Incidental Mutation 'R5924:Or4k15'
ID 461747
Institutional Source Beutler Lab
Gene Symbol Or4k15
Ensembl Gene ENSMUSG00000059488
Gene Name olfactory receptor family 4 subfamily K member 15
Synonyms Olfr727, GA_x6K02T2PMLR-5817082-5818056, MOR246-2
MMRRC Submission 044119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R5924 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50364010-50365044 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50364139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 35 (Y35C)
Ref Sequence ENSEMBL: ENSMUSP00000149886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079142] [ENSMUST00000215317]
AlphaFold A2RTN7
Predicted Effect probably damaging
Transcript: ENSMUST00000079142
AA Change: Y35C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078145
Gene: ENSMUSG00000059488
AA Change: Y35C

Pfam:7tm_4 31 304 8.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 290 1.5e-7 PFAM
Pfam:7tm_1 41 287 1.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205947
Predicted Effect probably damaging
Transcript: ENSMUST00000215317
AA Change: Y35C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd3 T C 18: 10,706,085 (GRCm39) Y76C probably damaging Het
Agbl1 C T 7: 76,058,982 (GRCm39) T204I probably benign Het
Apc2 A T 10: 80,147,984 (GRCm39) I984F probably damaging Het
Art3 A T 5: 92,560,091 (GRCm39) probably benign Het
B4galnt4 A G 7: 140,650,742 (GRCm39) M839V probably damaging Het
Bnip2 A G 9: 69,904,444 (GRCm39) D67G probably benign Het
Cdhr2 A C 13: 54,874,496 (GRCm39) D856A probably benign Het
Cep78 A T 19: 15,938,430 (GRCm39) L506Q probably damaging Het
Col6a1 A G 10: 76,554,205 (GRCm39) probably null Het
Cyp3a44 A T 5: 145,731,137 (GRCm39) F221Y possibly damaging Het
Dcakd C A 11: 102,890,646 (GRCm39) R47L probably benign Het
Ddr2 A G 1: 169,822,197 (GRCm39) V417A probably benign Het
Dnah5 A T 15: 28,307,473 (GRCm39) T1734S probably benign Het
Eefsec A T 6: 88,332,529 (GRCm39) M227K probably damaging Het
Eif4g3 T G 4: 137,929,237 (GRCm39) N1628K probably damaging Het
Epha5 A T 5: 84,381,533 (GRCm39) Y439* probably null Het
Esrp1 G T 4: 11,361,174 (GRCm39) T324K probably damaging Het
Flnb T A 14: 7,890,765 (GRCm38) M549K probably benign Het
Fndc1 T A 17: 7,992,442 (GRCm39) Q418L unknown Het
Ggnbp2 A G 11: 84,749,363 (GRCm39) S144P possibly damaging Het
Gk5 T C 9: 96,032,563 (GRCm39) probably null Het
Gpr137 A G 19: 6,916,729 (GRCm39) L228P probably damaging Het
Gpt2 C A 8: 86,219,633 (GRCm39) S26R probably damaging Het
Hras C T 7: 140,772,374 (GRCm39) E91K possibly damaging Het
Ighv1-36 G A 12: 114,843,777 (GRCm39) P28S possibly damaging Het
Kalrn G A 16: 34,064,203 (GRCm39) T807M probably damaging Het
Lifr A G 15: 7,202,453 (GRCm39) T365A probably benign Het
Lpin1 A T 12: 16,594,658 (GRCm39) S795T possibly damaging Het
Magi2 A C 5: 20,816,067 (GRCm39) M1128L probably benign Het
Magi3 A T 3: 103,961,854 (GRCm39) probably null Het
Mier1 T A 4: 103,016,899 (GRCm39) L380* probably null Het
Mtmr14 A G 6: 113,230,750 (GRCm39) Y118C probably damaging Het
Myof A T 19: 37,971,421 (GRCm39) M277K probably damaging Het
Nlrp6 T C 7: 140,503,403 (GRCm39) V473A probably damaging Het
Nsfl1c T A 2: 151,347,320 (GRCm39) N164K probably benign Het
Olfm3 A T 3: 114,916,187 (GRCm39) Q353L probably benign Het
Opn5 A T 17: 42,922,199 (GRCm39) M1K probably null Het
Or2y3 A G 17: 38,393,254 (GRCm39) V205A probably benign Het
Or5d41 T C 2: 88,054,891 (GRCm39) I162V probably benign Het
Pax8 A G 2: 24,311,634 (GRCm39) S434P probably damaging Het
Pigo G A 4: 43,023,389 (GRCm39) Q256* probably null Het
Pik3ap1 A C 19: 41,284,895 (GRCm39) F597V probably damaging Het
Pkd2 A G 5: 104,646,424 (GRCm39) K744E probably damaging Het
Prom1 T C 5: 44,162,305 (GRCm39) T729A probably benign Het
Rasal1 T C 5: 120,813,582 (GRCm39) L652P probably damaging Het
Sebox T C 11: 78,395,017 (GRCm39) probably null Het
Setd2 A T 9: 110,403,112 (GRCm39) I1918F probably benign Het
Slc24a2 A T 4: 86,929,825 (GRCm39) probably null Het
Slc28a1 G T 7: 80,765,360 (GRCm39) G25V probably benign Het
Slc51a A G 16: 32,295,990 (GRCm39) F259L possibly damaging Het
Slco2a1 T A 9: 102,923,898 (GRCm39) C37* probably null Het
Speer4f2 A G 5: 17,581,622 (GRCm39) D188G probably damaging Het
Stim2 A G 5: 54,259,985 (GRCm39) K156E probably benign Het
Strn4 T C 7: 16,572,246 (GRCm39) I653T probably damaging Het
Tacr3 G T 3: 134,638,060 (GRCm39) D406Y possibly damaging Het
Utp20 G A 10: 88,651,784 (GRCm39) R400C probably benign Het
V1rd19 C T 7: 23,703,374 (GRCm39) S280L probably benign Het
Vmn2r4 C T 3: 64,296,685 (GRCm39) C700Y probably damaging Het
Zup1 A T 10: 33,803,543 (GRCm39) C514S probably damaging Het
Other mutations in Or4k15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Or4k15 APN 14 50,364,214 (GRCm39) missense probably damaging 1.00
IGL01306:Or4k15 APN 14 50,364,039 (GRCm39) missense probably benign 0.00
ANU23:Or4k15 UTSW 14 50,364,039 (GRCm39) missense probably benign 0.00
R0498:Or4k15 UTSW 14 50,364,750 (GRCm39) missense probably damaging 1.00
R0574:Or4k15 UTSW 14 50,364,139 (GRCm39) missense probably damaging 1.00
R1201:Or4k15 UTSW 14 50,364,813 (GRCm39) missense probably damaging 1.00
R2112:Or4k15 UTSW 14 50,364,080 (GRCm39) missense probably damaging 1.00
R2435:Or4k15 UTSW 14 50,364,211 (GRCm39) missense probably damaging 1.00
R4238:Or4k15 UTSW 14 50,364,889 (GRCm39) missense probably benign
R4611:Or4k15 UTSW 14 50,364,530 (GRCm39) missense probably benign 0.12
R4663:Or4k15 UTSW 14 50,364,939 (GRCm39) missense probably benign 0.00
R4672:Or4k15 UTSW 14 50,364,714 (GRCm39) missense probably benign 0.02
R5022:Or4k15 UTSW 14 50,364,469 (GRCm39) missense possibly damaging 0.78
R5062:Or4k15 UTSW 14 50,364,894 (GRCm39) missense probably damaging 1.00
R6702:Or4k15 UTSW 14 50,364,688 (GRCm39) missense probably damaging 1.00
R6703:Or4k15 UTSW 14 50,364,688 (GRCm39) missense probably damaging 1.00
R7497:Or4k15 UTSW 14 50,364,952 (GRCm39) missense probably benign 0.20
R7615:Or4k15 UTSW 14 50,364,446 (GRCm39) missense probably benign 0.07
R7798:Or4k15 UTSW 14 50,364,895 (GRCm39) missense probably damaging 1.00
R8413:Or4k15 UTSW 14 50,364,827 (GRCm39) missense probably benign 0.19
R8439:Or4k15 UTSW 14 50,364,604 (GRCm39) missense probably benign
R8841:Or4k15 UTSW 14 50,364,666 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
(F):5'- tcaggctttatataactagatcc -3'
Posted On 2017-02-28