Incidental Mutation 'R5899:Morn3'
ID 457725
Institutional Source Beutler Lab
Gene Symbol Morn3
Ensembl Gene ENSMUSG00000029477
Gene Name MORN repeat containing 3
Synonyms 4930438O03Rik
MMRRC Submission 044098-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R5899 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 123173832-123185079 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 123179166 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 95 (W95R)
Ref Sequence ENSEMBL: ENSMUSP00000122306 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031437] [ENSMUST00000045843] [ENSMUST00000132775] [ENSMUST00000145257]
AlphaFold Q8C5T4
Predicted Effect probably damaging
Transcript: ENSMUST00000031437
AA Change: W95R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: W95R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 1.15e-4 SMART
MORN 158 179 2.57e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000045843
AA Change: W95R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
AA Change: W95R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129934
Predicted Effect probably damaging
Transcript: ENSMUST00000132775
AA Change: W95R

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
AA Change: W95R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000137490
Predicted Effect probably damaging
Transcript: ENSMUST00000145257
AA Change: W95R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
AA Change: W95R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197455
Meta Mutation Damage Score 0.9486 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.5%
Validation Efficiency 93% (56/60)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 T C 10: 20,876,465 (GRCm39) I792T probably benign Het
Anks1b T A 10: 90,759,379 (GRCm39) probably null Het
Ano3 T G 2: 110,693,232 (GRCm39) D122A probably benign Het
Atp12a T C 14: 56,610,801 (GRCm39) V315A probably benign Het
B230104I21Rik G T 4: 154,433,986 (GRCm39) G57* probably null Het
Bpifb2 A G 2: 153,733,050 (GRCm39) K378E probably damaging Het
Cdk5rap2 T C 4: 70,161,830 (GRCm39) probably benign Het
Ceacam23 A G 7: 17,651,369 (GRCm39) D840G possibly damaging Het
Cflar A G 1: 58,791,927 (GRCm39) D410G probably benign Het
Clcn6 A G 4: 148,102,049 (GRCm39) V345A probably benign Het
Cnga1 C T 5: 72,776,404 (GRCm39) V20I possibly damaging Het
Ddx50 T A 10: 62,476,596 (GRCm39) K226* probably null Het
Dnah5 T C 15: 28,448,513 (GRCm39) V4192A possibly damaging Het
Dnah8 G A 17: 30,875,659 (GRCm39) D494N probably benign Het
Dock7 A T 4: 98,879,660 (GRCm39) C965S probably benign Het
Dst C T 1: 34,334,370 (GRCm39) A5083V probably damaging Het
E130208F15Rik T C 7: 30,021,726 (GRCm39) Q10R probably damaging Het
Fbxw15 T C 9: 109,384,741 (GRCm39) probably null Het
Fxr2 A G 11: 69,543,511 (GRCm39) N671D probably damaging Het
Gbp7 A G 3: 142,252,303 (GRCm39) T629A probably benign Het
Grm1 T C 10: 10,565,092 (GRCm39) Y1072C probably benign Het
Hmcn2 A T 2: 31,244,685 (GRCm39) E714V possibly damaging Het
Hsd17b13 T A 5: 104,113,730 (GRCm39) E205D probably benign Het
Igf2bp3 A G 6: 49,094,084 (GRCm39) probably benign Het
Il2ra A G 2: 11,689,248 (GRCm39) H259R probably benign Het
Klk15 G T 7: 43,588,247 (GRCm39) R185L probably benign Het
Map3k11 T G 19: 5,745,937 (GRCm39) probably null Het
Nipbl A G 15: 8,364,328 (GRCm39) probably null Het
Nrap A T 19: 56,329,006 (GRCm39) V1145D possibly damaging Het
Or1e35 A G 11: 73,797,755 (GRCm39) S188P probably damaging Het
Or2l13b C T 16: 19,349,551 (GRCm39) G40R probably damaging Het
Or9k2 T A 10: 129,998,542 (GRCm39) I218F probably benign Het
Pdcd11 A G 19: 47,093,198 (GRCm39) N492S possibly damaging Het
Ptgfr C T 3: 151,540,738 (GRCm39) V257I probably damaging Het
Racgap1 T C 15: 99,521,509 (GRCm39) E549G possibly damaging Het
Rfx3 T C 19: 27,808,165 (GRCm39) T193A probably damaging Het
Rplp0 T A 5: 115,699,489 (GRCm39) I149N probably benign Het
Samd7 T G 3: 30,810,883 (GRCm39) I300S probably benign Het
Scpep1 A G 11: 88,825,402 (GRCm39) probably null Het
Senp6 T C 9: 80,049,352 (GRCm39) probably benign Het
Serpinb2 G T 1: 107,447,446 (GRCm39) G78V probably damaging Het
Sesn1 T C 10: 41,687,189 (GRCm39) S58P probably benign Het
Skic3 A G 13: 76,259,938 (GRCm39) probably null Het
Spg11 T C 2: 121,928,680 (GRCm39) D591G possibly damaging Het
Spire2 A C 8: 124,080,833 (GRCm39) S26R probably damaging Het
Strip2 T A 6: 29,956,957 (GRCm39) probably benign Het
Ttn G A 2: 76,697,519 (GRCm39) probably benign Het
Vmn2r77 A G 7: 86,460,924 (GRCm39) Y750C probably damaging Het
Wnt11 T A 7: 98,488,383 (GRCm39) Y23* probably null Het
Zbp1 T A 2: 173,052,340 (GRCm39) D272V probably benign Het
Other mutations in Morn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Morn3 APN 5 123,184,825 (GRCm39) missense probably damaging 1.00
IGL02257:Morn3 APN 5 123,175,788 (GRCm39) missense probably damaging 1.00
IGL02516:Morn3 APN 5 123,175,363 (GRCm39) nonsense probably null
R0052:Morn3 UTSW 5 123,184,726 (GRCm39) missense probably damaging 1.00
R0052:Morn3 UTSW 5 123,184,726 (GRCm39) missense probably damaging 1.00
R0433:Morn3 UTSW 5 123,177,396 (GRCm39) missense probably benign 0.01
R1854:Morn3 UTSW 5 123,184,692 (GRCm39) critical splice donor site probably null
R4893:Morn3 UTSW 5 123,175,745 (GRCm39) missense probably damaging 1.00
R5854:Morn3 UTSW 5 123,179,178 (GRCm39) missense probably damaging 1.00
R5983:Morn3 UTSW 5 123,175,851 (GRCm39) missense possibly damaging 0.80
R6106:Morn3 UTSW 5 123,184,823 (GRCm39) missense possibly damaging 0.83
R6766:Morn3 UTSW 5 123,179,270 (GRCm39) missense probably damaging 0.98
R7512:Morn3 UTSW 5 123,175,343 (GRCm39) critical splice donor site probably null
R8722:Morn3 UTSW 5 123,179,177 (GRCm39) missense probably damaging 1.00
R8780:Morn3 UTSW 5 123,175,825 (GRCm39) missense probably damaging 1.00
R9782:Morn3 UTSW 5 123,175,822 (GRCm39) missense probably damaging 1.00
Z1177:Morn3 UTSW 5 123,184,783 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TTGAAAAGCACTACAGTCCCTC -3'
(R):5'- CTGTTCAGGGCAGAGATTCC -3'

Sequencing Primer
(F):5'- AGCACTACAGTCCCTCCCTCC -3'
(R):5'- CATGTGGCTTCCAGCTTCAGG -3'
Posted On 2017-02-15