Incidental Mutation 'R5908:Marchf10'
ID 460803
Institutional Source Beutler Lab
Gene Symbol Marchf10
Ensembl Gene ENSMUSG00000078627
Gene Name membrane associated ring-CH-type finger 10
Synonyms Rnf190, 4933417C16Rik, OTTMUSG00000002847, March10
MMRRC Submission 044105-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R5908 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 105251624-105347561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 105281065 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 407 (V407I)
Ref Sequence ENSEMBL: ENSMUSP00000121919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049995] [ENSMUST00000138977]
AlphaFold E9PX79
Predicted Effect probably benign
Transcript: ENSMUST00000049995
AA Change: V407I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000063198
Gene: ENSMUSG00000078627
AA Change: V407I

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138977
AA Change: V407I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000121919
Gene: ENSMUSG00000078627
AA Change: V407I

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153672
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 97.3%
  • 20x: 91.8%
Validation Efficiency 97% (69/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,624,730 (GRCm39) L198H probably damaging Het
Anks1 C T 17: 28,214,993 (GRCm39) T480I probably damaging Het
Arhgef18 G A 8: 3,503,165 (GRCm39) R857Q probably damaging Het
B230208B08Rik A G 4: 78,132,297 (GRCm39) noncoding transcript Het
B9d2 T A 7: 25,382,724 (GRCm39) W33R probably damaging Het
Bcl2a1c A G 9: 114,159,572 (GRCm39) T117A probably benign Het
Btbd8 T G 5: 107,655,460 (GRCm39) D574E probably damaging Het
Cabin1 A G 10: 75,557,366 (GRCm39) S1091P probably damaging Het
Clip3 C A 7: 29,996,298 (GRCm39) D64E probably damaging Het
Col6a5 C G 9: 105,740,000 (GRCm39) D2540H possibly damaging Het
Commd5 A T 15: 76,785,136 (GRCm39) M178L probably benign Het
Crtc3 T A 7: 80,245,542 (GRCm39) H361L possibly damaging Het
Dip2b T A 15: 100,049,065 (GRCm39) L153Q possibly damaging Het
Eif2s1 T A 12: 78,926,817 (GRCm39) V189D probably damaging Het
Etl4 C T 2: 20,748,718 (GRCm39) A483V probably damaging Het
Foxo3 T C 10: 42,072,583 (GRCm39) I645V probably benign Het
Gm4841 A G 18: 60,403,506 (GRCm39) S196P possibly damaging Het
Hip1 A G 5: 135,453,717 (GRCm39) probably null Het
Il36rn G T 2: 24,167,502 (GRCm39) probably benign Het
Ints2 A G 11: 86,106,371 (GRCm39) probably null Het
Khnyn A G 14: 56,124,523 (GRCm39) D259G probably benign Het
Lyst T A 13: 13,871,346 (GRCm39) Y2694* probably null Het
Map4k2 T C 19: 6,401,346 (GRCm39) probably benign Het
Mast4 C A 13: 102,874,764 (GRCm39) V1367F probably damaging Het
Mrgprb3 A T 7: 48,293,366 (GRCm39) S62T probably damaging Het
Mthfd1l T C 10: 4,039,392 (GRCm39) F801S probably damaging Het
Nhsl3 A G 4: 129,115,941 (GRCm39) S908P probably damaging Het
Notch2 T C 3: 98,031,239 (GRCm39) probably benign Het
Nr2e1 T C 10: 42,448,765 (GRCm39) S158G probably benign Het
Nup214 A G 2: 31,881,353 (GRCm39) I404V probably benign Het
Or13n4 T C 7: 106,423,404 (GRCm39) T110A probably benign Het
Pik3c2g G A 6: 139,714,436 (GRCm39) R196H Het
Pik3r3 A T 4: 116,129,955 (GRCm39) D213V probably benign Het
Pip5k1b A T 19: 24,374,501 (GRCm39) S27T possibly damaging Het
Pkp1 G A 1: 135,846,621 (GRCm39) Q44* probably null Het
Pnma8b C T 7: 16,680,968 (GRCm39) R651C unknown Het
Pnpt1 T A 11: 29,080,887 (GRCm39) S44T probably benign Het
Polb A T 8: 23,132,319 (GRCm39) probably null Het
Pom121l2 A G 13: 22,165,984 (GRCm39) N85S probably damaging Het
Prim1 A G 10: 127,853,893 (GRCm39) K104E probably damaging Het
Prl8a1 T A 13: 27,758,040 (GRCm39) Y223F probably benign Het
Rbak T G 5: 143,159,391 (GRCm39) H554P probably damaging Het
Serpina3c T C 12: 104,117,970 (GRCm39) R123G probably benign Het
Sh3bp4 T G 1: 89,073,605 (GRCm39) S818A probably damaging Het
Sh3rf3 C G 10: 58,885,270 (GRCm39) H384Q probably benign Het
Slc9a8 C T 2: 167,293,090 (GRCm39) probably benign Het
Sptbn4 T C 7: 27,103,678 (GRCm39) E1181G probably benign Het
Taf2 G A 15: 54,935,402 (GRCm39) probably benign Het
Taf7l2 A T 10: 115,949,133 (GRCm39) I131N probably benign Het
Tbc1d9 A T 8: 83,976,174 (GRCm39) M578L probably benign Het
Tinagl1 G T 4: 130,066,763 (GRCm39) Y111* probably null Het
Tor2a T C 2: 32,651,697 (GRCm39) L304P probably damaging Het
Trp53bp1 A G 2: 121,067,304 (GRCm39) V474A probably benign Het
Trrap C A 5: 144,723,518 (GRCm39) A325E probably damaging Het
Ube4a A G 9: 44,859,322 (GRCm39) probably null Het
Use1 G C 8: 71,822,257 (GRCm39) K239N probably damaging Het
Vps9d1 G T 8: 123,973,563 (GRCm39) Q407K probably benign Het
Zfp36l1 A T 12: 80,156,449 (GRCm39) S311T possibly damaging Het
Zfp729b T C 13: 67,739,374 (GRCm39) K964E probably benign Het
Zfp974 T A 7: 27,610,382 (GRCm39) M448L probably benign Het
Zfyve28 A T 5: 34,374,214 (GRCm39) V600E possibly damaging Het
Other mutations in Marchf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Marchf10 APN 11 105,293,014 (GRCm39) missense possibly damaging 0.82
IGL01461:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
IGL01473:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
Forward UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
PIT4142001:Marchf10 UTSW 11 105,281,346 (GRCm39) missense probably benign 0.17
R0195:Marchf10 UTSW 11 105,276,351 (GRCm39) missense probably damaging 1.00
R0520:Marchf10 UTSW 11 105,280,708 (GRCm39) missense probably benign
R0628:Marchf10 UTSW 11 105,280,986 (GRCm39) missense probably benign 0.00
R1087:Marchf10 UTSW 11 105,281,488 (GRCm39) missense probably damaging 1.00
R1440:Marchf10 UTSW 11 105,281,409 (GRCm39) missense probably damaging 1.00
R1802:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R1855:Marchf10 UTSW 11 105,281,218 (GRCm39) missense probably benign
R1860:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R2504:Marchf10 UTSW 11 105,276,398 (GRCm39) missense probably damaging 1.00
R3788:Marchf10 UTSW 11 105,287,905 (GRCm39) missense probably damaging 1.00
R4629:Marchf10 UTSW 11 105,280,664 (GRCm39) missense probably benign 0.28
R4755:Marchf10 UTSW 11 105,255,302 (GRCm39) intron probably benign
R4776:Marchf10 UTSW 11 105,280,863 (GRCm39) missense probably benign 0.42
R5067:Marchf10 UTSW 11 105,280,933 (GRCm39) missense possibly damaging 0.51
R5192:Marchf10 UTSW 11 105,262,752 (GRCm39) missense possibly damaging 0.68
R5436:Marchf10 UTSW 11 105,292,991 (GRCm39) missense possibly damaging 0.92
R5541:Marchf10 UTSW 11 105,280,957 (GRCm39) missense probably damaging 1.00
R5888:Marchf10 UTSW 11 105,292,972 (GRCm39) missense possibly damaging 0.92
R5914:Marchf10 UTSW 11 105,276,308 (GRCm39) missense probably damaging 1.00
R6038:Marchf10 UTSW 11 105,292,877 (GRCm39) missense probably damaging 0.96
R6178:Marchf10 UTSW 11 105,280,440 (GRCm39) missense probably damaging 1.00
R6300:Marchf10 UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
R6612:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R6894:Marchf10 UTSW 11 105,287,787 (GRCm39) missense possibly damaging 0.94
R6921:Marchf10 UTSW 11 105,280,603 (GRCm39) missense probably benign 0.00
R7134:Marchf10 UTSW 11 105,299,502 (GRCm39) missense probably benign
R7199:Marchf10 UTSW 11 105,281,532 (GRCm39) missense probably damaging 0.99
R7546:Marchf10 UTSW 11 105,280,906 (GRCm39) missense not run
R7792:Marchf10 UTSW 11 105,281,054 (GRCm39) missense probably benign
R8241:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R8467:Marchf10 UTSW 11 105,280,979 (GRCm39) nonsense probably null
R8843:Marchf10 UTSW 11 105,292,802 (GRCm39) missense possibly damaging 0.83
R8962:Marchf10 UTSW 11 105,280,815 (GRCm39) nonsense probably null
R9214:Marchf10 UTSW 11 105,281,100 (GRCm39) missense probably benign 0.02
R9323:Marchf10 UTSW 11 105,280,581 (GRCm39) missense probably damaging 0.98
Z1088:Marchf10 UTSW 11 105,281,185 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCGTCTATCAGAGCAGAATGG -3'
(R):5'- TAAGATGGAGTGAGCCCAGC -3'

Sequencing Primer
(F):5'- CAGTGACCCATGAGCACTGTAAG -3'
(R):5'- GCCCTGGATCTCCAAGAAAAAC -3'
Posted On 2017-02-28