Incidental Mutation 'R5937:Or5b108'
ID 462350
Institutional Source Beutler Lab
Gene Symbol Or5b108
Ensembl Gene ENSMUSG00000094721
Gene Name olfactory receptor family 5 subfamily B member 108
Synonyms GA_x6K02T2RE5P-3517488-3518411, Olfr1462, MOR202-13
MMRRC Submission 043242-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5937 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13168033-13168956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13168675 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 215 (S215T)
Ref Sequence ENSEMBL: ENSMUSP00000147174 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076832] [ENSMUST00000208533]
AlphaFold Q8VFW3
Predicted Effect probably damaging
Transcript: ENSMUST00000076832
AA Change: S215T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076107
Gene: ENSMUSG00000094721
AA Change: S215T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-51 PFAM
Pfam:7tm_1 39 288 6e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208533
AA Change: S215T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.3%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,791,495 (GRCm39) W314R probably benign Het
Adgrv1 A T 13: 81,255,194 (GRCm39) V6143E probably damaging Het
Agap3 C T 5: 24,682,815 (GRCm39) T261I probably damaging Het
Ano6 T C 15: 95,811,838 (GRCm39) I241T probably damaging Het
Arhgef28 T C 13: 98,076,051 (GRCm39) T1328A probably benign Het
Capn10 C T 1: 92,867,105 (GRCm39) R112W probably damaging Het
Car5a A T 8: 122,666,560 (GRCm39) W46R probably damaging Het
Cntn6 C A 6: 104,810,064 (GRCm39) T582K possibly damaging Het
Ctsh T C 9: 89,943,509 (GRCm39) V60A probably benign Het
Ctsll3 A G 13: 60,947,410 (GRCm39) F259L probably damaging Het
Dennd2b A T 7: 109,156,478 (GRCm39) C91S possibly damaging Het
Fam228a T C 12: 4,787,725 (GRCm39) E16G probably damaging Het
G3bp2 A G 5: 92,203,256 (GRCm39) I388T probably damaging Het
Galnt5 A T 2: 57,928,949 (GRCm39) K926N probably benign Het
Gm10097 G A 10: 5,019,485 (GRCm39) probably benign Het
Gm9978 T A 10: 78,322,675 (GRCm39) noncoding transcript Het
Gria1 A G 11: 57,080,559 (GRCm39) T112A probably benign Het
Hnrnpk A C 13: 58,543,016 (GRCm39) V134G probably damaging Het
Insr A G 8: 3,224,808 (GRCm39) V220A probably benign Het
Lhx4 A G 1: 155,586,023 (GRCm39) I96T probably damaging Het
Lrp1 T C 10: 127,419,745 (GRCm39) T955A possibly damaging Het
Lrtm1 T C 14: 28,743,787 (GRCm39) V85A possibly damaging Het
Man2a2 T C 7: 80,013,251 (GRCm39) Y514C probably damaging Het
Npas1 T A 7: 16,197,187 (GRCm39) D226V probably benign Het
Nrcam G A 12: 44,619,074 (GRCm39) V858I probably benign Het
Or14c40 G T 7: 86,313,684 (GRCm39) L271F probably benign Het
Pde6b G T 5: 108,572,193 (GRCm39) A478S probably benign Het
Pex1 T A 5: 3,674,487 (GRCm39) N789K possibly damaging Het
Plekha6 A G 1: 133,187,839 (GRCm39) D120G possibly damaging Het
Pomgnt1 A G 4: 116,011,110 (GRCm39) T220A probably benign Het
Sdr39u1 A T 14: 56,135,364 (GRCm39) I193K probably damaging Het
Sec61a2 C A 2: 5,891,368 (GRCm39) M54I probably benign Het
Sema5a A G 15: 32,574,987 (GRCm39) Y365C probably damaging Het
Sra1 C T 18: 36,804,652 (GRCm39) probably null Het
Taf5 C T 19: 47,070,334 (GRCm39) S640L probably damaging Het
Tas2r140 T A 6: 133,032,236 (GRCm39) H174L probably benign Het
Tmem63a T A 1: 180,788,716 (GRCm39) V351D probably damaging Het
Ttll7 C T 3: 146,649,847 (GRCm39) Q626* probably null Het
Ubn2 T A 6: 38,440,917 (GRCm39) V263E possibly damaging Het
Vmn2r106 C T 17: 20,505,667 (GRCm39) W9* probably null Het
Xrcc3 C G 12: 111,774,406 (GRCm39) C141S probably null Het
Zfp516 T A 18: 82,974,958 (GRCm39) D385E probably damaging Het
Other mutations in Or5b108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01114:Or5b108 APN 19 13,168,598 (GRCm39) missense possibly damaging 0.60
IGL01999:Or5b108 APN 19 13,168,924 (GRCm39) missense probably damaging 0.99
IGL02326:Or5b108 APN 19 13,168,779 (GRCm39) nonsense probably null
IGL03381:Or5b108 APN 19 13,168,769 (GRCm39) missense probably damaging 0.98
R1184:Or5b108 UTSW 19 13,168,739 (GRCm39) missense probably damaging 0.99
R1434:Or5b108 UTSW 19 13,168,662 (GRCm39) missense probably benign 0.19
R2161:Or5b108 UTSW 19 13,168,673 (GRCm39) missense probably damaging 0.99
R2399:Or5b108 UTSW 19 13,168,709 (GRCm39) missense probably benign 0.02
R4583:Or5b108 UTSW 19 13,168,062 (GRCm39) missense probably damaging 1.00
R7164:Or5b108 UTSW 19 13,168,270 (GRCm39) missense probably benign 0.00
R7270:Or5b108 UTSW 19 13,168,768 (GRCm39) missense possibly damaging 0.90
R7645:Or5b108 UTSW 19 13,168,937 (GRCm39) missense probably benign 0.01
R7649:Or5b108 UTSW 19 13,168,136 (GRCm39) missense possibly damaging 0.94
R9713:Or5b108 UTSW 19 13,168,727 (GRCm39) missense probably benign 0.15
R9742:Or5b108 UTSW 19 13,168,769 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGCTTCCATCTATACAGTGGATG -3'
(R):5'- TCATGCTGTAGACCAGAGGG -3'

Sequencing Primer
(F):5'- ACAGTGGATGTATTTAGTCTCTCC -3'
(R):5'- TGGAGTAGAACACAGACACAATTTTG -3'
Posted On 2017-02-28