Incidental Mutation 'R5921:Or9s13'
ID 461550
Institutional Source Beutler Lab
Gene Symbol Or9s13
Ensembl Gene ENSMUSG00000061616
Gene Name olfactory receptor family 9 subfamily S member 13
Synonyms GA_x6K02T2R7CC-81134096-81133095, Olfr12, MOR208-5
MMRRC Submission 044118-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5921 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 92547603-92548723 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 92548344 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 239 (S239T)
Ref Sequence ENSEMBL: ENSMUSP00000150858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081274] [ENSMUST00000213247]
AlphaFold Q60894
Predicted Effect probably benign
Transcript: ENSMUST00000081274
AA Change: S239T

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000080027
Gene: ENSMUSG00000061616
AA Change: S239T

DomainStartEndE-ValueType
transmembrane domain 13 30 N/A INTRINSIC
Pfam:7tm_4 38 314 8e-53 PFAM
Pfam:7tm_1 48 297 1.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213247
AA Change: S239T

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.7%
Validation Efficiency 95% (70/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 G A 5: 35,969,555 (GRCm39) V223M probably damaging Het
Adamts7 T C 9: 90,070,747 (GRCm39) S623P probably benign Het
Aqp7 G T 4: 41,036,093 (GRCm39) N48K probably benign Het
Asic4 A G 1: 75,428,017 (GRCm39) N181S probably benign Het
Blvra A T 2: 126,929,283 (GRCm39) probably benign Het
Bmf C A 2: 118,363,034 (GRCm39) probably benign Het
Bnc2 A T 4: 84,211,292 (GRCm39) I454N possibly damaging Het
Catsperg1 A T 7: 28,889,948 (GRCm39) L700H possibly damaging Het
Ccdc14 T C 16: 34,526,761 (GRCm39) V222A probably damaging Het
Cfap97d2 G T 8: 13,784,840 (GRCm39) A34S probably damaging Het
Clstn3 A T 6: 124,408,539 (GRCm39) probably benign Het
Col15a1 A T 4: 47,300,602 (GRCm39) I1066F probably damaging Het
Dcdc2c T C 12: 28,574,774 (GRCm39) E116G possibly damaging Het
Dop1a G A 9: 86,383,975 (GRCm39) S310N probably damaging Het
Dync1h1 T A 12: 110,584,802 (GRCm39) V735E probably damaging Het
Eva1a T C 6: 82,069,140 (GRCm39) Y156H probably damaging Het
Fbxw26 A G 9: 109,575,086 (GRCm39) I13T probably damaging Het
Fermt2 A T 14: 45,702,203 (GRCm39) L527Q probably damaging Het
Fxyd4 G A 6: 117,913,099 (GRCm39) probably benign Het
Gal A G 19: 3,460,100 (GRCm39) S124P probably damaging Het
Glmp T C 3: 88,233,283 (GRCm39) S56P probably benign Het
Gm5600 T C 7: 113,307,413 (GRCm39) noncoding transcript Het
Golga2 A G 2: 32,187,767 (GRCm39) N194S probably benign Het
Gon4l T C 3: 88,817,254 (GRCm39) probably benign Het
Gtf2ird2 T A 5: 134,246,426 (GRCm39) Y895N probably damaging Het
Hsd3b1 C A 3: 98,765,215 (GRCm39) M22I probably benign Het
Ipo13 A C 4: 117,769,286 (GRCm39) L169V probably benign Het
Kif13a G T 13: 46,978,776 (GRCm39) T208K probably damaging Het
Klhl5 G T 5: 65,320,299 (GRCm39) A618S probably damaging Het
Lrig2 A T 3: 104,370,070 (GRCm39) L496* probably null Het
Macf1 A G 4: 123,420,504 (GRCm39) I250T probably benign Het
Man1a A G 10: 53,783,606 (GRCm39) I632T probably damaging Het
Nav2 A G 7: 48,954,324 (GRCm39) probably benign Het
Nek8 A G 11: 78,063,885 (GRCm39) M40T probably damaging Het
Oas3 T C 5: 120,908,046 (GRCm39) D298G probably damaging Het
Ociad1 A G 5: 73,467,725 (GRCm39) D167G probably benign Het
Or14j4 A T 17: 37,921,110 (GRCm39) C177* probably null Het
Or8s5 T C 15: 98,238,310 (GRCm39) T187A probably benign Het
Pafah2 G T 4: 134,145,380 (GRCm39) V255L probably benign Het
Pde10a A G 17: 9,149,369 (GRCm39) Y407C probably damaging Het
Pirb A C 7: 3,719,693 (GRCm39) Y484* probably null Het
Prl8a6 A G 13: 27,621,171 (GRCm39) S20P probably damaging Het
R3hdm4 A T 10: 79,749,453 (GRCm39) V52E probably damaging Het
Rab3ip A G 10: 116,775,152 (GRCm39) Y69H probably damaging Het
Rxrg T C 1: 167,466,808 (GRCm39) M330T possibly damaging Het
Sema4g G T 19: 44,987,143 (GRCm39) G460V probably benign Het
Sidt1 T C 16: 44,094,098 (GRCm39) probably benign Het
Slc12a2 T A 18: 58,065,595 (GRCm39) D943E probably benign Het
Slc12a4 T C 8: 106,671,876 (GRCm39) probably null Het
Slc4a3 T G 1: 75,534,088 (GRCm39) probably null Het
Slc4a8 C T 15: 100,712,328 (GRCm39) probably benign Het
Srcap T A 7: 127,158,005 (GRCm39) probably benign Het
Stk39 A G 2: 68,196,449 (GRCm39) S327P probably damaging Het
Tbc1d5 G A 17: 51,270,721 (GRCm39) T170M probably damaging Het
Trim13 T A 14: 61,842,538 (GRCm39) F185Y probably benign Het
Ttc17 A G 2: 94,209,193 (GRCm39) V87A probably damaging Het
Ttn A T 2: 76,551,207 (GRCm39) M31395K possibly damaging Het
Usp34 T A 11: 23,414,686 (GRCm39) D2876E probably damaging Het
Uvssa T C 5: 33,547,096 (GRCm39) S221P probably benign Het
Vmn2r93 T A 17: 18,546,030 (GRCm39) L634Q probably damaging Het
Vmp1 C T 11: 86,477,336 (GRCm39) A355T probably benign Het
Xpo5 A T 17: 46,532,347 (GRCm39) M461L probably benign Het
Zfp759 T A 13: 67,288,558 (GRCm39) F703Y probably damaging Het
Other mutations in Or9s13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Or9s13 APN 1 92,547,921 (GRCm39) missense possibly damaging 0.88
IGL01309:Or9s13 APN 1 92,548,057 (GRCm39) missense probably damaging 1.00
IGL02025:Or9s13 APN 1 92,548,269 (GRCm39) missense probably benign 0.00
IGL02517:Or9s13 APN 1 92,548,183 (GRCm39) missense probably benign
IGL02837:Or9s13 UTSW 1 92,548,404 (GRCm39) missense possibly damaging 0.73
R1394:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1395:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1590:Or9s13 UTSW 1 92,548,467 (GRCm39) missense possibly damaging 0.64
R1778:Or9s13 UTSW 1 92,548,342 (GRCm39) missense possibly damaging 0.94
R1924:Or9s13 UTSW 1 92,548,525 (GRCm39) missense probably damaging 1.00
R2011:Or9s13 UTSW 1 92,548,471 (GRCm39) missense probably benign 0.01
R3877:Or9s13 UTSW 1 92,547,805 (GRCm39) missense probably damaging 1.00
R5286:Or9s13 UTSW 1 92,548,084 (GRCm39) missense probably benign 0.38
R5513:Or9s13 UTSW 1 92,548,102 (GRCm39) missense probably benign
R5727:Or9s13 UTSW 1 92,547,900 (GRCm39) missense probably benign 0.00
R5905:Or9s13 UTSW 1 92,547,864 (GRCm39) missense possibly damaging 0.49
R7614:Or9s13 UTSW 1 92,548,183 (GRCm39) missense probably damaging 0.99
R7959:Or9s13 UTSW 1 92,548,029 (GRCm39) missense probably damaging 0.96
R8073:Or9s13 UTSW 1 92,547,806 (GRCm39) missense probably damaging 1.00
R8161:Or9s13 UTSW 1 92,548,078 (GRCm39) missense probably benign 0.00
R8680:Or9s13 UTSW 1 92,547,643 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- GCAGCTCCAACCGTATTGAC -3'
(R):5'- CTGCAGAGCATCTTTCACATC -3'

Sequencing Primer
(F):5'- ATTGACCACTTCTACTGTGATGTG -3'
(R):5'- CACATCCTTGTTGCGTAGACTGTAG -3'
Posted On 2017-02-28