Mutagenetix > Incidental Mutation

Incidental Mutation 'R5930:Itpr3'

460217

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

Itpr-3, Ip3r3, tf

MMRRC Submission

044125-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5930 (G1)

Quality Score

207

Status

Validated

Chromosome

Chromosomal Location

27276278-27341197 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 27329895 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 1563 (Q1563L)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000049308
AA Change: Q1563L

PolyPhen 2 Score 0.488 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: Q1563L

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Meta Mutation Damage Score

0.2642

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

94% (102/109)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	C	T	13: 81,545,570 (GRCm39)	V5572I	probably benign	Het
Agap1	C	T	1: 89,770,818 (GRCm39)	T656I	probably damaging	Het
Als2cl	C	T	9: 110,716,432 (GRCm39)	R247W	probably damaging	Het
Ankfy1	A	T	11: 72,603,071 (GRCm39)	R33S	probably benign	Het
Ano5	T	C	7: 51,235,079 (GRCm39)	F671L	probably damaging	Het
Arhgap26	A	G	18: 39,283,145 (GRCm39)	M361V	probably damaging	Het
Bckdk	A	G	7: 127,505,145 (GRCm39)	E175G	probably damaging	Het
Bptf	G	T	11: 106,964,022 (GRCm39)	T1724K	probably damaging	Het
Btn2a2	T	A	13: 23,670,398 (GRCm39)	I112F	probably damaging	Het
Cln8	T	A	8: 14,946,621 (GRCm39)	W212R	probably damaging	Het
Cnbd1	T	C	4: 18,886,119 (GRCm39)	E300G	probably benign	Het
Cnksr3	T	C	10: 7,092,993 (GRCm39)	I173V	probably benign	Het
Cntn2	T	A	1: 132,451,170 (GRCm39)	D484V	probably damaging	Het
Cyp4a14	C	A	4: 115,348,607 (GRCm39)	G319V	probably damaging	Het
Cyp4f37	G	A	17: 32,848,957 (GRCm39)	R275Q	possibly damaging	Het
Def8	C	T	8: 124,186,809 (GRCm39)		probably benign	Het
Dnaaf4	T	C	9: 72,879,280 (GRCm39)	V356A	probably damaging	Het
Dnah10	T	C	5: 124,868,855 (GRCm39)		probably null	Het
Dock6	A	G	9: 21,735,712 (GRCm39)	V1012A	probably benign	Het
Dus3l	T	A	17: 57,076,579 (GRCm39)	N586K	probably damaging	Het
Dyrk2	T	A	10: 118,696,173 (GRCm39)	I362F	probably damaging	Het
Eeig2	A	T	3: 108,887,468 (GRCm39)	S265R	probably benign	Het
Erc2	T	A	14: 27,498,815 (GRCm39)	D230E	probably damaging	Het
Fat1	A	G	8: 45,497,073 (GRCm39)	H4186R	probably benign	Het
Fbxo44	A	G	4: 148,241,052 (GRCm39)	F179S	probably damaging	Het
Fech	A	G	18: 64,611,720 (GRCm39)		probably null	Het
Fer1l5	T	A	1: 36,424,254 (GRCm39)	C289*	probably null	Het
Fhl5	T	A	4: 25,214,756 (GRCm39)	D7V	probably benign	Het
Flvcr1	G	T	1: 190,741,748 (GRCm39)	T514K	probably damaging	Het
Fmo1	A	T	1: 162,667,185 (GRCm39)		probably null	Het
Gabra6	G	A	11: 42,198,268 (GRCm39)	T384M	probably benign	Het
Gli3	A	G	13: 15,723,210 (GRCm39)	Y117C	probably damaging	Het
Gnao1	A	G	8: 94,622,873 (GRCm39)	D59G	probably benign	Het
Gria2	T	C	3: 80,614,556 (GRCm39)	I495V	possibly damaging	Het
Hnf1b	C	A	11: 83,754,811 (GRCm39)	H161Q	probably benign	Het
Itga8	T	A	2: 12,235,019 (GRCm39)	D413V	possibly damaging	Het
Kctd16	A	G	18: 40,663,882 (GRCm39)	N337S	probably benign	Het
Klra4	C	T	6: 130,030,016 (GRCm39)	V190M	possibly damaging	Het
Krtap4-9	T	A	11: 99,676,462 (GRCm39)		probably benign	Het
L3mbtl1	GGCCG	GG	2: 162,809,256 (GRCm39)		probably benign	Het
Mchr1	T	C	15: 81,122,044 (GRCm39)	F265L	probably damaging	Het
Megf8	T	A	7: 25,025,866 (GRCm39)	Y83*	probably null	Het
Mettl18	A	G	1: 163,824,746 (GRCm39)	M356V	probably null	Het
Mrm1	G	A	11: 84,710,018 (GRCm39)	R61W	probably damaging	Het
Muc4	A	T	16: 32,570,523 (GRCm39)	T528S	probably benign	Het
Myef2	A	T	2: 124,937,651 (GRCm39)	L530*	probably null	Het
Nhlrc4	T	C	17: 26,162,693 (GRCm39)	E18G	probably benign	Het
Nisch	C	T	14: 30,895,102 (GRCm39)	V1065I	probably benign	Het
Nlgn2	C	T	11: 69,724,975 (GRCm39)	R97H	probably damaging	Het
Nos2	T	C	11: 78,828,741 (GRCm39)	L321S	probably damaging	Het
Oaz3	T	C	3: 94,343,717 (GRCm39)	M49V	possibly damaging	Het
Olfm5	A	G	7: 103,803,362 (GRCm39)	V367A	probably damaging	Het
Omd	C	T	13: 49,743,112 (GRCm39)	P54L	possibly damaging	Het
Or10ak12	C	T	4: 118,666,575 (GRCm39)	R162H	probably benign	Het
Or11g26	C	A	14: 50,753,249 (GRCm39)	A196D	probably benign	Het
Or2g7	C	A	17: 38,378,641 (GRCm39)	A193D	probably benign	Het
Or51f23	A	T	7: 102,453,481 (GRCm39)	R265S	probably damaging	Het
Or7d10	A	G	9: 19,832,206 (GRCm39)	K234E	probably damaging	Het
Pard3b	T	A	1: 61,807,289 (GRCm39)		probably benign	Het
Pcdhb18	A	C	18: 37,624,988 (GRCm39)	I773L	possibly damaging	Het
Pde11a	T	C	2: 75,970,175 (GRCm39)		probably null	Het
Pfkfb4	A	C	9: 108,859,462 (GRCm39)		probably benign	Het
Phb2	T	G	6: 124,692,612 (GRCm39)	I260S	probably damaging	Het
Pkd1l1	G	A	11: 8,908,969 (GRCm39)	T345I	unknown	Het
Pla2g6	T	C	15: 79,187,728 (GRCm39)		probably benign	Het
Pou4f2	G	A	8: 79,163,020 (GRCm39)	S5F	unknown	Het
Ppp1r9a	A	T	6: 5,157,002 (GRCm39)		probably null	Het
Pramel5	A	G	4: 143,999,553 (GRCm39)	I178T	probably benign	Het
Prom2	C	T	2: 127,372,053 (GRCm39)	W745*	probably null	Het
Pros1	T	A	16: 62,748,424 (GRCm39)	N632K	probably damaging	Het
Rab4b	A	G	7: 26,873,927 (GRCm39)	I117T	probably benign	Het
Rbm25	T	A	12: 83,724,640 (GRCm39)	H796Q	possibly damaging	Het
Rnf151	A	T	17: 24,937,004 (GRCm39)		probably null	Het
Rps6ka1	A	T	4: 133,598,882 (GRCm39)	L97I	probably damaging	Het
Scart1	C	T	7: 139,810,359 (GRCm39)	P984S	probably benign	Het
Semp2l2a	T	A	8: 13,887,263 (GRCm39)	D276V	probably benign	Het
Sergef	T	A	7: 46,092,888 (GRCm39)	T374S	probably benign	Het
Sh3rf3	G	T	10: 58,966,808 (GRCm39)	G717C	probably damaging	Het
Slc29a4	C	T	5: 142,707,157 (GRCm39)	T500I	possibly damaging	Het
Smc1b	T	A	15: 84,970,322 (GRCm39)	D977V	probably damaging	Het
Spata31d1d	C	T	13: 59,874,829 (GRCm39)	C902Y	probably benign	Het
St14	A	T	9: 31,015,056 (GRCm39)	V314D	probably damaging	Het
Stat3	A	T	11: 100,784,496 (GRCm39)	I602N	possibly damaging	Het
Stx4a	T	A	7: 127,445,661 (GRCm39)	I189N	probably damaging	Het
Tacc1	A	G	8: 25,672,215 (GRCm39)	S338P	probably benign	Het
Tcirg1	T	A	19: 3,952,424 (GRCm39)	T315S	possibly damaging	Het
Tenm4	A	T	7: 96,503,926 (GRCm39)	N1295I	probably damaging	Het
Tm7sf3	T	C	6: 146,505,409 (GRCm39)	K516E	possibly damaging	Het
Tmem198b	T	C	10: 128,637,323 (GRCm39)	E272G	possibly damaging	Het
Tnip3	A	G	6: 65,582,937 (GRCm39)	Q237R	probably damaging	Het
Trim15	C	T	17: 37,173,252 (GRCm39)		probably null	Het
Trim30a	T	A	7: 104,070,657 (GRCm39)	N252I	possibly damaging	Het
Ttc39a	A	G	4: 109,288,075 (GRCm39)	E227G	probably benign	Het
Ttll13	A	G	7: 79,902,914 (GRCm39)	E194G	probably damaging	Het
Upf1	G	A	8: 70,796,912 (GRCm39)	T107I	probably benign	Het
Vac14	A	G	8: 111,436,981 (GRCm39)	I565V	probably damaging	Het
Zcchc14	A	T	8: 122,338,097 (GRCm39)		probably benign	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,302,603 (GRCm39)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,329,930 (GRCm39)	missense	probably benign
IGL01151:Itpr3	APN	17	27,310,503 (GRCm39)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,318,739 (GRCm39)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,337,569 (GRCm39)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,336,152 (GRCm39)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,330,236 (GRCm39)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,340,449 (GRCm39)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,323,069 (GRCm39)	missense	probably benign
IGL02063:Itpr3	APN	17	27,338,997 (GRCm39)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,336,249 (GRCm39)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,317,416 (GRCm39)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,318,588 (GRCm39)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,317,153 (GRCm39)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,333,486 (GRCm39)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,325,372 (GRCm39)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,323,530 (GRCm39)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,308,586 (GRCm39)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,316,952 (GRCm39)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,310,907 (GRCm39)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,338,240 (GRCm39)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,330,242 (GRCm39)	missense	probably benign
IGL03404:Itpr3	APN	17	27,310,492 (GRCm39)	missense	probably damaging	1.00
Allure	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
alopecia	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98
Beauty	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
Paradox	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,339,951 (GRCm39)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,317,296 (GRCm39)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,314,966 (GRCm39)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,333,088 (GRCm39)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,308,293 (GRCm39)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,332,793 (GRCm39)	missense	probably benign
R0485:Itpr3	UTSW	17	27,330,903 (GRCm39)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,326,263 (GRCm39)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,329,529 (GRCm39)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,307,985 (GRCm39)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,310,343 (GRCm39)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,333,897 (GRCm39)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,337,346 (GRCm39)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,336,128 (GRCm39)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,333,199 (GRCm39)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,324,459 (GRCm39)	splice site	probably null
R1533:Itpr3	UTSW	17	27,314,534 (GRCm39)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,333,121 (GRCm39)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,335,581 (GRCm39)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,307,987 (GRCm39)	missense	probably benign
R1726:Itpr3	UTSW	17	27,330,664 (GRCm39)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,338,997 (GRCm39)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,321,785 (GRCm39)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,334,027 (GRCm39)	missense	probably benign
R2248:Itpr3	UTSW	17	27,334,033 (GRCm39)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,332,553 (GRCm39)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,314,889 (GRCm39)	missense	probably benign
R2864:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,314,446 (GRCm39)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,332,814 (GRCm39)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,310,546 (GRCm39)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,304,105 (GRCm39)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,326,232 (GRCm39)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,325,298 (GRCm39)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,330,948 (GRCm39)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,323,586 (GRCm39)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,312,257 (GRCm39)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,304,121 (GRCm39)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,316,979 (GRCm39)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,302,582 (GRCm39)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,308,885 (GRCm39)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,317,397 (GRCm39)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,335,663 (GRCm39)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,326,308 (GRCm39)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,334,926 (GRCm39)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,322,880 (GRCm39)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,332,493 (GRCm39)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,337,540 (GRCm39)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,326,852 (GRCm39)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,325,379 (GRCm39)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,305,950 (GRCm39)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,334,039 (GRCm39)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,336,867 (GRCm39)	missense	probably damaging	1.00
R5987:Itpr3	UTSW	17	27,323,575 (GRCm39)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,330,174 (GRCm39)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,314,449 (GRCm39)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6515:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6516:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6955:Itpr3	UTSW	17	27,340,441 (GRCm39)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,329,554 (GRCm39)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,308,269 (GRCm39)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,337,535 (GRCm39)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,326,786 (GRCm39)	splice site	probably null
R7469:Itpr3	UTSW	17	27,340,028 (GRCm39)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,313,774 (GRCm39)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,308,013 (GRCm39)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,329,862 (GRCm39)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,307,951 (GRCm39)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,317,088 (GRCm39)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,315,037 (GRCm39)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,337,571 (GRCm39)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,336,153 (GRCm39)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,335,751 (GRCm39)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,331,002 (GRCm39)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,326,711 (GRCm39)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,334,887 (GRCm39)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,323,086 (GRCm39)	synonymous	silent
R8269:Itpr3	UTSW	17	27,312,258 (GRCm39)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,306,622 (GRCm39)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,325,199 (GRCm39)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,334,893 (GRCm39)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,330,900 (GRCm39)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,330,996 (GRCm39)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,335,628 (GRCm39)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,326,636 (GRCm39)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,314,899 (GRCm39)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,324,523 (GRCm39)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,334,927 (GRCm39)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,308,915 (GRCm39)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,330,000 (GRCm39)	splice site	probably null
V7732:Itpr3	UTSW	17	27,329,998 (GRCm39)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,332,502 (GRCm39)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,338,961 (GRCm39)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,333,903 (GRCm39)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CTGACTGCAAAGGATCAGGC -3'
(R):5'- GTGTCCAACCAAGAAGCAGC -3'

Sequencing Primer
(F):5'- AGATTCCTTGTGTGCCTACCAGG -3'
(R):5'- ACCAAGAAGCAGCAACTCTG -3'

Posted On

2017-02-28