Incidental Mutation 'R0062:Scara3'
ID 46648
Institutional Source Beutler Lab
Gene Symbol Scara3
Ensembl Gene ENSMUSG00000034463
Gene Name scavenger receptor class A, member 3
Synonyms C130058N24Rik
MMRRC Submission 038354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R0062 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 66156843-66191384 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66168417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 400 (N400S)
Ref Sequence ENSEMBL: ENSMUSP00000046525 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042046]
AlphaFold Q8C850
Predicted Effect probably damaging
Transcript: ENSMUST00000042046
AA Change: N400S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000046525
Gene: ENSMUSG00000034463
AA Change: N400S

DomainStartEndE-ValueType
transmembrane domain 55 77 N/A INTRINSIC
coiled coil region 117 155 N/A INTRINSIC
low complexity region 300 311 N/A INTRINSIC
Pfam:Collagen 455 513 3.1e-12 PFAM
Pfam:Collagen 499 558 4.2e-11 PFAM
Pfam:Collagen 544 606 2.9e-12 PFAM
Meta Mutation Damage Score 0.5757 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513I03Rik G T 10: 120,614,511 (GRCm39) probably benign Het
4930407I10Rik T A 15: 81,947,267 (GRCm39) I388K probably benign Het
4930407I10Rik T A 15: 81,950,504 (GRCm39) V1467D probably damaging Het
Abi2 T A 1: 60,492,884 (GRCm39) N182K probably benign Het
Adam25 A T 8: 41,207,829 (GRCm39) H365L probably damaging Het
Ankfy1 T A 11: 72,603,030 (GRCm39) Y20N probably damaging Het
Aqp11 C T 7: 97,387,068 (GRCm39) V43M probably benign Het
Arhgef10l A T 4: 140,279,843 (GRCm39) L503Q probably damaging Het
Arhgef28 A T 13: 98,093,150 (GRCm39) I977N possibly damaging Het
Cacna1b A G 2: 24,648,343 (GRCm39) Y161H probably damaging Het
Cacna1c T C 6: 118,579,198 (GRCm39) D1480G probably damaging Het
Clk3 A G 9: 57,659,449 (GRCm39) M533T probably damaging Het
Cnbd1 A G 4: 18,860,504 (GRCm39) I414T possibly damaging Het
Commd3 A T 2: 18,679,514 (GRCm39) probably null Het
Crybg1 G T 10: 43,873,902 (GRCm39) Q1069K probably damaging Het
Dnah8 T A 17: 30,984,685 (GRCm39) F3128I probably damaging Het
Dnmt3b C T 2: 153,514,192 (GRCm39) P382S probably benign Het
Dock1 A G 7: 134,379,224 (GRCm39) probably null Het
Dpysl3 C T 18: 43,466,941 (GRCm39) probably null Het
Ebf2 T A 14: 67,475,989 (GRCm39) probably benign Het
F830045P16Rik T C 2: 129,305,624 (GRCm39) E250G possibly damaging Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Fetub T C 16: 22,747,836 (GRCm39) probably benign Het
Fmn2 A T 1: 174,436,015 (GRCm39) probably benign Het
Fryl T C 5: 73,179,621 (GRCm39) I2929V probably benign Het
Gm11232 T A 4: 71,675,112 (GRCm39) Q130L possibly damaging Het
Gm9637 G T 14: 19,402,570 (GRCm38) noncoding transcript Het
Gna15 A G 10: 81,348,239 (GRCm39) probably null Het
Gtf3c5 T C 2: 28,462,198 (GRCm39) probably benign Het
Irs2 G A 8: 11,055,723 (GRCm39) T903I possibly damaging Het
Itga2 G A 13: 115,007,032 (GRCm39) S432L possibly damaging Het
Izumo1 A G 7: 45,276,621 (GRCm39) T395A probably benign Het
Kcnd2 G A 6: 21,727,225 (GRCm39) V593M possibly damaging Het
Kprp T C 3: 92,731,989 (GRCm39) S354G probably damaging Het
Krt72 T C 15: 101,694,443 (GRCm39) K151E probably damaging Het
Letm2 A T 8: 26,077,464 (GRCm39) probably benign Het
Lipe A G 7: 25,097,874 (GRCm39) V23A possibly damaging Het
Mcc C G 18: 44,652,583 (GRCm39) probably benign Het
Mef2c A G 13: 83,800,992 (GRCm39) N231D possibly damaging Het
Mtdh T A 15: 34,134,426 (GRCm39) probably benign Het
Mthfd1 G A 12: 76,344,363 (GRCm39) probably benign Het
Nbeal1 C A 1: 60,286,876 (GRCm39) N899K probably benign Het
Noc3l T C 19: 38,803,253 (GRCm39) S129G probably benign Het
Odad2 T A 18: 7,129,593 (GRCm39) probably benign Het
Or10ak14 T C 4: 118,611,100 (GRCm39) I212V probably benign Het
Or2aj6 T C 16: 19,443,167 (GRCm39) M228V probably benign Het
Or4c118 T C 2: 88,974,966 (GRCm39) I134V possibly damaging Het
Or8b1c T A 9: 38,384,554 (GRCm39) D170E probably benign Het
Pik3r6 T A 11: 68,419,635 (GRCm39) Y149N probably damaging Het
Pja2 C A 17: 64,615,966 (GRCm39) V310L probably damaging Het
Plcd3 G A 11: 102,965,720 (GRCm39) A504V probably benign Het
Rint1 G A 5: 23,992,826 (GRCm39) probably benign Het
Ripor3 A G 2: 167,826,358 (GRCm39) probably benign Het
Rpa2 C A 4: 132,505,125 (GRCm39) N251K probably damaging Het
Rttn T C 18: 89,029,090 (GRCm39) probably null Het
Ryr2 C T 13: 11,884,002 (GRCm39) probably null Het
Slc7a6 G T 8: 106,916,263 (GRCm39) V180L possibly damaging Het
Slc7a6 T A 8: 106,916,264 (GRCm39) V180E probably damaging Het
Slc8b1 T A 5: 120,659,928 (GRCm39) probably null Het
Slco1a4 G A 6: 141,765,205 (GRCm39) Q346* probably null Het
Stk32b A G 5: 37,618,792 (GRCm39) S229P probably damaging Het
Syde2 A G 3: 145,704,508 (GRCm39) R487G probably benign Het
Tbc1d2b T C 9: 90,104,355 (GRCm39) probably benign Het
Ticrr T C 7: 79,317,654 (GRCm39) V396A probably benign Het
Trrap T C 5: 144,719,003 (GRCm39) probably benign Het
Vmn1r124 A T 7: 20,993,743 (GRCm39) I267K probably benign Het
Vps13a A T 19: 16,646,054 (GRCm39) H1994Q probably damaging Het
Wdr36 T G 18: 32,997,802 (GRCm39) V820G possibly damaging Het
Wdr83 G A 8: 85,806,456 (GRCm39) T114I possibly damaging Het
Zc3h7a T C 16: 10,957,011 (GRCm39) N866S probably damaging Het
Zfc3h1 A G 10: 115,252,658 (GRCm39) K1324E probably benign Het
Other mutations in Scara3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Scara3 APN 14 66,170,570 (GRCm39) missense probably benign 0.01
IGL00646:Scara3 APN 14 66,158,605 (GRCm39) nonsense probably null
IGL00718:Scara3 APN 14 66,168,876 (GRCm39) missense possibly damaging 0.67
IGL01948:Scara3 APN 14 66,168,261 (GRCm39) missense probably damaging 0.99
IGL01979:Scara3 APN 14 66,168,412 (GRCm39) missense probably benign 0.01
IGL02399:Scara3 APN 14 66,170,559 (GRCm39) nonsense probably null
IGL02939:Scara3 APN 14 66,169,105 (GRCm39) missense probably benign 0.00
IGL02945:Scara3 APN 14 66,168,660 (GRCm39) missense probably damaging 1.00
IGL03075:Scara3 APN 14 66,168,603 (GRCm39) missense probably damaging 1.00
IGL03100:Scara3 APN 14 66,168,722 (GRCm39) missense probably damaging 1.00
IGL03156:Scara3 APN 14 66,168,603 (GRCm39) missense probably damaging 1.00
IGL03179:Scara3 APN 14 66,168,603 (GRCm39) missense probably damaging 1.00
condor UTSW 14 66,168,651 (GRCm39) missense probably damaging 1.00
PIT4362001:Scara3 UTSW 14 66,173,851 (GRCm39) missense probably benign
R0062:Scara3 UTSW 14 66,168,417 (GRCm39) missense probably damaging 1.00
R0124:Scara3 UTSW 14 66,168,670 (GRCm39) missense probably benign 0.01
R0349:Scara3 UTSW 14 66,169,230 (GRCm39) missense probably damaging 0.98
R1584:Scara3 UTSW 14 66,158,553 (GRCm39) missense probably damaging 1.00
R4785:Scara3 UTSW 14 66,190,950 (GRCm39) start codon destroyed probably null 0.06
R5336:Scara3 UTSW 14 66,168,487 (GRCm39) missense probably damaging 1.00
R6307:Scara3 UTSW 14 66,175,710 (GRCm39) missense probably benign 0.24
R6420:Scara3 UTSW 14 66,175,701 (GRCm39) missense possibly damaging 0.92
R6610:Scara3 UTSW 14 66,168,670 (GRCm39) missense probably damaging 0.97
R7159:Scara3 UTSW 14 66,158,229 (GRCm39) missense probably damaging 0.98
R7208:Scara3 UTSW 14 66,168,715 (GRCm39) missense possibly damaging 0.62
R7246:Scara3 UTSW 14 66,169,093 (GRCm39) missense probably damaging 0.97
R7315:Scara3 UTSW 14 66,168,889 (GRCm39) missense probably damaging 1.00
R7324:Scara3 UTSW 14 66,168,865 (GRCm39) missense probably benign 0.03
R7497:Scara3 UTSW 14 66,168,651 (GRCm39) missense probably damaging 1.00
R7504:Scara3 UTSW 14 66,168,780 (GRCm39) missense possibly damaging 0.82
R7554:Scara3 UTSW 14 66,158,299 (GRCm39) missense possibly damaging 0.69
R8143:Scara3 UTSW 14 66,169,269 (GRCm39) missense probably damaging 0.96
R9043:Scara3 UTSW 14 66,169,070 (GRCm39) missense probably damaging 1.00
R9226:Scara3 UTSW 14 66,169,233 (GRCm39) missense possibly damaging 0.69
R9363:Scara3 UTSW 14 66,168,720 (GRCm39) missense probably benign 0.01
R9730:Scara3 UTSW 14 66,168,261 (GRCm39) missense probably damaging 0.99
YA93:Scara3 UTSW 14 66,168,398 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGCCCTGGGAATTGGTTAAAGGATG -3'
(R):5'- TCGAGTCTCTGGAAGGACGTATGG -3'

Sequencing Primer
(F):5'- TCTATCTAATGGACACACTCTTGG -3'
(R):5'- CTGGAAGGACGTATGGCTTCTC -3'
Posted On 2013-06-11