Incidental Mutation 'R5601:Olfr881'
Institutional Source Beutler Lab
Gene Symbol Olfr881
Ensembl Gene ENSMUSG00000060583
Gene Nameolfactory receptor 881
SynonymsGA_x6K02T2PVTD-31676771-31677700, MOR162-7
MMRRC Submission 043153-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #R5601 (G1)
Quality Score225
Status Not validated
Chromosomal Location37991825-37996408 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to G at 37992714 bp
Amino Acid Change Threonine to Arginine at position 74 (T74R)
Ref Sequence ENSEMBL: ENSMUSP00000074193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074611] [ENSMUST00000212489]
Predicted Effect possibly damaging
Transcript: ENSMUST00000074611
AA Change: T74R

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000074193
Gene: ENSMUSG00000060583
AA Change: T74R

Pfam:7tm_4 36 311 4.6e-46 PFAM
Pfam:7tm_1 46 293 1.4e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212489
AA Change: T69R

PolyPhen 2 Score 0.755 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 G A 13: 91,782,910 V426I probably benign Het
Asmt T C X: 170,676,392 V212A probably damaging Het
Atn1 A G 6: 124,743,228 probably null Het
Auts2 G T 5: 131,476,823 probably benign Het
AW551984 C T 9: 39,591,267 V672M possibly damaging Het
Ccdc13 G A 9: 121,800,572 Q114* probably null Het
Ces2e A T 8: 104,929,494 I146F probably benign Het
Cfap44 A G 16: 44,460,186 K1443E probably damaging Het
Cma2 T A 14: 55,973,789 H179Q possibly damaging Het
Cpsf2 G T 12: 101,985,355 probably null Het
Cwh43 A G 5: 73,417,940 probably null Het
Dnajb12 GC G 10: 59,892,752 probably null Het
Dram1 A G 10: 88,324,767 S231P probably damaging Het
Fbxw7 A G 3: 84,976,208 D482G probably damaging Het
Fstl1 T C 16: 37,826,799 I177T probably benign Het
Fut9 T C 4: 25,620,299 T172A probably benign Het
Gm10436 T C 12: 88,176,047 D267G probably damaging Het
Gm5134 G A 10: 75,985,952 V207M probably damaging Het
Hccs G A X: 169,313,601 R203C probably damaging Het
Hmgxb3 A T 18: 61,137,622 F877I probably damaging Het
Ide A G 19: 37,314,980 V272A unknown Het
Impact C T 18: 12,976,007 T65I probably benign Het
Lgr6 C T 1: 134,994,010 A199T probably damaging Het
Muc3 A G 5: 137,138,015 S309P probably damaging Het
Myf6 A C 10: 107,494,614 S31A probably damaging Het
Olfr733 C A 14: 50,298,861 W149C probably damaging Het
P4hb T A 11: 120,571,615 E88D possibly damaging Het
Pcdhb9 T C 18: 37,402,206 C418R probably damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,893,123 probably null Het
Prss58 A T 6: 40,897,849 N19K possibly damaging Het
Ptprq C T 10: 107,608,430 A1438T probably benign Het
Rfx4 A T 10: 84,798,578 T61S probably damaging Het
Sclt1 T A 3: 41,730,919 N35Y probably benign Het
Sec24b CTG CTGGTG 3: 130,040,834 probably benign Het
Serpinb12 T C 1: 106,953,697 I188T probably damaging Het
Slc27a4 A T 2: 29,805,660 Y69F probably benign Het
Slc3a1 T C 17: 85,032,891 V247A probably benign Het
Slc4a2 C T 5: 24,438,774 T854I probably benign Het
Stat5b G A 11: 100,783,175 T761M probably damaging Het
Stkld1 T C 2: 26,952,705 L563P probably damaging Het
Tbc1d23 C A 16: 57,198,309 C283F probably benign Het
Tcaf3 T C 6: 42,587,528 N900S possibly damaging Het
Tkfc T C 19: 10,594,563 T370A probably benign Het
Tpr T C 1: 150,435,853 V1868A possibly damaging Het
Triobp T A 15: 78,973,633 W1145R probably damaging Het
Uhrf1bp1 C A 17: 27,884,494 A392D probably damaging Het
Vmn2r82 T G 10: 79,396,191 L675V probably damaging Het
Zfp423 T C 8: 87,782,009 E444G probably damaging Het
Other mutations in Olfr881
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Olfr881 APN 9 37992560 missense probably damaging 1.00
IGL02282:Olfr881 APN 9 37993022 missense probably damaging 0.98
IGL02714:Olfr881 APN 9 37993086 missense possibly damaging 0.83
R0308:Olfr881 UTSW 9 37992845 missense probably benign 0.01
R0486:Olfr881 UTSW 9 37992702 missense possibly damaging 0.72
R0504:Olfr881 UTSW 9 37993142 missense probably benign 0.05
R1939:Olfr881 UTSW 9 37993089 missense probably benign 0.12
R4669:Olfr881 UTSW 9 37993085 missense possibly damaging 0.83
R5377:Olfr881 UTSW 9 37992612 missense probably benign 0.13
R5468:Olfr881 UTSW 9 37993011 missense probably damaging 1.00
R6799:Olfr881 UTSW 9 37993182 missense possibly damaging 0.79
R7212:Olfr881 UTSW 9 37992957 missense possibly damaging 0.47
R7648:Olfr881 UTSW 9 37992560 missense probably damaging 1.00
R8286:Olfr881 UTSW 9 37993105 nonsense probably null
X0064:Olfr881 UTSW 9 37993340 missense probably benign 0.07
Predicted Primers
Posted On2017-02-16