Incidental Mutation 'R5936:Kif21a'
| ID |
462289 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
044130-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5936 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
90933276-91049948 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90935647 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 1594
(F1594S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000067205
AA Change: F1594S
PolyPhen 2
Score 0.947 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: F1594S
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000088614
AA Change: F1638S
PolyPhen 2
Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: F1638S
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100304
AA Change: F1638S
PolyPhen 2
Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: F1638S
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109287
AA Change: F1533S
PolyPhen 2
Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: F1533S
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109288
AA Change: F1539S
PolyPhen 2
Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: F1539S
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000230487
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 93.0%
|
| Validation Efficiency |
91% (77/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933409G03Rik |
A |
T |
2: 68,615,504 (GRCm38) |
|
probably benign |
Het |
| Acnat2 |
T |
C |
4: 49,383,362 (GRCm38) |
T64A |
probably benign |
Het |
| Afap1 |
A |
G |
5: 35,974,396 (GRCm38) |
N356D |
possibly damaging |
Het |
| Ahi1 |
A |
G |
10: 20,965,933 (GRCm38) |
D301G |
probably damaging |
Het |
| Alpk2 |
G |
A |
18: 65,350,520 (GRCm38) |
T139M |
probably damaging |
Het |
| Ankrd46 |
T |
C |
15: 36,479,282 (GRCm38) |
D221G |
probably benign |
Het |
| Ano6 |
T |
A |
15: 95,972,601 (GRCm38) |
L900H |
probably damaging |
Het |
| Asphd2 |
G |
A |
5: 112,385,757 (GRCm38) |
R343* |
probably null |
Het |
| BC055324 |
T |
G |
1: 163,987,012 (GRCm38) |
I121L |
probably benign |
Het |
| Brdt |
A |
G |
5: 107,359,395 (GRCm38) |
T554A |
probably damaging |
Het |
| Cacna1d |
A |
G |
14: 30,171,314 (GRCm38) |
V401A |
possibly damaging |
Het |
| Cbs |
T |
C |
17: 31,625,094 (GRCm38) |
T188A |
probably damaging |
Het |
| Cfap54 |
T |
A |
10: 92,962,412 (GRCm38) |
T1662S |
probably benign |
Het |
| Chka |
A |
G |
19: 3,884,580 (GRCm38) |
I205V |
probably benign |
Het |
| Chsy1 |
T |
A |
7: 66,172,277 (GRCm38) |
N753K |
possibly damaging |
Het |
| Cpz |
A |
G |
5: 35,502,643 (GRCm38) |
S553P |
probably benign |
Het |
| Crtac1 |
A |
G |
19: 42,323,837 (GRCm38) |
Y146H |
probably damaging |
Het |
| Csf1r |
A |
T |
18: 61,125,808 (GRCm38) |
I700F |
probably damaging |
Het |
| Ddx20 |
C |
A |
3: 105,680,587 (GRCm38) |
E392D |
possibly damaging |
Het |
| Dhrs11 |
G |
T |
11: 84,825,524 (GRCm38) |
Y67* |
probably null |
Het |
| Diaph3 |
G |
T |
14: 86,772,116 (GRCm38) |
Q1076K |
possibly damaging |
Het |
| Dopey1 |
T |
A |
9: 86,536,512 (GRCm38) |
L2037* |
probably null |
Het |
| Dst |
G |
T |
1: 34,307,458 (GRCm38) |
V5336L |
probably damaging |
Het |
| Etv1 |
C |
A |
12: 38,835,210 (GRCm38) |
H248Q |
probably damaging |
Het |
| Fam214a |
T |
C |
9: 75,009,304 (GRCm38) |
L395P |
probably benign |
Het |
| Fcgbp |
T |
C |
7: 28,086,692 (GRCm38) |
V518A |
probably damaging |
Het |
| Fchsd2 |
T |
C |
7: 101,191,701 (GRCm38) |
L139S |
probably damaging |
Het |
| Fer |
A |
T |
17: 63,924,063 (GRCm38) |
T270S |
probably benign |
Het |
| Fgd5 |
A |
G |
6: 91,987,911 (GRCm38) |
E375G |
probably damaging |
Het |
| Gabarapl1 |
T |
A |
6: 129,538,603 (GRCm38) |
I68N |
probably benign |
Het |
| Gopc |
C |
T |
10: 52,346,199 (GRCm38) |
V30M |
probably damaging |
Het |
| Hbp1 |
T |
C |
12: 31,937,096 (GRCm38) |
|
probably null |
Het |
| Helz2 |
A |
G |
2: 181,230,767 (GRCm38) |
V2480A |
probably damaging |
Het |
| Igfbp3 |
T |
A |
11: 7,209,472 (GRCm38) |
Y247F |
probably damaging |
Het |
| Kbtbd11 |
C |
A |
8: 15,027,534 (GRCm38) |
S44R |
probably benign |
Het |
| Kcnk10 |
G |
T |
12: 98,489,932 (GRCm38) |
S213R |
probably benign |
Het |
| Kcnq3 |
T |
A |
15: 66,000,110 (GRCm38) |
D570V |
probably damaging |
Het |
| Klf3 |
A |
G |
5: 64,822,960 (GRCm38) |
D31G |
probably damaging |
Het |
| Mapkapk3 |
T |
C |
9: 107,289,170 (GRCm38) |
K59E |
probably damaging |
Het |
| Myo18a |
A |
G |
11: 77,818,213 (GRCm38) |
T484A |
probably damaging |
Het |
| Nlrp6 |
T |
A |
7: 140,922,812 (GRCm38) |
L277* |
probably null |
Het |
| Nr5a1 |
G |
T |
2: 38,701,778 (GRCm38) |
|
probably benign |
Het |
| Nsmaf |
C |
T |
4: 6,421,017 (GRCm38) |
|
probably benign |
Het |
| Olfr1311 |
T |
A |
2: 112,021,587 (GRCm38) |
H89L |
probably benign |
Het |
| Orc1 |
A |
G |
4: 108,601,983 (GRCm38) |
T450A |
probably benign |
Het |
| Pacsin1 |
A |
T |
17: 27,704,997 (GRCm38) |
I122F |
probably benign |
Het |
| Pced1b |
T |
A |
15: 97,385,180 (GRCm38) |
Y367N |
possibly damaging |
Het |
| Pced1b |
T |
A |
15: 97,385,182 (GRCm38) |
Y367* |
probably null |
Het |
| Pdpk1 |
A |
G |
17: 24,093,229 (GRCm38) |
F281L |
probably damaging |
Het |
| Piwil1 |
T |
C |
5: 128,751,078 (GRCm38) |
V714A |
probably benign |
Het |
| Plcd3 |
C |
T |
11: 103,078,347 (GRCm38) |
V265M |
probably damaging |
Het |
| Ppp1r1c |
A |
T |
2: 79,756,454 (GRCm38) |
E48V |
possibly damaging |
Het |
| Prl2b1 |
T |
G |
13: 27,388,449 (GRCm38) |
T53P |
probably damaging |
Het |
| Ptch2 |
T |
G |
4: 117,108,294 (GRCm38) |
F359V |
probably benign |
Het |
| R3hdm2 |
G |
A |
10: 127,471,812 (GRCm38) |
S314N |
probably damaging |
Het |
| Rictor |
A |
T |
15: 6,784,161 (GRCm38) |
S1043C |
probably damaging |
Het |
| Rtn4rl2 |
A |
T |
2: 84,880,431 (GRCm38) |
L163Q |
probably damaging |
Het |
| Sarnp |
T |
A |
10: 128,848,771 (GRCm38) |
S129T |
probably benign |
Het |
| Scube3 |
A |
T |
17: 28,165,487 (GRCm38) |
K585M |
probably damaging |
Het |
| Sgk3 |
C |
T |
1: 9,885,820 (GRCm38) |
|
probably benign |
Het |
| Skint6 |
C |
T |
4: 113,096,593 (GRCm38) |
S458N |
probably benign |
Het |
| Slc25a54 |
A |
G |
3: 109,098,638 (GRCm38) |
H154R |
possibly damaging |
Het |
| Sorbs1 |
A |
C |
19: 40,324,772 (GRCm38) |
I690S |
probably damaging |
Het |
| Sqle |
C |
A |
15: 59,330,829 (GRCm38) |
A512D |
probably damaging |
Het |
| Tedc2 |
A |
C |
17: 24,216,341 (GRCm38) |
L358R |
probably damaging |
Het |
| Tfr2 |
A |
G |
5: 137,587,006 (GRCm38) |
S767G |
probably benign |
Het |
| Thoc5 |
A |
G |
11: 4,904,133 (GRCm38) |
E27G |
probably damaging |
Het |
| Trappc8 |
A |
T |
18: 20,874,688 (GRCm38) |
F123L |
probably damaging |
Het |
| Ube2cbp |
C |
T |
9: 86,372,459 (GRCm38) |
G323D |
probably benign |
Het |
| Unc13c |
T |
A |
9: 73,578,492 (GRCm38) |
H1642L |
probably damaging |
Het |
| Vmn1r10 |
A |
T |
6: 57,114,317 (GRCm38) |
H298L |
probably benign |
Het |
| Xpo4 |
A |
T |
14: 57,643,499 (GRCm38) |
Y26N |
probably benign |
Het |
| Zer1 |
A |
G |
2: 30,107,667 (GRCm38) |
L409P |
probably damaging |
Het |
| Zfyve28 |
A |
T |
5: 34,224,988 (GRCm38) |
L256Q |
probably damaging |
Het |
| Zgrf1 |
A |
G |
3: 127,562,253 (GRCm38) |
E376G |
possibly damaging |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,937,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,943,864 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,995,637 (GRCm38) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,959,745 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,956,430 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,991,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,965,535 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,985,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,985,395 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,997,963 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,956,376 (GRCm38) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,968,358 (GRCm38) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,970,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,970,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,976,521 (GRCm38) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,969,774 (GRCm38) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,968,054 (GRCm38) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,959,683 (GRCm38) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,997,541 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,940,581 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,935,650 (GRCm38) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,993,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,948,322 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,956,419 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,942,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,984,805 (GRCm38) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,994,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,994,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,959,743 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,949,047 (GRCm38) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,972,727 (GRCm38) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,971,766 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,994,371 (GRCm38) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,971,196 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,998,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,994,391 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,934,464 (GRCm38) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,972,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,965,595 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,968,074 (GRCm38) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,937,294 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,985,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,970,833 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,971,142 (GRCm38) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,968,089 (GRCm38) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,968,223 (GRCm38) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,940,545 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,940,545 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,956,305 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,984,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,937,190 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,949,010 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,968,358 (GRCm38) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,956,376 (GRCm38) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,993,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,968,113 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,951,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5976:Kif21a
|
UTSW |
15 |
90,935,812 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,980,892 (GRCm38) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,966,407 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,940,446 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,935,730 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,980,837 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,948,903 (GRCm38) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,980,883 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,967,229 (GRCm38) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,993,796 (GRCm38) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,943,861 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,980,919 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,956,314 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,968,442 (GRCm38) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,935,761 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,971,196 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,959,124 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,968,179 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,971,727 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,956,356 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,937,196 (GRCm38) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,969,827 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,959,748 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,969,827 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,969,778 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,956,473 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,995,512 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,985,325 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,971,127 (GRCm38) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGGCTCATCGTAGAGATTCAAAATC -3'
(R):5'- CACAAAGACTGGGTGTGTGC -3'
Sequencing Primer
(F):5'- GACTATGAGTTCTAAGCCACCCTGG -3'
(R):5'- CTCTGGAATGTGGACACT -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation