Incidental Mutation 'R5941:Duox1'
| ID |
460233 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
044133-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5941 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 122174637 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1265
(L1265Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048635]
[ENSMUST00000099461]
[ENSMUST00000110531]
[ENSMUST00000110532]
[ENSMUST00000125826]
[ENSMUST00000139819]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000048635
|
| SMART Domains |
Protein: ENSMUSP00000045135
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
48 |
67 |
N/A |
INTRINSIC |
|
SH2
|
136 |
220 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099461
AA Change: L1265Q
PolyPhen 2
Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: L1265Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110531
|
| SMART Domains |
Protein: ENSMUSP00000106160
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
48 |
67 |
N/A |
INTRINSIC |
|
SH2
|
136 |
220 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110532
|
| SMART Domains |
Protein: ENSMUSP00000106161
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
61 |
N/A |
INTRINSIC |
|
low complexity region
|
77 |
87 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
165 |
N/A |
INTRINSIC |
|
Blast:SH2
|
225 |
278 |
2e-22 |
BLAST |
|
SCOP:d1ayaa_
|
237 |
291 |
1e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125826
|
| SMART Domains |
Protein: ENSMUSP00000117099
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
56 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
129 |
148 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
275 |
N/A |
INTRINSIC |
|
SH2
|
344 |
428 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139819
|
| SMART Domains |
Protein: ENSMUSP00000119980
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
83 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
163 |
N/A |
INTRINSIC |
|
SH2
|
218 |
302 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151130
|
| SMART Domains |
Protein: ENSMUSP00000114524
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
140 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
163 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
267 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9527 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.8%
- 20x: 93.2%
|
| Validation Efficiency |
97% (95/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm2 |
T |
A |
7: 119,190,321 (GRCm39) |
D70E |
probably damaging |
Het |
| Adamts14 |
C |
T |
10: 61,057,674 (GRCm39) |
G561R |
probably damaging |
Het |
| Alpk3 |
A |
T |
7: 80,728,401 (GRCm39) |
K510N |
probably damaging |
Het |
| Ap3b1 |
A |
G |
13: 94,576,781 (GRCm39) |
N269D |
probably benign |
Het |
| Ap3b1 |
T |
C |
13: 94,619,773 (GRCm39) |
S144P |
probably damaging |
Het |
| Apba2 |
C |
A |
7: 64,395,464 (GRCm39) |
Q635K |
probably benign |
Het |
| Aspg |
C |
T |
12: 112,079,519 (GRCm39) |
T99I |
probably benign |
Het |
| Atp7b |
A |
G |
8: 22,487,512 (GRCm39) |
V1179A |
probably damaging |
Het |
| Bbs12 |
T |
C |
3: 37,374,197 (GRCm39) |
V215A |
probably damaging |
Het |
| Bcl2l11 |
C |
A |
2: 127,969,703 (GRCm39) |
|
probably benign |
Het |
| Bglap3 |
T |
G |
3: 88,283,653 (GRCm39) |
|
probably benign |
Het |
| Cchcr1 |
G |
A |
17: 35,835,890 (GRCm39) |
R284Q |
probably damaging |
Het |
| Cdh26 |
C |
T |
2: 178,123,443 (GRCm39) |
Q662* |
probably null |
Het |
| Cftr |
T |
A |
6: 18,313,645 (GRCm39) |
F1290I |
probably damaging |
Het |
| Clip3 |
G |
A |
7: 29,991,731 (GRCm39) |
E36K |
probably damaging |
Het |
| Cog2 |
A |
G |
8: 125,272,825 (GRCm39) |
I541V |
probably benign |
Het |
| Cpt1b |
A |
T |
15: 89,309,417 (GRCm39) |
W39R |
probably damaging |
Het |
| Csmd1 |
A |
G |
8: 15,982,471 (GRCm39) |
V2732A |
probably damaging |
Het |
| Dlec1 |
A |
G |
9: 118,955,380 (GRCm39) |
D688G |
probably damaging |
Het |
| Dnah12 |
A |
G |
14: 26,428,022 (GRCm39) |
E216G |
probably benign |
Het |
| Dnah7b |
C |
A |
1: 46,226,450 (GRCm39) |
L1294I |
probably damaging |
Het |
| Fam91a1 |
T |
A |
15: 58,303,166 (GRCm39) |
D358E |
probably benign |
Het |
| Fat3 |
A |
C |
9: 15,910,797 (GRCm39) |
I1735S |
probably benign |
Het |
| Fkbpl |
G |
A |
17: 34,864,303 (GRCm39) |
A24T |
probably benign |
Het |
| Gabrr1 |
T |
A |
4: 33,162,676 (GRCm39) |
M414K |
probably benign |
Het |
| Gm21915 |
A |
C |
9: 40,581,995 (GRCm39) |
E29D |
possibly damaging |
Het |
| Gm9955 |
G |
A |
18: 24,842,320 (GRCm39) |
|
probably benign |
Het |
| Gpat2 |
C |
A |
2: 127,270,195 (GRCm39) |
D69E |
possibly damaging |
Het |
| Grin2b |
T |
G |
6: 135,713,371 (GRCm39) |
I837L |
probably damaging |
Het |
| Gucy2g |
T |
C |
19: 55,203,563 (GRCm39) |
D745G |
probably damaging |
Het |
| H2-Q1 |
A |
G |
17: 35,540,332 (GRCm39) |
Y139C |
probably damaging |
Het |
| Ints2 |
G |
C |
11: 86,141,798 (GRCm39) |
N216K |
probably benign |
Het |
| Jmy |
G |
A |
13: 93,635,333 (GRCm39) |
P161L |
probably benign |
Het |
| Kctd11 |
G |
A |
11: 69,770,799 (GRCm39) |
R80W |
possibly damaging |
Het |
| Kif7 |
A |
G |
7: 79,360,880 (GRCm39) |
|
probably benign |
Het |
| Kifc1 |
C |
T |
17: 34,102,059 (GRCm39) |
|
probably benign |
Het |
| Lcor |
G |
A |
19: 41,574,839 (GRCm39) |
R1198Q |
probably damaging |
Het |
| Mir412 |
C |
A |
12: 109,709,733 (GRCm39) |
|
noncoding transcript |
Het |
| Mknk1 |
T |
A |
4: 115,733,834 (GRCm39) |
|
probably benign |
Het |
| Mmp16 |
A |
G |
4: 18,054,354 (GRCm39) |
|
probably benign |
Het |
| Mmp7 |
A |
G |
9: 7,697,646 (GRCm39) |
H227R |
probably damaging |
Het |
| Myh4 |
A |
C |
11: 67,150,126 (GRCm39) |
D1861A |
probably damaging |
Het |
| Nup205 |
T |
C |
6: 35,209,343 (GRCm39) |
L1550P |
probably damaging |
Het |
| Or10g1 |
C |
T |
14: 52,647,525 (GRCm39) |
G268D |
probably benign |
Het |
| Or2a56 |
G |
T |
6: 42,932,650 (GRCm39) |
A73S |
possibly damaging |
Het |
| Or4c113 |
T |
A |
2: 88,884,963 (GRCm39) |
H269L |
probably benign |
Het |
| Or4c58 |
T |
A |
2: 89,674,859 (GRCm39) |
I153F |
probably benign |
Het |
| Or51af1 |
A |
G |
7: 103,141,927 (GRCm39) |
S53P |
possibly damaging |
Het |
| Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
| Pafah1b2 |
A |
T |
9: 45,887,405 (GRCm39) |
C35* |
probably null |
Het |
| Pappa |
T |
A |
4: 65,232,830 (GRCm39) |
F1323Y |
possibly damaging |
Het |
| Phtf2 |
A |
T |
5: 20,979,071 (GRCm39) |
F519Y |
probably damaging |
Het |
| Pigk |
T |
C |
3: 152,472,150 (GRCm39) |
I354T |
possibly damaging |
Het |
| Plekha7 |
T |
C |
7: 115,724,040 (GRCm39) |
D1265G |
possibly damaging |
Het |
| Prss12 |
A |
G |
3: 123,299,150 (GRCm39) |
R641G |
probably benign |
Het |
| Prss28 |
A |
G |
17: 25,528,717 (GRCm39) |
Y53C |
probably damaging |
Het |
| Rabgap1 |
G |
T |
2: 37,451,908 (GRCm39) |
C936F |
possibly damaging |
Het |
| Rap1a |
T |
C |
3: 105,639,385 (GRCm39) |
I91M |
possibly damaging |
Het |
| Rap1gap2 |
A |
T |
11: 74,283,063 (GRCm39) |
M679K |
probably damaging |
Het |
| Rapgef5 |
T |
A |
12: 117,692,473 (GRCm39) |
L352I |
probably damaging |
Het |
| Rhbdl3 |
G |
A |
11: 80,222,715 (GRCm39) |
V255M |
probably benign |
Het |
| Rhot1 |
T |
C |
11: 80,141,996 (GRCm39) |
|
probably benign |
Het |
| Rita1 |
A |
C |
5: 120,747,626 (GRCm39) |
V224G |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,702,788 (GRCm39) |
Y2900F |
probably damaging |
Het |
| Scaf11 |
A |
C |
15: 96,318,189 (GRCm39) |
H458Q |
probably damaging |
Het |
| Scamp4 |
T |
A |
10: 80,448,255 (GRCm39) |
S159T |
probably benign |
Het |
| Setd5 |
T |
A |
6: 113,105,451 (GRCm39) |
Y828N |
probably damaging |
Het |
| Sh3bp5 |
C |
A |
14: 31,099,452 (GRCm39) |
R265L |
probably benign |
Het |
| Sipa1l2 |
A |
G |
8: 126,200,275 (GRCm39) |
S684P |
probably damaging |
Het |
| Stard9 |
A |
T |
2: 120,544,039 (GRCm39) |
I4446F |
probably damaging |
Het |
| Sult1c2 |
T |
C |
17: 54,138,926 (GRCm39) |
D217G |
probably benign |
Het |
| Supt16 |
C |
A |
14: 52,419,653 (GRCm39) |
K148N |
probably benign |
Het |
| Syne3 |
G |
A |
12: 104,913,251 (GRCm39) |
S570L |
probably benign |
Het |
| Tcf3 |
G |
T |
10: 80,248,878 (GRCm39) |
D534E |
probably benign |
Het |
| Tmed6 |
G |
T |
8: 107,790,786 (GRCm39) |
T87K |
probably damaging |
Het |
| Trbv3 |
T |
C |
6: 41,025,335 (GRCm39) |
I3T |
probably benign |
Het |
| Trbv4 |
T |
A |
6: 41,036,563 (GRCm39) |
Y29* |
probably null |
Het |
| Ttl |
A |
G |
2: 128,917,904 (GRCm39) |
N122S |
probably benign |
Het |
| Txndc11 |
T |
C |
16: 10,892,935 (GRCm39) |
T932A |
probably benign |
Het |
| Ube2e2 |
G |
A |
14: 18,586,910 (GRCm38) |
A150V |
probably damaging |
Het |
| Ube2ql1 |
T |
C |
13: 69,887,459 (GRCm39) |
M1V |
probably null |
Het |
| Uqcrc1 |
A |
G |
9: 108,776,554 (GRCm39) |
|
probably benign |
Het |
| Utrn |
T |
C |
10: 12,362,227 (GRCm39) |
D2702G |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,840,810 (GRCm39) |
D618V |
probably damaging |
Het |
| Vdac3-ps1 |
A |
G |
13: 18,205,787 (GRCm39) |
|
noncoding transcript |
Het |
| Wee1 |
TCCCC |
TCCC |
7: 109,723,776 (GRCm39) |
|
probably null |
Het |
| Zap70 |
G |
A |
1: 36,810,030 (GRCm39) |
V47M |
probably damaging |
Het |
| Zfp770 |
A |
G |
2: 114,028,027 (GRCm39) |
M14T |
possibly damaging |
Het |
| Zup1 |
C |
T |
10: 33,825,458 (GRCm39) |
G8D |
probably damaging |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCTAAGGACAAAGCTGGC -3'
(R):5'- GGCCTAATCTAGCAAAGAACGTTTC -3'
Sequencing Primer
(F):5'- CAAAGCTGGCATCACAGTCTGTTG -3'
(R):5'- GAATTACTCCTTCCAATGGCTCTAGG -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation