Incidental Mutation 'R5897:Or2i1'
ID 457614
Institutional Source Beutler Lab
Gene Symbol Or2i1
Ensembl Gene ENSMUSG00000043827
Gene Name olfactory receptor family 2 subfamily I member 1
Synonyms GA_x6K02T2PSCP-1637650-1636712, MOR256-32P, Olfr94
MMRRC Submission 044096-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5897 (G1)
Quality Score 115
Status Not validated
Chromosome 17
Chromosomal Location 37507697-37508857 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37508151 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 161 (L161Q)
Ref Sequence ENSEMBL: ENSMUSP00000153315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038844] [ENSMUST00000055324] [ENSMUST00000222190]
AlphaFold Q6UAH0
Predicted Effect probably benign
Transcript: ENSMUST00000038844
SMART Domains Protein: ENSMUSP00000035808
Gene: ENSMUSG00000035186

DomainStartEndE-ValueType
UBQ 5 76 8.61e-9 SMART
UBQ 88 158 9.23e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000055324
AA Change: L236Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055232
Gene: ENSMUSG00000043827
AA Change: L236Q

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:7tm_4 105 382 6.5e-39 PFAM
Pfam:7TM_GPCR_Srsx 109 220 2.1e-9 PFAM
Pfam:7tm_1 115 365 3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208047
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208837
Predicted Effect probably damaging
Transcript: ENSMUST00000222190
AA Change: L161Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 97.0%
  • 20x: 90.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,425,032 (GRCm39) T489A possibly damaging Het
Adam3 T C 8: 25,187,244 (GRCm39) T416A probably benign Het
Agbl3 A G 6: 34,780,508 (GRCm39) I494V probably benign Het
Akap9 T C 5: 4,127,904 (GRCm39) S3747P probably benign Het
Arhgef18 G T 8: 3,489,682 (GRCm39) R338L probably damaging Het
Atg16l1 G T 1: 87,713,719 (GRCm39) probably null Het
BC024139 A G 15: 76,010,339 (GRCm39) S56P possibly damaging Het
Ccdc121 T C 5: 31,643,308 (GRCm39) probably benign Het
Ccdc175 T A 12: 72,206,578 (GRCm39) I223L probably benign Het
Cdcp3 A T 7: 130,798,280 (GRCm39) probably null Het
Cep76 T A 18: 67,771,398 (GRCm39) Q78L probably benign Het
Cyp20a1 A C 1: 60,392,220 (GRCm39) N92T probably damaging Het
Cyp2c68 T C 19: 39,700,975 (GRCm39) D281G probably benign Het
Cyp2j12 T C 4: 95,990,279 (GRCm39) N429S probably damaging Het
Dchs2 G A 3: 83,192,717 (GRCm39) V1721I possibly damaging Het
Elovl4 G A 9: 83,672,157 (GRCm39) T54M possibly damaging Het
Fam13b A G 18: 34,587,134 (GRCm39) V542A possibly damaging Het
Gje1 A T 10: 14,592,467 (GRCm39) I105N probably damaging Het
Grm4 G T 17: 27,654,137 (GRCm39) F349L probably benign Het
Hsd17b3 A G 13: 64,236,799 (GRCm39) probably null Het
Khdrbs1 A T 4: 129,614,448 (GRCm39) D368E probably benign Het
Klra10 T A 6: 130,258,792 (GRCm39) R32* probably null Het
Lrrc7 T A 3: 157,869,990 (GRCm39) I644F probably damaging Het
Or2t1 G T 14: 14,328,120 (GRCm38) G3V probably benign Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Pbx3 A T 2: 34,261,920 (GRCm39) S5T probably benign Het
Pcdhb13 T A 18: 37,576,264 (GRCm39) V214E probably benign Het
Pkd1l1 T C 11: 8,829,176 (GRCm39) D1022G probably benign Het
Pla2g4a T A 1: 149,740,899 (GRCm39) K380I probably damaging Het
Prl3b1 A G 13: 27,429,858 (GRCm39) T99A probably benign Het
Prr12 C T 7: 44,692,808 (GRCm39) V1575I probably damaging Het
Ptpn5 C T 7: 46,729,262 (GRCm39) V451I probably benign Het
Rab1a C T 11: 20,168,867 (GRCm39) R51* probably null Het
Skint9 A G 4: 112,271,113 (GRCm39) I99T possibly damaging Het
Tbc1d8 A G 1: 39,431,190 (GRCm39) V394A possibly damaging Het
Tcf20 A T 15: 82,735,984 (GRCm39) C1822* probably null Het
Tdrd6 T A 17: 43,935,768 (GRCm39) D1760V probably damaging Het
Tinag C A 9: 76,952,726 (GRCm39) C86F probably damaging Het
Tmtc2 A T 10: 105,249,459 (GRCm39) N91K probably damaging Het
Tmub1 G A 5: 24,651,925 (GRCm39) T13M probably benign Het
Txn2 G A 15: 77,808,726 (GRCm39) A135V probably benign Het
Ush2a G A 1: 188,553,935 (GRCm39) G3475R probably damaging Het
Usp38 T C 8: 81,732,082 (GRCm39) D276G probably benign Het
Vax1 T A 19: 59,158,233 (GRCm39) I77F unknown Het
Vmn2r108 C T 17: 20,691,580 (GRCm39) M314I probably benign Het
Vmn2r4 C A 3: 64,322,687 (GRCm39) G11* probably null Het
Zcchc14 T C 8: 122,331,899 (GRCm39) probably benign Het
Other mutations in Or2i1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01306:Or2i1 APN 17 37,507,833 (GRCm39) missense probably benign 0.03
IGL01413:Or2i1 APN 17 37,508,554 (GRCm39) missense possibly damaging 0.75
ANU23:Or2i1 UTSW 17 37,507,833 (GRCm39) missense probably benign 0.03
R1822:Or2i1 UTSW 17 37,507,722 (GRCm39) unclassified probably benign
R4731:Or2i1 UTSW 17 37,507,915 (GRCm39) missense probably damaging 0.98
R4732:Or2i1 UTSW 17 37,507,915 (GRCm39) missense probably damaging 0.98
R4733:Or2i1 UTSW 17 37,507,915 (GRCm39) missense probably damaging 0.98
R7894:Or2i1 UTSW 17 37,508,047 (GRCm39) missense probably damaging 1.00
R8716:Or2i1 UTSW 17 37,508,299 (GRCm39) missense possibly damaging 0.93
R8928:Or2i1 UTSW 17 37,507,861 (GRCm39) missense probably damaging 0.99
R9021:Or2i1 UTSW 17 37,508,380 (GRCm39) missense possibly damaging 0.88
R9594:Or2i1 UTSW 17 37,508,308 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- TAAAATAGGCAGACCGCGGTC -3'
(R):5'- ATGGCTCAGCTGTGCTCATC -3'

Sequencing Primer
(F):5'- TGAGAGCCACATGTGCTCG -3'
(R):5'- TCAGCTGTGCTCATCGCTGG -3'
Posted On 2017-02-15