Incidental Mutation 'R0511:Chd6'
| ID |
46875 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Chd6
|
| Ensembl Gene |
ENSMUSG00000057133 |
| Gene Name |
chromodomain helicase DNA binding protein 6 |
| Synonyms |
6330406J24Rik, 5430439G14Rik |
| MMRRC Submission |
038705-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.755)
|
| Stock # |
R0511 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
160946978-161109075 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 160992191 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 917
(F917S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042291
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039782]
[ENSMUST00000134178]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000039782
AA Change: F917S
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000042291
Gene: ENSMUSG00000057133
AA Change: F917S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
214 |
229 |
N/A |
INTRINSIC |
|
CHROMO
|
289 |
355 |
1.35e-4 |
SMART |
|
CHROMO
|
372 |
430 |
3.48e-7 |
SMART |
|
DEXDc
|
456 |
658 |
1.73e-39 |
SMART |
|
HELICc
|
812 |
896 |
3.84e-23 |
SMART |
|
low complexity region
|
1080 |
1094 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1108 |
1153 |
4e-23 |
BLAST |
|
SANT
|
1445 |
1504 |
1.51e0 |
SMART |
|
low complexity region
|
1866 |
1875 |
N/A |
INTRINSIC |
|
low complexity region
|
2048 |
2057 |
N/A |
INTRINSIC |
|
low complexity region
|
2130 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2277 |
2290 |
N/A |
INTRINSIC |
|
low complexity region
|
2333 |
2349 |
N/A |
INTRINSIC |
|
low complexity region
|
2437 |
2446 |
N/A |
INTRINSIC |
|
low complexity region
|
2539 |
2563 |
N/A |
INTRINSIC |
|
low complexity region
|
2652 |
2659 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104607
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000134178
AA Change: F916S
PolyPhen 2
Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000123240
Gene: ENSMUSG00000057133
AA Change: F916S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
228 |
N/A |
INTRINSIC |
|
CHROMO
|
288 |
354 |
1.35e-4 |
SMART |
|
CHROMO
|
371 |
429 |
3.48e-7 |
SMART |
|
DEXDc
|
455 |
657 |
1.73e-39 |
SMART |
|
HELICc
|
811 |
895 |
3.84e-23 |
SMART |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1107 |
1152 |
4e-23 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149866
|
| Meta Mutation Damage Score |
0.8999 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (116/116) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610009O20Rik |
T |
C |
18: 38,254,071 (GRCm38) |
|
probably null |
Het |
| A630095E13Rik |
A |
T |
9: 36,638,577 (GRCm38) |
|
probably null |
Het |
| Abca13 |
G |
T |
11: 9,294,559 (GRCm38) |
V2141L |
probably benign |
Het |
| Adam17 |
T |
C |
12: 21,340,458 (GRCm38) |
|
probably benign |
Het |
| Adam3 |
A |
T |
8: 24,695,315 (GRCm38) |
C456S |
probably damaging |
Het |
| AI464131 |
A |
G |
4: 41,498,538 (GRCm38) |
F364S |
probably damaging |
Het |
| Aldh4a1 |
G |
T |
4: 139,642,571 (GRCm38) |
|
probably benign |
Het |
| Anapc4 |
A |
G |
5: 52,842,017 (GRCm38) |
|
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,882,368 (GRCm38) |
Q483L |
probably damaging |
Het |
| Ankle2 |
A |
G |
5: 110,242,059 (GRCm38) |
|
probably benign |
Het |
| Ankrd13b |
T |
A |
11: 77,473,288 (GRCm38) |
T150S |
possibly damaging |
Het |
| Apeh |
A |
G |
9: 108,087,055 (GRCm38) |
M524T |
probably benign |
Het |
| Arl14epl |
T |
A |
18: 46,926,417 (GRCm38) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,252,539 (GRCm38) |
F964S |
possibly damaging |
Het |
| Atg2b |
C |
T |
12: 105,617,153 (GRCm38) |
V2050M |
probably damaging |
Het |
| Atp2b4 |
A |
T |
1: 133,732,218 (GRCm38) |
|
probably benign |
Het |
| Bbof1 |
T |
A |
12: 84,430,271 (GRCm38) |
S512T |
probably benign |
Het |
| BC055324 |
T |
C |
1: 163,971,843 (GRCm38) |
|
probably null |
Het |
| C130079G13Rik |
A |
G |
3: 59,936,350 (GRCm38) |
H155R |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,075,140 (GRCm38) |
R1614L |
probably damaging |
Het |
| Car10 |
T |
C |
11: 93,490,582 (GRCm38) |
Y100H |
probably damaging |
Het |
| Ccdc81 |
T |
A |
7: 89,893,296 (GRCm38) |
E124V |
probably damaging |
Het |
| Cd84 |
A |
G |
1: 171,872,927 (GRCm38) |
T204A |
probably benign |
Het |
| Celf2 |
A |
G |
2: 6,604,176 (GRCm38) |
S178P |
probably damaging |
Het |
| Chat |
G |
A |
14: 32,409,019 (GRCm38) |
T555M |
probably damaging |
Het |
| Chrna2 |
C |
A |
14: 66,149,104 (GRCm38) |
T233N |
probably damaging |
Het |
| Cnpy2 |
T |
C |
10: 128,326,185 (GRCm38) |
V109A |
probably benign |
Het |
| Col4a1 |
T |
C |
8: 11,208,333 (GRCm38) |
|
probably null |
Het |
| Csmd1 |
C |
T |
8: 15,932,529 (GRCm38) |
V2713M |
possibly damaging |
Het |
| Cuedc1 |
G |
A |
11: 88,183,405 (GRCm38) |
R255Q |
probably damaging |
Het |
| Cxcl15 |
A |
T |
5: 90,798,038 (GRCm38) |
|
probably benign |
Het |
| Dach1 |
A |
T |
14: 97,901,329 (GRCm38) |
H559Q |
possibly damaging |
Het |
| Dennd4c |
C |
T |
4: 86,826,022 (GRCm38) |
T1367M |
probably damaging |
Het |
| Depdc5 |
T |
A |
5: 32,945,028 (GRCm38) |
Y365* |
probably null |
Het |
| Dicer1 |
T |
C |
12: 104,702,841 (GRCm38) |
Y1194C |
possibly damaging |
Het |
| Dmxl1 |
C |
G |
18: 49,891,467 (GRCm38) |
S1736* |
probably null |
Het |
| Dnah7a |
C |
T |
1: 53,497,126 (GRCm38) |
R2586K |
probably benign |
Het |
| Dnajb8 |
T |
C |
6: 88,222,485 (GRCm38) |
M1T |
probably null |
Het |
| Dync2h1 |
G |
A |
9: 7,122,692 (GRCm38) |
P2088L |
probably benign |
Het |
| Eftud2 |
T |
G |
11: 102,844,222 (GRCm38) |
H617P |
probably damaging |
Het |
| Ephb1 |
A |
G |
9: 101,995,980 (GRCm38) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,698,879 (GRCm38) |
H155Q |
probably benign |
Het |
| Ganc |
G |
T |
2: 120,448,401 (GRCm38) |
E700* |
probably null |
Het |
| Gm10912 |
A |
G |
2: 104,066,945 (GRCm38) |
|
probably benign |
Het |
| Gm9047 |
G |
T |
6: 29,478,170 (GRCm38) |
|
probably benign |
Het |
| Haus5 |
A |
T |
7: 30,659,067 (GRCm38) |
I294N |
probably damaging |
Het |
| Hmgcr |
G |
T |
13: 96,660,143 (GRCm38) |
|
probably null |
Het |
| Hr |
T |
A |
14: 70,561,912 (GRCm38) |
C641* |
probably null |
Het |
| Itga10 |
A |
G |
3: 96,658,174 (GRCm38) |
N1038S |
probably damaging |
Het |
| Itgb1bp1 |
T |
G |
12: 21,271,435 (GRCm38) |
Y172S |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,824,723 (GRCm38) |
N340S |
probably damaging |
Het |
| Kremen1 |
A |
G |
11: 5,215,447 (GRCm38) |
I41T |
probably damaging |
Het |
| Krt6b |
A |
G |
15: 101,677,607 (GRCm38) |
|
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,463,627 (GRCm38) |
R24L |
possibly damaging |
Het |
| Ldhd |
A |
G |
8: 111,629,677 (GRCm38) |
Y86H |
probably benign |
Het |
| Lilra6 |
A |
T |
7: 3,912,785 (GRCm38) |
I76N |
possibly damaging |
Het |
| Mak |
T |
C |
13: 41,046,267 (GRCm38) |
T299A |
probably benign |
Het |
| Med25 |
A |
G |
7: 44,885,078 (GRCm38) |
|
probably null |
Het |
| Mpg |
A |
T |
11: 32,230,039 (GRCm38) |
N189I |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,229,918 (GRCm38) |
Y556H |
probably damaging |
Het |
| Myh8 |
T |
A |
11: 67,284,507 (GRCm38) |
S294T |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,084,317 (GRCm38) |
D842E |
probably benign |
Het |
| Nat2 |
C |
T |
8: 67,501,330 (GRCm38) |
Q31* |
probably null |
Het |
| Nf1 |
T |
A |
11: 79,438,769 (GRCm38) |
M653K |
probably benign |
Het |
| Nhs |
C |
A |
X: 161,837,359 (GRCm38) |
R1467I |
probably damaging |
Het |
| Npr2 |
A |
G |
4: 43,632,801 (GRCm38) |
E206G |
probably benign |
Het |
| Nsd3 |
G |
A |
8: 25,678,716 (GRCm38) |
G629D |
possibly damaging |
Het |
| Nwd1 |
G |
A |
8: 72,682,005 (GRCm38) |
C831Y |
probably damaging |
Het |
| Olfr1094 |
A |
G |
2: 86,829,606 (GRCm38) |
I285V |
probably benign |
Het |
| Olfr584 |
T |
C |
7: 103,085,851 (GRCm38) |
I111T |
probably damaging |
Het |
| P2ry14 |
A |
G |
3: 59,116,028 (GRCm38) |
S4P |
possibly damaging |
Het |
| Parp4 |
A |
G |
14: 56,635,715 (GRCm38) |
|
probably benign |
Het |
| Pclo |
T |
C |
5: 14,679,398 (GRCm38) |
|
probably benign |
Het |
| Pclo |
A |
G |
5: 14,678,285 (GRCm38) |
|
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,404,595 (GRCm38) |
S1202T |
possibly damaging |
Het |
| Pfkfb4 |
A |
G |
9: 109,027,757 (GRCm38) |
Y412C |
probably damaging |
Het |
| Pgm1 |
T |
A |
5: 64,110,555 (GRCm38) |
V449D |
probably damaging |
Het |
| Poldip3 |
T |
A |
15: 83,138,235 (GRCm38) |
D116V |
probably damaging |
Het |
| Pom121 |
G |
T |
5: 135,381,832 (GRCm38) |
Q824K |
unknown |
Het |
| Prkdc |
G |
T |
16: 15,831,282 (GRCm38) |
G3707* |
probably null |
Het |
| Prr14l |
T |
C |
5: 32,844,216 (GRCm38) |
|
probably benign |
Het |
| Ptbp2 |
T |
G |
3: 119,720,964 (GRCm38) |
I405L |
probably benign |
Het |
| Rad21l |
A |
T |
2: 151,649,069 (GRCm38) |
|
probably benign |
Het |
| Rbm6 |
G |
A |
9: 107,847,289 (GRCm38) |
Q488* |
probably null |
Het |
| Rdh1 |
T |
A |
10: 127,764,783 (GRCm38) |
M225K |
probably benign |
Het |
| Recql5 |
T |
C |
11: 115,928,383 (GRCm38) |
D119G |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,110,324 (GRCm38) |
|
probably benign |
Het |
| Robo1 |
T |
C |
16: 73,013,125 (GRCm38) |
|
probably null |
Het |
| Samd12 |
G |
A |
15: 53,860,171 (GRCm38) |
T42I |
probably benign |
Het |
| Scn10a |
A |
T |
9: 119,613,700 (GRCm38) |
M1494K |
probably damaging |
Het |
| Sec31a |
G |
A |
5: 100,375,240 (GRCm38) |
P864L |
probably benign |
Het |
| Senp2 |
T |
C |
16: 22,036,570 (GRCm38) |
V344A |
probably benign |
Het |
| Serpina5 |
G |
A |
12: 104,103,362 (GRCm38) |
D278N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,703,462 (GRCm38) |
V1017D |
probably damaging |
Het |
| Sin3a |
T |
A |
9: 57,096,895 (GRCm38) |
Y310* |
probably null |
Het |
| Slc25a32 |
T |
C |
15: 39,097,545 (GRCm38) |
T248A |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 72,492,571 (GRCm38) |
|
probably benign |
Het |
| Slc4a10 |
G |
A |
2: 62,286,862 (GRCm38) |
V722M |
probably damaging |
Het |
| Slco1a4 |
A |
G |
6: 141,830,860 (GRCm38) |
|
probably benign |
Het |
| Smg6 |
T |
A |
11: 74,929,058 (GRCm38) |
Y52N |
probably damaging |
Het |
| Sncb |
T |
G |
13: 54,765,587 (GRCm38) |
T33P |
probably damaging |
Het |
| Spef2 |
A |
G |
15: 9,583,984 (GRCm38) |
|
probably null |
Het |
| Sugp1 |
A |
G |
8: 70,059,363 (GRCm38) |
E203G |
probably damaging |
Het |
| Suv39h2 |
A |
T |
2: 3,472,579 (GRCm38) |
C105S |
probably damaging |
Het |
| Tlr1 |
A |
T |
5: 64,926,620 (GRCm38) |
F205I |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,917,873 (GRCm38) |
M496K |
probably damaging |
Het |
| Tnxb |
G |
A |
17: 34,718,245 (GRCm38) |
E2889K |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,365,803 (GRCm38) |
H126L |
possibly damaging |
Het |
| Trpm7 |
A |
T |
2: 126,826,718 (GRCm38) |
Y759* |
probably null |
Het |
| Ttc17 |
A |
G |
2: 94,323,120 (GRCm38) |
I1000T |
possibly damaging |
Het |
| Ttc27 |
A |
T |
17: 74,718,715 (GRCm38) |
N61I |
probably benign |
Het |
| Uba6 |
T |
C |
5: 86,112,750 (GRCm38) |
Y990C |
probably damaging |
Het |
| Vav3 |
A |
G |
3: 109,664,440 (GRCm38) |
|
probably benign |
Het |
| Vmn2r55 |
C |
T |
7: 12,671,018 (GRCm38) |
A153T |
possibly damaging |
Het |
| Wars2 |
A |
G |
3: 99,216,549 (GRCm38) |
D242G |
probably damaging |
Het |
| Xylt2 |
G |
A |
11: 94,669,936 (GRCm38) |
Q259* |
probably null |
Het |
| Zfp27 |
G |
A |
7: 29,894,522 (GRCm38) |
P673S |
probably damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,584,660 (GRCm38) |
I1023T |
possibly damaging |
Het |
|
| Other mutations in Chd6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00837:Chd6
|
APN |
2 |
161,042,079 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL00899:Chd6
|
APN |
2 |
161,029,298 (GRCm38) |
splice site |
probably benign |
|
|
IGL01104:Chd6
|
APN |
2 |
160,961,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01295:Chd6
|
APN |
2 |
160,988,370 (GRCm38) |
splice site |
probably benign |
|
|
IGL01717:Chd6
|
APN |
2 |
160,965,259 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL01795:Chd6
|
APN |
2 |
160,961,374 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01814:Chd6
|
APN |
2 |
161,059,929 (GRCm38) |
missense |
probably benign |
0.25 |
|
IGL02016:Chd6
|
APN |
2 |
160,983,678 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02104:Chd6
|
APN |
2 |
160,977,512 (GRCm38) |
missense |
probably benign |
|
|
IGL02158:Chd6
|
APN |
2 |
161,026,292 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL02313:Chd6
|
APN |
2 |
160,965,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02472:Chd6
|
APN |
2 |
160,984,452 (GRCm38) |
splice site |
probably benign |
|
|
IGL02522:Chd6
|
APN |
2 |
160,965,796 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL02626:Chd6
|
APN |
2 |
161,039,350 (GRCm38) |
splice site |
probably benign |
|
|
IGL02727:Chd6
|
APN |
2 |
160,969,463 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02738:Chd6
|
APN |
2 |
160,965,698 (GRCm38) |
missense |
probably benign |
0.45 |
|
IGL02743:Chd6
|
APN |
2 |
160,960,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02800:Chd6
|
APN |
2 |
160,984,632 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02811:Chd6
|
APN |
2 |
160,990,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02850:Chd6
|
APN |
2 |
161,019,616 (GRCm38) |
nonsense |
probably null |
|
|
IGL02979:Chd6
|
APN |
2 |
160,966,170 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02993:Chd6
|
APN |
2 |
161,052,384 (GRCm38) |
splice site |
probably benign |
|
|
IGL03277:Chd6
|
APN |
2 |
160,983,061 (GRCm38) |
missense |
probably null |
1.00 |
|
IGL03346:Chd6
|
APN |
2 |
160,960,362 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03357:Chd6
|
APN |
2 |
161,018,016 (GRCm38) |
splice site |
probably benign |
|
|
IGL03134:Chd6
|
UTSW |
2 |
160,965,483 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0106:Chd6
|
UTSW |
2 |
160,967,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Chd6
|
UTSW |
2 |
160,967,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0212:Chd6
|
UTSW |
2 |
161,052,847 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0363:Chd6
|
UTSW |
2 |
161,014,324 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0399:Chd6
|
UTSW |
2 |
161,052,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0771:Chd6
|
UTSW |
2 |
161,019,580 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,990,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,990,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1184:Chd6
|
UTSW |
2 |
161,030,802 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1277:Chd6
|
UTSW |
2 |
160,967,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Chd6
|
UTSW |
2 |
160,983,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1647:Chd6
|
UTSW |
2 |
161,042,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1648:Chd6
|
UTSW |
2 |
161,042,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1745:Chd6
|
UTSW |
2 |
160,981,667 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1766:Chd6
|
UTSW |
2 |
160,966,639 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1871:Chd6
|
UTSW |
2 |
160,990,256 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1928:Chd6
|
UTSW |
2 |
160,968,000 (GRCm38) |
splice site |
probably benign |
|
|
R1973:Chd6
|
UTSW |
2 |
160,966,387 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2200:Chd6
|
UTSW |
2 |
160,983,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2340:Chd6
|
UTSW |
2 |
160,965,759 (GRCm38) |
frame shift |
probably null |
|
|
R2341:Chd6
|
UTSW |
2 |
160,965,759 (GRCm38) |
frame shift |
probably null |
|
|
R2519:Chd6
|
UTSW |
2 |
161,029,876 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R2919:Chd6
|
UTSW |
2 |
160,967,880 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R3025:Chd6
|
UTSW |
2 |
160,966,552 (GRCm38) |
small deletion |
probably benign |
|
|
R3426:Chd6
|
UTSW |
2 |
160,990,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3427:Chd6
|
UTSW |
2 |
160,990,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4042:Chd6
|
UTSW |
2 |
160,988,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4273:Chd6
|
UTSW |
2 |
160,961,291 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4360:Chd6
|
UTSW |
2 |
160,949,856 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R4399:Chd6
|
UTSW |
2 |
160,965,318 (GRCm38) |
missense |
probably benign |
|
|
R4458:Chd6
|
UTSW |
2 |
161,029,876 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4583:Chd6
|
UTSW |
2 |
161,014,194 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4625:Chd6
|
UTSW |
2 |
160,969,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4740:Chd6
|
UTSW |
2 |
160,970,183 (GRCm38) |
missense |
probably benign |
|
|
R4765:Chd6
|
UTSW |
2 |
160,966,244 (GRCm38) |
nonsense |
probably null |
|
|
R4779:Chd6
|
UTSW |
2 |
160,949,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4877:Chd6
|
UTSW |
2 |
161,029,299 (GRCm38) |
splice site |
probably benign |
|
|
R5068:Chd6
|
UTSW |
2 |
160,966,369 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R5215:Chd6
|
UTSW |
2 |
160,949,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5275:Chd6
|
UTSW |
2 |
160,969,363 (GRCm38) |
missense |
probably benign |
|
|
R5405:Chd6
|
UTSW |
2 |
160,965,390 (GRCm38) |
missense |
probably benign |
|
|
R5598:Chd6
|
UTSW |
2 |
161,014,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5693:Chd6
|
UTSW |
2 |
160,965,265 (GRCm38) |
missense |
probably benign |
|
|
R5697:Chd6
|
UTSW |
2 |
161,018,051 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5715:Chd6
|
UTSW |
2 |
160,949,878 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5759:Chd6
|
UTSW |
2 |
160,983,762 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R5761:Chd6
|
UTSW |
2 |
160,957,079 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5761:Chd6
|
UTSW |
2 |
160,957,078 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5954:Chd6
|
UTSW |
2 |
160,965,827 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6025:Chd6
|
UTSW |
2 |
160,965,582 (GRCm38) |
missense |
probably benign |
|
|
R6104:Chd6
|
UTSW |
2 |
161,014,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6247:Chd6
|
UTSW |
2 |
160,950,048 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6393:Chd6
|
UTSW |
2 |
160,979,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6452:Chd6
|
UTSW |
2 |
160,965,498 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R6468:Chd6
|
UTSW |
2 |
161,013,067 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6784:Chd6
|
UTSW |
2 |
160,966,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6803:Chd6
|
UTSW |
2 |
160,960,359 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R6869:Chd6
|
UTSW |
2 |
160,965,730 (GRCm38) |
missense |
probably benign |
|
|
R6895:Chd6
|
UTSW |
2 |
160,988,340 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6925:Chd6
|
UTSW |
2 |
161,013,127 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7061:Chd6
|
UTSW |
2 |
161,025,965 (GRCm38) |
nonsense |
probably null |
|
|
R7064:Chd6
|
UTSW |
2 |
160,950,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7248:Chd6
|
UTSW |
2 |
160,961,279 (GRCm38) |
nonsense |
probably null |
|
|
R7287:Chd6
|
UTSW |
2 |
161,008,392 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7431:Chd6
|
UTSW |
2 |
161,026,328 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7486:Chd6
|
UTSW |
2 |
160,950,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7509:Chd6
|
UTSW |
2 |
161,013,154 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7699:Chd6
|
UTSW |
2 |
161,025,943 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7748:Chd6
|
UTSW |
2 |
160,966,619 (GRCm38) |
missense |
probably benign |
0.37 |
|
R7785:Chd6
|
UTSW |
2 |
160,970,175 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R8002:Chd6
|
UTSW |
2 |
160,990,321 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8261:Chd6
|
UTSW |
2 |
160,957,082 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8317:Chd6
|
UTSW |
2 |
160,990,321 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8388:Chd6
|
UTSW |
2 |
161,019,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8865:Chd6
|
UTSW |
2 |
161,021,069 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8867:Chd6
|
UTSW |
2 |
161,021,069 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8996:Chd6
|
UTSW |
2 |
160,981,623 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9091:Chd6
|
UTSW |
2 |
161,029,873 (GRCm38) |
nonsense |
probably null |
|
|
R9270:Chd6
|
UTSW |
2 |
161,029,873 (GRCm38) |
nonsense |
probably null |
|
|
R9310:Chd6
|
UTSW |
2 |
161,039,261 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9367:Chd6
|
UTSW |
2 |
161,029,864 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9438:Chd6
|
UTSW |
2 |
160,957,158 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9756:Chd6
|
UTSW |
2 |
160,960,339 (GRCm38) |
missense |
probably benign |
|
|
Z1088:Chd6
|
UTSW |
2 |
160,966,488 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGTCTGACTCAGAGAGCCATC -3'
(R):5'- CATTCACAGAGGTAGAGCAGCATCC -3'
Sequencing Primer
(F):5'- CTGTCTGGTGCTGCAATCAAAG -3'
(R):5'- TACCCAAGAGTCTGTGAACCTG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation