Incidental Mutation 'R0570:Trip12'
| ID |
46340 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
038761-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0570 (G1)
|
| Quality Score |
185 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 84729269 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Phenylalanine
at position 1083
(S1083F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139563
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000186894]
[ENSMUST00000189670]
[ENSMUST00000189841]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: S1116F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: S1116F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: S1116F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: S1116F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: S1083F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: S1083F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186894
|
| SMART Domains |
Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
3e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
7e-6 |
PDB |
|
Blast:ARM
|
476 |
516 |
6e-6 |
BLAST |
|
WWE
|
764 |
839 |
6.9e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189670
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189841
|
| SMART Domains |
Protein: ENSMUSP00000140879
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
51 |
63 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190125
|
| Meta Mutation Damage Score |
0.1424 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.9%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
100% (85/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700067K01Rik |
C |
A |
8: 84,729,733 (GRCm39) |
|
probably benign |
Het |
| Aadacl3 |
C |
T |
4: 144,190,130 (GRCm39) |
W57* |
probably null |
Het |
| Abca2 |
G |
T |
2: 25,337,417 (GRCm39) |
|
probably null |
Het |
| Abca3 |
A |
G |
17: 24,593,373 (GRCm39) |
I257V |
probably benign |
Het |
| Adamts2 |
A |
G |
11: 50,666,963 (GRCm39) |
D420G |
probably damaging |
Het |
| Adamts5 |
A |
G |
16: 85,696,135 (GRCm39) |
F341L |
probably damaging |
Het |
| Ahnak |
T |
A |
19: 8,991,062 (GRCm39) |
D4115E |
probably damaging |
Het |
| Arhgap20 |
T |
C |
9: 51,751,751 (GRCm39) |
S365P |
possibly damaging |
Het |
| Atrn |
G |
A |
2: 130,822,054 (GRCm39) |
V916I |
probably benign |
Het |
| Blmh |
T |
C |
11: 76,856,651 (GRCm39) |
V82A |
probably damaging |
Het |
| C1ra |
A |
T |
6: 124,490,664 (GRCm39) |
Y19F |
probably benign |
Het |
| Cactin |
A |
G |
10: 81,159,067 (GRCm39) |
E306G |
probably damaging |
Het |
| Celsr1 |
C |
T |
15: 85,787,566 (GRCm39) |
R2724Q |
probably benign |
Het |
| Clca4b |
T |
C |
3: 144,631,110 (GRCm39) |
E250G |
probably benign |
Het |
| Col17a1 |
A |
T |
19: 47,654,317 (GRCm39) |
S647T |
possibly damaging |
Het |
| Cope |
T |
A |
8: 70,759,181 (GRCm39) |
D74E |
probably damaging |
Het |
| Dsg1c |
T |
C |
18: 20,403,435 (GRCm39) |
I198T |
probably damaging |
Het |
| Elfn2 |
T |
C |
15: 78,557,434 (GRCm39) |
N371S |
probably damaging |
Het |
| Elmo2 |
G |
T |
2: 165,146,839 (GRCm39) |
A246D |
probably benign |
Het |
| Ewsr1 |
A |
T |
11: 5,035,935 (GRCm39) |
M187K |
possibly damaging |
Het |
| Faap100 |
A |
T |
11: 120,265,114 (GRCm39) |
S587R |
possibly damaging |
Het |
| Fam234b |
C |
T |
6: 135,186,247 (GRCm39) |
S85L |
probably benign |
Het |
| Fanca |
A |
T |
8: 124,033,169 (GRCm39) |
S292R |
probably benign |
Het |
| Fanci |
G |
A |
7: 79,093,711 (GRCm39) |
C1021Y |
probably damaging |
Het |
| Fhod3 |
T |
C |
18: 25,245,640 (GRCm39) |
I1230T |
probably benign |
Het |
| Fmo5 |
T |
C |
3: 97,536,456 (GRCm39) |
L27S |
probably damaging |
Het |
| Fmo9 |
A |
G |
1: 166,502,031 (GRCm39) |
V147A |
probably null |
Het |
| Fnbp4 |
A |
G |
2: 90,583,301 (GRCm39) |
Y309C |
probably damaging |
Het |
| Foxb1 |
T |
C |
9: 69,666,844 (GRCm39) |
T229A |
probably benign |
Het |
| Gapvd1 |
A |
G |
2: 34,618,552 (GRCm39) |
Y274H |
probably damaging |
Het |
| Gbp8 |
T |
C |
5: 105,165,541 (GRCm39) |
|
probably null |
Het |
| Gcn1 |
T |
A |
5: 115,730,480 (GRCm39) |
L888Q |
probably damaging |
Het |
| Gm17490 |
T |
C |
2: 11,630,460 (GRCm39) |
|
probably benign |
Het |
| Gtf2ird2 |
T |
A |
5: 134,237,785 (GRCm39) |
|
probably null |
Het |
| H2-Q1 |
A |
G |
17: 35,540,373 (GRCm39) |
T153A |
possibly damaging |
Het |
| Ina |
A |
C |
19: 47,011,938 (GRCm39) |
E452A |
probably benign |
Het |
| Kars1 |
A |
G |
8: 112,721,494 (GRCm39) |
|
probably null |
Het |
| Kif1c |
A |
G |
11: 70,595,291 (GRCm39) |
E124G |
probably damaging |
Het |
| Lpin3 |
T |
C |
2: 160,745,944 (GRCm39) |
|
probably benign |
Het |
| Lrp1 |
A |
T |
10: 127,390,878 (GRCm39) |
C3006* |
probably null |
Het |
| Lyst |
T |
C |
13: 13,883,971 (GRCm39) |
L2953P |
probably benign |
Het |
| Mb21d2 |
G |
A |
16: 28,748,324 (GRCm39) |
A31V |
probably benign |
Het |
| Melk |
T |
C |
4: 44,308,906 (GRCm39) |
Y88H |
probably damaging |
Het |
| Myrf |
A |
G |
19: 10,189,161 (GRCm39) |
S857P |
probably damaging |
Het |
| Nos2 |
A |
G |
11: 78,826,187 (GRCm39) |
I153M |
possibly damaging |
Het |
| Or4n4 |
T |
G |
14: 50,519,370 (GRCm39) |
L113F |
probably benign |
Het |
| Otof |
A |
G |
5: 30,529,225 (GRCm39) |
|
probably benign |
Het |
| Patl2 |
A |
G |
2: 121,955,789 (GRCm39) |
V249A |
probably damaging |
Het |
| Pcgf5 |
A |
G |
19: 36,389,580 (GRCm39) |
Y19C |
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,247,941 (GRCm39) |
V951E |
probably damaging |
Het |
| Pcolce2 |
T |
C |
9: 95,520,710 (GRCm39) |
V29A |
probably benign |
Het |
| Pdgfrb |
A |
T |
18: 61,210,775 (GRCm39) |
M761L |
probably benign |
Het |
| Pi16 |
A |
T |
17: 29,538,189 (GRCm39) |
M1L |
possibly damaging |
Het |
| Pkd2 |
T |
A |
5: 104,603,471 (GRCm39) |
|
probably benign |
Het |
| Plcb2 |
A |
G |
2: 118,547,806 (GRCm39) |
W474R |
probably benign |
Het |
| Psapl1 |
A |
G |
5: 36,361,624 (GRCm39) |
D72G |
possibly damaging |
Het |
| Ptpn5 |
T |
A |
7: 46,728,681 (GRCm39) |
|
probably benign |
Het |
| Ptprg |
A |
G |
14: 12,215,896 (GRCm38) |
E1115G |
probably damaging |
Het |
| Rassf1 |
C |
T |
9: 107,435,165 (GRCm39) |
T224I |
probably damaging |
Het |
| Rbpms2 |
T |
A |
9: 65,566,476 (GRCm39) |
C168* |
probably null |
Het |
| Rhag |
A |
G |
17: 41,139,804 (GRCm39) |
|
probably benign |
Het |
| Rhebl1 |
C |
T |
15: 98,779,034 (GRCm39) |
V17I |
probably benign |
Het |
| Rnf130 |
A |
T |
11: 49,986,703 (GRCm39) |
D349V |
possibly damaging |
Het |
| Rprd1a |
A |
G |
18: 24,642,952 (GRCm39) |
L60P |
probably damaging |
Het |
| Rspry1 |
T |
C |
8: 95,356,420 (GRCm39) |
I25T |
probably damaging |
Het |
| Ruvbl2 |
C |
T |
7: 45,071,621 (GRCm39) |
V421M |
probably damaging |
Het |
| Sap30 |
T |
C |
8: 57,936,000 (GRCm39) |
N209D |
possibly damaging |
Het |
| Sfswap |
T |
C |
5: 129,581,042 (GRCm39) |
|
probably benign |
Het |
| Slc1a2 |
G |
A |
2: 102,586,352 (GRCm39) |
V319M |
probably damaging |
Het |
| Smad2 |
T |
C |
18: 76,422,250 (GRCm39) |
|
probably benign |
Het |
| Spdya |
T |
C |
17: 71,869,585 (GRCm39) |
|
probably null |
Het |
| Stk39 |
G |
A |
2: 68,240,392 (GRCm39) |
T113M |
probably damaging |
Het |
| Tanc1 |
A |
G |
2: 59,626,382 (GRCm39) |
|
probably benign |
Het |
| Tas2r122 |
T |
C |
6: 132,688,774 (GRCm39) |
K40E |
probably damaging |
Het |
| Tph2 |
G |
T |
10: 115,010,039 (GRCm39) |
|
probably benign |
Het |
| Tsc2 |
A |
T |
17: 24,845,701 (GRCm39) |
C206S |
probably damaging |
Het |
| Tsc22d4 |
A |
G |
5: 137,760,681 (GRCm39) |
Q34R |
possibly damaging |
Het |
| Uroc1 |
G |
T |
6: 90,315,546 (GRCm39) |
M142I |
possibly damaging |
Het |
| Uso1 |
T |
C |
5: 92,347,682 (GRCm39) |
S766P |
probably benign |
Het |
| Usp21 |
G |
A |
1: 171,111,319 (GRCm39) |
|
probably benign |
Het |
| Usp48 |
T |
A |
4: 137,360,437 (GRCm39) |
I658K |
possibly damaging |
Het |
| Vmn1r206 |
T |
C |
13: 22,804,583 (GRCm39) |
H208R |
probably damaging |
Het |
| Vmn2r109 |
C |
T |
17: 20,760,937 (GRCm39) |
A807T |
probably damaging |
Het |
| Zfp329 |
A |
T |
7: 12,544,379 (GRCm39) |
C382S |
probably damaging |
Het |
| Zfp341 |
A |
G |
2: 154,487,988 (GRCm39) |
E817G |
probably benign |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTTGAACACACAGGCAAATCCTC -3'
(R):5'- TCAAGGTGAGACCTCTGGTGAGATG -3'
Sequencing Primer
(F):5'- AGGCAAATCCTCATAAGAATGTAAC -3'
(R):5'- TTAAGCGCACAGTCCAACAG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation