|Institutional Source||Beutler Lab|
|Gene Name||kinetochore associated 1|
|Is this an essential gene?||Probably essential (E-score: 0.940)|
|Stock #||R5757 (G1)|
|Chromosomal Location||123749716-123821593 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 123807309 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000031366 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031366]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Kntc1||
(F):5'- TTACTGCAATGTGTTGTCCAC -3'
(R):5'- ACAGAAGAGTCTCCCCTTGC -3'
(F):5'- CAACGAGTGCTCTTAGCTACTGAG -3'
(R):5'- TTGCCTGGCACTGCATAAG -3'