Incidental Mutation 'R5914:Zeb2'
ID |
461166 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zeb2
|
Ensembl Gene |
ENSMUSG00000026872 |
Gene Name |
zinc finger E-box binding homeobox 2 |
Synonyms |
SIP1, D130016B08Rik, 9130203F04Rik, Zfhx1b, Zfx1b |
MMRRC Submission |
044111-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R5914 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
2 |
Chromosomal Location |
44873644-45007407 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 44887064 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Methionine
at position 596
(I596M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000144421
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028229]
[ENSMUST00000068415]
[ENSMUST00000076836]
[ENSMUST00000176438]
[ENSMUST00000176732]
[ENSMUST00000177302]
[ENSMUST00000200844]
[ENSMUST00000201804]
[ENSMUST00000201211]
[ENSMUST00000201623]
|
AlphaFold |
Q9R0G7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000028229
AA Change: I664M
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000028229 Gene: ENSMUSG00000026872 AA Change: I664M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000068415
AA Change: I620M
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000069685 Gene: ENSMUSG00000026872 AA Change: I620M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000076836
AA Change: I619M
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000076111 Gene: ENSMUSG00000026872 AA Change: I619M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
210 |
233 |
2.09e-3 |
SMART |
ZnF_C2H2
|
240 |
262 |
9.88e-5 |
SMART |
ZnF_C2H2
|
281 |
303 |
4.87e-4 |
SMART |
ZnF_C2H2
|
309 |
329 |
1.86e1 |
SMART |
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
ZnF_C2H2
|
580 |
600 |
5.54e1 |
SMART |
HOX
|
643 |
705 |
2.05e-3 |
SMART |
low complexity region
|
777 |
807 |
N/A |
INTRINSIC |
low complexity region
|
840 |
855 |
N/A |
INTRINSIC |
low complexity region
|
869 |
880 |
N/A |
INTRINSIC |
ZnF_C2H2
|
998 |
1020 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1026 |
1048 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1054 |
1075 |
1.89e-1 |
SMART |
low complexity region
|
1082 |
1096 |
N/A |
INTRINSIC |
low complexity region
|
1133 |
1149 |
N/A |
INTRINSIC |
low complexity region
|
1157 |
1167 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176438
AA Change: I620M
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000134849 Gene: ENSMUSG00000026872 AA Change: I620M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176732
|
SMART Domains |
Protein: ENSMUSP00000135393 Gene: ENSMUSG00000026872
Domain | Start | End | E-Value | Type |
low complexity region
|
14 |
26 |
N/A |
INTRINSIC |
ZnF_C2H2
|
60 |
83 |
2.09e-3 |
SMART |
ZnF_C2H2
|
90 |
112 |
9.88e-5 |
SMART |
ZnF_C2H2
|
131 |
153 |
4.87e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000177302
AA Change: I620M
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000134747 Gene: ENSMUSG00000026872 AA Change: I620M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
211 |
234 |
2.09e-3 |
SMART |
ZnF_C2H2
|
241 |
263 |
9.88e-5 |
SMART |
ZnF_C2H2
|
282 |
304 |
4.87e-4 |
SMART |
ZnF_C2H2
|
310 |
330 |
1.86e1 |
SMART |
low complexity region
|
352 |
364 |
N/A |
INTRINSIC |
ZnF_C2H2
|
581 |
601 |
5.54e1 |
SMART |
HOX
|
644 |
706 |
2.05e-3 |
SMART |
low complexity region
|
778 |
808 |
N/A |
INTRINSIC |
low complexity region
|
841 |
856 |
N/A |
INTRINSIC |
low complexity region
|
870 |
881 |
N/A |
INTRINSIC |
ZnF_C2H2
|
999 |
1021 |
4.47e-3 |
SMART |
ZnF_C2H2
|
1027 |
1049 |
2.17e-1 |
SMART |
ZnF_C2H2
|
1055 |
1076 |
1.89e-1 |
SMART |
low complexity region
|
1083 |
1097 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1150 |
N/A |
INTRINSIC |
low complexity region
|
1158 |
1168 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000200844
AA Change: I596M
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000144421 Gene: ENSMUSG00000026872 AA Change: I596M
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
187 |
210 |
9.2e-6 |
SMART |
ZnF_C2H2
|
217 |
239 |
4.2e-7 |
SMART |
ZnF_C2H2
|
258 |
280 |
2e-6 |
SMART |
ZnF_C2H2
|
286 |
306 |
8e-2 |
SMART |
low complexity region
|
328 |
340 |
N/A |
INTRINSIC |
ZnF_C2H2
|
557 |
577 |
2.4e-1 |
SMART |
HOX
|
620 |
682 |
1.1e-5 |
SMART |
low complexity region
|
754 |
784 |
N/A |
INTRINSIC |
low complexity region
|
817 |
832 |
N/A |
INTRINSIC |
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
ZnF_C2H2
|
975 |
997 |
1.9e-5 |
SMART |
ZnF_C2H2
|
1003 |
1025 |
9.6e-4 |
SMART |
ZnF_C2H2
|
1031 |
1052 |
7.9e-4 |
SMART |
low complexity region
|
1059 |
1073 |
N/A |
INTRINSIC |
low complexity region
|
1110 |
1126 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1144 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000201804
AA Change: I649M
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000144637 Gene: ENSMUSG00000026872 AA Change: I649M
Domain | Start | End | E-Value | Type |
low complexity region
|
107 |
119 |
N/A |
INTRINSIC |
ZnF_C2H2
|
240 |
263 |
9.2e-6 |
SMART |
ZnF_C2H2
|
270 |
292 |
4.2e-7 |
SMART |
ZnF_C2H2
|
311 |
333 |
2e-6 |
SMART |
ZnF_C2H2
|
339 |
359 |
8e-2 |
SMART |
low complexity region
|
381 |
393 |
N/A |
INTRINSIC |
ZnF_C2H2
|
610 |
630 |
2.4e-1 |
SMART |
HOX
|
673 |
731 |
1.2e-3 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209076
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000201211
|
SMART Domains |
Protein: ENSMUSP00000144406 Gene: ENSMUSG00000026872
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000202432
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000201623
|
SMART Domains |
Protein: ENSMUSP00000144075 Gene: ENSMUSG00000026872
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
ZnF_C2H2
|
187 |
210 |
9.2e-6 |
SMART |
|
Meta Mutation Damage Score |
0.0604 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.5%
|
Validation Efficiency |
95% (87/92) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] PHENOTYPE: Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 83 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adgrb1 |
G |
A |
15: 74,410,219 (GRCm39) |
R286H |
possibly damaging |
Het |
Ank3 |
A |
T |
10: 69,828,774 (GRCm39) |
|
probably benign |
Het |
Arhgap24 |
G |
A |
5: 102,700,025 (GRCm39) |
|
probably null |
Het |
Arhgef2 |
T |
C |
3: 88,543,176 (GRCm39) |
Y396H |
probably benign |
Het |
Asap3 |
G |
T |
4: 135,968,720 (GRCm39) |
G722C |
probably benign |
Het |
Birc2 |
A |
C |
9: 7,857,343 (GRCm39) |
*377E |
probably null |
Het |
Cdc123 |
G |
T |
2: 5,803,174 (GRCm39) |
Q282K |
possibly damaging |
Het |
Cdkl4 |
C |
T |
17: 80,855,120 (GRCm39) |
|
probably null |
Het |
Cep97 |
T |
C |
16: 55,725,820 (GRCm39) |
N689S |
probably benign |
Het |
Cfap97 |
T |
G |
8: 46,634,895 (GRCm39) |
S407A |
probably damaging |
Het |
Cfh |
A |
T |
1: 140,063,967 (GRCm39) |
N436K |
probably benign |
Het |
Chpf2 |
A |
T |
5: 24,797,421 (GRCm39) |
|
probably benign |
Het |
Cnnm2 |
A |
G |
19: 46,751,616 (GRCm39) |
T469A |
probably benign |
Het |
Col6a3 |
T |
A |
1: 90,703,922 (GRCm39) |
I2275F |
unknown |
Het |
Ctdspl2 |
A |
T |
2: 121,809,414 (GRCm39) |
N122Y |
probably damaging |
Het |
Dcaf6 |
A |
T |
1: 165,178,724 (GRCm39) |
C602S |
probably benign |
Het |
Dda1 |
T |
A |
8: 71,927,294 (GRCm39) |
|
probably benign |
Het |
Dixdc1 |
T |
C |
9: 50,609,888 (GRCm39) |
|
probably benign |
Het |
Dnah2 |
C |
T |
11: 69,349,746 (GRCm39) |
R2399Q |
probably benign |
Het |
Emilin3 |
T |
A |
2: 160,750,990 (GRCm39) |
N253I |
probably damaging |
Het |
Epg5 |
T |
A |
18: 78,002,847 (GRCm39) |
|
probably null |
Het |
Fam204a |
A |
T |
19: 60,209,525 (GRCm39) |
Y68* |
probably null |
Het |
Fbln5 |
T |
G |
12: 101,727,002 (GRCm39) |
D329A |
possibly damaging |
Het |
Fkbp15 |
T |
A |
4: 62,246,047 (GRCm39) |
|
probably null |
Het |
Fnbp4 |
C |
G |
2: 90,605,137 (GRCm39) |
|
probably benign |
Het |
Foxn2 |
C |
A |
17: 88,770,138 (GRCm39) |
|
probably null |
Het |
Frem1 |
T |
C |
4: 82,920,012 (GRCm39) |
D448G |
probably damaging |
Het |
Fzd9 |
T |
C |
5: 135,278,199 (GRCm39) |
Y562C |
probably benign |
Het |
Gcn1 |
A |
G |
5: 115,748,194 (GRCm39) |
|
silent |
Het |
Gm6003 |
A |
G |
7: 32,864,691 (GRCm39) |
|
noncoding transcript |
Het |
Gnl3 |
C |
A |
14: 30,738,853 (GRCm39) |
E65D |
possibly damaging |
Het |
Hax1 |
GTCATCATCATCATCATC |
GTCATCATCATCATCATCATC |
3: 89,905,247 (GRCm39) |
|
probably benign |
Het |
Hk2 |
C |
T |
6: 82,713,615 (GRCm39) |
R461K |
probably benign |
Het |
Ice1 |
A |
G |
13: 70,754,496 (GRCm39) |
F530S |
possibly damaging |
Het |
Ing3 |
T |
A |
6: 21,968,904 (GRCm39) |
S129T |
probably benign |
Het |
Ino80 |
G |
A |
2: 119,288,697 (GRCm39) |
S3L |
probably damaging |
Het |
Ints2 |
T |
A |
11: 86,113,000 (GRCm39) |
Q839H |
probably benign |
Het |
Kcnrg |
T |
C |
14: 61,849,280 (GRCm39) |
M247T |
probably benign |
Het |
Kpna6 |
T |
C |
4: 129,566,485 (GRCm39) |
|
probably benign |
Het |
Krtap28-13 |
T |
A |
1: 83,039,044 (GRCm39) |
|
probably benign |
Het |
Lgr4 |
T |
A |
2: 109,748,617 (GRCm39) |
V51E |
possibly damaging |
Het |
Map3k5 |
A |
C |
10: 19,980,001 (GRCm39) |
E836D |
probably benign |
Het |
Mapk11 |
T |
C |
15: 89,030,038 (GRCm39) |
I193V |
probably benign |
Het |
Marchf10 |
A |
T |
11: 105,276,308 (GRCm39) |
V660E |
probably damaging |
Het |
Matn4 |
T |
C |
2: 164,235,144 (GRCm39) |
E435G |
probably damaging |
Het |
Mre11a |
G |
T |
9: 14,723,232 (GRCm39) |
R402M |
probably damaging |
Het |
Msr1 |
C |
T |
8: 40,034,868 (GRCm39) |
G428R |
probably damaging |
Het |
Ndufv3 |
C |
T |
17: 31,750,206 (GRCm39) |
R99* |
probably null |
Het |
Nkx6-1 |
C |
T |
5: 101,811,847 (GRCm39) |
S85N |
unknown |
Het |
Nop2 |
A |
T |
6: 125,111,691 (GRCm39) |
E141D |
probably benign |
Het |
Or5b3 |
A |
G |
19: 13,388,326 (GRCm39) |
H131R |
probably benign |
Het |
Or8b1 |
G |
C |
9: 38,399,657 (GRCm39) |
E111Q |
probably damaging |
Het |
Paox |
T |
C |
7: 139,709,101 (GRCm39) |
S205P |
probably damaging |
Het |
Pcdh15 |
T |
C |
10: 74,466,768 (GRCm39) |
V995A |
probably benign |
Het |
Pdcd1 |
T |
A |
1: 93,968,550 (GRCm39) |
K161N |
probably benign |
Het |
Pfkfb2 |
C |
A |
1: 130,627,832 (GRCm39) |
V372L |
probably damaging |
Het |
Phldb1 |
G |
A |
9: 44,622,948 (GRCm39) |
T19I |
probably damaging |
Het |
Pik3c2g |
G |
T |
6: 139,599,477 (GRCm39) |
V198L |
probably benign |
Het |
Pnpla8 |
T |
A |
12: 44,342,753 (GRCm39) |
L41* |
probably null |
Het |
Postn |
C |
T |
3: 54,281,221 (GRCm39) |
Q449* |
probably null |
Het |
Ppp1r3a |
C |
T |
6: 14,718,988 (GRCm39) |
S642N |
probably benign |
Het |
Ptpn23 |
G |
A |
9: 110,214,511 (GRCm39) |
|
probably benign |
Het |
Ptprj |
T |
C |
2: 90,283,684 (GRCm39) |
N923S |
possibly damaging |
Het |
Rai1 |
T |
C |
11: 60,078,630 (GRCm39) |
V898A |
probably benign |
Het |
Rasgef1a |
A |
T |
6: 118,057,515 (GRCm39) |
Y72F |
possibly damaging |
Het |
Serpinb7 |
T |
C |
1: 107,379,580 (GRCm39) |
V329A |
probably damaging |
Het |
Slc24a4 |
T |
A |
12: 102,201,049 (GRCm39) |
I311N |
probably damaging |
Het |
Slc45a1 |
C |
A |
4: 150,713,997 (GRCm39) |
L749F |
possibly damaging |
Het |
Spon1 |
G |
A |
7: 113,630,056 (GRCm39) |
D428N |
probably damaging |
Het |
Tcf7l2 |
G |
A |
19: 55,886,992 (GRCm39) |
E2K |
probably benign |
Het |
Thoc5 |
A |
G |
11: 4,870,416 (GRCm39) |
M472V |
possibly damaging |
Het |
Tm6sf2 |
T |
C |
8: 70,528,213 (GRCm39) |
Y121H |
probably damaging |
Het |
Tmc4 |
T |
A |
7: 3,675,008 (GRCm39) |
D221V |
probably benign |
Het |
Trim30b |
A |
T |
7: 104,006,572 (GRCm39) |
S95T |
probably damaging |
Het |
Trip12 |
T |
C |
1: 84,741,179 (GRCm39) |
E571G |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,781,656 (GRCm39) |
|
probably null |
Het |
Ubp1 |
A |
T |
9: 113,785,807 (GRCm39) |
R161W |
probably benign |
Het |
Usp21 |
G |
A |
1: 171,109,745 (GRCm39) |
|
probably benign |
Het |
Vmn1r61 |
T |
A |
7: 5,613,529 (GRCm39) |
R262W |
probably damaging |
Het |
Vmn2r67 |
A |
T |
7: 84,801,044 (GRCm39) |
D297E |
probably damaging |
Het |
Vwa5a |
T |
C |
9: 38,653,038 (GRCm39) |
L784S |
probably benign |
Het |
Vwc2 |
G |
A |
11: 11,104,244 (GRCm39) |
V259M |
probably damaging |
Het |
Zgrf1 |
T |
A |
3: 127,354,672 (GRCm39) |
L97H |
probably damaging |
Het |
|
Other mutations in Zeb2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00900:Zeb2
|
APN |
2 |
44,887,287 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01639:Zeb2
|
APN |
2 |
44,887,269 (GRCm39) |
missense |
probably benign |
|
IGL02016:Zeb2
|
APN |
2 |
44,878,886 (GRCm39) |
missense |
possibly damaging |
0.71 |
IGL02337:Zeb2
|
APN |
2 |
44,887,242 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02745:Zeb2
|
APN |
2 |
44,884,487 (GRCm39) |
unclassified |
probably benign |
|
IGL02893:Zeb2
|
APN |
2 |
44,886,619 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03412:Zeb2
|
APN |
2 |
44,892,720 (GRCm39) |
intron |
probably benign |
|
Blight
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
Dropped
|
UTSW |
2 |
45,000,053 (GRCm39) |
missense |
possibly damaging |
0.66 |
Okapi
|
UTSW |
2 |
44,887,168 (GRCm39) |
missense |
probably damaging |
1.00 |
sable
|
UTSW |
2 |
44,887,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R0514:Zeb2
|
UTSW |
2 |
44,892,659 (GRCm39) |
missense |
possibly damaging |
0.52 |
R0603:Zeb2
|
UTSW |
2 |
44,907,438 (GRCm39) |
missense |
probably benign |
0.45 |
R0608:Zeb2
|
UTSW |
2 |
44,886,138 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1236:Zeb2
|
UTSW |
2 |
44,884,658 (GRCm39) |
missense |
probably damaging |
1.00 |
R1529:Zeb2
|
UTSW |
2 |
44,887,206 (GRCm39) |
missense |
probably damaging |
1.00 |
R1581:Zeb2
|
UTSW |
2 |
44,887,012 (GRCm39) |
missense |
probably damaging |
0.99 |
R1636:Zeb2
|
UTSW |
2 |
44,892,623 (GRCm39) |
missense |
probably damaging |
1.00 |
R1924:Zeb2
|
UTSW |
2 |
44,892,624 (GRCm39) |
missense |
probably damaging |
1.00 |
R2012:Zeb2
|
UTSW |
2 |
44,887,962 (GRCm39) |
missense |
probably damaging |
1.00 |
R2097:Zeb2
|
UTSW |
2 |
44,887,168 (GRCm39) |
missense |
probably damaging |
1.00 |
R2156:Zeb2
|
UTSW |
2 |
44,878,821 (GRCm39) |
missense |
probably benign |
0.20 |
R4385:Zeb2
|
UTSW |
2 |
44,913,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R4472:Zeb2
|
UTSW |
2 |
44,913,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R4678:Zeb2
|
UTSW |
2 |
44,886,353 (GRCm39) |
missense |
probably damaging |
0.99 |
R4769:Zeb2
|
UTSW |
2 |
44,886,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R4816:Zeb2
|
UTSW |
2 |
44,887,780 (GRCm39) |
missense |
probably damaging |
0.99 |
R4918:Zeb2
|
UTSW |
2 |
44,886,894 (GRCm39) |
missense |
probably damaging |
1.00 |
R4969:Zeb2
|
UTSW |
2 |
44,888,931 (GRCm39) |
missense |
probably damaging |
1.00 |
R5191:Zeb2
|
UTSW |
2 |
44,892,612 (GRCm39) |
missense |
probably benign |
0.00 |
R5195:Zeb2
|
UTSW |
2 |
44,891,647 (GRCm39) |
missense |
probably damaging |
1.00 |
R5322:Zeb2
|
UTSW |
2 |
44,887,107 (GRCm39) |
missense |
probably damaging |
1.00 |
R5699:Zeb2
|
UTSW |
2 |
44,887,800 (GRCm39) |
missense |
probably damaging |
1.00 |
R5750:Zeb2
|
UTSW |
2 |
44,887,530 (GRCm39) |
missense |
probably damaging |
0.96 |
R5764:Zeb2
|
UTSW |
2 |
44,886,931 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5918:Zeb2
|
UTSW |
2 |
45,001,271 (GRCm39) |
intron |
probably benign |
|
R6037:Zeb2
|
UTSW |
2 |
44,878,652 (GRCm39) |
nonsense |
probably null |
|
R6037:Zeb2
|
UTSW |
2 |
44,878,652 (GRCm39) |
nonsense |
probably null |
|
R6302:Zeb2
|
UTSW |
2 |
44,887,771 (GRCm39) |
missense |
probably benign |
0.18 |
R6372:Zeb2
|
UTSW |
2 |
44,892,551 (GRCm39) |
missense |
probably damaging |
1.00 |
R6402:Zeb2
|
UTSW |
2 |
44,886,987 (GRCm39) |
missense |
probably damaging |
1.00 |
R6492:Zeb2
|
UTSW |
2 |
45,000,508 (GRCm39) |
intron |
probably benign |
|
R6554:Zeb2
|
UTSW |
2 |
44,887,524 (GRCm39) |
missense |
probably damaging |
1.00 |
R6675:Zeb2
|
UTSW |
2 |
44,887,457 (GRCm39) |
nonsense |
probably null |
|
R6735:Zeb2
|
UTSW |
2 |
45,000,028 (GRCm39) |
missense |
probably null |
0.99 |
R6870:Zeb2
|
UTSW |
2 |
44,878,922 (GRCm39) |
missense |
probably damaging |
0.98 |
R6925:Zeb2
|
UTSW |
2 |
44,884,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R6963:Zeb2
|
UTSW |
2 |
44,878,811 (GRCm39) |
missense |
probably damaging |
0.97 |
R6972:Zeb2
|
UTSW |
2 |
44,887,330 (GRCm39) |
missense |
probably damaging |
1.00 |
R7144:Zeb2
|
UTSW |
2 |
45,000,053 (GRCm39) |
missense |
possibly damaging |
0.66 |
R7178:Zeb2
|
UTSW |
2 |
44,887,006 (GRCm39) |
missense |
probably damaging |
0.97 |
R7379:Zeb2
|
UTSW |
2 |
44,891,829 (GRCm39) |
splice site |
probably null |
|
R7419:Zeb2
|
UTSW |
2 |
44,886,359 (GRCm39) |
missense |
probably benign |
0.20 |
R7580:Zeb2
|
UTSW |
2 |
44,884,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R7599:Zeb2
|
UTSW |
2 |
44,884,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R7625:Zeb2
|
UTSW |
2 |
44,892,584 (GRCm39) |
missense |
probably damaging |
1.00 |
R7917:Zeb2
|
UTSW |
2 |
44,886,421 (GRCm39) |
missense |
possibly damaging |
0.50 |
R8132:Zeb2
|
UTSW |
2 |
44,879,142 (GRCm39) |
missense |
probably damaging |
1.00 |
R8412:Zeb2
|
UTSW |
2 |
44,888,964 (GRCm39) |
missense |
probably damaging |
1.00 |
R8413:Zeb2
|
UTSW |
2 |
44,886,183 (GRCm39) |
missense |
probably damaging |
0.99 |
R8417:Zeb2
|
UTSW |
2 |
44,913,008 (GRCm39) |
missense |
probably damaging |
0.99 |
R8750:Zeb2
|
UTSW |
2 |
44,887,939 (GRCm39) |
missense |
probably damaging |
1.00 |
R8865:Zeb2
|
UTSW |
2 |
44,886,139 (GRCm39) |
missense |
probably benign |
0.02 |
R8916:Zeb2
|
UTSW |
2 |
44,886,796 (GRCm39) |
missense |
probably damaging |
0.99 |
R9068:Zeb2
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9094:Zeb2
|
UTSW |
2 |
45,003,136 (GRCm39) |
intron |
probably benign |
|
R9139:Zeb2
|
UTSW |
2 |
44,878,637 (GRCm39) |
missense |
possibly damaging |
0.52 |
R9187:Zeb2
|
UTSW |
2 |
45,000,040 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9309:Zeb2
|
UTSW |
2 |
44,892,575 (GRCm39) |
missense |
probably damaging |
0.99 |
R9310:Zeb2
|
UTSW |
2 |
44,886,988 (GRCm39) |
missense |
probably benign |
0.01 |
R9337:Zeb2
|
UTSW |
2 |
44,912,912 (GRCm39) |
missense |
probably benign |
0.35 |
R9350:Zeb2
|
UTSW |
2 |
44,887,158 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9371:Zeb2
|
UTSW |
2 |
44,888,912 (GRCm39) |
missense |
probably damaging |
1.00 |
R9389:Zeb2
|
UTSW |
2 |
44,887,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R9509:Zeb2
|
UTSW |
2 |
44,887,876 (GRCm39) |
missense |
possibly damaging |
0.74 |
R9600:Zeb2
|
UTSW |
2 |
44,987,180 (GRCm39) |
missense |
unknown |
|
R9674:Zeb2
|
UTSW |
2 |
44,891,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R9756:Zeb2
|
UTSW |
2 |
44,887,414 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Predicted Primers |
PCR Primer
(F):5'- GGAGATTTTCAGCAGTTCATCAGAG -3'
(R):5'- CCGACTCAAGGAGACAGATCAG -3'
Sequencing Primer
(F):5'- CAGTTCATCAGAGTTGGGCTCC -3'
(R):5'- GCGTACTTTGATAGATTTGGTCAC -3'
|
Posted On |
2017-02-28 |