Incidental Mutation 'IGL00309:Ccnjl'
ID4616
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnjl
Ensembl Gene ENSMUSG00000044707
Gene Namecyclin J-like
SynonymsLOC380694
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #IGL00309
Quality Score
Status
Chromosome11
Chromosomal Location43528784-43586997 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 43583196 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 199 (K199N)
Ref Sequence ENSEMBL: ENSMUSP00000058111 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050574] [ENSMUST00000056256]
Predicted Effect probably benign
Transcript: ENSMUST00000050574
AA Change: K199N

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000058111
Gene: ENSMUSG00000044707
AA Change: K199N

DomainStartEndE-ValueType
CYCLIN 43 135 7.96e-14 SMART
Cyclin_C 144 281 2.52e-22 SMART
CYCLIN 153 247 1.58e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000056256
SMART Domains Protein: ENSMUSP00000062657
Gene: ENSMUSG00000045877

DomainStartEndE-ValueType
transmembrane domain 30 62 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130874
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T C 4: 62,532,666 probably benign Het
Abca9 T A 11: 110,160,516 D118V probably benign Het
Adgrb2 T A 4: 130,018,805 I1241N probably damaging Het
Arsb A G 13: 93,790,100 D126G probably benign Het
BB014433 G T 8: 15,042,510 N114K probably benign Het
Ccne2 T A 4: 11,199,322 V241E probably benign Het
Cyp2c55 A G 19: 39,011,746 T130A probably benign Het
Cyp2c70 A T 19: 40,156,826 N395K probably benign Het
Dst T C 1: 34,160,652 V67A probably damaging Het
Dysf G A 6: 84,108,099 R806H probably damaging Het
Extl3 G A 14: 65,076,989 P248L probably benign Het
Fcgbp A G 7: 28,085,130 D205G probably damaging Het
Gga1 G T 15: 78,883,355 V98L possibly damaging Het
Gpr6 C T 10: 41,070,816 A257T probably damaging Het
Mex3c C T 18: 73,589,889 T351M probably damaging Het
Olfr1019 A T 2: 85,841,362 V143D probably benign Het
Olfr1513 A G 14: 52,349,710 V112A probably benign Het
Olfr154 A T 2: 85,664,356 V26D probably benign Het
Olfr961 T A 9: 39,647,340 S205T probably benign Het
Prex1 A G 2: 166,609,823 Y412H probably damaging Het
Slc25a25 A T 2: 32,419,160 V75E probably benign Het
Sv2c A G 13: 96,048,429 C247R probably damaging Het
Trpm5 A T 7: 143,082,991 V403E probably benign Het
Wdr17 A G 8: 54,687,711 V202A probably damaging Het
Zscan25 A G 5: 145,283,749 E118G probably damaging Het
Other mutations in Ccnjl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Ccnjl APN 11 43585327 missense probably benign 0.06
IGL01623:Ccnjl APN 11 43585327 missense probably benign 0.06
IGL02268:Ccnjl APN 11 43579788 missense probably benign 0.00
PIT4431001:Ccnjl UTSW 11 43579707 small insertion probably benign
R3434:Ccnjl UTSW 11 43579861 missense probably damaging 0.98
R4867:Ccnjl UTSW 11 43583228 missense possibly damaging 0.73
R4897:Ccnjl UTSW 11 43579891 missense probably damaging 1.00
R5111:Ccnjl UTSW 11 43556717 missense probably benign
R6345:Ccnjl UTSW 11 43585338 missense probably benign
R7691:Ccnjl UTSW 11 43583201 missense probably benign 0.01
Posted On2012-04-20