Incidental Mutation 'R5917:Zscan29'
ID 461375
Institutional Source Beutler Lab
Gene Symbol Zscan29
Ensembl Gene ENSMUSG00000050619
Gene Name zinc finger SCAN domains 29
Synonyms Zfp690
MMRRC Submission 044114-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R5917 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 120988754-121001606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 120994518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 489 (T489N)
Ref Sequence ENSEMBL: ENSMUSP00000125987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079024] [ENSMUST00000110661] [ENSMUST00000146243] [ENSMUST00000163766]
AlphaFold E9Q5B4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079024
AA Change: T454N

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000078033
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 3e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 4.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110661
AA Change: T454N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106289
Gene: ENSMUSG00000050619
AA Change: T454N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.4e-21 PFAM
Pfam:Myb_DNA-bind_4 399 484 7.4e-22 PFAM
low complexity region 518 532 N/A INTRINSIC
ZnF_C2H2 665 687 2.99e-4 SMART
ZnF_C2H2 693 715 2.75e-3 SMART
ZnF_C2H2 721 743 8.02e-5 SMART
ZnF_C2H2 749 771 1.13e-4 SMART
ZnF_C2H2 777 799 1.18e-2 SMART
ZnF_C2H2 805 827 1.33e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146243
SMART Domains Protein: ENSMUSP00000120997
Gene: ENSMUSG00000050619

DomainStartEndE-ValueType
SCAN 13 118 4.23e-58 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156370
Predicted Effect probably damaging
Transcript: ENSMUST00000163766
AA Change: T489N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125987
Gene: ENSMUSG00000050619
AA Change: T489N

DomainStartEndE-ValueType
SCAN 13 125 5.83e-70 SMART
Pfam:Myb_DNA-bind_4 238 323 5.9e-21 PFAM
Pfam:Myb_DNA-bind_4 434 519 1.3e-21 PFAM
low complexity region 553 567 N/A INTRINSIC
ZnF_C2H2 700 722 2.99e-4 SMART
ZnF_C2H2 728 750 2.75e-3 SMART
ZnF_C2H2 756 778 8.02e-5 SMART
ZnF_C2H2 784 806 1.13e-4 SMART
ZnF_C2H2 812 834 1.18e-2 SMART
ZnF_C2H2 840 862 1.33e-1 SMART
Meta Mutation Damage Score 0.1673 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,832,516 (GRCm39) R1153* probably null Het
Amdhd1 T C 10: 93,360,332 (GRCm39) H409R possibly damaging Het
Anks1b C T 10: 90,412,803 (GRCm39) probably benign Het
Ascc2 T C 11: 4,631,506 (GRCm39) L649P probably benign Het
Chst15 A G 7: 131,872,246 (GRCm39) F12L probably benign Het
Clec4a4 A T 6: 122,981,017 (GRCm39) K83N probably benign Het
Comp T A 8: 70,829,011 (GRCm39) probably null Het
Cryz T A 3: 154,327,403 (GRCm39) S144T probably benign Het
Ctss A G 3: 95,450,424 (GRCm39) D125G probably benign Het
Dact1 G T 12: 71,365,456 (GRCm39) V746L possibly damaging Het
Dhx29 A G 13: 113,099,377 (GRCm39) H1134R probably damaging Het
Dlgap4 A G 2: 156,546,460 (GRCm39) D376G probably damaging Het
Dnah3 T A 7: 119,615,749 (GRCm39) H1660L probably damaging Het
Ep300 T A 15: 81,512,808 (GRCm39) probably benign Het
Fbxo30 A T 10: 11,165,262 (GRCm39) probably null Het
Fcrl2 T A 3: 87,164,094 (GRCm39) H345L probably damaging Het
Galnt11 C A 5: 25,452,670 (GRCm39) probably null Het
Il31ra A G 13: 112,682,846 (GRCm39) C87R probably benign Het
Itga4 A T 2: 79,117,442 (GRCm39) Q416L probably damaging Het
Kcnt2 A T 1: 140,461,666 (GRCm39) T806S probably damaging Het
Lama2 A G 10: 27,066,693 (GRCm39) S1063P probably damaging Het
Lama4 T A 10: 38,924,028 (GRCm39) S479T probably benign Het
Lgi4 C T 7: 30,759,603 (GRCm39) T53M possibly damaging Het
Limk1 A G 5: 134,686,789 (GRCm39) F533L probably damaging Het
Loxl1 A G 9: 58,220,006 (GRCm39) L55P probably damaging Het
Map1a A G 2: 121,135,697 (GRCm39) E1933G probably damaging Het
Matn2 T A 15: 34,409,912 (GRCm39) C447* probably null Het
Mmrn1 T C 6: 60,950,134 (GRCm39) probably null Het
Or2a7 C T 6: 43,151,646 (GRCm39) S242F probably damaging Het
Or4a66 A T 2: 88,531,049 (GRCm39) I208N possibly damaging Het
Or4d1 A T 11: 87,805,215 (GRCm39) N172K probably damaging Het
Otor A G 2: 142,920,431 (GRCm39) I4M probably benign Het
P2rx3 A T 2: 84,865,591 (GRCm39) V18E probably damaging Het
Pcdh7 T C 5: 57,879,097 (GRCm39) V884A probably damaging Het
Pcdhb4 T A 18: 37,442,619 (GRCm39) V643D probably damaging Het
Pelo A G 13: 115,225,930 (GRCm39) S176P possibly damaging Het
Ppp2r3d A T 9: 101,089,183 (GRCm39) V380E probably benign Het
Proc T A 18: 32,260,513 (GRCm39) D204V probably benign Het
Prpsap2 C T 11: 61,627,870 (GRCm39) R202H probably damaging Het
Resf1 T C 6: 149,236,179 (GRCm39) F1500L probably damaging Het
Rtl1 T G 12: 109,558,087 (GRCm39) T1251P possibly damaging Het
Sema6a T G 18: 47,414,405 (GRCm39) I482L probably benign Het
Smpdl3a T A 10: 57,681,654 (GRCm39) probably null Het
Strc T A 2: 121,209,790 (GRCm39) M178L probably benign Het
Taok1 A T 11: 77,451,144 (GRCm39) M312K probably damaging Het
Tle2 T C 10: 81,416,750 (GRCm39) probably null Het
Tle3 A G 9: 61,316,190 (GRCm39) D296G probably benign Het
Trank1 A G 9: 111,191,485 (GRCm39) D498G probably benign Het
Vars1 C A 17: 35,231,491 (GRCm39) L672M probably damaging Het
Vps13d G A 4: 144,826,580 (GRCm39) T2866I probably damaging Het
Zfp423 C A 8: 88,508,860 (GRCm39) E370* probably null Het
Zfp521 T A 18: 13,978,612 (GRCm39) K600N probably damaging Het
Zfp788 A G 7: 41,298,572 (GRCm39) K351E probably benign Het
Zfp963 A T 8: 70,195,510 (GRCm39) probably null Het
Other mutations in Zscan29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zscan29 APN 2 121,000,538 (GRCm39) missense probably damaging 1.00
IGL01938:Zscan29 APN 2 120,996,690 (GRCm39) missense probably benign 0.16
IGL02220:Zscan29 APN 2 120,997,170 (GRCm39) missense probably damaging 0.99
IGL02370:Zscan29 APN 2 120,994,314 (GRCm39) missense probably benign 0.00
IGL02585:Zscan29 APN 2 120,994,357 (GRCm39) nonsense probably null
R0284:Zscan29 UTSW 2 120,997,214 (GRCm39) unclassified probably benign
R0842:Zscan29 UTSW 2 120,991,960 (GRCm39) missense possibly damaging 0.84
R1245:Zscan29 UTSW 2 120,996,984 (GRCm39) missense probably damaging 1.00
R1586:Zscan29 UTSW 2 120,991,641 (GRCm39) missense probably damaging 1.00
R1654:Zscan29 UTSW 2 120,995,260 (GRCm39) missense probably benign 0.06
R1958:Zscan29 UTSW 2 121,000,289 (GRCm39) critical splice donor site probably null
R2073:Zscan29 UTSW 2 120,991,336 (GRCm39) nonsense probably null
R2085:Zscan29 UTSW 2 121,000,427 (GRCm39) nonsense probably null
R2145:Zscan29 UTSW 2 121,000,587 (GRCm39) missense probably damaging 1.00
R2201:Zscan29 UTSW 2 120,999,883 (GRCm39) missense probably damaging 1.00
R2875:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R2876:Zscan29 UTSW 2 120,994,581 (GRCm39) missense probably damaging 1.00
R3861:Zscan29 UTSW 2 120,991,212 (GRCm39) missense probably benign 0.01
R4244:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4245:Zscan29 UTSW 2 120,995,275 (GRCm39) splice site probably null
R4447:Zscan29 UTSW 2 121,000,367 (GRCm39) splice site probably null
R4662:Zscan29 UTSW 2 120,997,096 (GRCm39) missense probably benign 0.26
R4757:Zscan29 UTSW 2 120,991,392 (GRCm39) missense possibly damaging 0.92
R4777:Zscan29 UTSW 2 120,999,805 (GRCm39) missense probably damaging 0.96
R4905:Zscan29 UTSW 2 120,991,864 (GRCm39) missense possibly damaging 0.53
R4970:Zscan29 UTSW 2 120,999,676 (GRCm39) splice site probably null
R5860:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5861:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5862:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5916:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R5918:Zscan29 UTSW 2 120,994,518 (GRCm39) missense probably damaging 1.00
R6335:Zscan29 UTSW 2 120,991,917 (GRCm39) missense possibly damaging 0.49
R7214:Zscan29 UTSW 2 120,999,761 (GRCm39) nonsense probably null
R7326:Zscan29 UTSW 2 120,991,469 (GRCm39) missense probably damaging 1.00
R7997:Zscan29 UTSW 2 120,991,221 (GRCm39) missense probably benign 0.01
R8787:Zscan29 UTSW 2 120,996,876 (GRCm39) missense probably damaging 1.00
RF001:Zscan29 UTSW 2 120,994,477 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTGGTTCTCTGGAGGCAACAAG -3'
(R):5'- TCCTAGAAGCCGGCAGTAAAAC -3'

Sequencing Primer
(F):5'- CTCTGGAGGCAACAAGAAACTGTTTC -3'
(R):5'- AGGTGATGCTGAAATCTCTCTTC -3'
Posted On 2017-02-28