Incidental Mutation 'R5941:Myh4'
| ID |
460282 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh4
|
| Ensembl Gene |
ENSMUSG00000057003 |
| Gene Name |
myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms |
MYH-2B, MM, MHC2B, MyHC-IIb, Myhsf, Minimsc, Minmus |
| MMRRC Submission |
044133-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.386)
|
| Stock # |
R5941 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
67128855-67151272 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 67150126 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Alanine
at position 1861
(D1861A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018632]
[ENSMUST00000170942]
|
| AlphaFold |
Q5SX39 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018632
AA Change: D1861A
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000018632
Gene: ENSMUSG00000057003
AA Change: D1861A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
4.7e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
2.5e-168 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170942
AA Change: D1861A
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000127514
Gene: ENSMUSG00000057003
AA Change: D1861A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-15 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
low complexity region
|
928 |
942 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Meta Mutation Damage Score |
0.7903 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.8%
- 20x: 93.2%
|
| Validation Efficiency |
97% (95/98) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, knock-out(1) Targeted, other(2) |
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm2 |
T |
A |
7: 119,190,321 (GRCm39) |
D70E |
probably damaging |
Het |
| Adamts14 |
C |
T |
10: 61,057,674 (GRCm39) |
G561R |
probably damaging |
Het |
| Alpk3 |
A |
T |
7: 80,728,401 (GRCm39) |
K510N |
probably damaging |
Het |
| Ap3b1 |
A |
G |
13: 94,576,781 (GRCm39) |
N269D |
probably benign |
Het |
| Ap3b1 |
T |
C |
13: 94,619,773 (GRCm39) |
S144P |
probably damaging |
Het |
| Apba2 |
C |
A |
7: 64,395,464 (GRCm39) |
Q635K |
probably benign |
Het |
| Aspg |
C |
T |
12: 112,079,519 (GRCm39) |
T99I |
probably benign |
Het |
| Atp7b |
A |
G |
8: 22,487,512 (GRCm39) |
V1179A |
probably damaging |
Het |
| Bbs12 |
T |
C |
3: 37,374,197 (GRCm39) |
V215A |
probably damaging |
Het |
| Bcl2l11 |
C |
A |
2: 127,969,703 (GRCm39) |
|
probably benign |
Het |
| Bglap3 |
T |
G |
3: 88,283,653 (GRCm39) |
|
probably benign |
Het |
| Cchcr1 |
G |
A |
17: 35,835,890 (GRCm39) |
R284Q |
probably damaging |
Het |
| Cdh26 |
C |
T |
2: 178,123,443 (GRCm39) |
Q662* |
probably null |
Het |
| Cftr |
T |
A |
6: 18,313,645 (GRCm39) |
F1290I |
probably damaging |
Het |
| Clip3 |
G |
A |
7: 29,991,731 (GRCm39) |
E36K |
probably damaging |
Het |
| Cog2 |
A |
G |
8: 125,272,825 (GRCm39) |
I541V |
probably benign |
Het |
| Cpt1b |
A |
T |
15: 89,309,417 (GRCm39) |
W39R |
probably damaging |
Het |
| Csmd1 |
A |
G |
8: 15,982,471 (GRCm39) |
V2732A |
probably damaging |
Het |
| Dlec1 |
A |
G |
9: 118,955,380 (GRCm39) |
D688G |
probably damaging |
Het |
| Dnah12 |
A |
G |
14: 26,428,022 (GRCm39) |
E216G |
probably benign |
Het |
| Dnah7b |
C |
A |
1: 46,226,450 (GRCm39) |
L1294I |
probably damaging |
Het |
| Duox1 |
T |
A |
2: 122,174,637 (GRCm39) |
L1265Q |
probably damaging |
Het |
| Fam91a1 |
T |
A |
15: 58,303,166 (GRCm39) |
D358E |
probably benign |
Het |
| Fat3 |
A |
C |
9: 15,910,797 (GRCm39) |
I1735S |
probably benign |
Het |
| Fkbpl |
G |
A |
17: 34,864,303 (GRCm39) |
A24T |
probably benign |
Het |
| Gabrr1 |
T |
A |
4: 33,162,676 (GRCm39) |
M414K |
probably benign |
Het |
| Gm21915 |
A |
C |
9: 40,581,995 (GRCm39) |
E29D |
possibly damaging |
Het |
| Gm9955 |
G |
A |
18: 24,842,320 (GRCm39) |
|
probably benign |
Het |
| Gpat2 |
C |
A |
2: 127,270,195 (GRCm39) |
D69E |
possibly damaging |
Het |
| Grin2b |
T |
G |
6: 135,713,371 (GRCm39) |
I837L |
probably damaging |
Het |
| Gucy2g |
T |
C |
19: 55,203,563 (GRCm39) |
D745G |
probably damaging |
Het |
| H2-Q1 |
A |
G |
17: 35,540,332 (GRCm39) |
Y139C |
probably damaging |
Het |
| Ints2 |
G |
C |
11: 86,141,798 (GRCm39) |
N216K |
probably benign |
Het |
| Jmy |
G |
A |
13: 93,635,333 (GRCm39) |
P161L |
probably benign |
Het |
| Kctd11 |
G |
A |
11: 69,770,799 (GRCm39) |
R80W |
possibly damaging |
Het |
| Kif7 |
A |
G |
7: 79,360,880 (GRCm39) |
|
probably benign |
Het |
| Kifc1 |
C |
T |
17: 34,102,059 (GRCm39) |
|
probably benign |
Het |
| Lcor |
G |
A |
19: 41,574,839 (GRCm39) |
R1198Q |
probably damaging |
Het |
| Mir412 |
C |
A |
12: 109,709,733 (GRCm39) |
|
noncoding transcript |
Het |
| Mknk1 |
T |
A |
4: 115,733,834 (GRCm39) |
|
probably benign |
Het |
| Mmp16 |
A |
G |
4: 18,054,354 (GRCm39) |
|
probably benign |
Het |
| Mmp7 |
A |
G |
9: 7,697,646 (GRCm39) |
H227R |
probably damaging |
Het |
| Nup205 |
T |
C |
6: 35,209,343 (GRCm39) |
L1550P |
probably damaging |
Het |
| Or10g1 |
C |
T |
14: 52,647,525 (GRCm39) |
G268D |
probably benign |
Het |
| Or2a56 |
G |
T |
6: 42,932,650 (GRCm39) |
A73S |
possibly damaging |
Het |
| Or4c113 |
T |
A |
2: 88,884,963 (GRCm39) |
H269L |
probably benign |
Het |
| Or4c58 |
T |
A |
2: 89,674,859 (GRCm39) |
I153F |
probably benign |
Het |
| Or51af1 |
A |
G |
7: 103,141,927 (GRCm39) |
S53P |
possibly damaging |
Het |
| Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
| Pafah1b2 |
A |
T |
9: 45,887,405 (GRCm39) |
C35* |
probably null |
Het |
| Pappa |
T |
A |
4: 65,232,830 (GRCm39) |
F1323Y |
possibly damaging |
Het |
| Phtf2 |
A |
T |
5: 20,979,071 (GRCm39) |
F519Y |
probably damaging |
Het |
| Pigk |
T |
C |
3: 152,472,150 (GRCm39) |
I354T |
possibly damaging |
Het |
| Plekha7 |
T |
C |
7: 115,724,040 (GRCm39) |
D1265G |
possibly damaging |
Het |
| Prss12 |
A |
G |
3: 123,299,150 (GRCm39) |
R641G |
probably benign |
Het |
| Prss28 |
A |
G |
17: 25,528,717 (GRCm39) |
Y53C |
probably damaging |
Het |
| Rabgap1 |
G |
T |
2: 37,451,908 (GRCm39) |
C936F |
possibly damaging |
Het |
| Rap1a |
T |
C |
3: 105,639,385 (GRCm39) |
I91M |
possibly damaging |
Het |
| Rap1gap2 |
A |
T |
11: 74,283,063 (GRCm39) |
M679K |
probably damaging |
Het |
| Rapgef5 |
T |
A |
12: 117,692,473 (GRCm39) |
L352I |
probably damaging |
Het |
| Rhbdl3 |
G |
A |
11: 80,222,715 (GRCm39) |
V255M |
probably benign |
Het |
| Rhot1 |
T |
C |
11: 80,141,996 (GRCm39) |
|
probably benign |
Het |
| Rita1 |
A |
C |
5: 120,747,626 (GRCm39) |
V224G |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,702,788 (GRCm39) |
Y2900F |
probably damaging |
Het |
| Scaf11 |
A |
C |
15: 96,318,189 (GRCm39) |
H458Q |
probably damaging |
Het |
| Scamp4 |
T |
A |
10: 80,448,255 (GRCm39) |
S159T |
probably benign |
Het |
| Setd5 |
T |
A |
6: 113,105,451 (GRCm39) |
Y828N |
probably damaging |
Het |
| Sh3bp5 |
C |
A |
14: 31,099,452 (GRCm39) |
R265L |
probably benign |
Het |
| Sipa1l2 |
A |
G |
8: 126,200,275 (GRCm39) |
S684P |
probably damaging |
Het |
| Stard9 |
A |
T |
2: 120,544,039 (GRCm39) |
I4446F |
probably damaging |
Het |
| Sult1c2 |
T |
C |
17: 54,138,926 (GRCm39) |
D217G |
probably benign |
Het |
| Supt16 |
C |
A |
14: 52,419,653 (GRCm39) |
K148N |
probably benign |
Het |
| Syne3 |
G |
A |
12: 104,913,251 (GRCm39) |
S570L |
probably benign |
Het |
| Tcf3 |
G |
T |
10: 80,248,878 (GRCm39) |
D534E |
probably benign |
Het |
| Tmed6 |
G |
T |
8: 107,790,786 (GRCm39) |
T87K |
probably damaging |
Het |
| Trbv3 |
T |
C |
6: 41,025,335 (GRCm39) |
I3T |
probably benign |
Het |
| Trbv4 |
T |
A |
6: 41,036,563 (GRCm39) |
Y29* |
probably null |
Het |
| Ttl |
A |
G |
2: 128,917,904 (GRCm39) |
N122S |
probably benign |
Het |
| Txndc11 |
T |
C |
16: 10,892,935 (GRCm39) |
T932A |
probably benign |
Het |
| Ube2e2 |
G |
A |
14: 18,586,910 (GRCm38) |
A150V |
probably damaging |
Het |
| Ube2ql1 |
T |
C |
13: 69,887,459 (GRCm39) |
M1V |
probably null |
Het |
| Uqcrc1 |
A |
G |
9: 108,776,554 (GRCm39) |
|
probably benign |
Het |
| Utrn |
T |
C |
10: 12,362,227 (GRCm39) |
D2702G |
probably damaging |
Het |
| Vcan |
T |
A |
13: 89,840,810 (GRCm39) |
D618V |
probably damaging |
Het |
| Vdac3-ps1 |
A |
G |
13: 18,205,787 (GRCm39) |
|
noncoding transcript |
Het |
| Wee1 |
TCCCC |
TCCC |
7: 109,723,776 (GRCm39) |
|
probably null |
Het |
| Zap70 |
G |
A |
1: 36,810,030 (GRCm39) |
V47M |
probably damaging |
Het |
| Zfp770 |
A |
G |
2: 114,028,027 (GRCm39) |
M14T |
possibly damaging |
Het |
| Zup1 |
C |
T |
10: 33,825,458 (GRCm39) |
G8D |
probably damaging |
Het |
|
| Other mutations in Myh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01471:Myh4
|
APN |
11 |
67,146,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Myh4
|
APN |
11 |
67,151,015 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01737:Myh4
|
APN |
11 |
67,134,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Myh4
|
APN |
11 |
67,142,760 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02334:Myh4
|
APN |
11 |
67,136,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02376:Myh4
|
APN |
11 |
67,136,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Myh4
|
APN |
11 |
67,149,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02450:Myh4
|
APN |
11 |
67,142,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02524:Myh4
|
APN |
11 |
67,140,066 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02612:Myh4
|
APN |
11 |
67,147,305 (GRCm39) |
missense |
probably benign |
|
|
IGL03024:Myh4
|
APN |
11 |
67,139,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Myh4
|
APN |
11 |
67,149,982 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03084:Myh4
|
APN |
11 |
67,142,777 (GRCm39) |
splice site |
probably null |
|
|
IGL03188:Myh4
|
APN |
11 |
67,137,369 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03204:Myh4
|
APN |
11 |
67,141,122 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL03252:Myh4
|
APN |
11 |
67,143,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03345:Myh4
|
APN |
11 |
67,146,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mr_chicken
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Mrs_muir
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Willies
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F6893:Myh4
|
UTSW |
11 |
67,146,283 (GRCm39) |
missense |
probably null |
0.12 |
|
PIT1430001:Myh4
|
UTSW |
11 |
67,149,658 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4458001:Myh4
|
UTSW |
11 |
67,131,821 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0099:Myh4
|
UTSW |
11 |
67,150,173 (GRCm39) |
missense |
probably benign |
|
|
R0194:Myh4
|
UTSW |
11 |
67,143,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0346:Myh4
|
UTSW |
11 |
67,151,152 (GRCm39) |
missense |
probably benign |
|
|
R0427:Myh4
|
UTSW |
11 |
67,149,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0483:Myh4
|
UTSW |
11 |
67,143,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Myh4
|
UTSW |
11 |
67,141,157 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0854:Myh4
|
UTSW |
11 |
67,149,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0940:Myh4
|
UTSW |
11 |
67,133,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Myh4
|
UTSW |
11 |
67,142,577 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1108:Myh4
|
UTSW |
11 |
67,146,532 (GRCm39) |
missense |
probably null |
0.01 |
|
R1162:Myh4
|
UTSW |
11 |
67,149,439 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1194:Myh4
|
UTSW |
11 |
67,146,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1347:Myh4
|
UTSW |
11 |
67,135,567 (GRCm39) |
splice site |
probably benign |
|
|
R1457:Myh4
|
UTSW |
11 |
67,139,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1531:Myh4
|
UTSW |
11 |
67,141,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1716:Myh4
|
UTSW |
11 |
67,141,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1766:Myh4
|
UTSW |
11 |
67,147,121 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1796:Myh4
|
UTSW |
11 |
67,151,150 (GRCm39) |
missense |
probably benign |
|
|
R1856:Myh4
|
UTSW |
11 |
67,146,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Myh4
|
UTSW |
11 |
67,145,569 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2069:Myh4
|
UTSW |
11 |
67,137,192 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Myh4
|
UTSW |
11 |
67,146,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2406:Myh4
|
UTSW |
11 |
67,150,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2414:Myh4
|
UTSW |
11 |
67,141,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2848:Myh4
|
UTSW |
11 |
67,139,459 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3111:Myh4
|
UTSW |
11 |
67,137,276 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3744:Myh4
|
UTSW |
11 |
67,146,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Myh4
|
UTSW |
11 |
67,149,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3877:Myh4
|
UTSW |
11 |
67,148,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4498:Myh4
|
UTSW |
11 |
67,142,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Myh4
|
UTSW |
11 |
67,146,395 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4601:Myh4
|
UTSW |
11 |
67,141,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4673:Myh4
|
UTSW |
11 |
67,137,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4684:Myh4
|
UTSW |
11 |
67,136,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4736:Myh4
|
UTSW |
11 |
67,131,746 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4837:Myh4
|
UTSW |
11 |
67,149,818 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4866:Myh4
|
UTSW |
11 |
67,139,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4869:Myh4
|
UTSW |
11 |
67,143,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Myh4
|
UTSW |
11 |
67,131,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4921:Myh4
|
UTSW |
11 |
67,144,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Myh4
|
UTSW |
11 |
67,144,241 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Myh4
|
UTSW |
11 |
67,144,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Myh4
|
UTSW |
11 |
67,147,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5087:Myh4
|
UTSW |
11 |
67,146,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Myh4
|
UTSW |
11 |
67,143,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Myh4
|
UTSW |
11 |
67,150,017 (GRCm39) |
splice site |
probably null |
|
|
R5354:Myh4
|
UTSW |
11 |
67,146,551 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5371:Myh4
|
UTSW |
11 |
67,150,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Myh4
|
UTSW |
11 |
67,142,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5774:Myh4
|
UTSW |
11 |
67,144,034 (GRCm39) |
nonsense |
probably null |
|
|
R5902:Myh4
|
UTSW |
11 |
67,141,733 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6045:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6156:Myh4
|
UTSW |
11 |
67,141,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6301:Myh4
|
UTSW |
11 |
67,146,159 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6318:Myh4
|
UTSW |
11 |
67,134,268 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6352:Myh4
|
UTSW |
11 |
67,143,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Myh4
|
UTSW |
11 |
67,146,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Myh4
|
UTSW |
11 |
67,149,455 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6666:Myh4
|
UTSW |
11 |
67,142,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Myh4
|
UTSW |
11 |
67,137,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Myh4
|
UTSW |
11 |
67,143,794 (GRCm39) |
splice site |
probably null |
|
|
R6857:Myh4
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7029:Myh4
|
UTSW |
11 |
67,137,251 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7076:Myh4
|
UTSW |
11 |
67,143,999 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7145:Myh4
|
UTSW |
11 |
67,151,054 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7179:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7365:Myh4
|
UTSW |
11 |
67,133,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Myh4
|
UTSW |
11 |
67,134,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7553:Myh4
|
UTSW |
11 |
67,147,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Myh4
|
UTSW |
11 |
67,147,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Myh4
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Myh4
|
UTSW |
11 |
67,131,756 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8154:Myh4
|
UTSW |
11 |
67,144,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8343:Myh4
|
UTSW |
11 |
67,143,390 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R8446:Myh4
|
UTSW |
11 |
67,144,347 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8534:Myh4
|
UTSW |
11 |
67,134,335 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8710:Myh4
|
UTSW |
11 |
67,143,158 (GRCm39) |
missense |
probably benign |
|
|
R8775:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8775-TAIL:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8852:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Myh4
|
UTSW |
11 |
67,137,362 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8954:Myh4
|
UTSW |
11 |
67,143,806 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8957:Myh4
|
UTSW |
11 |
67,141,780 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9065:Myh4
|
UTSW |
11 |
67,139,573 (GRCm39) |
missense |
probably benign |
|
|
R9280:Myh4
|
UTSW |
11 |
67,146,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9296:Myh4
|
UTSW |
11 |
67,146,130 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9310:Myh4
|
UTSW |
11 |
67,145,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9314:Myh4
|
UTSW |
11 |
67,151,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Myh4
|
UTSW |
11 |
67,141,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9516:Myh4
|
UTSW |
11 |
67,141,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Myh4
|
UTSW |
11 |
67,139,290 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9773:Myh4
|
UTSW |
11 |
67,137,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Myh4
|
UTSW |
11 |
67,137,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,147,097 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myh4
|
UTSW |
11 |
67,144,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,139,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACATCGAAGCCGTCAAGGG -3'
(R):5'- TCCAGACCCTTATTAACATAGTCCC -3'
Sequencing Primer
(F):5'- TCAAGGGTCTTCGTAAGCAC -3'
(R):5'- CATAGTCCCTATGATTGCTGGAAG -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation