Incidental Mutation 'R5894:Oas3'
ID 457369
Institutional Source Beutler Lab
Gene Symbol Oas3
Ensembl Gene ENSMUSG00000032661
Gene Name 2'-5' oligoadenylate synthetase 3
Synonyms Oasl10, 2'-5' oligoadenylate synthetase-like 10
MMRRC Submission 043238-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5894 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 120891163-120915726 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 120895019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 990 (P990L)
Ref Sequence ENSEMBL: ENSMUSP00000035588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044833] [ENSMUST00000165820]
AlphaFold Q8VI93
Predicted Effect probably damaging
Transcript: ENSMUST00000044833
AA Change: P990L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: P990L

DomainStartEndE-ValueType
Pfam:OAS1_C 159 341 6.3e-83 PFAM
Pfam:OAS1_C 610 795 3.1e-78 PFAM
Pfam:NTP_transf_2 831 920 4.5e-11 PFAM
Pfam:OAS1_C 954 1136 9e-85 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165820
SMART Domains Protein: ENSMUSP00000125873
Gene: ENSMUSG00000032661

DomainStartEndE-ValueType
Pfam:OAS1_C 1 130 3.8e-53 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200795
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik T A 3: 146,356,680 (GRCm39) E76V probably benign Het
Adcy2 A T 13: 68,773,971 (GRCm39) I1024N probably damaging Het
Agr2 A C 12: 36,045,509 (GRCm39) probably benign Het
Alpk2 T A 18: 65,414,143 (GRCm39) H1991L probably damaging Het
Amotl2 T A 9: 102,602,371 (GRCm39) M448K possibly damaging Het
Ankhd1 T A 18: 36,780,577 (GRCm39) F1876L probably damaging Het
Arl14 T C 3: 69,130,009 (GRCm39) V52A probably benign Het
Atp6v1b2 T A 8: 69,560,218 (GRCm39) probably null Het
Bmal2 A G 6: 146,724,732 (GRCm39) T409A possibly damaging Het
Bpifb4 G A 2: 153,782,852 (GRCm39) R19H possibly damaging Het
Cdh9 T A 15: 16,832,186 (GRCm39) L358I possibly damaging Het
Ces2h T G 8: 105,745,658 (GRCm39) I460M probably benign Het
Cog2 T C 8: 125,272,006 (GRCm39) Y507H probably benign Het
Crlf3 T A 11: 79,948,678 (GRCm39) R256W probably damaging Het
Csdc2 T A 15: 81,832,881 (GRCm39) F96I probably damaging Het
Csk A C 9: 57,535,958 (GRCm39) I264S probably damaging Het
Cyp2c29 G C 19: 39,318,833 (GRCm39) A438P possibly damaging Het
Ddx43 G A 9: 78,324,016 (GRCm39) G449D probably damaging Het
Fbxw18 G T 9: 109,529,235 (GRCm39) A106E possibly damaging Het
Fchsd2 C T 7: 100,840,959 (GRCm39) T156I probably benign Het
Frs2 T A 10: 116,917,011 (GRCm39) probably benign Het
Gm57858 C T 3: 36,074,124 (GRCm39) E342K possibly damaging Het
Grid2ip A T 5: 143,374,666 (GRCm39) T922S probably damaging Het
Grm1 A G 10: 10,955,999 (GRCm39) L95P probably damaging Het
Ift140 T C 17: 25,252,893 (GRCm39) V348A possibly damaging Het
Insr A G 8: 3,224,869 (GRCm39) S200P possibly damaging Het
Ints12 A T 3: 132,804,319 (GRCm39) D102V probably damaging Het
Kank1 A G 19: 25,401,564 (GRCm39) D1057G probably damaging Het
Kng1 T A 16: 22,892,113 (GRCm39) D225E probably benign Het
Lama1 A T 17: 68,086,042 (GRCm39) probably null Het
Lpin2 A G 17: 71,553,929 (GRCm39) D882G probably benign Het
Lrp1b A T 2: 41,388,233 (GRCm39) F464Y probably benign Het
Musk G A 4: 58,373,583 (GRCm39) C836Y probably damaging Het
Mx1 C T 16: 97,255,406 (GRCm39) D216N probably damaging Het
Ndrg3 A T 2: 156,770,698 (GRCm39) N350K probably benign Het
Or4c111 T A 2: 88,844,399 (GRCm39) N3I probably damaging Het
Or4c12b T C 2: 89,647,557 (GRCm39) S296P possibly damaging Het
Or6c2 A G 10: 129,362,357 (GRCm39) D87G probably damaging Het
Otoa T C 7: 120,721,092 (GRCm39) L369P probably damaging Het
Plcg2 A G 8: 118,231,088 (GRCm39) T57A probably damaging Het
Prune2 A T 19: 17,098,755 (GRCm39) T1420S possibly damaging Het
Ptpdc1 A G 13: 48,743,798 (GRCm39) F201S probably damaging Het
Rnf214 A G 9: 45,777,916 (GRCm39) V630A probably damaging Het
Rxrb T A 17: 34,254,718 (GRCm39) I181N probably damaging Het
Scrib T C 15: 75,939,581 (GRCm39) N69S probably damaging Het
Scyl2 A G 10: 89,476,681 (GRCm39) S815P probably benign Het
Sgcd A G 11: 47,246,028 (GRCm39) V58A probably damaging Het
Slc13a3 C T 2: 165,266,543 (GRCm39) V374I probably benign Het
Slc22a4 A T 11: 53,888,341 (GRCm39) I229N probably benign Het
Slc44a5 A G 3: 153,962,210 (GRCm39) Y381C probably damaging Het
Sohlh1 A G 2: 25,734,679 (GRCm39) S205P possibly damaging Het
Spata20 T C 11: 94,374,444 (GRCm39) M308V probably damaging Het
Stag3 T G 5: 138,297,100 (GRCm39) I550R probably damaging Het
Tac2 A G 10: 127,561,971 (GRCm39) E25G possibly damaging Het
Tars2 T C 3: 95,654,964 (GRCm39) probably null Het
Tefm G A 11: 80,031,057 (GRCm39) R60C probably damaging Het
Trem3 T C 17: 48,565,483 (GRCm39) V179A probably benign Het
Trim37 G T 11: 87,092,266 (GRCm39) D692Y probably damaging Het
Trpc4ap T C 2: 155,508,133 (GRCm39) T173A probably benign Het
Unc13c C T 9: 73,600,486 (GRCm39) probably null Het
Usp18 A G 6: 121,238,456 (GRCm39) K201R probably benign Het
Usp35 T A 7: 96,962,284 (GRCm39) Y524F probably damaging Het
Usp53 A G 3: 122,752,734 (GRCm39) F208L probably damaging Het
Vmn1r80 A T 7: 11,927,654 (GRCm39) I255F probably damaging Het
Vstm2a A T 11: 16,211,483 (GRCm39) I98F probably benign Het
Wdfy4 T A 14: 32,855,317 (GRCm39) I766F possibly damaging Het
Wdr17 T A 8: 55,149,335 (GRCm39) Y55F probably damaging Het
Xpot T C 10: 121,449,551 (GRCm39) K172R probably damaging Het
Other mutations in Oas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Oas3 APN 5 120,915,507 (GRCm39) splice site probably benign
IGL01095:Oas3 APN 5 120,910,954 (GRCm39) missense probably damaging 1.00
IGL01835:Oas3 APN 5 120,904,193 (GRCm39) nonsense probably null
IGL02006:Oas3 APN 5 120,907,300 (GRCm39) missense probably benign 0.00
IGL02811:Oas3 APN 5 120,902,387 (GRCm39) missense unknown
IGL03194:Oas3 APN 5 120,897,018 (GRCm39) missense probably damaging 1.00
R0066:Oas3 UTSW 5 120,896,940 (GRCm39) missense probably damaging 1.00
R0195:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0196:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0197:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0445:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0523:Oas3 UTSW 5 120,904,209 (GRCm39) missense unknown
R0592:Oas3 UTSW 5 120,909,214 (GRCm39) missense probably damaging 1.00
R0946:Oas3 UTSW 5 120,907,128 (GRCm39) missense unknown
R1354:Oas3 UTSW 5 120,908,065 (GRCm39) missense possibly damaging 0.94
R1642:Oas3 UTSW 5 120,915,639 (GRCm39) missense possibly damaging 0.90
R1681:Oas3 UTSW 5 120,907,973 (GRCm39) missense probably benign 0.22
R1844:Oas3 UTSW 5 120,898,045 (GRCm39) missense probably damaging 0.99
R1981:Oas3 UTSW 5 120,899,900 (GRCm39) splice site probably benign
R2443:Oas3 UTSW 5 120,915,553 (GRCm39) missense probably benign 0.35
R2902:Oas3 UTSW 5 120,896,982 (GRCm39) missense probably damaging 1.00
R3034:Oas3 UTSW 5 120,909,121 (GRCm39) missense probably damaging 1.00
R4565:Oas3 UTSW 5 120,909,104 (GRCm39) missense probably damaging 1.00
R4692:Oas3 UTSW 5 120,907,420 (GRCm39) missense probably benign 0.03
R4723:Oas3 UTSW 5 120,904,321 (GRCm39) missense unknown
R4812:Oas3 UTSW 5 120,899,212 (GRCm39) unclassified probably benign
R5288:Oas3 UTSW 5 120,895,055 (GRCm39) missense probably damaging 1.00
R5343:Oas3 UTSW 5 120,894,303 (GRCm39) missense possibly damaging 0.70
R5494:Oas3 UTSW 5 120,899,709 (GRCm39) missense unknown
R5688:Oas3 UTSW 5 120,896,867 (GRCm39) missense probably benign 0.31
R5921:Oas3 UTSW 5 120,908,046 (GRCm39) missense probably damaging 1.00
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6066:Oas3 UTSW 5 120,910,989 (GRCm39) missense probably damaging 0.97
R6104:Oas3 UTSW 5 120,899,758 (GRCm39) missense unknown
R6134:Oas3 UTSW 5 120,907,113 (GRCm39) missense unknown
R6255:Oas3 UTSW 5 120,909,295 (GRCm39) missense probably benign 0.04
R6257:Oas3 UTSW 5 120,899,200 (GRCm39) unclassified probably benign
R6776:Oas3 UTSW 5 120,896,939 (GRCm39) missense probably damaging 1.00
R8022:Oas3 UTSW 5 120,895,031 (GRCm39) missense possibly damaging 0.91
R8137:Oas3 UTSW 5 120,915,565 (GRCm39) missense probably benign 0.07
R8967:Oas3 UTSW 5 120,896,907 (GRCm39) missense probably damaging 0.99
R9124:Oas3 UTSW 5 120,912,170 (GRCm39) missense probably damaging 1.00
R9287:Oas3 UTSW 5 120,892,754 (GRCm39) missense probably damaging 1.00
R9661:Oas3 UTSW 5 120,904,230 (GRCm39) missense unknown
R9745:Oas3 UTSW 5 120,899,284 (GRCm39) missense unknown
RF006:Oas3 UTSW 5 120,912,165 (GRCm39) missense probably damaging 1.00
X0024:Oas3 UTSW 5 120,899,793 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTGTTGCCAAACAGACCCGTG -3'
(R):5'- ACGCTAAGGGTCTCTCAGAC -3'

Sequencing Primer
(F):5'- GTCTCCTCTAATGAAATTTACTCAGG -3'
(R):5'- TTCTAAGCTGGCCCACCTGG -3'
Posted On 2017-02-15