|Institutional Source||Beutler Lab|
|Gene Name||GTP binding protein 4|
|Synonyms||Nog1, 2610028C09Rik, Crfg|
|Is this an essential gene?||Probably essential (E-score: 0.968)|
|Stock #||R5749 (G1)|
|Chromosomal Location||8966331-8996083 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 8995947 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000152412 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021574] [ENSMUST00000222098]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gtpbp4||
(F):5'- TCAGAGAGTGGGACTGATCTCC -3'
(R):5'- TGTGGGACTAGAAGCCTGTC -3'
(F):5'- ACTGATCTCCGAGGGTCG -3'
(R):5'- TCAGGAAATGATGTAACGCTTGAGTC -3'