Incidental Mutation 'R0571:Vmn2r74'
| ID |
46455 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| MMRRC Submission |
038762-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
R0571 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85601629 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 670
(T670A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166355
AA Change: T670A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: T670A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.7%
|
| Validation Efficiency |
100% (71/71) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd4 |
C |
T |
14: 54,500,706 (GRCm39) |
T165I |
possibly damaging |
Het |
| Acsl5 |
A |
G |
19: 55,277,343 (GRCm39) |
|
probably benign |
Het |
| Actl6b |
C |
A |
5: 137,565,046 (GRCm39) |
|
probably benign |
Het |
| Atg13 |
T |
C |
2: 91,509,063 (GRCm39) |
|
probably benign |
Het |
| Cabyr |
A |
G |
18: 12,883,909 (GRCm39) |
E132G |
probably damaging |
Het |
| Cadps2 |
C |
T |
6: 23,583,411 (GRCm39) |
V389I |
probably damaging |
Het |
| Capn2 |
C |
T |
1: 182,298,325 (GRCm39) |
V647I |
probably benign |
Het |
| Card10 |
G |
T |
15: 78,671,601 (GRCm39) |
P621Q |
possibly damaging |
Het |
| Catsperb |
C |
G |
12: 101,569,033 (GRCm39) |
H902D |
possibly damaging |
Het |
| Cers3 |
A |
G |
7: 66,435,805 (GRCm39) |
M255V |
possibly damaging |
Het |
| Cfh |
T |
C |
1: 140,030,071 (GRCm39) |
|
probably null |
Het |
| Chd3 |
A |
C |
11: 69,252,495 (GRCm39) |
|
probably null |
Het |
| Chpf2 |
G |
T |
5: 24,795,425 (GRCm39) |
R316L |
probably damaging |
Het |
| Clca3a1 |
T |
A |
3: 144,713,550 (GRCm39) |
N694Y |
probably damaging |
Het |
| Cplane1 |
A |
G |
15: 8,289,277 (GRCm39) |
D2909G |
unknown |
Het |
| Ctbp2 |
G |
A |
7: 132,616,534 (GRCm39) |
L44F |
probably damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,381,102 (GRCm39) |
M1365V |
probably benign |
Het |
| D130052B06Rik |
G |
A |
11: 33,573,922 (GRCm39) |
R173H |
probably benign |
Het |
| Dchs1 |
A |
G |
7: 105,421,203 (GRCm39) |
F406L |
probably damaging |
Het |
| Ddx43 |
T |
A |
9: 78,321,145 (GRCm39) |
N384K |
possibly damaging |
Het |
| Drd5 |
G |
A |
5: 38,477,270 (GRCm39) |
V88M |
probably damaging |
Het |
| Eefsec |
A |
T |
6: 88,274,881 (GRCm39) |
F361Y |
probably benign |
Het |
| Epb41 |
T |
C |
4: 131,717,215 (GRCm39) |
D313G |
probably damaging |
Het |
| Etl4 |
T |
C |
2: 20,748,580 (GRCm39) |
M104T |
probably damaging |
Het |
| Fabp7 |
A |
T |
10: 57,661,637 (GRCm39) |
T37S |
probably benign |
Het |
| Fam186b |
T |
C |
15: 99,184,834 (GRCm39) |
T30A |
probably benign |
Het |
| Fam83d |
G |
A |
2: 158,627,611 (GRCm39) |
W433* |
probably null |
Het |
| Fmnl2 |
A |
T |
2: 52,944,503 (GRCm39) |
T161S |
probably benign |
Het |
| Ghsr |
C |
T |
3: 27,426,165 (GRCm39) |
R74C |
probably damaging |
Het |
| Gtf3c3 |
C |
T |
1: 54,456,937 (GRCm39) |
A488T |
probably damaging |
Het |
| Gtpbp4 |
A |
T |
13: 9,040,722 (GRCm39) |
|
probably benign |
Het |
| Hamp2 |
A |
G |
7: 30,623,511 (GRCm39) |
L17P |
possibly damaging |
Het |
| Heatr1 |
C |
A |
13: 12,445,121 (GRCm39) |
S1581R |
probably damaging |
Het |
| Hpf1 |
T |
C |
8: 61,353,147 (GRCm39) |
V176A |
probably benign |
Het |
| Hydin |
T |
A |
8: 111,240,735 (GRCm39) |
|
probably null |
Het |
| Ighg2c |
G |
A |
12: 113,252,382 (GRCm39) |
Q57* |
probably null |
Het |
| Itgb4 |
A |
G |
11: 115,870,594 (GRCm39) |
N141S |
possibly damaging |
Het |
| Kif13b |
G |
T |
14: 64,988,977 (GRCm39) |
R786L |
probably damaging |
Het |
| Lhx3 |
C |
A |
2: 26,091,136 (GRCm39) |
W391L |
probably damaging |
Het |
| Map1s |
T |
A |
8: 71,365,551 (GRCm39) |
V152D |
probably damaging |
Het |
| Map4 |
T |
C |
9: 109,865,834 (GRCm39) |
M608T |
probably benign |
Het |
| Mb21d2 |
G |
A |
16: 28,748,324 (GRCm39) |
A31V |
probably benign |
Het |
| Mfn1 |
T |
C |
3: 32,615,621 (GRCm39) |
I328T |
probably damaging |
Het |
| Mif-ps9 |
G |
A |
19: 56,743,675 (GRCm39) |
|
noncoding transcript |
Het |
| Myh4 |
A |
T |
11: 67,141,157 (GRCm39) |
I740F |
possibly damaging |
Het |
| Neo1 |
A |
G |
9: 58,893,069 (GRCm39) |
V191A |
probably benign |
Het |
| Nfatc4 |
T |
C |
14: 56,067,485 (GRCm39) |
V565A |
probably damaging |
Het |
| Nrxn2 |
G |
C |
19: 6,523,563 (GRCm39) |
E525D |
probably damaging |
Het |
| Or12k8 |
T |
C |
2: 36,975,346 (GRCm39) |
H138R |
probably benign |
Het |
| Pcdhb12 |
A |
T |
18: 37,570,261 (GRCm39) |
D469V |
probably damaging |
Het |
| Pcdhb6 |
G |
T |
18: 37,468,167 (GRCm39) |
V363L |
probably benign |
Het |
| Pkd1l2 |
T |
C |
8: 117,808,957 (GRCm39) |
T78A |
probably benign |
Het |
| Primpol |
T |
G |
8: 47,034,674 (GRCm39) |
D418A |
probably damaging |
Het |
| Rbm12b1 |
G |
A |
4: 12,146,248 (GRCm39) |
S740N |
probably benign |
Het |
| Rpe65 |
T |
C |
3: 159,305,986 (GRCm39) |
L15P |
probably damaging |
Het |
| Rxrb |
CGCGGCGGCGGCGGCGGCGGC |
CGCGGCGGCGGCGGCGGC |
17: 34,251,106 (GRCm39) |
|
probably benign |
Het |
| Sectm1a |
A |
G |
11: 120,959,928 (GRCm39) |
|
probably benign |
Het |
| Sft2d1 |
C |
A |
17: 8,545,782 (GRCm39) |
|
probably benign |
Het |
| Slc22a18 |
A |
G |
7: 143,045,598 (GRCm39) |
|
probably benign |
Het |
| Slu7 |
G |
A |
11: 43,332,405 (GRCm39) |
|
probably null |
Het |
| Smc4 |
T |
C |
3: 68,931,622 (GRCm39) |
V572A |
probably damaging |
Het |
| Spire2 |
T |
A |
8: 124,080,855 (GRCm39) |
I33N |
probably damaging |
Het |
| Tbck |
T |
A |
3: 132,458,403 (GRCm39) |
C678S |
probably damaging |
Het |
| Tnrc6b |
T |
C |
15: 80,797,539 (GRCm39) |
V1362A |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,570,326 (GRCm39) |
K25110E |
possibly damaging |
Het |
| Ugt2b35 |
A |
G |
5: 87,148,793 (GRCm39) |
S15G |
possibly damaging |
Het |
| Upf3a |
T |
A |
8: 13,842,184 (GRCm39) |
I200K |
probably damaging |
Het |
| Vill |
G |
C |
9: 118,899,701 (GRCm39) |
G295A |
possibly damaging |
Het |
| Vmn1r191 |
A |
T |
13: 22,363,217 (GRCm39) |
V179D |
probably damaging |
Het |
| Zfp169 |
T |
C |
13: 48,643,166 (GRCm39) |
T654A |
possibly damaging |
Het |
| Zfp646 |
A |
G |
7: 127,481,138 (GRCm39) |
E1105G |
probably damaging |
Het |
| Zyg11b |
A |
T |
4: 108,117,239 (GRCm39) |
Y334N |
probably damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGAGGAGAAGTTCCCAGCCAAATTC -3'
(R):5'- GCCAATGAAGACCATACAGTCTGCC -3'
Sequencing Primer
(F):5'- GTTCCCAGCCAAATTCCACAAAG -3'
(R):5'- AGACCCTTTGGGTAAAGCTC -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation