Incidental Mutation 'R0571:Cadps2'
| ID |
46451 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
038762-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0571 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 23583411 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 389
(V389I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111018
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115356]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000125350]
[ENSMUST00000163871]
[ENSMUST00000166458]
[ENSMUST00000142913]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018122
AA Change: V389I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069074
AA Change: V389I
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115356
AA Change: V389I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111013
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115358
AA Change: V389I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115361
AA Change: V389I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000125350
AA Change: V34I
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
AA Change: V34I
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136279
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163871
AA Change: V389I
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: V389I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166458
AA Change: V360I
PolyPhen 2
Score 0.642 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: V360I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142913
AA Change: V360I
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: V360I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Meta Mutation Damage Score |
0.2405 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.7%
|
| Validation Efficiency |
100% (71/71) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd4 |
C |
T |
14: 54,500,706 (GRCm39) |
T165I |
possibly damaging |
Het |
| Acsl5 |
A |
G |
19: 55,277,343 (GRCm39) |
|
probably benign |
Het |
| Actl6b |
C |
A |
5: 137,565,046 (GRCm39) |
|
probably benign |
Het |
| Atg13 |
T |
C |
2: 91,509,063 (GRCm39) |
|
probably benign |
Het |
| Cabyr |
A |
G |
18: 12,883,909 (GRCm39) |
E132G |
probably damaging |
Het |
| Capn2 |
C |
T |
1: 182,298,325 (GRCm39) |
V647I |
probably benign |
Het |
| Card10 |
G |
T |
15: 78,671,601 (GRCm39) |
P621Q |
possibly damaging |
Het |
| Catsperb |
C |
G |
12: 101,569,033 (GRCm39) |
H902D |
possibly damaging |
Het |
| Cers3 |
A |
G |
7: 66,435,805 (GRCm39) |
M255V |
possibly damaging |
Het |
| Cfh |
T |
C |
1: 140,030,071 (GRCm39) |
|
probably null |
Het |
| Chd3 |
A |
C |
11: 69,252,495 (GRCm39) |
|
probably null |
Het |
| Chpf2 |
G |
T |
5: 24,795,425 (GRCm39) |
R316L |
probably damaging |
Het |
| Clca3a1 |
T |
A |
3: 144,713,550 (GRCm39) |
N694Y |
probably damaging |
Het |
| Cplane1 |
A |
G |
15: 8,289,277 (GRCm39) |
D2909G |
unknown |
Het |
| Ctbp2 |
G |
A |
7: 132,616,534 (GRCm39) |
L44F |
probably damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,381,102 (GRCm39) |
M1365V |
probably benign |
Het |
| D130052B06Rik |
G |
A |
11: 33,573,922 (GRCm39) |
R173H |
probably benign |
Het |
| Dchs1 |
A |
G |
7: 105,421,203 (GRCm39) |
F406L |
probably damaging |
Het |
| Ddx43 |
T |
A |
9: 78,321,145 (GRCm39) |
N384K |
possibly damaging |
Het |
| Drd5 |
G |
A |
5: 38,477,270 (GRCm39) |
V88M |
probably damaging |
Het |
| Eefsec |
A |
T |
6: 88,274,881 (GRCm39) |
F361Y |
probably benign |
Het |
| Epb41 |
T |
C |
4: 131,717,215 (GRCm39) |
D313G |
probably damaging |
Het |
| Etl4 |
T |
C |
2: 20,748,580 (GRCm39) |
M104T |
probably damaging |
Het |
| Fabp7 |
A |
T |
10: 57,661,637 (GRCm39) |
T37S |
probably benign |
Het |
| Fam186b |
T |
C |
15: 99,184,834 (GRCm39) |
T30A |
probably benign |
Het |
| Fam83d |
G |
A |
2: 158,627,611 (GRCm39) |
W433* |
probably null |
Het |
| Fmnl2 |
A |
T |
2: 52,944,503 (GRCm39) |
T161S |
probably benign |
Het |
| Ghsr |
C |
T |
3: 27,426,165 (GRCm39) |
R74C |
probably damaging |
Het |
| Gtf3c3 |
C |
T |
1: 54,456,937 (GRCm39) |
A488T |
probably damaging |
Het |
| Gtpbp4 |
A |
T |
13: 9,040,722 (GRCm39) |
|
probably benign |
Het |
| Hamp2 |
A |
G |
7: 30,623,511 (GRCm39) |
L17P |
possibly damaging |
Het |
| Heatr1 |
C |
A |
13: 12,445,121 (GRCm39) |
S1581R |
probably damaging |
Het |
| Hpf1 |
T |
C |
8: 61,353,147 (GRCm39) |
V176A |
probably benign |
Het |
| Hydin |
T |
A |
8: 111,240,735 (GRCm39) |
|
probably null |
Het |
| Ighg2c |
G |
A |
12: 113,252,382 (GRCm39) |
Q57* |
probably null |
Het |
| Itgb4 |
A |
G |
11: 115,870,594 (GRCm39) |
N141S |
possibly damaging |
Het |
| Kif13b |
G |
T |
14: 64,988,977 (GRCm39) |
R786L |
probably damaging |
Het |
| Lhx3 |
C |
A |
2: 26,091,136 (GRCm39) |
W391L |
probably damaging |
Het |
| Map1s |
T |
A |
8: 71,365,551 (GRCm39) |
V152D |
probably damaging |
Het |
| Map4 |
T |
C |
9: 109,865,834 (GRCm39) |
M608T |
probably benign |
Het |
| Mb21d2 |
G |
A |
16: 28,748,324 (GRCm39) |
A31V |
probably benign |
Het |
| Mfn1 |
T |
C |
3: 32,615,621 (GRCm39) |
I328T |
probably damaging |
Het |
| Mif-ps9 |
G |
A |
19: 56,743,675 (GRCm39) |
|
noncoding transcript |
Het |
| Myh4 |
A |
T |
11: 67,141,157 (GRCm39) |
I740F |
possibly damaging |
Het |
| Neo1 |
A |
G |
9: 58,893,069 (GRCm39) |
V191A |
probably benign |
Het |
| Nfatc4 |
T |
C |
14: 56,067,485 (GRCm39) |
V565A |
probably damaging |
Het |
| Nrxn2 |
G |
C |
19: 6,523,563 (GRCm39) |
E525D |
probably damaging |
Het |
| Or12k8 |
T |
C |
2: 36,975,346 (GRCm39) |
H138R |
probably benign |
Het |
| Pcdhb12 |
A |
T |
18: 37,570,261 (GRCm39) |
D469V |
probably damaging |
Het |
| Pcdhb6 |
G |
T |
18: 37,468,167 (GRCm39) |
V363L |
probably benign |
Het |
| Pkd1l2 |
T |
C |
8: 117,808,957 (GRCm39) |
T78A |
probably benign |
Het |
| Primpol |
T |
G |
8: 47,034,674 (GRCm39) |
D418A |
probably damaging |
Het |
| Rbm12b1 |
G |
A |
4: 12,146,248 (GRCm39) |
S740N |
probably benign |
Het |
| Rpe65 |
T |
C |
3: 159,305,986 (GRCm39) |
L15P |
probably damaging |
Het |
| Rxrb |
CGCGGCGGCGGCGGCGGCGGC |
CGCGGCGGCGGCGGCGGC |
17: 34,251,106 (GRCm39) |
|
probably benign |
Het |
| Sectm1a |
A |
G |
11: 120,959,928 (GRCm39) |
|
probably benign |
Het |
| Sft2d1 |
C |
A |
17: 8,545,782 (GRCm39) |
|
probably benign |
Het |
| Slc22a18 |
A |
G |
7: 143,045,598 (GRCm39) |
|
probably benign |
Het |
| Slu7 |
G |
A |
11: 43,332,405 (GRCm39) |
|
probably null |
Het |
| Smc4 |
T |
C |
3: 68,931,622 (GRCm39) |
V572A |
probably damaging |
Het |
| Spire2 |
T |
A |
8: 124,080,855 (GRCm39) |
I33N |
probably damaging |
Het |
| Tbck |
T |
A |
3: 132,458,403 (GRCm39) |
C678S |
probably damaging |
Het |
| Tnrc6b |
T |
C |
15: 80,797,539 (GRCm39) |
V1362A |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,570,326 (GRCm39) |
K25110E |
possibly damaging |
Het |
| Ugt2b35 |
A |
G |
5: 87,148,793 (GRCm39) |
S15G |
possibly damaging |
Het |
| Upf3a |
T |
A |
8: 13,842,184 (GRCm39) |
I200K |
probably damaging |
Het |
| Vill |
G |
C |
9: 118,899,701 (GRCm39) |
G295A |
possibly damaging |
Het |
| Vmn1r191 |
A |
T |
13: 22,363,217 (GRCm39) |
V179D |
probably damaging |
Het |
| Vmn2r74 |
T |
C |
7: 85,601,629 (GRCm39) |
T670A |
probably damaging |
Het |
| Zfp169 |
T |
C |
13: 48,643,166 (GRCm39) |
T654A |
possibly damaging |
Het |
| Zfp646 |
A |
G |
7: 127,481,138 (GRCm39) |
E1105G |
probably damaging |
Het |
| Zyg11b |
A |
T |
4: 108,117,239 (GRCm39) |
Y334N |
probably damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,297 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,646 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTGATCCCAGTAGATTTGAGACGAAG -3'
(R):5'- GAATGCCCACACTGCCATTCCT -3'
Sequencing Primer
(F):5'- TAGATTTGAGACGAAGGTAGCC -3'
(R):5'- cccagaagccatttactgcc -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation