Incidental Mutation 'R5939:Nrros'
ID 462448
Institutional Source Beutler Lab
Gene Symbol Nrros
Ensembl Gene ENSMUSG00000052384
Gene Name negative regulator of reactive oxygen species
Synonyms E430025L02Rik, Lrrc33
MMRRC Submission 043243-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5939 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 31961603-31984412 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 31962272 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 546 (F546L)
Ref Sequence ENSEMBL: ENSMUSP00000155965 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099991] [ENSMUST00000115163] [ENSMUST00000115165] [ENSMUST00000126869] [ENSMUST00000130410] [ENSMUST00000143682] [ENSMUST00000231836] [ENSMUST00000144345]
AlphaFold Q8BMT4
Predicted Effect probably benign
Transcript: ENSMUST00000099991
AA Change: F554L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000097571
Gene: ENSMUSG00000052384
AA Change: F554L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115163
AA Change: F582L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000110817
Gene: ENSMUSG00000052384
AA Change: F582L

DomainStartEndE-ValueType
LRRNT 59 89 1.05e1 SMART
LRR 108 131 1.01e2 SMART
LRR 159 183 5.27e1 SMART
LRR 184 207 4.05e-1 SMART
LRR_TYP 208 231 7.67e-2 SMART
LRR 232 255 1.49e1 SMART
LRR_TYP 355 378 1.67e-2 SMART
LRR 404 428 3.27e1 SMART
LRR_TYP 429 452 1.79e-2 SMART
LRR 489 512 1.45e1 SMART
LRR 563 584 1.76e1 SMART
LRR 587 608 3.36e1 SMART
transmembrane domain 681 703 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115165
AA Change: F530L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000110819
Gene: ENSMUSG00000052384
AA Change: F530L

DomainStartEndE-ValueType
Blast:LRRNT 8 37 5e-8 BLAST
LRR 56 79 1.01e2 SMART
LRR 107 131 5.27e1 SMART
LRR 132 155 4.05e-1 SMART
LRR_TYP 156 179 7.67e-2 SMART
LRR 180 203 1.49e1 SMART
LRR_TYP 303 326 1.67e-2 SMART
LRR 352 376 3.27e1 SMART
LRR_TYP 377 400 1.79e-2 SMART
LRR 437 460 1.45e1 SMART
LRR 511 532 1.76e1 SMART
LRR 535 556 3.36e1 SMART
transmembrane domain 629 651 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126869
AA Change: F554L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000116388
Gene: ENSMUSG00000052384
AA Change: F554L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127287
Predicted Effect probably benign
Transcript: ENSMUST00000130410
SMART Domains Protein: ENSMUSP00000122290
Gene: ENSMUSG00000052384

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
Pfam:LRR_7 81 97 1.9e-2 PFAM
Pfam:LRR_7 105 121 6.8e-2 PFAM
Pfam:LRR_7 133 144 2e-1 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000143682
AA Change: F554L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000119349
Gene: ENSMUSG00000052384
AA Change: F554L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136809
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150250
Predicted Effect probably benign
Transcript: ENSMUST00000231836
AA Change: F546L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000144345
SMART Domains Protein: ENSMUSP00000121492
Gene: ENSMUSG00000052384

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout leads to increased oxidative stress and susceptibility to experimental autoimmune encephalomyelitis, but to reduced susceptibility to bacterial infections. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,404,138 (GRCm39) F225I probably damaging Het
Ager G T 17: 34,817,175 (GRCm39) C38F probably damaging Het
Arel1 C A 12: 84,973,066 (GRCm39) R577L probably damaging Het
Armh1 T C 4: 117,087,119 (GRCm39) Y182C probably damaging Het
Cabp2 G T 19: 4,136,470 (GRCm39) C172F possibly damaging Het
Cenps C A 4: 149,214,658 (GRCm39) probably benign Het
D630045J12Rik A C 6: 38,171,904 (GRCm39) S755A possibly damaging Het
Duox1 A T 2: 122,176,832 (GRCm39) H1451L probably damaging Het
Dync2h1 A G 9: 7,037,801 (GRCm39) V3359A probably damaging Het
Erlin2 T C 8: 27,526,554 (GRCm39) F305L probably benign Het
Gm10428 A C 11: 62,644,288 (GRCm39) probably benign Het
Gnal G A 18: 67,324,456 (GRCm39) V204M probably damaging Het
Intu T C 3: 40,647,014 (GRCm39) V629A probably damaging Het
Lrguk G T 6: 34,055,688 (GRCm39) C435F probably damaging Het
Man1c1 C T 4: 134,293,147 (GRCm39) V543M probably damaging Het
Mcm3ap A G 10: 76,344,195 (GRCm39) H1779R probably benign Het
Neb T C 2: 52,147,606 (GRCm39) T2776A probably benign Het
Nek10 A T 14: 14,931,290 (GRCm38) Y754F possibly damaging Het
Nr3c1 A G 18: 39,553,706 (GRCm39) I664T probably benign Het
Nrip1 T C 16: 76,089,010 (GRCm39) E849G probably damaging Het
Or12e8 A C 2: 87,188,048 (GRCm39) I87L possibly damaging Het
Or5d39 T C 2: 87,979,853 (GRCm39) Y170C probably damaging Het
Pcdhb16 A G 18: 37,611,117 (GRCm39) T26A probably benign Het
Penk A G 4: 4,138,010 (GRCm39) F45S probably benign Het
Pgap4 T A 4: 49,586,412 (GRCm39) Q252L probably damaging Het
Ppp2r3d A T 9: 101,089,824 (GRCm39) N166K probably benign Het
Psmb1 A G 17: 15,718,440 (GRCm39) F29L probably damaging Het
Rab23 T C 1: 33,762,990 (GRCm39) V20A probably damaging Het
Ryr1 C T 7: 28,815,552 (GRCm39) A113T probably damaging Het
Ryr2 C T 13: 11,805,218 (GRCm39) R882K probably damaging Het
Slc6a6 A G 6: 91,731,929 (GRCm39) N586S probably benign Het
Slc9c1 A G 16: 45,368,031 (GRCm39) I207V probably benign Het
Spef2 G A 15: 9,614,301 (GRCm39) T1215I probably benign Het
Thoc2l T C 5: 104,667,073 (GRCm39) Y532H possibly damaging Het
Tmc7 C T 7: 118,144,950 (GRCm39) A537T probably benign Het
Tmem70 T C 1: 16,747,615 (GRCm39) V243A probably benign Het
Top2b T C 14: 16,422,786 (GRCm38) Y1408H probably damaging Het
Tpcn1 A T 5: 120,677,892 (GRCm39) F642I probably damaging Het
Xirp1 T G 9: 119,847,575 (GRCm39) D436A probably benign Het
Other mutations in Nrros
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00920:Nrros APN 16 31,966,438 (GRCm39) missense probably benign 0.06
IGL01097:Nrros APN 16 31,963,003 (GRCm39) missense possibly damaging 0.71
IGL02065:Nrros APN 16 31,963,492 (GRCm39) missense possibly damaging 0.84
IGL03372:Nrros APN 16 31,963,588 (GRCm39) missense probably damaging 1.00
R0615:Nrros UTSW 16 31,962,903 (GRCm39) missense probably damaging 1.00
R0669:Nrros UTSW 16 31,962,241 (GRCm39) missense probably damaging 1.00
R0840:Nrros UTSW 16 31,962,241 (GRCm39) missense probably damaging 1.00
R1398:Nrros UTSW 16 31,961,962 (GRCm39) missense probably damaging 0.98
R1796:Nrros UTSW 16 31,962,329 (GRCm39) missense probably damaging 1.00
R2031:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2033:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2034:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2087:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2089:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2090:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2091:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2091:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2151:Nrros UTSW 16 31,962,076 (GRCm39) missense probably benign 0.11
R2438:Nrros UTSW 16 31,963,117 (GRCm39) missense probably benign 0.25
R2438:Nrros UTSW 16 31,962,929 (GRCm39) splice site probably null
R5474:Nrros UTSW 16 31,963,170 (GRCm39) missense probably benign 0.00
R5527:Nrros UTSW 16 31,963,288 (GRCm39) missense probably damaging 1.00
R5629:Nrros UTSW 16 31,963,223 (GRCm39) missense probably damaging 1.00
R5888:Nrros UTSW 16 31,961,905 (GRCm39) missense probably benign 0.15
R5982:Nrros UTSW 16 31,963,411 (GRCm39) missense probably damaging 0.96
R6869:Nrros UTSW 16 31,963,249 (GRCm39) missense probably damaging 1.00
R6912:Nrros UTSW 16 31,981,057 (GRCm39) missense probably null 0.01
R7010:Nrros UTSW 16 31,962,398 (GRCm39) missense probably damaging 0.96
R7469:Nrros UTSW 16 31,963,030 (GRCm39) missense probably benign 0.14
R7673:Nrros UTSW 16 31,981,099 (GRCm39) missense unknown
R7770:Nrros UTSW 16 31,962,346 (GRCm39) missense probably benign 0.01
R7948:Nrros UTSW 16 31,981,076 (GRCm39) missense unknown
R8375:Nrros UTSW 16 31,966,456 (GRCm39) missense probably damaging 1.00
R8702:Nrros UTSW 16 31,966,589 (GRCm39) intron probably benign
R9740:Nrros UTSW 16 31,963,667 (GRCm39) missense possibly damaging 0.95
X0022:Nrros UTSW 16 31,961,858 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TTGCAAGTGACCATGGACAAG -3'
(R):5'- TTAGACCTGTCTAGCAACTGGG -3'

Sequencing Primer
(F):5'- TCCGCAACAGTCTTGAAGTG -3'
(R):5'- GGGGTTCTGAATGGGAGCATC -3'
Posted On 2017-02-28