Mutagenetix > Incidental Mutation

Incidental Mutation 'R5927:Lcorl'

459934

Institutional Source

Beutler Lab

Gene Symbol

Lcorl

Ensembl Gene

ENSMUSG00000015882

Gene Name

ligand dependent nuclear receptor corepressor-like

Synonyms

A830039H10Rik, Mlr1

MMRRC Submission

044122-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.348) question?

Stock #

R5927 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

45854523-46014957 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

G to T at 45882766 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140503 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000016026] [ENSMUST00000045586] [ENSMUST00000087164] [ENSMUST00000121573] [ENSMUST00000190036]

AlphaFold

Q3U285

Predicted Effect

probably benign
Transcript: ENSMUST00000016026

SMART Domains

Protein: ENSMUSP00000016026
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	234	253	N/A	INTRINSIC
Pfam:HTH_psq	276	313	5.1e-9	PFAM
Pfam:HTH_psq	525	570	1.9e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000045586

SMART Domains

Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	234	253	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000087164

SMART Domains

Protein: ENSMUSP00000084408
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	151	170	N/A	INTRINSIC
Pfam:HTH_psq	193	230	3.4e-7	PFAM
Pfam:HTH_psq	442	487	9.4e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000121573

SMART Domains

Protein: ENSMUSP00000112416
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	151	170	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190036

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199744

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200142

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.0%

Validation Efficiency

100% (73/73)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadm	T	A	3: 153,644,745 (GRCm39)	I60F	probably damaging	Het
Ankrd26	A	G	6: 118,484,597 (GRCm39)		probably null	Het
Arhgdib	A	T	6: 136,901,136 (GRCm39)	W198R	probably damaging	Het
Atad5	T	A	11: 80,018,111 (GRCm39)	I1354N	probably damaging	Het
Ccdc146	T	A	5: 21,513,619 (GRCm39)	K500*	probably null	Het
Cdk11b	G	A	4: 155,732,697 (GRCm39)		probably benign	Het
Cmip	A	T	8: 117,984,048 (GRCm39)	T70S	possibly damaging	Het
Col22a1	G	T	15: 71,878,815 (GRCm39)	A114E	probably damaging	Het
Cpeb1	T	C	7: 81,011,428 (GRCm39)	D171G	possibly damaging	Het
Crebzf	C	T	7: 90,093,531 (GRCm39)		probably benign	Het
Cybb	C	G	X: 9,316,989 (GRCm39)	D246H	probably benign	Het
D630036H23Rik	C	A	12: 36,431,671 (GRCm39)		probably benign	Het
Dnah5	A	T	15: 28,335,864 (GRCm39)	T2277S	probably benign	Het
Dysf	T	A	6: 84,184,194 (GRCm39)	F2083Y	probably damaging	Het
Elavl4	T	A	4: 110,147,440 (GRCm39)		probably benign	Het
Elp3	A	G	14: 65,819,626 (GRCm39)	Y111H	probably damaging	Het
Eps8l2	A	T	7: 140,936,259 (GRCm39)	Q243L	probably benign	Het
Eri2	C	A	7: 119,385,291 (GRCm39)	L403F	probably damaging	Het
Fgfr4	T	A	13: 55,314,700 (GRCm39)	N614K	probably damaging	Het
Gm5108	T	G	5: 68,134,214 (GRCm39)	I74S	unknown	Het
Gpn1	T	C	5: 31,658,235 (GRCm39)	F130L	probably damaging	Het
Gpr176	T	A	2: 118,203,521 (GRCm39)	I50F	probably benign	Het
Gramd1a	A	G	7: 30,839,246 (GRCm39)	S221P	probably benign	Het
Hivep3	A	G	4: 119,954,305 (GRCm39)	T874A	possibly damaging	Het
Igkv12-40	A	G	6: 69,856,383 (GRCm39)		noncoding transcript	Het
Itgb2	C	A	10: 77,381,868 (GRCm39)	P57T	probably damaging	Het
Kcmf1	T	A	6: 72,819,988 (GRCm39)	D286V	possibly damaging	Het
Kcnt1	T	A	2: 25,799,388 (GRCm39)		probably benign	Het
Kif15	A	G	9: 122,846,326 (GRCm39)	S76G	probably benign	Het
Kpna3	C	T	14: 61,622,096 (GRCm39)	V223I	probably damaging	Het
Krt80	A	G	15: 101,262,089 (GRCm39)		probably benign	Het
Lama4	A	G	10: 38,948,808 (GRCm39)	Y857C	probably damaging	Het
Map4k3	A	G	17: 80,921,348 (GRCm39)	V528A	probably benign	Het
Mmp8	T	A	9: 7,563,203 (GRCm39)	N255K	possibly damaging	Het
Npat	A	T	9: 53,473,521 (GRCm39)	K438*	probably null	Het
Or4a73	T	A	2: 89,421,444 (GRCm39)	N5I	possibly damaging	Het
P4htm	T	C	9: 108,474,582 (GRCm39)	Y61C	probably damaging	Het
Pgap6	T	C	17: 26,340,972 (GRCm39)	Y692H	probably benign	Het
Polr3h	G	T	15: 81,801,480 (GRCm39)		probably null	Het
Prlr	C	T	15: 10,322,532 (GRCm39)	T176I	probably benign	Het
Psme4	T	G	11: 30,754,294 (GRCm39)	F184V	possibly damaging	Het
Ptgfrn	A	T	3: 100,967,968 (GRCm39)	F542I	possibly damaging	Het
Rock1	T	C	18: 10,116,792 (GRCm39)	E448G	probably damaging	Het
Rpf1	A	T	3: 146,225,218 (GRCm39)		probably null	Het
Sectm1b	T	C	11: 120,946,500 (GRCm39)	I132V	probably benign	Het
Sestd1	T	A	2: 77,017,503 (GRCm39)	H688L	probably benign	Het
Sidt2	T	C	9: 45,855,752 (GRCm39)	Y530C	probably damaging	Het
Sin3a	A	T	9: 57,018,395 (GRCm39)	K938M	probably damaging	Het
Sin3b	C	A	8: 73,476,506 (GRCm39)	R647S	probably benign	Het
Slc16a14	T	C	1: 84,889,988 (GRCm39)	H439R	possibly damaging	Het
Stc1	T	C	14: 69,269,822 (GRCm39)	V134A	probably benign	Het
Stk11ip	G	A	1: 75,501,335 (GRCm39)	V24I	possibly damaging	Het
Tbx6	G	A	7: 126,384,025 (GRCm39)	A359T	possibly damaging	Het
Thra	G	A	11: 98,654,514 (GRCm39)	V295I	possibly damaging	Het
Tnr	T	C	1: 159,740,336 (GRCm39)	M1170T	probably damaging	Het
Tpcn2	T	A	7: 144,832,521 (GRCm39)	I112F	probably damaging	Het
Trdv2-2	T	C	14: 54,198,998 (GRCm39)	L96P	probably damaging	Het
Trim24	T	A	6: 37,935,504 (GRCm39)	W832R	probably damaging	Het
Usp4	T	G	9: 108,268,959 (GRCm39)	S891A	probably benign	Het
Vmn1r88	A	T	7: 12,912,440 (GRCm39)	R265S	probably benign	Het
Vmn2r118	A	G	17: 55,931,494 (GRCm39)	L60S	probably benign	Het
Wdr74	T	C	19: 8,717,197 (GRCm39)	C220R	possibly damaging	Het
Xpo1	A	T	11: 23,218,653 (GRCm39)		probably benign	Het
Xpo1	A	T	11: 23,218,656 (GRCm39)		probably benign	Het
Zfp850	C	A	7: 27,689,620 (GRCm39)	G196V	probably benign	Het

Other mutations in Lcorl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00780:Lcorl	APN	5	45,904,637 (GRCm39)	missense	probably damaging	1.00
IGL01611:Lcorl	APN	5	45,904,434 (GRCm39)	missense	probably damaging	1.00
IGL03014:Lcorl	UTSW	5	45,931,371 (GRCm39)	intron	probably benign
R0070:Lcorl	UTSW	5	45,891,043 (GRCm39)	missense	probably damaging	1.00
R0070:Lcorl	UTSW	5	45,891,043 (GRCm39)	missense	probably damaging	1.00
R0499:Lcorl	UTSW	5	45,891,711 (GRCm39)	missense	probably benign	0.00
R1518:Lcorl	UTSW	5	45,891,543 (GRCm39)	missense	possibly damaging	0.94
R1817:Lcorl	UTSW	5	45,952,688 (GRCm39)	missense	probably damaging	1.00
R1977:Lcorl	UTSW	5	45,932,762 (GRCm39)	missense	probably null	0.16
R2171:Lcorl	UTSW	5	45,904,493 (GRCm39)	missense	probably damaging	0.99
R3737:Lcorl	UTSW	5	45,891,383 (GRCm39)	missense	possibly damaging	0.95
R3738:Lcorl	UTSW	5	45,891,383 (GRCm39)	missense	possibly damaging	0.95
R3739:Lcorl	UTSW	5	45,891,383 (GRCm39)	missense	possibly damaging	0.95
R3825:Lcorl	UTSW	5	45,932,729 (GRCm39)	splice site	probably benign
R4035:Lcorl	UTSW	5	45,891,383 (GRCm39)	missense	possibly damaging	0.95
R4199:Lcorl	UTSW	5	45,891,130 (GRCm39)	missense	possibly damaging	0.83
R4583:Lcorl	UTSW	5	45,890,931 (GRCm39)	nonsense	probably null
R4647:Lcorl	UTSW	5	45,890,931 (GRCm39)	nonsense	probably null
R4803:Lcorl	UTSW	5	45,904,623 (GRCm39)	unclassified	probably null
R5524:Lcorl	UTSW	5	45,932,865 (GRCm39)	critical splice acceptor site	probably null
R5524:Lcorl	UTSW	5	45,932,864 (GRCm39)	critical splice acceptor site	probably null
R5526:Lcorl	UTSW	5	45,891,069 (GRCm39)	missense	probably benign
R5533:Lcorl	UTSW	5	45,891,219 (GRCm39)	missense	possibly damaging	0.47
R5772:Lcorl	UTSW	5	45,952,709 (GRCm39)	splice site	probably null
R6175:Lcorl	UTSW	5	45,933,832 (GRCm39)	missense	probably damaging	1.00
R6734:Lcorl	UTSW	5	45,890,839 (GRCm39)	missense	probably damaging	0.98
R6864:Lcorl	UTSW	5	45,904,546 (GRCm39)	missense	probably damaging	1.00
R7078:Lcorl	UTSW	5	45,904,566 (GRCm39)	missense	probably damaging	1.00
R7396:Lcorl	UTSW	5	46,014,801 (GRCm39)	splice site	probably null
R7624:Lcorl	UTSW	5	45,859,307 (GRCm39)	missense	probably benign
R9008:Lcorl	UTSW	5	45,931,516 (GRCm39)	intron	probably benign
R9354:Lcorl	UTSW	5	45,890,968 (GRCm39)	nonsense	probably null
R9497:Lcorl	UTSW	5	45,891,339 (GRCm39)	missense	probably benign
X0023:Lcorl	UTSW	5	45,891,354 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GAAACACTGACATTTGTTTGACCAG -3'
(R):5'- TGACTTCCGTCAGCACATCAC -3'

Sequencing Primer
(F):5'- CTGACATTTGTTTGACCAGCTTTAG -3'
(R):5'- CACATCACAGTCAAATGCTGATTTTG -3'

Posted On

2017-02-28