|Institutional Source||Beutler Lab|
|Gene Name||histone deacetylase 3|
|Essential gene?||Essential (E-score: 1.000)|
|Stock #||R5929 (G1)|
|Chromosomal Location||37935844-37954988 bp(-) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||C to T at 37941341 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000037981 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000043498]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (84/85)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hdac3||
(F):5'- AAGATTGTCTGGCGGATCTG -3'
(R):5'- ACTCTGGTGTCTCAGCCATAC -3'
(F):5'- TCTGGTCCAGATACTAGTTTAGAAG -3'
(R):5'- GGTGTCTCAGCCATACTCTTG -3'