Incidental Mutation 'IGL00401:Lyz2'
ID4659
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lyz2
Ensembl Gene ENSMUSG00000069516
Gene Namelysozyme 2
SynonymsLyzs, Lys, Lzm-s1, Lzp, Lysm, Lzm
Accession Numbers

NCBI RefSeq: NM_017327; MGI:96897

Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL00401
Quality Score
Status
Chromosome10
Chromosomal Location117277331-117282321 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 117282185 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 20 (V20I)
Ref Sequence ENSEMBL: ENSMUSP00000089801 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092163]
PDB Structure
Solution structure of mouse lysozyme M [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000092163
AA Change: V20I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000089801
Gene: ENSMUSG00000069516
AA Change: V20I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LYZ1 19 147 1.77e-98 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages. [provided by MGI curators]
Allele List at MGI

All alleles(5) : Targeted(5)

Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alk T A 17: 71,895,748 D1164V probably damaging Het
Baiap3 T G 17: 25,244,328 L964F probably damaging Het
Cacna2d2 T A 9: 107,514,873 V471E probably damaging Het
Carmil3 C T 14: 55,498,298 T569M probably damaging Het
Dapk2 G T 9: 66,268,778 probably benign Het
Eps15l1 A T 8: 72,384,838 Y291* probably null Het
Fancd2 T C 6: 113,564,396 probably null Het
Fmnl2 T G 2: 53,114,917 D674E probably damaging Het
Foxq1 A T 13: 31,559,277 I121F probably damaging Het
Galnt13 C T 2: 54,516,535 probably benign Het
Git1 T C 11: 77,498,956 probably benign Het
Gm10220 A T 5: 26,118,611 F146Y possibly damaging Het
Gm7353 A G 7: 3,110,630 noncoding transcript Het
Hspa9 G A 18: 34,938,580 probably benign Het
Kptn A G 7: 16,120,125 D56G possibly damaging Het
Krtap4-13 A T 11: 99,809,717 C39S unknown Het
Lgsn A G 1: 31,203,566 K243R possibly damaging Het
Mettl3 T A 14: 52,296,967 probably benign Het
Myh6 T A 14: 54,953,417 M934L probably benign Het
Nmnat2 A G 1: 153,094,117 probably null Het
Pias2 T A 18: 77,133,211 C381S probably damaging Het
Psme4 T C 11: 30,821,079 probably benign Het
Smc4 T A 3: 69,030,379 D887E probably damaging Het
Sorcs2 C A 5: 36,037,401 probably null Het
Tet2 T C 3: 133,466,882 E1873G possibly damaging Het
Txlng T A X: 162,782,309 K341* probably null Het
Ugt2b37 T A 5: 87,242,481 T369S possibly damaging Het
Usp46 C A 5: 74,003,171 V302F probably damaging Het
Zfp292 A G 4: 34,808,683 C1454R probably benign Het
Other mutations in Lyz2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02649:Lyz2 APN 10 117282185 missense probably benign
R0200:Lyz2 UTSW 10 117280773 missense possibly damaging 0.59
R2520:Lyz2 UTSW 10 117278653 missense probably damaging 0.96
R4898:Lyz2 UTSW 10 117278709 missense possibly damaging 0.84
R5730:Lyz2 UTSW 10 117278682 missense probably damaging 1.00
R6960:Lyz2 UTSW 10 117278702 missense possibly damaging 0.88
R7493:Lyz2 UTSW 10 117282239 missense probably damaging 1.00
Posted On2012-04-20