Mutagenetix > Incidental Mutations

Incidental Mutation 'R5615:Olfr811'

458003

Institutional Source

Beutler Lab

Gene Symbol

Olfr811

Ensembl Gene

ENSMUSG00000063173

Gene Name

olfactory receptor 811

Synonyms

MOR110-6, GA_x6K02T2PULF-11481207-11480248

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R5615 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

129800615-129804396 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 129801767 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 253 (C253S)

Ref Sequence

ENSEMBL: ENSMUSP00000149970 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076437] [ENSMUST00000215058] [ENSMUST00000217571]

Predicted Effect

probably damaging
Transcript: ENSMUST00000076437
AA Change: C253S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000075768
Gene: ENSMUSG00000063173
AA Change: C253S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	306	1.1e-51	PFAM
Pfam:7tm_1	39	288	1.5e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215058
AA Change: C253S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216283

Predicted Effect

probably damaging
Transcript: ENSMUST00000217571
AA Change: C253S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.8%
3x: 99.5%
10x: 97.6%
20x: 92.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	A	T	11: 23,606,759	L407H	probably damaging	Het
Abca12	A	T	1: 71,307,059	L884H	probably damaging	Het
Ahr	A	G	12: 35,503,885	V745A	probably benign	Het
Ankrd17	A	T	5: 90,283,436	S830T	possibly damaging	Het
Aox1	A	G	1: 58,096,966	T1123A	probably benign	Het
Arhgef11	T	C	3: 87,722,485		probably null	Het
Bcas3	T	A	11: 85,470,761	C250S	probably damaging	Het
Bckdk	T	C	7: 127,907,317	I272T	probably damaging	Het
Cacna1e	T	C	1: 154,412,170	K1897E	probably damaging	Het
Cd180	A	T	13: 102,706,203	I586F	probably benign	Het
Cep290	A	G	10: 100,531,150	D1121G	probably damaging	Het
Clasrp	A	G	7: 19,586,447		probably benign	Het
Col27a1	G	T	4: 63,281,114	K912N	probably damaging	Het
Dock4	G	T	12: 40,649,480	R231L	probably benign	Het
Ell	G	A	8: 70,590,732	S505N	probably benign	Het
Ephb6	A	G	6: 41,619,291	T833A	probably benign	Het
Hemk1	T	A	9: 107,330,824		probably null	Het
Hjurp	GT	GTT	1: 88,266,524		probably null	Het
Hspa12a	T	C	19: 58,804,650	I368V	possibly damaging	Het
Igkv3-3	A	T	6: 70,687,230	T19S	probably benign	Het
Itpr1	G	A	6: 108,488,600	A2158T	possibly damaging	Het
Lancl2	T	C	6: 57,722,511	Y104H	probably damaging	Het
Leng8	G	T	7: 4,144,958	E634*	probably null	Het
Lrrk1	A	T	7: 66,287,615	C930S	probably damaging	Het
Lvrn	C	T	18: 46,850,328	S46L	possibly damaging	Het
Mcidas	G	A	13: 112,997,425	V148I	probably benign	Het
Mprip	A	T	11: 59,758,487	T1006S	probably benign	Het
Mrgprb3	T	A	7: 48,643,486	M106L	probably benign	Het
Mroh2a	GCCC	GC	1: 88,232,257		probably null	Het
Mtor	G	A	4: 148,538,276	V1938I	possibly damaging	Het
Muc2	A	G	7: 141,691,203	D46G	probably damaging	Het
Nfkb2	G	T	19: 46,307,567	E170D	probably benign	Het
Olfr1113	T	A	2: 87,213,739	F282L	probably benign	Het
Osbp2	C	T	11: 3,863,356	G171D	probably benign	Het
Otud6b	A	T	4: 14,818,187	M238K	possibly damaging	Het
Pcdhac2	G	A	18: 37,146,423	G819R	probably benign	Het
Pcdhac2	G	T	18: 37,146,424	G819V	probably benign	Het
Pcdhga12	T	G	18: 37,768,079	S655A	probably damaging	Het
Pkd1l3	A	G	8: 109,630,210	I756V	probably benign	Het
Plekhd1	T	A	12: 80,720,590	S251T	probably damaging	Het
Ppp2r1a	A	T	17: 20,958,987	T96S	probably benign	Het
Qser1	A	C	2: 104,789,694	S258A	possibly damaging	Het
Rsph4a	G	A	10: 33,909,328	A412T	probably benign	Het
Sass6	T	A	3: 116,607,486	C159S	probably benign	Het
Scaf4	T	C	16: 90,251,960	Q322R	unknown	Het
Sema6d	C	T	2: 124,656,901	H244Y	probably damaging	Het
Sigirr	T	G	7: 141,092,719	L163F	probably damaging	Het
Spata31d1c	C	A	13: 65,035,264	L207I	possibly damaging	Het
Tacstd2	A	G	6: 67,535,049	F220L	probably damaging	Het
Tdpoz4	A	T	3: 93,797,499	T368S	probably benign	Het
Tnxb	C	A	17: 34,683,418	Q1082K	probably damaging	Het
Trim41	GCCTAGGCGCCCA	G	11: 48,807,365		probably benign	Het
Trpm6	C	T	19: 18,829,933	R1014C	probably damaging	Het
Ugt1a10	TTCATCA	TTCA	1: 88,216,158		probably benign	Het
Vmn2r114	ATTT	ATT	17: 23,290,932		probably null	Het
Vmn2r61	A	G	7: 42,300,493	E779G	probably damaging	Het
Vmn2r61	T	A	7: 42,267,253	M430K	probably benign	Het
Zfp599	T	C	9: 22,253,869	D70G	probably benign	Het
Zmym1	A	T	4: 127,049,398	I301N	probably damaging	Het

Other mutations in Olfr811

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00945:Olfr811	APN	10	129801907	missense	possibly damaging	0.64
IGL01957:Olfr811	APN	10	129802250	missense	probably damaging	1.00
IGL02394:Olfr811	APN	10	129802313	missense	possibly damaging	0.90
IGL02451:Olfr811	APN	10	129801833	nonsense	probably null
IGL03111:Olfr811	APN	10	129802078	missense	probably benign	0.00
IGL03369:Olfr811	APN	10	129802471	missense	probably damaging	0.99
R0704:Olfr811	UTSW	10	129802303	missense	probably benign	0.01
R1393:Olfr811	UTSW	10	129801932	missense	probably benign	0.22
R1941:Olfr811	UTSW	10	129802412	missense	probably benign	0.00
R1994:Olfr811	UTSW	10	129801661	missense	probably damaging	1.00
R3427:Olfr811	UTSW	10	129801851	missense	possibly damaging	0.85
R4296:Olfr811	UTSW	10	129802300	missense	probably damaging	0.97
R4937:Olfr811	UTSW	10	129802063	missense	probably benign	0.31
R5016:Olfr811	UTSW	10	129801793	missense	probably benign	0.01
R5662:Olfr811	UTSW	10	129802307	missense	possibly damaging	0.83
R5750:Olfr811	UTSW	10	129801620	missense	probably benign	0.01
R6109:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6109:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6110:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6110:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6117:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6117:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6119:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6119:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6120:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6120:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6124:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6124:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6395:Olfr811	UTSW	10	129802144	missense	probably damaging	1.00
R6440:Olfr811	UTSW	10	129801968	missense	probably damaging	1.00
R6559:Olfr811	UTSW	10	129801664	missense	probably damaging	1.00
R6707:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6708:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6868:Olfr811	UTSW	10	129802168	missense	probably damaging	1.00
R8024:Olfr811	UTSW	10	129801943	missense	probably damaging	1.00
Z1177:Olfr811	UTSW	10	129802309	missense	probably damaging	0.98

Predicted Primers

Posted On

2017-02-16