Incidental Mutation 'R5601:Or8b35'
ID 458043
Institutional Source Beutler Lab
Gene Symbol Or8b35
Ensembl Gene ENSMUSG00000060583
Gene Name olfactory receptor family 8 subfamily B member 35
Synonyms Olfr881, MOR162-7, GA_x6K02T2PVTD-31676771-31677700
MMRRC Submission 043153-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5601 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 37903788-37904735 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 37904010 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Arginine at position 74 (T74R)
Ref Sequence ENSEMBL: ENSMUSP00000074193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074611] [ENSMUST00000212489]
AlphaFold Q8VF63
Predicted Effect possibly damaging
Transcript: ENSMUST00000074611
AA Change: T74R

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000074193
Gene: ENSMUSG00000060583
AA Change: T74R

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 4.6e-46 PFAM
Pfam:7tm_1 46 293 1.4e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212489
AA Change: T69R

PolyPhen 2 Score 0.755 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 G A 13: 91,931,029 (GRCm39) V426I probably benign Het
Asmt T C X: 169,110,127 (GRCm39) V212A probably damaging Het
Atn1 A G 6: 124,720,191 (GRCm39) probably null Het
Auts2 G T 5: 131,505,662 (GRCm39) probably benign Het
AW551984 C T 9: 39,502,563 (GRCm39) V672M possibly damaging Het
Bltp3a C A 17: 28,103,468 (GRCm39) A392D probably damaging Het
Ccdc13 G A 9: 121,629,638 (GRCm39) Q114* probably null Het
Ces2e A T 8: 105,656,126 (GRCm39) I146F probably benign Het
Cfap44 A G 16: 44,280,549 (GRCm39) K1443E probably damaging Het
Cma2 T A 14: 56,211,246 (GRCm39) H179Q possibly damaging Het
Cpsf2 G T 12: 101,951,614 (GRCm39) probably null Het
Cwh43 A G 5: 73,575,283 (GRCm39) probably null Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dram1 A G 10: 88,160,629 (GRCm39) S231P probably damaging Het
Fbxw7 A G 3: 84,883,515 (GRCm39) D482G probably damaging Het
Fstl1 T C 16: 37,647,161 (GRCm39) I177T probably benign Het
Fut9 T C 4: 25,620,299 (GRCm39) T172A probably benign Het
Gm5134 G A 10: 75,821,786 (GRCm39) V207M probably damaging Het
Hccs G A X: 168,096,597 (GRCm39) R203C probably damaging Het
Hmgxb3 A T 18: 61,270,694 (GRCm39) F877I probably damaging Het
Ide A G 19: 37,292,379 (GRCm39) V272A unknown Het
Impact C T 18: 13,109,064 (GRCm39) T65I probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Muc17 A G 5: 137,166,863 (GRCm39) S309P probably damaging Het
Myf6 A C 10: 107,330,475 (GRCm39) S31A probably damaging Het
Or4n4b C A 14: 50,536,318 (GRCm39) W149C probably damaging Het
P4hb T A 11: 120,462,441 (GRCm39) E88D possibly damaging Het
Pcdhb9 T C 18: 37,535,259 (GRCm39) C418R probably damaging Het
Pramel51 T C 12: 88,142,817 (GRCm39) D267G probably damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Prss58 A T 6: 40,874,783 (GRCm39) N19K possibly damaging Het
Ptprq C T 10: 107,444,291 (GRCm39) A1438T probably benign Het
Rfx4 A T 10: 84,634,442 (GRCm39) T61S probably damaging Het
Sclt1 T A 3: 41,685,354 (GRCm39) N35Y probably benign Het
Sec24b CTG CTGGTG 3: 129,834,483 (GRCm39) probably benign Het
Serpinb12 T C 1: 106,881,427 (GRCm39) I188T probably damaging Het
Slc27a4 A T 2: 29,695,672 (GRCm39) Y69F probably benign Het
Slc3a1 T C 17: 85,340,319 (GRCm39) V247A probably benign Het
Slc4a2 C T 5: 24,643,772 (GRCm39) T854I probably benign Het
Stat5b G A 11: 100,674,001 (GRCm39) T761M probably damaging Het
Stkld1 T C 2: 26,842,717 (GRCm39) L563P probably damaging Het
Tbc1d23 C A 16: 57,018,672 (GRCm39) C283F probably benign Het
Tcaf3 T C 6: 42,564,462 (GRCm39) N900S possibly damaging Het
Tkfc T C 19: 10,571,927 (GRCm39) T370A probably benign Het
Tpr T C 1: 150,311,604 (GRCm39) V1868A possibly damaging Het
Triobp T A 15: 78,857,833 (GRCm39) W1145R probably damaging Het
Vmn2r82 T G 10: 79,232,025 (GRCm39) L675V probably damaging Het
Zfp423 T C 8: 88,508,637 (GRCm39) E444G probably damaging Het
Other mutations in Or8b35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Or8b35 APN 9 37,903,856 (GRCm39) missense probably damaging 1.00
IGL02282:Or8b35 APN 9 37,904,318 (GRCm39) missense probably damaging 0.98
IGL02714:Or8b35 APN 9 37,904,382 (GRCm39) missense possibly damaging 0.83
R0308:Or8b35 UTSW 9 37,904,141 (GRCm39) missense probably benign 0.01
R0486:Or8b35 UTSW 9 37,903,998 (GRCm39) missense possibly damaging 0.72
R0504:Or8b35 UTSW 9 37,904,438 (GRCm39) missense probably benign 0.05
R1939:Or8b35 UTSW 9 37,904,385 (GRCm39) missense probably benign 0.12
R4669:Or8b35 UTSW 9 37,904,381 (GRCm39) missense possibly damaging 0.83
R5377:Or8b35 UTSW 9 37,903,908 (GRCm39) missense probably benign 0.13
R5468:Or8b35 UTSW 9 37,904,307 (GRCm39) missense probably damaging 1.00
R6799:Or8b35 UTSW 9 37,904,478 (GRCm39) missense possibly damaging 0.79
R7212:Or8b35 UTSW 9 37,904,253 (GRCm39) missense possibly damaging 0.47
R7648:Or8b35 UTSW 9 37,903,856 (GRCm39) missense probably damaging 1.00
R8286:Or8b35 UTSW 9 37,904,401 (GRCm39) nonsense probably null
X0064:Or8b35 UTSW 9 37,904,636 (GRCm39) missense probably benign 0.07
Predicted Primers
Posted On 2017-02-16