
|
UTSW |
3 |
64,012,873 (GRCm39) |
missense |
probably benign |
0.02 |
R6443:Vmn2r1
|
UTSW |
3 |
64,012,374 (GRCm39) |
missense |
possibly damaging |
0.78 |
R6464:Vmn2r1
|
UTSW |
3 |
64,008,766 (GRCm39) |
missense |
probably benign |
|
R6826:Vmn2r1
|
UTSW |
3 |
64,012,567 (GRCm39) |
nonsense |
probably null |
|
R6874:Vmn2r1
|
UTSW |
3 |
64,012,376 (GRCm39) |
missense |
probably damaging |
1.00 |
R6882:Vmn2r1
|
UTSW |
3 |
63,997,529 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6983:Vmn2r1
|
UTSW |
3 |
63,989,118 (GRCm39) |
missense |
probably benign |
|
R7010:Vmn2r1
|
UTSW |
3 |
64,012,146 (GRCm39) |
missense |
probably benign |
0.19 |
R7144:Vmn2r1
|
UTSW |
3 |
63,997,362 (GRCm39) |
missense |
probably damaging |
1.00 |
R7341:Vmn2r1
|
UTSW |
3 |
64,012,877 (GRCm39) |
makesense |
probably null |
|
R7510:Vmn2r1
|
UTSW |
3 |
63,993,922 (GRCm39) |
missense |
probably damaging |
1.00 |
R7557:Vmn2r1
|
UTSW |
3 |
63,997,475 (GRCm39) |
missense |
probably damaging |
0.99 |
R7895:Vmn2r1
|
UTSW |
3 |
63,997,130 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8108:Vmn2r1
|
UTSW |
3 |
64,010,471 (GRCm39) |
missense |
probably damaging |
0.98 |
R8209:Vmn2r1
|
UTSW |
3 |
63,997,199 (GRCm39) |
missense |
possibly damaging |
0.64 |
R8365:Vmn2r1
|
UTSW |
3 |
63,994,034 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8514:Vmn2r1
|
UTSW |
3 |
63,993,942 (GRCm39) |
missense |
probably benign |
0.11 |
R8554:Vmn2r1
|
UTSW |
3 |
63,997,334 (GRCm39) |
missense |
probably damaging |
0.98 |
R8980:Vmn2r1
|
UTSW |
3 |
64,010,501 (GRCm39) |
missense |
|
|
R9140:Vmn2r1
|
UTSW |
3 |
63,997,465 (GRCm39) |
missense |
probably benign |
0.05 |
R9239:Vmn2r1
|
UTSW |
3 |
64,011,959 (GRCm39) |
missense |
probably damaging |
0.99 |
R9441:Vmn2r1
|
UTSW |
3 |
64,012,674 (GRCm39) |
missense |
probably damaging |
1.00 |
R9549:Vmn2r1
|
UTSW |
3 |
63,997,493 (GRCm39) |
missense |
probably benign |
0.17 |
R9771:Vmn2r1
|
UTSW |
3 |
63,997,559 (GRCm39) |
missense |
possibly damaging |
0.79 |
X0065:Vmn2r1
|
UTSW |
3 |
63,997,678 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GACAACTAAGATACCTGCTGCTG -3'
(R):5'- CCTAGAATTCGTGAAGCAGCAAC -3'
Sequencing Primer
(F):5'- GCTGCTGCTTCTACAAAAAGCTG -3'
(R):5'- CTGACAAAGATGATCCCCCTG -3'
|
Posted On |
2017-02-15 |