Incidental Mutation 'R0568:Lxn'
ID 46249
Institutional Source Beutler Lab
Gene Symbol Lxn
Ensembl Gene ENSMUSG00000047557
Gene Name latexin
Synonyms
MMRRC Submission 038759-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.217) question?
Stock # R0568 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 67365332-67371240 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 67368335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 143 (A143T)
Ref Sequence ENSEMBL: ENSMUSP00000060732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058981] [ENSMUST00000077271]
AlphaFold P70202
PDB Structure Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor) [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000058981
AA Change: A143T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060732
Gene: ENSMUSG00000047557
AA Change: A143T

DomainStartEndE-ValueType
Pfam:Latexin 3 219 8.7e-99 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077271
SMART Domains Protein: ENSMUSP00000076503
Gene: ENSMUSG00000027774

DomainStartEndE-ValueType
Pfam:GTP_EFTU 45 320 3.5e-65 PFAM
Pfam:GTP_EFTU_D2 366 432 6e-18 PFAM
Pfam:EFG_II 446 520 1.9e-31 PFAM
EFG_IV 522 642 1.64e-47 SMART
EFG_C 644 731 2.16e-24 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160202
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160529
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160827
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161009
SMART Domains Protein: ENSMUSP00000125161
Gene: ENSMUSG00000027774

DomainStartEndE-ValueType
Pfam:GTP_EFTU 45 320 3.4e-63 PFAM
Pfam:GTP_EFTU_D2 366 432 4.1e-18 PFAM
Pfam:EFG_II 446 520 4.4e-33 PFAM
Meta Mutation Damage Score 0.7587 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.4%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat1 G A 4: 49,451,003 (GRCm39) T36I possibly damaging Het
Adamts20 T C 15: 94,189,594 (GRCm39) probably benign Het
Adamtsl1 T C 4: 86,336,789 (GRCm39) L1558S probably damaging Het
Ap3b2 A G 7: 81,114,377 (GRCm39) probably null Het
Bag2 T C 1: 33,786,059 (GRCm39) M88V probably benign Het
Brms1l A G 12: 55,908,173 (GRCm39) probably null Het
C8b A G 4: 104,650,577 (GRCm39) I462V probably benign Het
Cfap410 C T 10: 77,818,872 (GRCm39) T181I possibly damaging Het
Cfap410 A T 10: 77,820,381 (GRCm39) *250C probably null Het
Cnpy4 A G 5: 138,190,839 (GRCm39) E167G probably damaging Het
Copa T C 1: 171,939,704 (GRCm39) V624A possibly damaging Het
Gm4553 G T 7: 141,719,357 (GRCm39) P24T unknown Het
Gna12 A G 5: 140,746,638 (GRCm39) V269A possibly damaging Het
Gtf2ird2 G T 5: 134,240,083 (GRCm39) E302* probably null Het
Hmcn2 C A 2: 31,305,248 (GRCm39) S3140R probably benign Het
Hspa4 A G 11: 53,153,703 (GRCm39) probably benign Het
Hspbp1 A T 7: 4,687,431 (GRCm39) L60* probably null Het
Lats1 A T 10: 7,588,292 (GRCm39) I970F possibly damaging Het
Lipo3 T C 19: 33,559,442 (GRCm39) probably benign Het
Lrrc3 T A 10: 77,737,419 (GRCm39) R6W probably damaging Het
Mga T C 2: 119,765,903 (GRCm39) I1390T probably damaging Het
Ncapg2 T A 12: 116,386,835 (GRCm39) I286N probably damaging Het
Or4c107 T A 2: 88,789,387 (GRCm39) Y192* probably null Het
Pitpnm2 A G 5: 124,278,580 (GRCm39) probably benign Het
Plxna2 T C 1: 194,433,694 (GRCm39) V581A probably benign Het
Polr3d A T 14: 70,676,959 (GRCm39) H378Q possibly damaging Het
Ptpn13 T C 5: 103,637,631 (GRCm39) V173A probably damaging Het
Rbpms2 ACTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 9: 65,558,948 (GRCm39) probably benign Het
Smc4 T C 3: 68,929,794 (GRCm39) probably null Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Syngr3 C T 17: 24,905,555 (GRCm39) A140T probably benign Het
Tent2 A G 13: 93,291,500 (GRCm39) S381P probably benign Het
Tprn T C 2: 25,154,333 (GRCm39) V545A probably damaging Het
Trim66 T C 7: 109,059,902 (GRCm39) H828R probably benign Het
Ugt2b5 G A 5: 87,285,224 (GRCm39) probably benign Het
Vps9d1 A G 8: 123,973,487 (GRCm39) V432A probably damaging Het
Zswim9 A T 7: 12,994,952 (GRCm39) D401E probably damaging Het
Other mutations in Lxn
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4791001:Lxn UTSW 3 67,365,979 (GRCm39) missense probably damaging 1.00
R4556:Lxn UTSW 3 67,365,953 (GRCm39) missense possibly damaging 0.95
R7000:Lxn UTSW 3 67,369,704 (GRCm39) missense probably benign 0.00
R9090:Lxn UTSW 3 67,368,651 (GRCm39) missense probably damaging 1.00
R9271:Lxn UTSW 3 67,368,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTAAGCTGACTGACTAGCAGTGCC -3'
(R):5'- ACTTGAGATGCACCTCTGCTGTCC -3'

Sequencing Primer
(F):5'- TGACTAGCAGTGCCTTCAGAC -3'
(R):5'- TACTTACTTCGAATCTAAGCCAGC -3'
Posted On 2013-06-11