Mutagenetix > Incidental Mutation

Incidental Mutation 'R5916:Or10x1'

461303

Institutional Source

Beutler Lab

Gene Symbol

Or10x1

Ensembl Gene

ENSMUSG00000066672

Gene Name

olfactory receptor family 10 subfamily X member 1

Synonyms

Olfr417, MOR267-11, GA_x6K02T2P20D-20787051-20786119

MMRRC Submission

044113-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R5916 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

174196485-174197414 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 174196698 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 72 (T72S)

Ref Sequence

ENSEMBL: ENSMUSP00000151947 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085862] [ENSMUST00000217962] [ENSMUST00000220394]

AlphaFold

F8VQB1

Predicted Effect

probably damaging
Transcript: ENSMUST00000085862
AA Change: T72S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083024
Gene: ENSMUSG00000066672
AA Change: T72S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	304	5.7e-46	PFAM
Pfam:7tm_1	39	303	6.6e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000217962
AA Change: T72S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000220394
AA Change: T72S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.8%
3x: 99.3%
10x: 97.2%
20x: 92.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4	A	T	4: 144,349,550 (GRCm39)	N269I	possibly damaging	Het
Abcc1	G	T	16: 14,283,006 (GRCm39)	V1161F	possibly damaging	Het
Adam3	A	T	8: 25,174,555 (GRCm39)		probably null	Het
Agt	A	T	8: 125,290,597 (GRCm39)	S237T	possibly damaging	Het
Ano3	A	T	2: 110,512,181 (GRCm39)	F674L	probably benign	Het
Asb2	G	T	12: 103,290,135 (GRCm39)	A504E	probably damaging	Het
Atp13a1	T	A	8: 70,259,748 (GRCm39)	I1113N	probably damaging	Het
Atxn7l2	T	C	3: 108,112,978 (GRCm39)		probably null	Het
Bambi	A	G	18: 3,511,463 (GRCm39)	T95A	probably benign	Het
Cfap210	A	T	2: 69,619,806 (GRCm39)	M1K	probably null	Het
Clrn1	T	C	3: 58,753,783 (GRCm39)	T193A	probably benign	Het
Colgalt2	T	A	1: 152,379,873 (GRCm39)	D437E	probably damaging	Het
Dchs1	C	A	7: 105,408,373 (GRCm39)	A1820S	probably damaging	Het
Dnah12	T	A	14: 26,428,073 (GRCm39)	I233N	possibly damaging	Het
Dsc3	T	C	18: 20,120,077 (GRCm39)	N194D	probably damaging	Het
Dync2h1	A	G	9: 7,102,309 (GRCm39)		probably null	Het
Erich3	A	T	3: 154,401,460 (GRCm39)	R36S	probably damaging	Het
Fam243	T	A	16: 92,117,559 (GRCm39)	E243V	probably damaging	Het
Fmnl3	A	T	15: 99,219,709 (GRCm39)	C680S	probably damaging	Het
Focad	T	C	4: 88,275,778 (GRCm39)	L1129P	unknown	Het
Fzd3	G	A	14: 65,440,178 (GRCm39)	T664I	probably benign	Het
Glb1l3	T	C	9: 26,766,032 (GRCm39)	I129V	probably benign	Het
Heatr1	T	C	13: 12,449,352 (GRCm39)	F1950S	probably damaging	Het
Herc6	G	A	6: 57,623,188 (GRCm39)	G597E	probably benign	Het
Hmcn2	T	A	2: 31,286,151 (GRCm39)	V2101D	probably damaging	Het
Il17re	T	A	6: 113,447,084 (GRCm39)	C612S	probably damaging	Het
Il36g	T	G	2: 24,082,806 (GRCm39)	*194E	probably null	Het
Junb	T	C	8: 85,704,505 (GRCm39)	Y185C	probably benign	Het
Lrriq1	G	A	10: 103,057,243 (GRCm39)	Q186*	probably null	Het
Lrrn2	T	A	1: 132,865,538 (GRCm39)	V201E	probably damaging	Het
Ly6l	A	T	15: 75,323,027 (GRCm39)	T68S	probably benign	Het
Marchf1	G	T	8: 66,839,763 (GRCm39)	R182L	possibly damaging	Het
Megf6	A	G	4: 154,333,882 (GRCm39)		probably null	Het
Mga	T	A	2: 119,794,793 (GRCm39)	S2708T	probably benign	Het
Mx1	T	C	16: 97,252,933 (GRCm39)	T396A	probably benign	Het
Naip5	A	C	13: 100,359,209 (GRCm39)	S676A	probably benign	Het
Npepl1	G	T	2: 173,963,337 (GRCm39)	W456C	probably benign	Het
Ntrk2	A	G	13: 58,956,543 (GRCm39)	M1V	probably null	Het
Nufip1	T	C	14: 76,372,340 (GRCm39)	*485Q	probably null	Het
Ocln	T	G	13: 100,642,687 (GRCm39)	D216A	possibly damaging	Het
Or1o11	C	T	17: 37,756,570 (GRCm39)	L53F	probably benign	Het
Or4f57	A	G	2: 111,791,175 (GRCm39)	M81T	probably damaging	Het
Or55b4	G	A	7: 102,133,586 (GRCm39)	S247F	probably damaging	Het
Ptprq	A	T	10: 107,359,374 (GRCm39)	M2243K	probably damaging	Het
Rad51b	C	T	12: 79,371,856 (GRCm39)	Q190*	probably null	Het
Resf1	C	T	6: 149,228,076 (GRCm39)	T374I	probably damaging	Het
Rfx8	T	C	1: 39,727,779 (GRCm39)	Y182C	probably benign	Het
Rpgrip1l	C	A	8: 91,979,541 (GRCm39)	R967L	possibly damaging	Het
Scube2	A	G	7: 109,430,931 (GRCm39)	Y423H	possibly damaging	Het
Sipa1l2	A	T	8: 126,195,312 (GRCm39)	Y809N	probably damaging	Het
Slc35f1	C	A	10: 52,809,317 (GRCm39)	Y101*	probably null	Het
Tbc1d22a	A	G	15: 86,098,809 (GRCm39)	K12E	possibly damaging	Het
Tent2	T	C	13: 93,312,055 (GRCm39)	D215G	probably damaging	Het
Tmcc2	C	T	1: 132,285,429 (GRCm39)	V646M	probably damaging	Het
Tpp1	A	T	7: 105,398,587 (GRCm39)	M243K	probably damaging	Het
Trappc12	A	G	12: 28,741,513 (GRCm39)	L732P	probably damaging	Het
U2af2	A	T	7: 5,082,179 (GRCm39)		probably null	Het
Utrn	T	A	10: 12,540,795 (GRCm39)	N1877Y	probably damaging	Het
Vsir	C	T	10: 60,193,816 (GRCm39)	T93I	probably damaging	Het
Zkscan5	T	A	5: 145,142,112 (GRCm39)	M3K	possibly damaging	Het
Zscan29	G	T	2: 120,994,518 (GRCm39)	T489N	probably damaging	Het

Other mutations in Or10x1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01885:Or10x1	APN	1	174,196,967 (GRCm39)	missense	probably damaging	0.99
PIT4366001:Or10x1	UTSW	1	174,196,656 (GRCm39)	missense	probably damaging	1.00
R0131:Or10x1	UTSW	1	174,197,152 (GRCm39)	missense	probably damaging	0.99
R0131:Or10x1	UTSW	1	174,197,152 (GRCm39)	missense	probably damaging	0.99
R0132:Or10x1	UTSW	1	174,197,152 (GRCm39)	missense	probably damaging	0.99
R1623:Or10x1	UTSW	1	174,196,515 (GRCm39)	missense	probably benign	0.43
R1862:Or10x1	UTSW	1	174,197,018 (GRCm39)	missense	probably damaging	0.97
R1901:Or10x1	UTSW	1	174,196,734 (GRCm39)	missense	probably benign
R1972:Or10x1	UTSW	1	174,197,136 (GRCm39)	missense	probably benign	0.05
R2180:Or10x1	UTSW	1	174,196,967 (GRCm39)	missense	probably damaging	0.99
R4413:Or10x1	UTSW	1	174,197,040 (GRCm39)	missense	probably damaging	0.98
R4528:Or10x1	UTSW	1	174,196,822 (GRCm39)	missense	probably damaging	1.00
R4750:Or10x1	UTSW	1	174,196,488 (GRCm39)	missense	probably benign	0.02
R4849:Or10x1	UTSW	1	174,196,966 (GRCm39)	missense	probably damaging	0.97
R4851:Or10x1	UTSW	1	174,196,562 (GRCm39)	missense	probably benign	0.44
R5394:Or10x1	UTSW	1	174,196,836 (GRCm39)	missense	probably damaging	1.00
R6248:Or10x1	UTSW	1	174,197,236 (GRCm39)	missense	probably benign
R7311:Or10x1	UTSW	1	174,196,759 (GRCm39)	missense	probably benign	0.30
R7868:Or10x1	UTSW	1	174,196,551 (GRCm39)	missense	probably benign	0.00
Z1088:Or10x1	UTSW	1	174,197,310 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AGGCTTCTCAGCTTACCCAC -3'
(R):5'- AGCAGAGGCCACAAGTTGTC -3'

Sequencing Primer
(F):5'- TACCCACTTGTACAGACCTGG -3'
(R):5'- GTTGTCCACATGCAACATTGG -3'

Posted On

2017-02-28