Incidental Mutation 'R5932:Or10ad1'
ID 461958
Institutional Source Beutler Lab
Gene Symbol Or10ad1
Ensembl Gene ENSMUSG00000090129
Gene Name olfactory receptor family 10 subfamily AD member 1
Synonyms MOR286-1, Olfr287, GA_x6K02T2NBG7-5548201-5549154
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5932 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 98104852-98118937 bp(-) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to G at 98105296 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Serine at position 323 (*323S)
Ref Sequence ENSEMBL: ENSMUSP00000129271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000142443] [ENSMUST00000170618]
AlphaFold E9PZS7
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132068
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141911
SMART Domains Protein: ENSMUSP00000121254
Gene: ENSMUSG00000090129

DomainStartEndE-ValueType
low complexity region 28 43 N/A INTRINSIC
Pfam:7tm_1 47 208 3.8e-26 PFAM
Pfam:7tm_4 145 212 6.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142443
SMART Domains Protein: ENSMUSP00000119026
Gene: ENSMUSG00000075427

DomainStartEndE-ValueType
low complexity region 19 34 N/A INTRINSIC
Pfam:7tm_1 38 287 1.2e-32 PFAM
Pfam:7tm_4 136 280 3.9e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142443
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155603
SMART Domains Protein: ENSMUSP00000118682
Gene: ENSMUSG00000090129

DomainStartEndE-ValueType
Pfam:7tm_1 7 205 2.5e-30 PFAM
Pfam:7tm_4 105 209 4.5e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000170618
AA Change: *323S
SMART Domains Protein: ENSMUSP00000129271
Gene: ENSMUSG00000090129
AA Change: *323S

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 1e-50 PFAM
Pfam:7tm_1 47 296 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205339
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206224
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T A 19: 31,870,518 (GRCm39) S7T possibly damaging Het
Aatk C T 11: 119,912,359 (GRCm39) G29S probably damaging Het
Akap1 A G 11: 88,722,585 (GRCm39) L890P probably damaging Het
Akap13 T A 7: 75,259,932 (GRCm39) M49K probably damaging Het
Ankrd17 A T 5: 90,413,295 (GRCm39) N1206K probably damaging Het
Bbs7 G A 3: 36,636,847 (GRCm39) T480I probably benign Het
Bbs9 A G 9: 22,723,627 (GRCm39) E769G probably damaging Het
Bpgm T A 6: 34,464,860 (GRCm39) S192R probably damaging Het
Brinp1 C A 4: 68,711,178 (GRCm39) K343N probably benign Het
Cabyr T G 18: 12,887,407 (GRCm39) V185G probably damaging Het
Cadm1 C A 9: 47,710,749 (GRCm39) D217E probably damaging Het
Camk1g T A 1: 193,036,347 (GRCm39) E171V probably benign Het
Casz1 T A 4: 149,023,570 (GRCm39) M825K possibly damaging Het
Ccdc27 A G 4: 154,111,231 (GRCm39) V627A probably benign Het
Ccdc40 T G 11: 119,141,838 (GRCm39) I808R probably damaging Het
Cdh23 G A 10: 60,228,763 (GRCm39) R1140C probably damaging Het
Celsr1 A G 15: 85,916,905 (GRCm39) V356A probably damaging Het
Cep126 T A 9: 8,103,509 (GRCm39) D167V probably damaging Het
Chmp4b C T 2: 154,533,201 (GRCm39) T147I probably benign Het
Clstn3 A T 6: 124,415,291 (GRCm39) M728K probably benign Het
Col7a1 A T 9: 108,809,279 (GRCm39) E2618V unknown Het
Cplane1 T A 15: 8,274,079 (GRCm39) probably null Het
Crls1 T A 2: 132,706,087 (GRCm39) Y170* probably null Het
Dennd2b G A 7: 109,169,223 (GRCm39) T24M probably damaging Het
Epas1 T G 17: 87,135,074 (GRCm39) I569S possibly damaging Het
Fhl3 T C 4: 124,599,520 (GRCm39) Y32H probably damaging Het
Fibp G A 19: 5,514,453 (GRCm39) G333D probably benign Het
Frmd4a C T 2: 4,534,650 (GRCm39) T156I probably damaging Het
Gcn1 T C 5: 115,730,435 (GRCm39) L873P possibly damaging Het
Gpr141b C A 13: 19,913,646 (GRCm39) noncoding transcript Het
Hectd3 G A 4: 116,859,470 (GRCm39) R698H possibly damaging Het
Il17a T C 1: 20,803,977 (GRCm39) V124A probably damaging Het
Kif14 A T 1: 136,444,128 (GRCm39) E1373D probably benign Het
Klra4 C T 6: 130,030,016 (GRCm39) V190M possibly damaging Het
Kmt2a T C 9: 44,731,944 (GRCm39) probably benign Het
L3mbtl1 GGCCG GG 2: 162,809,256 (GRCm39) probably benign Het
Lamb2 T C 9: 108,357,810 (GRCm39) I111T probably damaging Het
Lrch3 A T 16: 32,796,106 (GRCm39) D204V probably damaging Het
Mansc1 C A 6: 134,587,478 (GRCm39) R233L possibly damaging Het
Mkrn3 A G 7: 62,068,655 (GRCm39) C379R probably damaging Het
Ncoa3 T A 2: 165,912,045 (GRCm39) probably null Het
Neu3 A T 7: 99,462,525 (GRCm39) C399* probably null Het
Or52e8 G A 7: 104,624,862 (GRCm39) T114M probably damaging Het
Pcare T C 17: 72,058,748 (GRCm39) R310G probably damaging Het
Pde5a T C 3: 122,634,693 (GRCm39) F713L probably benign Het
Pdk1 T A 2: 71,713,760 (GRCm39) probably null Het
Plin4 A G 17: 56,413,356 (GRCm39) V423A possibly damaging Het
Pstpip1 T A 9: 56,033,214 (GRCm39) Y249N probably damaging Het
Ptprf A T 4: 118,068,964 (GRCm39) C1673S probably benign Het
Pum1 A G 4: 130,457,677 (GRCm39) T230A probably benign Het
Qsox1 A T 1: 155,665,079 (GRCm39) D287E probably benign Het
Rad51ap2 A G 12: 11,508,387 (GRCm39) N770D probably damaging Het
Rtp3 T A 9: 110,815,760 (GRCm39) I202F probably benign Het
Slc26a4 C T 12: 31,585,248 (GRCm39) probably null Het
Spmip7 A G 11: 11,438,513 (GRCm39) probably benign Het
Sptbn1 C G 11: 30,086,136 (GRCm39) V1191L probably damaging Het
Tead2 T C 7: 44,882,323 (GRCm39) Y121H probably benign Het
Thsd7b T C 1: 129,358,575 (GRCm39) L3P probably benign Het
Trim24 T C 6: 37,934,010 (GRCm39) I651T probably damaging Het
Usp2 A G 9: 44,003,630 (GRCm39) I481V probably benign Het
Vps13d C A 4: 144,771,611 (GRCm39) V4056F possibly damaging Het
Yeats2 A G 16: 20,011,913 (GRCm39) E496G probably benign Het
Zap70 A G 1: 36,820,227 (GRCm39) K503E probably damaging Het
Zbtb46 A G 2: 181,053,713 (GRCm39) L333P probably benign Het
Zfc3h1 A T 10: 115,236,815 (GRCm39) T430S probably benign Het
Zfp618 C T 4: 63,036,803 (GRCm39) R368* probably null Het
Other mutations in Or10ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Or10ad1 APN 15 98,105,381 (GRCm39) missense probably damaging 0.99
IGL02952:Or10ad1 APN 15 98,105,470 (GRCm39) missense probably damaging 1.00
PIT4378001:Or10ad1 UTSW 15 98,105,452 (GRCm39) missense probably damaging 1.00
R1079:Or10ad1 UTSW 15 98,106,223 (GRCm39) missense probably damaging 0.98
R7839:Or10ad1 UTSW 15 98,106,026 (GRCm39) missense probably damaging 0.99
R8395:Or10ad1 UTSW 15 98,105,500 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- CTGTGCTGAAAGCCAACTAGAG -3'
(R):5'- AATCCCCGCAGTACACATGG -3'

Sequencing Primer
(F):5'- CTGGAGGACCTGAGAGTTCTACATC -3'
(R):5'- CAGTACACATGGGCCTGAC -3'
Posted On 2017-02-28