Incidental Mutation 'R0567:Denr'
ID 46206
Institutional Source Beutler Lab
Gene Symbol Denr
Ensembl Gene ENSMUSG00000023106
Gene Name density-regulated protein
Synonyms 1500003K04Rik
MMRRC Submission 038758-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0567 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 124045309-124066705 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 124046221 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 17 (T17M)
Ref Sequence ENSEMBL: ENSMUSP00000023869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023869] [ENSMUST00000166233]
AlphaFold Q9CQJ6
Predicted Effect probably benign
Transcript: ENSMUST00000023869
AA Change: T17M

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000023869
Gene: ENSMUSG00000023106
AA Change: T17M

DomainStartEndE-ValueType
Pfam:SUI1 111 184 3.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166233
AA Change: T17M

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000126174
Gene: ENSMUSG00000023106
AA Change: T17M

DomainStartEndE-ValueType
Pfam:SUI1 108 183 4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168899
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171639
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198321
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 A G 4: 86,146,253 (GRCm39) E303G probably damaging Het
Akr1b1 A T 6: 34,281,280 (GRCm39) probably null Het
Alox8 A T 11: 69,082,348 (GRCm39) probably null Het
Apcdd1 G A 18: 63,067,107 (GRCm39) E74K possibly damaging Het
Atr T C 9: 95,747,882 (GRCm39) V388A probably benign Het
AW554918 G A 18: 25,533,092 (GRCm39) E452K possibly damaging Het
C1galt1 A G 6: 7,866,874 (GRCm39) D240G probably damaging Het
Ceacam10 T A 7: 24,477,834 (GRCm39) D116E probably damaging Het
Col15a1 G T 4: 47,293,231 (GRCm39) V912L possibly damaging Het
Cyp3a11 G A 5: 145,805,959 (GRCm39) T136I probably damaging Het
Doc2b A G 11: 75,670,950 (GRCm39) F227S probably damaging Het
Dsp A T 13: 38,376,414 (GRCm39) T1400S probably benign Het
Egfr A T 11: 16,822,873 (GRCm39) D412V probably benign Het
Fryl C T 5: 73,222,734 (GRCm39) G1949D possibly damaging Het
Gstp3 A T 19: 4,107,636 (GRCm39) L176Q possibly damaging Het
H2ac12 T C 13: 22,219,734 (GRCm39) probably benign Het
Heatr5a T A 12: 51,956,872 (GRCm39) N1075I probably damaging Het
Ighv1-69 C T 12: 115,587,169 (GRCm39) probably benign Het
Lama3 A G 18: 12,682,309 (GRCm39) I1092V probably benign Het
Lipg A T 18: 75,090,440 (GRCm39) H36Q probably benign Het
Myh7b T C 2: 155,468,318 (GRCm39) W836R probably damaging Het
Oit3 A T 10: 59,271,800 (GRCm39) C186S probably damaging Het
Or4m1 A T 14: 50,558,115 (GRCm39) M59K probably damaging Het
P2ry2 T C 7: 100,647,748 (GRCm39) T186A probably damaging Het
Pyroxd2 T C 19: 42,724,364 (GRCm39) T300A probably benign Het
Rab26 C A 17: 24,748,556 (GRCm39) V283F probably damaging Het
Rad50 C T 11: 53,545,783 (GRCm39) R1180Q probably damaging Het
Rbpms2 ACTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 9: 65,558,948 (GRCm39) probably benign Het
Shroom3 A G 5: 93,112,312 (GRCm39) D1891G possibly damaging Het
Syne2 G A 12: 75,937,004 (GRCm39) E201K probably damaging Het
Taf6 A T 5: 138,181,988 (GRCm39) probably null Het
Tbc1d32 A T 10: 56,050,059 (GRCm39) M493K possibly damaging Het
Uaca A G 9: 60,778,663 (GRCm39) T1017A probably benign Het
Usp17le C T 7: 104,418,105 (GRCm39) V346I possibly damaging Het
Vmn1r71 T C 7: 10,482,556 (GRCm39) D44G probably damaging Het
Vmn2r80 A G 10: 79,030,665 (GRCm39) I830M possibly damaging Het
Yju2b A G 8: 84,987,294 (GRCm39) L93P probably damaging Het
Zfp994 T C 17: 22,419,449 (GRCm39) Y500C possibly damaging Het
Zscan20 A G 4: 128,483,243 (GRCm39) probably null Het
Other mutations in Denr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01367:Denr APN 5 124,046,182 (GRCm39) missense probably benign 0.19
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0007:Denr UTSW 5 124,062,877 (GRCm39) missense probably damaging 1.00
R0025:Denr UTSW 5 124,065,298 (GRCm39) unclassified probably benign
R0079:Denr UTSW 5 124,062,908 (GRCm39) missense probably damaging 1.00
R1818:Denr UTSW 5 124,055,283 (GRCm39) missense probably benign 0.00
R5125:Denr UTSW 5 124,065,144 (GRCm39) missense probably damaging 1.00
R6930:Denr UTSW 5 124,046,250 (GRCm39) missense probably benign 0.02
R7657:Denr UTSW 5 124,046,263 (GRCm39) missense probably damaging 0.96
R8379:Denr UTSW 5 124,065,124 (GRCm39) missense possibly damaging 0.59
R8970:Denr UTSW 5 124,055,279 (GRCm39) missense probably damaging 1.00
R9680:Denr UTSW 5 124,065,117 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- ACAGTGGAAGCTAAGACTGCACCC -3'
(R):5'- AAGTGCTGTGCCACCAAGCAAC -3'

Sequencing Primer
(F):5'- TAAGACTGCACCCCACCC -3'
(R):5'- GGCTCCTTAGCTTCCAACAAG -3'
Posted On 2013-06-11