Incidental Mutation 'R0472:Or9r3'
ID 46833
Institutional Source Beutler Lab
Gene Symbol Or9r3
Ensembl Gene ENSMUSG00000096747
Gene Name olfactory receptor family 9 subfamily R member 3
Synonyms Olfr823, MOR210-4, GA_x6K02T2PULF-11783479-11782532
MMRRC Submission 038672-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R0472 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129947710-129948657 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 129948449 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 70 (S70F)
Ref Sequence ENSEMBL: ENSMUSP00000150794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081469] [ENSMUST00000213145]
AlphaFold Q7TRH2
Predicted Effect probably damaging
Transcript: ENSMUST00000081469
AA Change: S70F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000080189
Gene: ENSMUSG00000096747
AA Change: S70F

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.6e-54 PFAM
Pfam:7tm_1 44 293 7.6e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213145
AA Change: S70F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700128F08Rik A G 9: 8,222,123 (GRCm39) noncoding transcript Het
AI182371 T C 2: 34,975,218 (GRCm39) N337S probably benign Het
Aldh3b1 C T 19: 3,964,024 (GRCm39) R426H probably damaging Het
Arap2 A G 5: 62,864,002 (GRCm39) F541L probably damaging Het
Asap2 G T 12: 21,263,186 (GRCm39) R267L possibly damaging Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Bmp8b T A 4: 123,015,692 (GRCm39) D226E probably benign Het
C1ra T A 6: 124,494,403 (GRCm39) D283E possibly damaging Het
Cacul1 G T 19: 60,531,464 (GRCm39) H268Q probably damaging Het
Cd9 T C 6: 125,449,396 (GRCm39) N49D probably benign Het
Cdc42bpa A G 1: 179,867,744 (GRCm39) H193R probably damaging Het
Cep290 G A 10: 100,387,317 (GRCm39) G1935E probably benign Het
Cep350 A T 1: 155,790,469 (GRCm39) I1362N probably damaging Het
Chchd7 A T 4: 3,943,416 (GRCm39) N61I possibly damaging Het
Clca3a1 A T 3: 144,733,106 (GRCm39) L134Q probably damaging Het
Clec2j T C 6: 128,633,565 (GRCm39) noncoding transcript Het
Clvs1 G A 4: 9,281,801 (GRCm39) A82T probably damaging Het
Csn1s1 A T 5: 87,825,486 (GRCm39) Y231F possibly damaging Het
Cyp2c55 A T 19: 39,019,823 (GRCm39) T254S probably benign Het
Decr1 A G 4: 15,919,849 (GRCm39) S290P probably damaging Het
Dnai2 T A 11: 114,636,015 (GRCm39) probably benign Het
Dock4 C A 12: 40,888,437 (GRCm39) probably benign Het
Dst T C 1: 34,306,041 (GRCm39) probably null Het
Elmo2 A G 2: 165,140,250 (GRCm39) I315T probably damaging Het
Fcho2 A G 13: 98,884,775 (GRCm39) F431L probably benign Het
Fez2 A G 17: 78,692,261 (GRCm39) probably benign Het
Gas2l3 C T 10: 89,262,339 (GRCm39) A128T probably damaging Het
Hpse2 T C 19: 43,001,602 (GRCm39) I222M probably damaging Het
Katnip A G 7: 125,472,139 (GRCm39) N1548S probably damaging Het
Kcna2 A G 3: 107,012,832 (GRCm39) D471G probably benign Het
Kcnj13 T A 1: 87,314,568 (GRCm39) Y218F probably benign Het
Kif1a T C 1: 92,946,719 (GRCm39) H1763R probably damaging Het
Krt1c C T 15: 101,721,688 (GRCm39) R451H probably damaging Het
Lama2 A G 10: 26,866,863 (GRCm39) V2877A probably damaging Het
Lrrc2 A T 9: 110,791,685 (GRCm39) M80L probably benign Het
Naip6 A G 13: 100,438,768 (GRCm39) V343A probably benign Het
Nedd4l T C 18: 65,341,532 (GRCm39) Y753H probably damaging Het
Nif3l1 A C 1: 58,486,987 (GRCm39) S58R probably damaging Het
Or51h7 A T 7: 102,591,258 (GRCm39) C175* probably null Het
Or5w20 T A 2: 87,726,837 (GRCm39) V98E possibly damaging Het
Osbpl11 C A 16: 33,054,814 (GRCm39) Y632* probably null Het
Pask A T 1: 93,248,639 (GRCm39) D920E probably benign Het
Pclo T C 5: 14,731,608 (GRCm39) V3370A unknown Het
Ptpn21 G A 12: 98,670,499 (GRCm39) probably benign Het
Rph3al T C 11: 75,799,795 (GRCm39) I55V probably benign Het
Rsad2 T G 12: 26,504,167 (GRCm39) I121L possibly damaging Het
Sergef T G 7: 46,283,170 (GRCm39) probably benign Het
Sp110 C T 1: 85,516,841 (GRCm39) E219K possibly damaging Het
Tas2r104 T C 6: 131,662,434 (GRCm39) I92V probably benign Het
Tasor2 A G 13: 3,638,364 (GRCm39) S456P possibly damaging Het
Tbc1d23 T A 16: 56,993,469 (GRCm39) I566F possibly damaging Het
Tbc1d9b A G 11: 50,059,055 (GRCm39) probably null Het
Tie1 T A 4: 118,333,344 (GRCm39) I841L possibly damaging Het
Tpo A G 12: 30,150,485 (GRCm39) V465A probably benign Het
Ttll3 A T 6: 113,386,300 (GRCm39) Q711L probably damaging Het
Ttn C T 2: 76,783,385 (GRCm39) R869H probably benign Het
Uggt2 A G 14: 119,332,748 (GRCm39) V62A probably damaging Het
Usp34 T C 11: 23,334,509 (GRCm39) probably benign Het
Vmn1r17 C A 6: 57,338,304 (GRCm39) M20I probably benign Het
Vmn1r71 G C 7: 10,482,019 (GRCm39) S223C possibly damaging Het
Vmn2r120 C T 17: 57,831,518 (GRCm39) V424I probably benign Het
Vps13b T C 15: 35,417,779 (GRCm39) probably null Het
Wdfy3 C A 5: 102,105,309 (GRCm39) A173S probably benign Het
Wdr59 T C 8: 112,213,629 (GRCm39) probably null Het
Ythdc2 A T 18: 44,997,424 (GRCm39) M994L probably benign Het
Zfp808 T A 13: 62,320,120 (GRCm39) F450I probably damaging Het
Other mutations in Or9r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02728:Or9r3 APN 10 129,948,487 (GRCm39) missense probably damaging 1.00
R0609:Or9r3 UTSW 10 129,948,449 (GRCm39) missense probably damaging 1.00
R1619:Or9r3 UTSW 10 129,948,548 (GRCm39) missense possibly damaging 0.89
R1641:Or9r3 UTSW 10 129,947,872 (GRCm39) nonsense probably null
R2057:Or9r3 UTSW 10 129,947,859 (GRCm39) missense probably benign 0.00
R6049:Or9r3 UTSW 10 129,948,481 (GRCm39) missense probably benign 0.01
R6638:Or9r3 UTSW 10 129,947,739 (GRCm39) missense probably benign 0.04
R7291:Or9r3 UTSW 10 129,948,093 (GRCm39) missense probably benign 0.07
R7602:Or9r3 UTSW 10 129,948,179 (GRCm39) missense probably benign 0.00
R8167:Or9r3 UTSW 10 129,948,350 (GRCm39) missense probably damaging 1.00
R8815:Or9r3 UTSW 10 129,947,808 (GRCm39) missense probably damaging 0.98
R9169:Or9r3 UTSW 10 129,947,723 (GRCm39) missense probably benign 0.04
R9647:Or9r3 UTSW 10 129,948,029 (GRCm39) missense probably damaging 0.99
X0022:Or9r3 UTSW 10 129,948,576 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGAAGCGGTCATAAGCCATCACAG -3'
(R):5'- AGGTGTCTACCACTCACATGCCTC -3'

Sequencing Primer
(F):5'- GCCAGAAAGAAACCTTCTGTTC -3'
(R):5'- AGTTGACAACACTGCTCTGTG -3'
Posted On 2013-06-11