Incidental Mutation 'R5924:Gpr137'
ID 461759
Institutional Source Beutler Lab
Gene Symbol Gpr137
Ensembl Gene ENSMUSG00000024958
Gene Name G protein-coupled receptor 137
Synonyms
MMRRC Submission 044119-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5924 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 6915425-6919818 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6916729 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 228 (L228P)
Ref Sequence ENSEMBL: ENSMUSP00000130969 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025908] [ENSMUST00000025909] [ENSMUST00000025910] [ENSMUST00000099774] [ENSMUST00000099776] [ENSMUST00000099782] [ENSMUST00000166115] [ENSMUST00000113426] [ENSMUST00000113423]
AlphaFold Q80ZU9
Predicted Effect probably benign
Transcript: ENSMUST00000025908
SMART Domains Protein: ENSMUSP00000025908
Gene: ENSMUSG00000024957

DomainStartEndE-ValueType
Pfam:Ion_trans 2 147 8.1e-9 PFAM
Pfam:Ion_trans_2 64 145 1.7e-21 PFAM
Pfam:Ion_trans_2 174 260 5.3e-22 PFAM
low complexity region 303 319 N/A INTRINSIC
low complexity region 367 390 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000025909
AA Change: L228P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025909
Gene: ENSMUSG00000024958
AA Change: L228P

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 62 81 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 139 161 N/A INTRINSIC
transmembrane domain 176 198 N/A INTRINSIC
transmembrane domain 219 241 N/A INTRINSIC
transmembrane domain 273 295 N/A INTRINSIC
low complexity region 338 356 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000025910
SMART Domains Protein: ENSMUSP00000025910
Gene: ENSMUSG00000024959

DomainStartEndE-ValueType
Pfam:Bcl-2_BAD 43 204 5e-93 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000099774
AA Change: L46P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097362
Gene: ENSMUSG00000024958
AA Change: L46P

DomainStartEndE-ValueType
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 91 113 N/A INTRINSIC
low complexity region 156 174 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000099776
AA Change: L136P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097364
Gene: ENSMUSG00000024958
AA Change: L136P

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
transmembrane domain 26 48 N/A INTRINSIC
transmembrane domain 61 80 N/A INTRINSIC
transmembrane domain 95 117 N/A INTRINSIC
transmembrane domain 129 151 N/A INTRINSIC
transmembrane domain 181 203 N/A INTRINSIC
low complexity region 246 264 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000099782
AA Change: L214P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097370
Gene: ENSMUSG00000024958
AA Change: L214P

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 65 76 N/A INTRINSIC
low complexity region 78 90 N/A INTRINSIC
transmembrane domain 122 144 N/A INTRINSIC
transmembrane domain 162 184 N/A INTRINSIC
transmembrane domain 205 227 N/A INTRINSIC
transmembrane domain 259 281 N/A INTRINSIC
low complexity region 324 342 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000166115
AA Change: L228P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000130969
Gene: ENSMUSG00000024958
AA Change: L228P

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 62 81 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 139 161 N/A INTRINSIC
transmembrane domain 176 198 N/A INTRINSIC
transmembrane domain 219 241 N/A INTRINSIC
transmembrane domain 273 295 N/A INTRINSIC
low complexity region 338 356 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141410
SMART Domains Protein: ENSMUSP00000114597
Gene: ENSMUSG00000024959

DomainStartEndE-ValueType
Pfam:Bcl-2_BAD 1 134 2.9e-62 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113426
SMART Domains Protein: ENSMUSP00000109053
Gene: ENSMUSG00000024959

DomainStartEndE-ValueType
Pfam:Bcl-2_BAD 43 172 5.7e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113423
SMART Domains Protein: ENSMUSP00000109050
Gene: ENSMUSG00000024959

DomainStartEndE-ValueType
Pfam:Bcl-2_BAD 1 162 9.1e-92 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd3 T C 18: 10,706,085 (GRCm39) Y76C probably damaging Het
Agbl1 C T 7: 76,058,982 (GRCm39) T204I probably benign Het
Apc2 A T 10: 80,147,984 (GRCm39) I984F probably damaging Het
Art3 A T 5: 92,560,091 (GRCm39) probably benign Het
B4galnt4 A G 7: 140,650,742 (GRCm39) M839V probably damaging Het
Bnip2 A G 9: 69,904,444 (GRCm39) D67G probably benign Het
Cdhr2 A C 13: 54,874,496 (GRCm39) D856A probably benign Het
Cep78 A T 19: 15,938,430 (GRCm39) L506Q probably damaging Het
Col6a1 A G 10: 76,554,205 (GRCm39) probably null Het
Cyp3a44 A T 5: 145,731,137 (GRCm39) F221Y possibly damaging Het
Dcakd C A 11: 102,890,646 (GRCm39) R47L probably benign Het
Ddr2 A G 1: 169,822,197 (GRCm39) V417A probably benign Het
Dnah5 A T 15: 28,307,473 (GRCm39) T1734S probably benign Het
Eefsec A T 6: 88,332,529 (GRCm39) M227K probably damaging Het
Eif4g3 T G 4: 137,929,237 (GRCm39) N1628K probably damaging Het
Epha5 A T 5: 84,381,533 (GRCm39) Y439* probably null Het
Esrp1 G T 4: 11,361,174 (GRCm39) T324K probably damaging Het
Flnb T A 14: 7,890,765 (GRCm38) M549K probably benign Het
Fndc1 T A 17: 7,992,442 (GRCm39) Q418L unknown Het
Ggnbp2 A G 11: 84,749,363 (GRCm39) S144P possibly damaging Het
Gk5 T C 9: 96,032,563 (GRCm39) probably null Het
Gpt2 C A 8: 86,219,633 (GRCm39) S26R probably damaging Het
Hras C T 7: 140,772,374 (GRCm39) E91K possibly damaging Het
Ighv1-36 G A 12: 114,843,777 (GRCm39) P28S possibly damaging Het
Kalrn G A 16: 34,064,203 (GRCm39) T807M probably damaging Het
Lifr A G 15: 7,202,453 (GRCm39) T365A probably benign Het
Lpin1 A T 12: 16,594,658 (GRCm39) S795T possibly damaging Het
Magi2 A C 5: 20,816,067 (GRCm39) M1128L probably benign Het
Magi3 A T 3: 103,961,854 (GRCm39) probably null Het
Mier1 T A 4: 103,016,899 (GRCm39) L380* probably null Het
Mtmr14 A G 6: 113,230,750 (GRCm39) Y118C probably damaging Het
Myof A T 19: 37,971,421 (GRCm39) M277K probably damaging Het
Nlrp6 T C 7: 140,503,403 (GRCm39) V473A probably damaging Het
Nsfl1c T A 2: 151,347,320 (GRCm39) N164K probably benign Het
Olfm3 A T 3: 114,916,187 (GRCm39) Q353L probably benign Het
Opn5 A T 17: 42,922,199 (GRCm39) M1K probably null Het
Or2y3 A G 17: 38,393,254 (GRCm39) V205A probably benign Het
Or4k15 A G 14: 50,364,139 (GRCm39) Y35C probably damaging Het
Or5d41 T C 2: 88,054,891 (GRCm39) I162V probably benign Het
Pax8 A G 2: 24,311,634 (GRCm39) S434P probably damaging Het
Pigo G A 4: 43,023,389 (GRCm39) Q256* probably null Het
Pik3ap1 A C 19: 41,284,895 (GRCm39) F597V probably damaging Het
Pkd2 A G 5: 104,646,424 (GRCm39) K744E probably damaging Het
Prom1 T C 5: 44,162,305 (GRCm39) T729A probably benign Het
Rasal1 T C 5: 120,813,582 (GRCm39) L652P probably damaging Het
Sebox T C 11: 78,395,017 (GRCm39) probably null Het
Setd2 A T 9: 110,403,112 (GRCm39) I1918F probably benign Het
Slc24a2 A T 4: 86,929,825 (GRCm39) probably null Het
Slc28a1 G T 7: 80,765,360 (GRCm39) G25V probably benign Het
Slc51a A G 16: 32,295,990 (GRCm39) F259L possibly damaging Het
Slco2a1 T A 9: 102,923,898 (GRCm39) C37* probably null Het
Speer4f2 A G 5: 17,581,622 (GRCm39) D188G probably damaging Het
Stim2 A G 5: 54,259,985 (GRCm39) K156E probably benign Het
Strn4 T C 7: 16,572,246 (GRCm39) I653T probably damaging Het
Tacr3 G T 3: 134,638,060 (GRCm39) D406Y possibly damaging Het
Utp20 G A 10: 88,651,784 (GRCm39) R400C probably benign Het
V1rd19 C T 7: 23,703,374 (GRCm39) S280L probably benign Het
Vmn2r4 C T 3: 64,296,685 (GRCm39) C700Y probably damaging Het
Zup1 A T 10: 33,803,543 (GRCm39) C514S probably damaging Het
Other mutations in Gpr137
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Gpr137 APN 19 6,917,072 (GRCm39) missense probably damaging 1.00
R0355:Gpr137 UTSW 19 6,916,491 (GRCm39) missense probably damaging 1.00
R1465:Gpr137 UTSW 19 6,915,812 (GRCm39) missense probably benign 0.04
R1465:Gpr137 UTSW 19 6,915,812 (GRCm39) missense probably benign 0.04
R1789:Gpr137 UTSW 19 6,919,425 (GRCm39) unclassified probably benign
R4080:Gpr137 UTSW 19 6,917,791 (GRCm39) intron probably benign
R5673:Gpr137 UTSW 19 6,916,466 (GRCm39) missense probably damaging 1.00
R5802:Gpr137 UTSW 19 6,919,373 (GRCm39) nonsense probably null
R7172:Gpr137 UTSW 19 6,917,049 (GRCm39) missense possibly damaging 0.95
R7448:Gpr137 UTSW 19 6,917,726 (GRCm39) missense possibly damaging 0.84
R8032:Gpr137 UTSW 19 6,919,480 (GRCm39) missense unknown
R8204:Gpr137 UTSW 19 6,917,746 (GRCm39) missense probably benign 0.07
R8523:Gpr137 UTSW 19 6,917,803 (GRCm39) nonsense probably null
R8775:Gpr137 UTSW 19 6,915,800 (GRCm39) missense probably damaging 0.97
R8775-TAIL:Gpr137 UTSW 19 6,915,800 (GRCm39) missense probably damaging 0.97
R9119:Gpr137 UTSW 19 6,915,811 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- GTCATTCACCAGATCTGCCTG -3'
(R):5'- AGGTAGAGCCACCAACCTTG -3'

Sequencing Primer
(F):5'- GCTGAGGACATTCTGCCAC -3'
(R):5'- AACCTTGATGTAGCACCCTTGGG -3'
Posted On 2017-02-28