Mutagenetix > Incidental Mutation

Incidental Mutation 'R5906:Vmn1r29'

460627

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r29

Ensembl Gene

ENSMUSG00000091734

Gene Name

vomeronasal 1 receptor 29

Synonyms

V1rc2

MMRRC Submission

044103-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R5906 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

58284282-58285193 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 58284736 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 152 (S152N)

Ref Sequence

ENSEMBL: ENSMUSP00000154278 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168416] [ENSMUST00000226971] [ENSMUST00000227761] [ENSMUST00000228038] [ENSMUST00000228909]

AlphaFold

Q9EQ41

Predicted Effect

probably benign
Transcript: ENSMUST00000168416
AA Change: S152N

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000129069
Gene: ENSMUSG00000091734
AA Change: S152N

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.7e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226971
AA Change: S152N

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000227761
AA Change: S152N

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000228038
AA Change: S152N

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000228909
AA Change: S152N

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.4%
20x: 92.4%

Validation Efficiency

95% (81/85)

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930438A08Rik	C	A	11: 58,182,260 (GRCm39)		probably null	Het
9130023H24Rik	G	A	7: 127,835,664 (GRCm39)	P310S	probably benign	Het
Abcc10	G	T	17: 46,627,485 (GRCm39)	H652Q	probably benign	Het
Actl6b	A	G	5: 137,565,591 (GRCm39)	I396V	possibly damaging	Het
Acvr1b	T	C	15: 101,091,772 (GRCm39)		probably benign	Het
Adamts18	A	T	8: 114,436,251 (GRCm39)	H989Q	probably benign	Het
Adamtsl4	T	C	3: 95,588,094 (GRCm39)	Y631C	probably damaging	Het
Angptl3	A	G	4: 98,925,804 (GRCm39)	T377A	probably benign	Het
Ankmy2	G	A	12: 36,226,632 (GRCm39)	V109M	probably damaging	Het
Anpep	G	A	7: 79,483,423 (GRCm39)	A689V	probably benign	Het
Brwd1	A	T	16: 95,859,938 (GRCm39)	M350K	probably damaging	Het
Cacna1d	C	T	14: 29,818,917 (GRCm39)	V1213I	probably damaging	Het
Capn1	A	G	19: 6,061,451 (GRCm39)	F156L	possibly damaging	Het
Catsperb	C	A	12: 101,476,721 (GRCm39)	F408L	probably damaging	Het
Ccdc146	A	T	5: 21,506,350 (GRCm39)	L697Q	possibly damaging	Het
Cdc37l1	T	A	19: 28,989,386 (GRCm39)	V281E	probably benign	Het
Chia1	A	T	3: 106,039,304 (GRCm39)	T465S	probably benign	Het
Cidec	A	T	6: 113,405,282 (GRCm39)		probably null	Het
Clcnkb	T	C	4: 141,139,610 (GRCm39)	T131A	probably benign	Het
Clec5a	T	A	6: 40,558,793 (GRCm39)	M98L	probably benign	Het
Cnga1	A	T	5: 72,768,201 (GRCm39)	F162I	probably benign	Het
Cyp27b1	A	T	10: 126,884,267 (GRCm39)	I40F	probably damaging	Het
Edrf1	A	G	7: 133,265,144 (GRCm39)	S1027G	probably benign	Het
Entpd1	C	A	19: 40,727,283 (GRCm39)	A448E	probably damaging	Het
Espl1	T	C	15: 102,205,286 (GRCm39)		probably null	Het
Etfdh	T	C	3: 79,511,422 (GRCm39)	I520V	probably damaging	Het
Fchsd1	C	T	18: 38,092,926 (GRCm39)		probably benign	Het
Gabra4	G	A	5: 71,781,253 (GRCm39)	P386L	probably benign	Het
Gckr	G	T	5: 31,463,922 (GRCm39)	V281L	probably damaging	Het
Gfy	T	C	7: 44,827,167 (GRCm39)	T310A	probably benign	Het
Gjc2	C	A	11: 59,067,667 (GRCm39)	V272L	probably benign	Het
Gm13441	G	C	2: 31,777,511 (GRCm39)		silent	Het
H2-DMb2	T	A	17: 34,367,582 (GRCm39)	M1K	probably null	Het
Hipk3	T	C	2: 104,302,153 (GRCm39)	Y13C	probably damaging	Het
Kcnt1	A	T	2: 25,784,536 (GRCm39)		probably benign	Het
Kcnt1	T	C	2: 25,788,413 (GRCm39)	F336S	probably damaging	Het
Klhdc7b	A	G	15: 89,271,359 (GRCm39)	D747G	probably benign	Het
Krt78	T	A	15: 101,857,030 (GRCm39)	E359V	probably damaging	Het
Mast4	T	C	13: 102,872,252 (GRCm39)	D2195G	probably benign	Het
Matk	C	T	10: 81,096,753 (GRCm39)	L188F	probably damaging	Het
Mcoln2	T	C	3: 145,889,496 (GRCm39)	I399T	probably damaging	Het
Mroh2a	A	G	1: 88,186,386 (GRCm39)	S64G	probably benign	Het
Nap1l1	A	T	10: 111,326,891 (GRCm39)	K151*	probably null	Het
Ncbp3	T	A	11: 72,964,327 (GRCm39)	S426T	probably benign	Het
Nisch	T	A	14: 30,893,985 (GRCm39)		probably null	Het
Or4k15b	T	C	14: 50,272,306 (GRCm39)	T185A	probably benign	Het
Or5b113	T	C	19: 13,342,369 (GRCm39)	C126R	probably damaging	Het
Or8a1b	A	G	9: 37,623,101 (GRCm39)	I158T	probably benign	Het
Or8b8	A	G	9: 37,809,174 (GRCm39)	H158R	probably damaging	Het
Peg3	T	C	7: 6,720,854 (GRCm39)	D17G	probably damaging	Het
Pkd1	G	A	17: 24,791,894 (GRCm39)	V1194M	probably benign	Het
Pkd1l2	A	T	8: 117,756,387 (GRCm39)	I1615N	probably damaging	Het
Pkd2	A	T	5: 104,625,045 (GRCm39)		probably null	Het
Pkp4	T	A	2: 59,135,420 (GRCm39)	N97K	possibly damaging	Het
Prrx2	C	T	2: 30,769,522 (GRCm39)	R78C	probably damaging	Het
Pycr1	T	A	11: 120,532,988 (GRCm39)	I91F	probably damaging	Het
Rap1a	T	C	3: 105,645,081 (GRCm39)	N87S	possibly damaging	Het
Sbk2	T	G	7: 4,960,627 (GRCm39)	Y181S	probably damaging	Het
Scart1	T	A	7: 139,808,712 (GRCm39)	D874E	probably damaging	Het
Sec16a	A	T	2: 26,328,843 (GRCm39)	H1057Q	possibly damaging	Het
Sfswap	G	A	5: 129,619,107 (GRCm39)	E486K	probably benign	Het
Shank3	T	C	15: 89,433,119 (GRCm39)	V1213A	probably damaging	Het
Slfn5	T	A	11: 82,848,102 (GRCm39)	I329K	probably benign	Het
Slit1	T	A	19: 41,594,813 (GRCm39)	N1186Y	probably damaging	Het
Ssbp3	A	G	4: 106,867,018 (GRCm39)		probably benign	Het
Steap3	T	A	1: 120,171,731 (GRCm39)	I125F	probably damaging	Het
Synpr	C	A	14: 13,608,788 (GRCm38)		probably benign	Het
Tom1	T	C	8: 75,776,886 (GRCm39)	L69P	probably damaging	Het
Traf3ip3	T	A	1: 192,880,314 (GRCm39)	D5V	possibly damaging	Het
Vmn1r68	T	C	7: 10,261,550 (GRCm39)	I183V	probably benign	Het
Wdr17	C	G	8: 55,092,503 (GRCm39)	V1094L	probably benign	Het
Wdr95	A	G	5: 149,487,692 (GRCm39)	I109V	possibly damaging	Het
Zfp39	T	C	11: 58,793,717 (GRCm39)	D7G	probably benign	Het
Zfp512	A	T	5: 31,637,408 (GRCm39)	Q443L	probably damaging	Het
Zfp974	T	A	7: 27,610,230 (GRCm39)	K498N	possibly damaging	Het

Other mutations in Vmn1r29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02504:Vmn1r29	APN	6	58,284,655 (GRCm39)	missense	probably benign	0.03
IGL03351:Vmn1r29	APN	6	58,284,735 (GRCm39)	missense	probably damaging	1.00
R0457:Vmn1r29	UTSW	6	58,285,072 (GRCm39)	missense	probably benign	0.35
R0594:Vmn1r29	UTSW	6	58,284,757 (GRCm39)	missense	probably benign	0.35
R0735:Vmn1r29	UTSW	6	58,284,717 (GRCm39)	missense	probably damaging	0.96
R1422:Vmn1r29	UTSW	6	58,284,871 (GRCm39)	missense	probably damaging	1.00
R1476:Vmn1r29	UTSW	6	58,284,663 (GRCm39)	missense	probably benign	0.23
R1679:Vmn1r29	UTSW	6	58,285,003 (GRCm39)	missense	probably damaging	1.00
R1831:Vmn1r29	UTSW	6	58,284,692 (GRCm39)	nonsense	probably null
R1925:Vmn1r29	UTSW	6	58,285,087 (GRCm39)	missense	possibly damaging	0.79
R1933:Vmn1r29	UTSW	6	58,284,405 (GRCm39)	missense	probably benign	0.03
R4582:Vmn1r29	UTSW	6	58,285,017 (GRCm39)	missense	probably damaging	0.98
R4677:Vmn1r29	UTSW	6	58,284,285 (GRCm39)	missense	probably benign	0.02
R4706:Vmn1r29	UTSW	6	58,285,136 (GRCm39)	missense	probably benign	0.00
R5023:Vmn1r29	UTSW	6	58,285,052 (GRCm39)	nonsense	probably null
R5542:Vmn1r29	UTSW	6	58,285,108 (GRCm39)	missense	probably benign	0.14
R5649:Vmn1r29	UTSW	6	58,284,676 (GRCm39)	missense	probably benign	0.13
R5656:Vmn1r29	UTSW	6	58,285,152 (GRCm39)	missense	possibly damaging	0.94
R6078:Vmn1r29	UTSW	6	58,285,080 (GRCm39)	missense	probably benign	0.01
R6349:Vmn1r29	UTSW	6	58,284,412 (GRCm39)	missense	probably damaging	1.00
R7946:Vmn1r29	UTSW	6	58,284,834 (GRCm39)	missense	probably benign	0.18
R8554:Vmn1r29	UTSW	6	58,285,191 (GRCm39)	makesense	probably null
R8944:Vmn1r29	UTSW	6	58,284,274 (GRCm39)	start gained	probably benign
R8955:Vmn1r29	UTSW	6	58,284,284 (GRCm39)	start codon destroyed	probably null	1.00
R9268:Vmn1r29	UTSW	6	58,284,577 (GRCm39)	missense	probably damaging	1.00
R9688:Vmn1r29	UTSW	6	58,284,739 (GRCm39)	missense	probably benign	0.02
RF020:Vmn1r29	UTSW	6	58,284,528 (GRCm39)	missense	probably benign	0.01
U15987:Vmn1r29	UTSW	6	58,285,080 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GGCCTCTCTATCTGCAACAC -3'
(R):5'- GGGATGCTCTCAGATAGCTG -3'

Sequencing Primer
(F):5'- AACACCTGCCTCCTGAGTGTG -3'
(R):5'- ATGAAGATGCTTGCATTGCCTC -3'

Posted On

2017-02-28