Incidental Mutation 'R0574:Olfr98'
Institutional Source Beutler Lab
Gene Symbol Olfr98
Ensembl Gene ENSMUSG00000063660
Gene Nameolfactory receptor 98
SynonymsGA_x6K02T2PSCP-1703582-1702653, MOR156-4
MMRRC Submission 038764-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R0574 (G1)
Quality Score225
Status Validated
Chromosomal Location37262711-37263749 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 37262881 bp
Amino Acid Change Serine to Tyrosine at position 261 (S261Y)
Ref Sequence ENSEMBL: ENSMUSP00000094936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080759]
Predicted Effect probably damaging
Transcript: ENSMUST00000080759
AA Change: S261Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: S261Y

Pfam:7tm_4 28 305 9.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.9e-5 PFAM
Pfam:7tm_1 38 287 2.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174168
Meta Mutation Damage Score 0.3161 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.4%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700099C18Rik T C 17: 94,761,491 noncoding transcript Het
Abca14 A G 7: 120,224,497 I416V probably damaging Het
Actrt3 T C 3: 30,599,680 E57G probably benign Het
Adamts5 A G 16: 85,899,484 S262P probably damaging Het
Aldh1a2 T C 9: 71,281,708 probably null Het
Arhgap29 A G 3: 122,007,625 I670V probably benign Het
Bptf T C 11: 107,076,527 D1009G probably damaging Het
Ddr2 G T 1: 169,981,963 probably benign Het
Ift140 T A 17: 25,051,760 probably null Het
Itga1 A C 13: 114,966,561 S1111R probably damaging Het
Klk1b27 T A 7: 44,056,101 L199Q probably damaging Het
Lhx3 T C 2: 26,201,311 S329G probably benign Het
Man2b1 T G 8: 85,096,776 M913R probably benign Het
Mmp15 G A 8: 95,365,401 A80T possibly damaging Het
Mpo A T 11: 87,796,076 Y177F probably damaging Het
Mynn T C 3: 30,616,739 S587P probably benign Het
Nfkbib C T 7: 28,761,788 V145I probably benign Het
Olfr421-ps1 T C 1: 174,151,566 F17L probably benign Het
Olfr727 A T 14: 50,126,682 Y35F probably damaging Het
Pole2 G A 12: 69,211,457 probably benign Het
Ppargc1b C T 18: 61,302,739 G906D probably benign Het
Prl8a2 T A 13: 27,348,900 C32S probably damaging Het
Rhno1 A T 6: 128,358,150 probably null Het
Rprd2 T C 3: 95,774,357 E408G possibly damaging Het
Ryr2 T A 13: 11,731,669 H1999L probably benign Het
Shprh T C 10: 11,163,077 probably benign Het
Snx3 T A 10: 42,502,387 N19K probably benign Het
Stx8 C T 11: 67,973,252 T46M probably damaging Het
Tbc1d17 A G 7: 44,843,123 probably benign Het
Ush1c A G 7: 46,196,804 S855P possibly damaging Het
Usp54 A G 14: 20,556,254 V1338A probably benign Het
Vmn1r214 A G 13: 23,034,493 I52M probably benign Het
Other mutations in Olfr98
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02402:Olfr98 APN 17 37263220 missense possibly damaging 0.46
PIT4495001:Olfr98 UTSW 17 37262830 missense possibly damaging 0.88
R1490:Olfr98 UTSW 17 37262842 missense probably benign 0.00
R1633:Olfr98 UTSW 17 37263662 start codon destroyed probably benign 0.02
R2105:Olfr98 UTSW 17 37263073 missense probably benign 0.26
R4996:Olfr98 UTSW 17 37262867 missense probably benign 0.02
R5114:Olfr98 UTSW 17 37262839 missense probably damaging 1.00
R5225:Olfr98 UTSW 17 37263028 missense probably benign 0.30
R5338:Olfr98 UTSW 17 37263641 missense probably benign 0.00
R5995:Olfr98 UTSW 17 37263648 missense probably benign 0.01
R6190:Olfr98 UTSW 17 37262744 missense probably benign 0.00
R7006:Olfr98 UTSW 17 37262734 makesense probably null
R7246:Olfr98 UTSW 17 37263014 missense probably benign 0.00
R7261:Olfr98 UTSW 17 37263185 missense probably benign
R7611:Olfr98 UTSW 17 37262854 missense probably benign 0.02
R7642:Olfr98 UTSW 17 37263073 missense probably benign 0.26
Predicted Primers PCR Primer

Sequencing Primer
Posted On2013-06-11