Incidental Mutation 'R5055:Trpa1'
ID 459848
Institutional Source Beutler Lab
Gene Symbol Trpa1
Ensembl Gene ENSMUSG00000032769
Gene Name transient receptor potential cation channel, subfamily A, member 1
Synonyms ANKTM1
MMRRC Submission 042645-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R5055 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 14942872-14989086 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 14946183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 983 (V983M)
Ref Sequence ENSEMBL: ENSMUSP00000043594 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041447]
AlphaFold Q8BLA8
Predicted Effect probably damaging
Transcript: ENSMUST00000041447
AA Change: V983M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769
AA Change: V983M

DomainStartEndE-ValueType
ANK 63 94 1.01e2 SMART
ANK 98 127 9.7e-8 SMART
ANK 131 161 1.36e-2 SMART
ANK 165 194 5.45e-2 SMART
ANK 198 226 3.07e2 SMART
ANK 239 268 1.99e-4 SMART
ANK 272 302 1.33e2 SMART
ANK 309 338 4.19e-3 SMART
ANK 342 371 2.34e-1 SMART
ANK 413 442 3.41e-3 SMART
ANK 446 475 5.75e-1 SMART
ANK 482 511 4.1e-6 SMART
ANK 514 543 1.68e-2 SMART
ANK 548 577 4.97e-5 SMART
Blast:ANK 580 609 2e-11 BLAST
Pfam:Ion_trans 736 975 1.8e-11 PFAM
Meta Mutation Damage Score 0.1317 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 98% (84/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 G A 11: 46,013,996 (GRCm39) V329I probably damaging Het
Adgrl3 C A 5: 81,794,398 (GRCm39) A541E possibly damaging Het
Agbl1 A T 7: 76,063,325 (GRCm39) I263F probably damaging Het
Ash1l T C 3: 88,930,519 (GRCm39) probably null Het
Bccip A G 7: 133,316,652 (GRCm39) T91A probably benign Het
Bnc1 A T 7: 81,624,163 (GRCm39) F355I probably damaging Het
Bpifa2 A T 2: 153,855,630 (GRCm39) D185V probably damaging Het
Capn8 T A 1: 182,399,526 (GRCm39) V89D probably damaging Het
Cfap46 A T 7: 139,241,106 (GRCm39) M421K probably damaging Het
Chd2 A T 7: 73,130,256 (GRCm39) L800M probably damaging Het
Chd4 A G 6: 125,077,949 (GRCm39) D137G possibly damaging Het
Crtap A G 9: 114,219,208 (GRCm39) Y154H probably benign Het
Ctdp1 T A 18: 80,499,303 (GRCm39) Q213L probably damaging Het
Cts6 T C 13: 61,344,164 (GRCm39) Y296C probably damaging Het
Daxx G T 17: 34,131,134 (GRCm39) V354F probably benign Het
Dnah2 A G 11: 69,411,599 (GRCm39) I341T possibly damaging Het
Epha2 A G 4: 141,036,380 (GRCm39) D272G probably benign Het
Etfa A G 9: 55,407,417 (GRCm39) V24A probably damaging Het
Fbxl7 C A 15: 26,553,022 (GRCm39) G82W probably damaging Het
Fcamr G A 1: 130,739,174 (GRCm39) C158Y probably damaging Het
Fyb1 A C 15: 6,614,630 (GRCm39) probably benign Het
Gars1 G A 6: 55,045,077 (GRCm39) R454H probably damaging Het
Ghsr T C 3: 27,426,421 (GRCm39) V159A probably benign Het
Glp1r A T 17: 31,137,861 (GRCm39) Q97H probably benign Het
Gm27047 T C 6: 130,606,909 (GRCm39) noncoding transcript Het
Igkv3-3 A C 6: 70,664,223 (GRCm39) I22L probably benign Het
Inpp5b G T 4: 124,636,824 (GRCm39) probably null Het
Ipo9 C A 1: 135,330,097 (GRCm39) E448* probably null Het
Itgb2l A T 16: 96,229,003 (GRCm39) I400N probably damaging Het
Kat6b T A 14: 21,567,062 (GRCm39) H40Q probably damaging Het
Kcna7 G A 7: 45,056,015 (GRCm39) R77H probably damaging Het
Kcnq2 G T 2: 180,728,554 (GRCm39) probably benign Het
Klf7 T C 1: 64,118,439 (GRCm39) T53A probably benign Het
Kmt2a A G 9: 44,729,649 (GRCm39) probably benign Het
Lrp10 C T 14: 54,705,802 (GRCm39) R331C probably benign Het
Map4k5 A T 12: 69,878,332 (GRCm39) D289E probably benign Het
Mfsd4b2 A T 10: 39,799,773 (GRCm39) M43K possibly damaging Het
Msr1 T G 8: 40,076,997 (GRCm39) R138S possibly damaging Het
Myh7b G C 2: 155,474,293 (GRCm39) R1669S possibly damaging Het
Myh9 G A 15: 77,648,723 (GRCm39) A1711V probably benign Het
Myo18b A G 5: 113,023,083 (GRCm39) probably benign Het
Nampt A T 12: 32,883,120 (GRCm39) N102Y possibly damaging Het
Nell2 T C 15: 95,371,460 (GRCm39) I92V probably benign Het
Nes A G 3: 87,884,521 (GRCm39) N883D probably benign Het
Neurl3 T A 1: 36,312,463 (GRCm39) probably benign Het
Ocln T A 13: 100,675,930 (GRCm39) T188S probably benign Het
Or2ag20 T A 7: 106,464,937 (GRCm39) M250K probably damaging Het
Or5m10 T C 2: 85,717,585 (GRCm39) F147S probably benign Het
Parp14 T A 16: 35,664,733 (GRCm39) Q1305L probably benign Het
Pde3a C T 6: 141,433,682 (GRCm39) Q855* probably null Het
Pde4b T C 4: 102,052,311 (GRCm39) probably benign Het
Pdk2 T C 11: 94,930,242 (GRCm39) M65V probably benign Het
Phf21a T C 2: 92,182,201 (GRCm39) S377P probably damaging Het
Plcb2 T A 2: 118,548,703 (GRCm39) T408S probably benign Het
Ppp1r12b G T 1: 134,883,471 (GRCm39) A17E probably benign Het
Ppp6r2 A G 15: 89,167,152 (GRCm39) D789G probably benign Het
Prdm16 T C 4: 154,419,719 (GRCm39) M897V possibly damaging Het
Prss57 A G 10: 79,620,178 (GRCm39) probably null Het
Psd G T 19: 46,310,907 (GRCm39) L381I probably benign Het
Ptprq A T 10: 107,370,540 (GRCm39) D2050E probably benign Het
Rfc1 G T 5: 65,423,505 (GRCm39) N1034K probably damaging Het
Ryr3 C T 2: 112,661,504 (GRCm39) G1829S probably benign Het
Scaper T C 9: 55,767,003 (GRCm39) probably null Het
Scn5a A G 9: 119,351,632 (GRCm39) I783T probably damaging Het
Slc28a1 A G 7: 80,818,796 (GRCm39) N583S possibly damaging Het
Slc35e3 C T 10: 117,580,884 (GRCm39) G140D probably damaging Het
Slc6a9 G A 4: 117,725,347 (GRCm39) probably null Het
Sptlc1 A G 13: 53,496,218 (GRCm39) S376P probably benign Het
Sspo G A 6: 48,441,729 (GRCm39) C1913Y probably damaging Het
Taar7b A T 10: 23,876,845 (GRCm39) I337F possibly damaging Het
Tdpoz2 T A 3: 93,559,235 (GRCm39) I246F probably damaging Het
Trpm5 A T 7: 142,626,521 (GRCm39) M1112K probably benign Het
Tsbp1 G A 17: 34,667,770 (GRCm39) C154Y possibly damaging Het
Uso1 A T 5: 92,340,594 (GRCm39) K670I probably benign Het
Washc4 A G 10: 83,392,771 (GRCm39) D257G probably damaging Het
Wdr41 T A 13: 95,151,725 (GRCm39) probably null Het
Zbtb17 A G 4: 141,193,860 (GRCm39) Q668R possibly damaging Het
Other mutations in Trpa1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Trpa1 APN 1 14,961,557 (GRCm39) missense probably damaging 0.97
IGL00937:Trpa1 APN 1 14,950,501 (GRCm39) splice site probably benign
IGL00957:Trpa1 APN 1 14,951,892 (GRCm39) missense probably damaging 0.99
IGL01307:Trpa1 APN 1 14,966,771 (GRCm39) missense probably benign 0.23
IGL01336:Trpa1 APN 1 14,957,104 (GRCm39) splice site probably benign
IGL01408:Trpa1 APN 1 14,959,637 (GRCm39) missense probably benign 0.03
IGL01504:Trpa1 APN 1 14,952,443 (GRCm39) missense possibly damaging 0.79
IGL01543:Trpa1 APN 1 14,970,300 (GRCm39) missense probably damaging 1.00
IGL01609:Trpa1 APN 1 14,982,607 (GRCm39) missense probably damaging 0.99
IGL01895:Trpa1 APN 1 14,957,867 (GRCm39) missense possibly damaging 0.87
IGL02449:Trpa1 APN 1 14,968,381 (GRCm39) missense probably damaging 1.00
IGL02936:Trpa1 APN 1 14,946,193 (GRCm39) splice site probably null
fear-2 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
petrified UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0008:Trpa1 UTSW 1 14,973,439 (GRCm39) missense possibly damaging 0.53
R0317:Trpa1 UTSW 1 14,951,856 (GRCm39) missense probably benign 0.03
R0454:Trpa1 UTSW 1 14,955,972 (GRCm39) critical splice donor site probably null
R0828:Trpa1 UTSW 1 14,946,108 (GRCm39) missense probably damaging 1.00
R0944:Trpa1 UTSW 1 14,982,585 (GRCm39) splice site probably null
R0962:Trpa1 UTSW 1 14,968,387 (GRCm39) missense possibly damaging 0.61
R1025:Trpa1 UTSW 1 14,974,407 (GRCm39) missense probably benign 0.01
R1035:Trpa1 UTSW 1 14,961,527 (GRCm39) critical splice donor site probably null
R1134:Trpa1 UTSW 1 14,951,972 (GRCm39) missense possibly damaging 0.95
R1278:Trpa1 UTSW 1 14,988,947 (GRCm39) critical splice donor site probably null
R1497:Trpa1 UTSW 1 14,956,036 (GRCm39) missense probably benign 0.30
R1617:Trpa1 UTSW 1 14,943,899 (GRCm39) missense probably damaging 1.00
R1800:Trpa1 UTSW 1 14,944,648 (GRCm39) missense probably benign 0.04
R1856:Trpa1 UTSW 1 14,969,612 (GRCm39) nonsense probably null
R1886:Trpa1 UTSW 1 14,959,649 (GRCm39) missense probably benign 0.00
R2004:Trpa1 UTSW 1 14,976,207 (GRCm39) missense possibly damaging 0.83
R2152:Trpa1 UTSW 1 14,969,625 (GRCm39) missense probably damaging 1.00
R2172:Trpa1 UTSW 1 14,951,880 (GRCm39) missense probably benign 0.01
R2198:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign
R2221:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2223:Trpa1 UTSW 1 14,973,480 (GRCm39) missense probably null 0.12
R2307:Trpa1 UTSW 1 14,982,605 (GRCm39) missense probably benign 0.00
R2338:Trpa1 UTSW 1 14,954,469 (GRCm39) missense probably damaging 0.97
R2698:Trpa1 UTSW 1 14,976,222 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2872:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2873:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R2874:Trpa1 UTSW 1 14,957,844 (GRCm39) missense probably damaging 1.00
R3418:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3419:Trpa1 UTSW 1 14,944,605 (GRCm39) missense probably benign 0.01
R3796:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R3799:Trpa1 UTSW 1 14,963,488 (GRCm39) missense possibly damaging 0.74
R4238:Trpa1 UTSW 1 14,954,340 (GRCm39) missense probably damaging 1.00
R4320:Trpa1 UTSW 1 14,944,676 (GRCm39) missense probably benign 0.00
R4591:Trpa1 UTSW 1 14,952,332 (GRCm39) splice site probably null
R4834:Trpa1 UTSW 1 14,966,747 (GRCm39) missense possibly damaging 0.72
R4991:Trpa1 UTSW 1 14,980,970 (GRCm39) missense probably benign 0.00
R4999:Trpa1 UTSW 1 14,946,085 (GRCm39) missense probably benign 0.05
R5038:Trpa1 UTSW 1 14,981,090 (GRCm39) missense probably damaging 1.00
R5158:Trpa1 UTSW 1 14,951,885 (GRCm39) missense probably benign 0.01
R5193:Trpa1 UTSW 1 14,946,141 (GRCm39) missense possibly damaging 0.92
R5558:Trpa1 UTSW 1 14,968,492 (GRCm39) missense probably damaging 1.00
R5578:Trpa1 UTSW 1 14,957,232 (GRCm39) missense probably damaging 1.00
R5680:Trpa1 UTSW 1 14,946,078 (GRCm39) missense probably benign 0.00
R5738:Trpa1 UTSW 1 14,946,174 (GRCm39) missense probably damaging 1.00
R5801:Trpa1 UTSW 1 14,968,302 (GRCm39) missense probably damaging 1.00
R5945:Trpa1 UTSW 1 14,968,359 (GRCm39) missense probably benign 0.03
R6092:Trpa1 UTSW 1 14,959,710 (GRCm39) missense probably damaging 1.00
R6776:Trpa1 UTSW 1 14,982,601 (GRCm39) missense probably benign
R7126:Trpa1 UTSW 1 14,960,648 (GRCm39) missense probably benign 0.00
R7154:Trpa1 UTSW 1 14,952,457 (GRCm39) missense possibly damaging 0.46
R7175:Trpa1 UTSW 1 14,963,431 (GRCm39) missense possibly damaging 0.90
R7258:Trpa1 UTSW 1 14,973,473 (GRCm39) missense probably damaging 1.00
R7358:Trpa1 UTSW 1 14,968,334 (GRCm39) missense probably damaging 1.00
R7412:Trpa1 UTSW 1 14,954,422 (GRCm39) missense probably benign 0.43
R7639:Trpa1 UTSW 1 14,957,137 (GRCm39) missense probably benign 0.00
R7740:Trpa1 UTSW 1 14,982,625 (GRCm39) missense possibly damaging 0.72
R7815:Trpa1 UTSW 1 14,974,486 (GRCm39) missense probably benign 0.01
R7854:Trpa1 UTSW 1 14,951,918 (GRCm39) missense probably benign 0.00
R8112:Trpa1 UTSW 1 14,974,490 (GRCm39) missense probably benign
R8217:Trpa1 UTSW 1 14,957,247 (GRCm39) missense probably damaging 0.97
R8711:Trpa1 UTSW 1 14,980,998 (GRCm39) missense probably damaging 1.00
R8834:Trpa1 UTSW 1 14,963,528 (GRCm39) missense possibly damaging 0.60
R8907:Trpa1 UTSW 1 14,963,563 (GRCm39) missense probably damaging 1.00
R8907:Trpa1 UTSW 1 14,959,664 (GRCm39) missense probably benign 0.00
R9058:Trpa1 UTSW 1 14,959,618 (GRCm39) missense probably damaging 1.00
R9135:Trpa1 UTSW 1 14,952,435 (GRCm39) missense probably damaging 1.00
R9261:Trpa1 UTSW 1 14,963,465 (GRCm39) missense probably damaging 1.00
R9266:Trpa1 UTSW 1 14,980,953 (GRCm39) critical splice donor site probably null
R9287:Trpa1 UTSW 1 14,956,040 (GRCm39) nonsense probably null
R9323:Trpa1 UTSW 1 14,968,564 (GRCm39) missense probably benign 0.01
R9379:Trpa1 UTSW 1 14,966,739 (GRCm39) missense possibly damaging 0.64
R9497:Trpa1 UTSW 1 14,989,026 (GRCm39) missense probably benign 0.02
R9616:Trpa1 UTSW 1 14,989,077 (GRCm39) start gained probably benign
R9666:Trpa1 UTSW 1 14,973,455 (GRCm39) missense possibly damaging 0.67
X0028:Trpa1 UTSW 1 14,960,644 (GRCm39) missense probably benign 0.16
Z1176:Trpa1 UTSW 1 14,968,574 (GRCm39) missense probably damaging 1.00
Z1176:Trpa1 UTSW 1 14,961,530 (GRCm39) missense possibly damaging 0.80
Z1176:Trpa1 UTSW 1 14,951,916 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAAGGCTTCTTGGGGACTGC -3'
(R):5'- GGTCTCATGAGTAATGGATTAAGGG -3'

Sequencing Primer
(F):5'- CTTGGGGACTGCTGAGAAC -3'
(R):5'- GGAGGGAGGGGCAGCTC -3'
Posted On 2017-02-27