Mutagenetix > Incidental Mutation

Incidental Mutation 'R5888:Olfr938'

457804

Institutional Source

Beutler Lab

Gene Symbol

Olfr938

Ensembl Gene

ENSMUSG00000048501

Gene Name

olfactory receptor 938

Synonyms

GA_x6K02T2PVTD-32774646-32773699, MOR171-25

MMRRC Submission

044089-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R5888 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

39077698-39078887 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 39077967 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 259 (Y259*)

Ref Sequence

ENSEMBL: ENSMUSP00000055053 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056499]

AlphaFold

Q9EQ93

Predicted Effect

probably null
Transcript: ENSMUST00000056499
AA Change: Y259*

SMART Domains

Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: Y259*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8e-49	PFAM
Pfam:7tm_1	41	290	5.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175411

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215888

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.9%

Validation Efficiency

94% (96/102)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700029P11Rik	T	C	15: 81,980,671 (GRCm38)	S38P	probably benign	Het
Adcy1	T	A	11: 7,139,095 (GRCm38)	V503E	possibly damaging	Het
Alk	C	A	17: 71,874,943 (GRCm38)	V1362L	probably damaging	Het
Ankrd55	T	A	13: 112,355,919 (GRCm38)	I208N	possibly damaging	Het
Asap2	T	A	12: 21,218,190 (GRCm38)	I319N	probably damaging	Het
Atp11b	T	C	3: 35,837,547 (GRCm38)	I1036T	probably benign	Het
B4gat1	T	C	19: 5,039,532 (GRCm38)	F186L	probably benign	Het
C3	T	A	17: 57,214,831 (GRCm38)	T1079S	probably damaging	Het
Cacul1	G	T	19: 60,537,464 (GRCm38)	T287K	possibly damaging	Het
Cbr3	G	C	16: 93,690,726 (GRCm38)	G266R	probably damaging	Het
Cd63	T	A	10: 128,912,291 (GRCm38)		probably null	Het
Chd7	G	A	4: 8,866,382 (GRCm38)	M851I	probably damaging	Het
Chst13	T	A	6: 90,309,572 (GRCm38)	H136L	probably benign	Het
Cyp2d22	T	C	15: 82,373,813 (GRCm38)	T179A	probably benign	Het
Dclre1b	A	T	3: 103,803,737 (GRCm38)	V286E	probably damaging	Het
Defb45	G	A	2: 152,593,234 (GRCm38)		probably benign	Het
Dlg1	T	C	16: 31,791,886 (GRCm38)		probably null	Het
Dock3	A	G	9: 107,023,803 (GRCm38)	V321A	probably benign	Het
Dytn	A	T	1: 63,677,237 (GRCm38)	V59E	possibly damaging	Het
Eif2ak1	A	G	5: 143,886,915 (GRCm38)	I393M	probably damaging	Het
Fam83g	A	T	11: 61,702,594 (GRCm38)	E318V	probably benign	Het
Fbxo34	T	A	14: 47,529,719 (GRCm38)	F179I	probably damaging	Het
Fmo5	T	A	3: 97,641,725 (GRCm38)	Y230N	probably benign	Het
Fzd9	T	G	5: 135,249,463 (GRCm38)		probably null	Het
Gata2	T	C	6: 88,200,740 (GRCm38)	S251P	probably benign	Het
Gigyf1	A	G	5: 137,525,697 (GRCm38)	D1043G	probably damaging	Het
Gm10260	G	A	13: 97,760,393 (GRCm38)	R66*	probably null	Het
Gm10322	T	A	10: 59,616,303 (GRCm38)	S81T	probably benign	Het
Gm11639	T	C	11: 104,721,401 (GRCm38)		probably benign	Het
Gm15517	A	T	7: 44,260,642 (GRCm38)		probably benign	Het
Haus4	T	C	14: 54,544,219 (GRCm38)	T232A	probably benign	Het
Hgfac	A	T	5: 35,045,407 (GRCm38)	H417L	probably damaging	Het
Iqgap2	T	C	13: 95,635,610 (GRCm38)	K1354E	possibly damaging	Het
Kcnk12	C	A	17: 87,746,649 (GRCm38)	R195L	probably benign	Het
Kcnn2	A	T	18: 45,592,345 (GRCm38)	I303F	probably damaging	Het
Kcnt1	T	C	2: 25,908,110 (GRCm38)	F879S	probably damaging	Het
Kndc1	T	C	7: 139,895,217 (GRCm38)	F11L	probably benign	Het
Kpna7	A	G	5: 144,989,795 (GRCm38)	F449S	probably damaging	Het
Krt77	G	T	15: 101,865,453 (GRCm38)	N255K	probably benign	Het
Lair1	A	T	7: 4,010,845 (GRCm38)	D134E	probably damaging	Het
Loxhd1	T	C	18: 77,402,515 (GRCm38)	V1318A	probably damaging	Het
March10	A	T	11: 105,402,146 (GRCm38)	V145D	possibly damaging	Het
Mcpt1	T	A	14: 56,019,512 (GRCm38)	M169K	probably benign	Het
Mdc1	T	A	17: 35,847,820 (GRCm38)	V364E	probably benign	Het
Mfsd11	T	C	11: 116,871,384 (GRCm38)	F270S	probably damaging	Het
Mfsd4b2	T	G	10: 39,922,035 (GRCm38)	D108A	probably benign	Het
Mink1	A	T	11: 70,610,059 (GRCm38)		probably benign	Het
Mmp25	T	C	17: 23,631,074 (GRCm38)	Y504C	probably damaging	Het
Ms4a13	C	T	19: 11,191,506 (GRCm38)	V52I	probably benign	Het
Msh4	C	T	3: 153,867,723 (GRCm38)		probably null	Het
Muc5b	T	G	7: 141,858,421 (GRCm38)	S1701R	unknown	Het
Naalad2	A	T	9: 18,330,641 (GRCm38)	S656T	probably benign	Het
Ncapd2	T	C	6: 125,187,089 (GRCm38)	Y64C	probably damaging	Het
Ncapg2	T	A	12: 116,425,800 (GRCm38)	S347T	possibly damaging	Het
Nipal4	T	C	11: 46,151,339 (GRCm38)	T172A	probably damaging	Het
Nrros	T	C	16: 32,143,087 (GRCm38)	K652R	probably benign	Het
Nrxn3	G	T	12: 89,512,085 (GRCm38)	A983S	possibly damaging	Het
Olfr1084	A	C	2: 86,639,144 (GRCm38)	L188R	probably damaging	Het
Olfr1187-ps1	T	C	2: 88,540,244 (GRCm38)		noncoding transcript	Het
Olfr1220	T	A	2: 89,097,925 (GRCm38)	M1L	probably damaging	Het
Olfr1249	T	A	2: 89,630,799 (GRCm38)	Y33F	probably damaging	Het
Olfr1283	T	C	2: 111,368,743 (GRCm38)	M37T	probably benign	Het
Olfr631	A	G	7: 103,929,032 (GRCm38)	T70A	possibly damaging	Het
P2rx4	T	G	5: 122,727,208 (GRCm38)	Y299D	probably damaging	Het
P2rx4	T	A	5: 122,719,165 (GRCm38)	S155T	probably benign	Het
Pcsk6	A	T	7: 66,043,624 (GRCm38)	L7F	probably null	Het
Pdss2	T	C	10: 43,221,797 (GRCm38)		silent	Het
Pfkl	A	G	10: 77,991,370 (GRCm38)	V494A	possibly damaging	Het
Prep	G	T	10: 45,067,364 (GRCm38)	D12Y	possibly damaging	Het
Prg4	A	G	1: 150,452,350 (GRCm38)	F188S	probably damaging	Het
Ripor3	T	C	2: 167,997,287 (GRCm38)	Y98C	probably damaging	Het
Rnf216	T	A	5: 143,068,314 (GRCm38)		probably null	Het
Rnf24	A	G	2: 131,322,245 (GRCm38)		probably benign	Het
Scn3a	A	G	2: 65,497,398 (GRCm38)	M916T	probably benign	Het
Scnm1	T	C	3: 95,130,285 (GRCm38)	I157V	probably benign	Het
Sh2b3	C	G	5: 121,829,021 (GRCm38)	R10P	possibly damaging	Het
Slc25a27	T	C	17: 43,649,694 (GRCm38)	D211G	probably damaging	Het
Slc36a4	A	T	9: 15,727,028 (GRCm38)	Y250F	probably damaging	Het
Slc4a1	T	A	11: 102,356,525 (GRCm38)	E448V	probably damaging	Het
Slit1	C	A	19: 41,743,296 (GRCm38)	C38F	probably damaging	Het
Spock3	T	A	8: 63,355,300 (GRCm38)	N410K	unknown	Het
Supt20	G	T	3: 54,712,207 (GRCm38)	W370L	probably benign	Het
Tas2r139	T	A	6: 42,141,496 (GRCm38)	N187K	probably damaging	Het
Tbc1d9b	G	A	11: 50,140,484 (GRCm38)	V111I	probably benign	Het
Thsd7b	T	A	1: 130,210,320 (GRCm38)	Y1578*	probably null	Het
Tln2	T	A	9: 67,229,403 (GRCm38)	I1267F	probably damaging	Het
Tnk2	G	A	16: 32,671,367 (GRCm38)	V363I	probably damaging	Het
Ttc32	A	G	12: 9,035,870 (GRCm38)	K139R	possibly damaging	Het
Vmn1r30	G	C	6: 58,435,565 (GRCm38)	T94S	possibly damaging	Het
Vmn1r90	G	A	7: 14,561,855 (GRCm38)	T106I	probably damaging	Het
Zfp677	T	A	17: 21,398,258 (GRCm38)	C526S	probably damaging	Het
Zfp831	T	G	2: 174,643,627 (GRCm38)	S32A	probably benign	Het

Other mutations in Olfr938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr938	APN	9	39,078,451 (GRCm38)	missense	probably damaging	0.96
IGL01298:Olfr938	APN	9	39,078,724 (GRCm38)	missense	possibly damaging	0.63
IGL02930:Olfr938	APN	9	39,078,012 (GRCm38)	missense	probably damaging	1.00
IGL03346:Olfr938	APN	9	39,077,961 (GRCm38)	missense	probably benign	0.35
IGL03346:Olfr938	APN	9	39,077,962 (GRCm38)	missense	probably damaging	0.99
IGL03399:Olfr938	APN	9	39,078,237 (GRCm38)	nonsense	probably null
R0536:Olfr938	UTSW	9	39,078,329 (GRCm38)	missense	probably benign	0.03
R1170:Olfr938	UTSW	9	39,078,229 (GRCm38)	missense	possibly damaging	0.50
R1951:Olfr938	UTSW	9	39,078,284 (GRCm38)	missense	probably benign	0.07
R1952:Olfr938	UTSW	9	39,078,284 (GRCm38)	missense	probably benign	0.07
R2066:Olfr938	UTSW	9	39,078,214 (GRCm38)	missense	probably damaging	1.00
R2906:Olfr938	UTSW	9	39,078,373 (GRCm38)	missense	probably benign	0.39
R4707:Olfr938	UTSW	9	39,078,262 (GRCm38)	missense	probably benign	0.00
R4767:Olfr938	UTSW	9	39,078,692 (GRCm38)	missense	possibly damaging	0.71
R4951:Olfr938	UTSW	9	39,078,259 (GRCm38)	missense	probably benign	0.10
R5905:Olfr938	UTSW	9	39,078,083 (GRCm38)	missense	probably damaging	1.00
R6028:Olfr938	UTSW	9	39,078,083 (GRCm38)	missense	probably damaging	1.00
R6329:Olfr938	UTSW	9	39,077,903 (GRCm38)	missense	probably benign	0.02
R7240:Olfr938	UTSW	9	39,078,610 (GRCm38)	missense	probably damaging	0.99
R7345:Olfr938	UTSW	9	39,078,334 (GRCm38)	missense	probably damaging	1.00
R8058:Olfr938	UTSW	9	39,078,566 (GRCm38)	missense	probably damaging	1.00
R9023:Olfr938	UTSW	9	39,078,011 (GRCm38)	missense	probably benign	0.09
R9547:Olfr938	UTSW	9	39,078,631 (GRCm38)	missense	probably damaging	0.99
R9682:Olfr938	UTSW	9	39,078,578 (GRCm38)	missense	possibly damaging	0.95
R9760:Olfr938	UTSW	9	39,077,975 (GRCm38)	missense	possibly damaging	0.95
X0062:Olfr938	UTSW	9	39,078,466 (GRCm38)	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- CACACATAGAGTTATTAATGGCTGC -3'
(R):5'- AATGAAGTTCTAGCACTCTCCTTC -3'

Sequencing Primer
(F):5'- TCAGGCTGTAGATCAGAGG -3'
(R):5'- TTCAATCCACTGGAGGCA -3'

Posted On

2017-02-15