Incidental Mutation 'R5898:Fkbp15'
ID 457641
Institutional Source Beutler Lab
Gene Symbol Fkbp15
Ensembl Gene ENSMUSG00000066151
Gene Name FK506 binding protein 15
Synonyms C430014M02Rik, FKBP133
MMRRC Submission 044097-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5898 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 62218579-62278785 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 62244294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084527] [ENSMUST00000084528] [ENSMUST00000098033] [ENSMUST00000107461]
AlphaFold Q6P9Q6
Predicted Effect probably null
Transcript: ENSMUST00000084527
SMART Domains Protein: ENSMUSP00000081575
Gene: ENSMUSG00000066151

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 4.8e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 1.88e-10 PROSPERO
internal_repeat_1 472 500 1.88e-10 PROSPERO
coiled coil region 560 662 N/A INTRINSIC
coiled coil region 684 790 N/A INTRINSIC
coiled coil region 816 865 N/A INTRINSIC
coiled coil region 916 943 N/A INTRINSIC
low complexity region 952 964 N/A INTRINSIC
low complexity region 983 994 N/A INTRINSIC
low complexity region 1034 1045 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000084528
SMART Domains Protein: ENSMUSP00000081576
Gene: ENSMUSG00000066151

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 2.4e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 2.74e-10 PROSPERO
internal_repeat_1 472 500 2.74e-10 PROSPERO
coiled coil region 560 662 N/A INTRINSIC
coiled coil region 684 745 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098033
SMART Domains Protein: ENSMUSP00000095641
Gene: ENSMUSG00000066151

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 1.9e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 1.79e-8 PROSPERO
internal_repeat_1 472 500 1.79e-8 PROSPERO
coiled coil region 560 608 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000107461
SMART Domains Protein: ENSMUSP00000103085
Gene: ENSMUSG00000066151

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 2e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 1.86e-8 PROSPERO
internal_repeat_1 472 500 1.86e-8 PROSPERO
coiled coil region 560 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139308
Meta Mutation Damage Score 0.9495 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.8%
Validation Efficiency 96% (86/90)
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik G T 10: 100,448,762 (GRCm39) R158L possibly damaging Het
1700017N19Rik G A 10: 100,451,070 (GRCm39) M179I probably benign Het
Abhd12 T C 2: 150,681,698 (GRCm39) I231V possibly damaging Het
Adsl A G 15: 80,845,554 (GRCm39) probably null Het
Ahnak C A 19: 8,991,131 (GRCm39) N4138K possibly damaging Het
Ahnak T C 19: 8,995,575 (GRCm39) S5620P probably damaging Het
Akap13 C T 7: 75,378,894 (GRCm39) T2145I probably damaging Het
Alpk2 T A 18: 65,440,694 (GRCm39) Q700L probably damaging Het
Apobec1 T C 6: 122,557,732 (GRCm39) Y159C probably damaging Het
Atg9a T C 1: 75,162,916 (GRCm39) T395A probably damaging Het
Atp6v1f A G 6: 29,467,957 (GRCm39) I48V probably benign Het
BC051665 A C 13: 60,930,518 (GRCm39) V278G probably damaging Het
Bicd1 A T 6: 149,415,201 (GRCm39) H638L probably damaging Het
Cacna2d4 A G 6: 119,251,192 (GRCm39) Y460C probably damaging Het
Ccdc157 C A 11: 4,094,538 (GRCm39) R496L probably benign Het
Cdcp3 T G 7: 130,843,696 (GRCm39) probably null Het
Cep44 C G 8: 56,994,056 (GRCm39) V174L probably damaging Het
Clca3a1 G T 3: 144,722,522 (GRCm39) F283L possibly damaging Het
Csk T C 9: 57,537,585 (GRCm39) T110A probably benign Het
Cspg4 T A 9: 56,792,506 (GRCm39) probably null Het
Cutc A G 19: 43,748,468 (GRCm39) I124V probably benign Het
Cyp2d9 A G 15: 82,339,725 (GRCm39) T104A probably benign Het
Cyp2j9 G T 4: 96,465,951 (GRCm39) T294K probably benign Het
D630003M21Rik T A 2: 158,046,577 (GRCm39) probably null Het
Dcaf15 G T 8: 84,825,081 (GRCm39) F450L probably damaging Het
Ddhd1 A T 14: 45,840,125 (GRCm39) I723K probably damaging Het
Dnah17 C T 11: 118,005,039 (GRCm39) A782T probably benign Het
Dnah3 T C 7: 119,677,724 (GRCm39) D399G probably benign Het
Dync2h1 T C 9: 7,148,717 (GRCm39) N909S probably benign Het
Erbin A G 13: 103,975,813 (GRCm39) probably null Het
Fanci G A 7: 79,083,069 (GRCm39) V682I probably benign Het
Fap A T 2: 62,403,847 (GRCm39) F9L probably benign Het
Fat3 T C 9: 15,849,757 (GRCm39) I3882V probably benign Het
Fsd2 T C 7: 81,186,975 (GRCm39) Y601C probably damaging Het
Gm5900 T C 7: 104,599,468 (GRCm39) noncoding transcript Het
Gramd4 G T 15: 85,984,985 (GRCm39) G82V probably damaging Het
Hc C T 2: 34,887,449 (GRCm39) V1352I probably benign Het
Hsph1 A T 5: 149,548,623 (GRCm39) N466K probably damaging Het
Ice2 T A 9: 69,315,544 (GRCm39) D133E probably benign Het
Ifi213 T C 1: 173,396,545 (GRCm39) M510V probably benign Het
Itpkb T G 1: 180,248,880 (GRCm39) L861R probably damaging Het
Kbtbd3 T A 9: 4,330,476 (GRCm39) D283E probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Masp1 T A 16: 23,310,677 (GRCm39) I252F probably damaging Het
Megf11 G T 9: 64,593,246 (GRCm39) C586F probably damaging Het
Myh2 C A 11: 67,083,545 (GRCm39) A1476E possibly damaging Het
Myo18b A T 5: 112,950,196 (GRCm39) probably null Het
Naip6 A T 13: 100,435,829 (GRCm39) V898E possibly damaging Het
Nav1 T C 1: 135,512,884 (GRCm39) M59V probably benign Het
Nlrp3 A T 11: 59,437,678 (GRCm39) Y119F probably benign Het
Oxa1l T A 14: 54,600,758 (GRCm39) I77N possibly damaging Het
Pcdhb8 T A 18: 37,490,537 (GRCm39) D738E possibly damaging Het
Pdia5 A T 16: 35,243,335 (GRCm39) W269R probably damaging Het
Peak1 T A 9: 56,114,622 (GRCm39) T1440S probably benign Het
Piezo1 A G 8: 123,214,682 (GRCm39) V1547A probably benign Het
Pkp1 T C 1: 135,810,259 (GRCm39) Y437C probably damaging Het
Pla2r1 T C 2: 60,253,104 (GRCm39) D1329G probably damaging Het
Ppip5k2 T C 1: 97,671,887 (GRCm39) probably benign Het
Prrg4 C T 2: 104,675,378 (GRCm39) S75N probably benign Het
Psmb9 T A 17: 34,401,266 (GRCm39) I198F probably damaging Het
Rcbtb2 T A 14: 73,399,405 (GRCm39) L23* probably null Het
Sbno1 A T 5: 124,524,854 (GRCm39) probably benign Het
Scn3a T C 2: 65,345,039 (GRCm39) E483G probably damaging Het
Sdccag8 T A 1: 176,652,388 (GRCm39) D46E probably benign Het
Selenov A G 7: 27,987,579 (GRCm39) F293L probably damaging Het
Septin2 A C 1: 93,407,023 (GRCm39) D20A probably benign Het
Shc1 T A 3: 89,334,274 (GRCm39) Y313* probably null Het
Siglec1 T A 2: 130,915,553 (GRCm39) Y1346F probably damaging Het
Slc22a5 T A 11: 53,764,559 (GRCm39) I296F probably damaging Het
Slc9c1 A G 16: 45,365,123 (GRCm39) N152S probably damaging Het
Smoc1 C T 12: 81,151,531 (GRCm39) R83* probably null Het
Ssx2ip A G 3: 146,133,586 (GRCm39) D227G possibly damaging Het
Tbrg4 T C 11: 6,567,372 (GRCm39) D576G probably damaging Het
Tbx20 T A 9: 24,670,155 (GRCm39) Y226F probably damaging Het
Trav10d G T 14: 53,048,929 (GRCm39) A107S probably damaging Het
Trim60 A T 8: 65,453,016 (GRCm39) L411* probably null Het
Ttbk2 A T 2: 120,575,521 (GRCm39) V1083D probably benign Het
Unc93a T A 17: 13,344,464 (GRCm39) Q26L probably damaging Het
Usp14 T A 18: 10,022,819 (GRCm39) N65I possibly damaging Het
Vip A T 10: 5,593,988 (GRCm39) S114C probably damaging Het
Vmn1r237 A T 17: 21,534,813 (GRCm39) I179F probably damaging Het
Wdr47 T A 3: 108,545,201 (GRCm39) probably null Het
Zfp975 A T 7: 42,311,963 (GRCm39) C217S probably damaging Het
Other mutations in Fkbp15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00659:Fkbp15 APN 4 62,251,917 (GRCm39) splice site probably benign
IGL01326:Fkbp15 APN 4 62,241,487 (GRCm39) missense probably damaging 0.98
IGL01822:Fkbp15 APN 4 62,270,741 (GRCm39) missense probably benign
IGL01925:Fkbp15 APN 4 62,241,450 (GRCm39) missense probably damaging 1.00
IGL02190:Fkbp15 APN 4 62,223,059 (GRCm39) missense possibly damaging 0.69
IGL02276:Fkbp15 APN 4 62,254,703 (GRCm39) nonsense probably null
IGL02310:Fkbp15 APN 4 62,258,553 (GRCm39) missense probably damaging 1.00
IGL02954:Fkbp15 APN 4 62,239,302 (GRCm39) splice site probably benign
IGL02967:Fkbp15 APN 4 62,222,627 (GRCm39) missense probably damaging 0.96
IGL03136:Fkbp15 APN 4 62,258,466 (GRCm39) splice site probably benign
IGL03185:Fkbp15 APN 4 62,250,423 (GRCm39) splice site probably null
IGL03280:Fkbp15 APN 4 62,221,504 (GRCm39) unclassified probably benign
dura UTSW 4 62,242,363 (GRCm39) missense probably damaging 0.96
mater UTSW 4 62,244,373 (GRCm39) missense probably benign 0.22
R0419:Fkbp15 UTSW 4 62,244,373 (GRCm39) missense probably benign 0.22
R0838:Fkbp15 UTSW 4 62,242,363 (GRCm39) missense probably damaging 0.96
R1241:Fkbp15 UTSW 4 62,222,846 (GRCm39) missense possibly damaging 0.87
R1394:Fkbp15 UTSW 4 62,246,109 (GRCm39) missense probably benign 0.00
R1622:Fkbp15 UTSW 4 62,241,439 (GRCm39) missense possibly damaging 0.94
R1682:Fkbp15 UTSW 4 62,242,431 (GRCm39) missense probably damaging 0.98
R1823:Fkbp15 UTSW 4 62,255,328 (GRCm39) missense probably damaging 1.00
R1994:Fkbp15 UTSW 4 62,222,618 (GRCm39) missense probably benign 0.00
R2132:Fkbp15 UTSW 4 62,246,136 (GRCm39) missense probably damaging 1.00
R2133:Fkbp15 UTSW 4 62,246,136 (GRCm39) missense probably damaging 1.00
R2425:Fkbp15 UTSW 4 62,230,602 (GRCm39) missense probably benign 0.00
R2938:Fkbp15 UTSW 4 62,222,900 (GRCm39) missense probably benign 0.23
R3034:Fkbp15 UTSW 4 62,225,129 (GRCm39) splice site probably null
R3957:Fkbp15 UTSW 4 62,252,489 (GRCm39) missense probably benign 0.01
R3963:Fkbp15 UTSW 4 62,258,914 (GRCm39) missense probably damaging 1.00
R4235:Fkbp15 UTSW 4 62,254,693 (GRCm39) missense probably benign 0.38
R4334:Fkbp15 UTSW 4 62,221,456 (GRCm39) missense possibly damaging 0.95
R4366:Fkbp15 UTSW 4 62,254,651 (GRCm39) missense probably benign 0.38
R4717:Fkbp15 UTSW 4 62,226,306 (GRCm39) missense probably damaging 1.00
R4790:Fkbp15 UTSW 4 62,226,234 (GRCm39) missense probably benign 0.05
R5075:Fkbp15 UTSW 4 62,239,266 (GRCm39) missense probably damaging 0.96
R5176:Fkbp15 UTSW 4 62,230,560 (GRCm39) missense possibly damaging 0.68
R5419:Fkbp15 UTSW 4 62,246,114 (GRCm39) missense probably damaging 0.98
R5503:Fkbp15 UTSW 4 62,246,124 (GRCm39) missense probably benign 0.05
R5731:Fkbp15 UTSW 4 62,225,166 (GRCm39) missense probably benign 0.01
R5733:Fkbp15 UTSW 4 62,225,166 (GRCm39) missense probably benign 0.01
R5820:Fkbp15 UTSW 4 62,263,783 (GRCm39) missense probably benign 0.00
R5878:Fkbp15 UTSW 4 62,225,145 (GRCm39) missense probably benign
R5914:Fkbp15 UTSW 4 62,246,047 (GRCm39) splice site probably null
R6113:Fkbp15 UTSW 4 62,258,884 (GRCm39) missense probably benign 0.38
R6377:Fkbp15 UTSW 4 62,242,429 (GRCm39) missense probably damaging 1.00
R6427:Fkbp15 UTSW 4 62,241,439 (GRCm39) missense probably benign 0.01
R6464:Fkbp15 UTSW 4 62,226,315 (GRCm39) missense possibly damaging 0.92
R6528:Fkbp15 UTSW 4 62,250,507 (GRCm39) missense probably damaging 1.00
R6790:Fkbp15 UTSW 4 62,222,996 (GRCm39) missense probably benign 0.01
R6880:Fkbp15 UTSW 4 62,254,732 (GRCm39) missense possibly damaging 0.71
R6911:Fkbp15 UTSW 4 62,258,527 (GRCm39) missense probably damaging 1.00
R7371:Fkbp15 UTSW 4 62,239,293 (GRCm39) missense possibly damaging 0.89
R7410:Fkbp15 UTSW 4 62,258,536 (GRCm39) missense probably damaging 1.00
R7660:Fkbp15 UTSW 4 62,232,578 (GRCm39) missense probably benign 0.08
R7992:Fkbp15 UTSW 4 62,230,538 (GRCm39) missense probably damaging 1.00
R8486:Fkbp15 UTSW 4 62,230,521 (GRCm39) nonsense probably null
R8697:Fkbp15 UTSW 4 62,239,295 (GRCm39) nonsense probably null
R8880:Fkbp15 UTSW 4 62,232,602 (GRCm39) missense probably benign
R8998:Fkbp15 UTSW 4 62,242,365 (GRCm39) missense probably damaging 1.00
R9236:Fkbp15 UTSW 4 62,254,664 (GRCm39) missense probably damaging 0.97
R9382:Fkbp15 UTSW 4 62,237,210 (GRCm39) missense probably damaging 0.99
R9654:Fkbp15 UTSW 4 62,230,553 (GRCm39) missense probably benign 0.01
X0013:Fkbp15 UTSW 4 62,230,607 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- TCACTAAAGGGCTGGTGGGAG -3'
(R):5'- CCCTGGTTAATGTGCTTTGC -3'

Sequencing Primer
(F):5'- AGGTGATTCCTGAAAGCTCC -3'
(R):5'- GTGCTTTGCTCTATCACAGGAAAC -3'
Posted On 2017-02-15