Incidental Mutation 'R0511:Myh8'
| ID |
46938 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh8
|
| Ensembl Gene |
ENSMUSG00000055775 |
| Gene Name |
myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms |
Myhsp, 4832426G23Rik, MyHC-pn, Myhs-p |
| MMRRC Submission |
038705-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.818)
|
| Stock # |
R0511 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
67277124-67308634 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67284507 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 294
(S294T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019625
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019625]
[ENSMUST00000108685]
|
| AlphaFold |
P13542 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019625
AA Change: S294T
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775
AA Change: S294T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
76 |
2.1e-13 |
PFAM |
|
MYSc
|
82 |
782 |
N/A |
SMART |
|
IQ
|
783 |
805 |
5.44e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
846 |
1927 |
2.4e-164 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108685
|
| SMART Domains |
Protein: ENSMUSP00000104325
Gene: ENSMUSG00000055775
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
78 |
3.8e-17 |
PFAM |
|
Pfam:Myosin_head
|
90 |
172 |
1.7e-31 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000108686
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139052
|
| Meta Mutation Damage Score |
0.1723 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (116/116) |
| MGI Phenotype |
FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610009O20Rik |
T |
C |
18: 38,254,071 (GRCm38) |
|
probably null |
Het |
| A630095E13Rik |
A |
T |
9: 36,638,577 (GRCm38) |
|
probably null |
Het |
| Abca13 |
G |
T |
11: 9,294,559 (GRCm38) |
V2141L |
probably benign |
Het |
| Adam17 |
T |
C |
12: 21,340,458 (GRCm38) |
|
probably benign |
Het |
| Adam3 |
A |
T |
8: 24,695,315 (GRCm38) |
C456S |
probably damaging |
Het |
| AI464131 |
A |
G |
4: 41,498,538 (GRCm38) |
F364S |
probably damaging |
Het |
| Aldh4a1 |
G |
T |
4: 139,642,571 (GRCm38) |
|
probably benign |
Het |
| Anapc4 |
A |
G |
5: 52,842,017 (GRCm38) |
|
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,882,368 (GRCm38) |
Q483L |
probably damaging |
Het |
| Ankle2 |
A |
G |
5: 110,242,059 (GRCm38) |
|
probably benign |
Het |
| Ankrd13b |
T |
A |
11: 77,473,288 (GRCm38) |
T150S |
possibly damaging |
Het |
| Apeh |
A |
G |
9: 108,087,055 (GRCm38) |
M524T |
probably benign |
Het |
| Arl14epl |
T |
A |
18: 46,926,417 (GRCm38) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,252,539 (GRCm38) |
F964S |
possibly damaging |
Het |
| Atg2b |
C |
T |
12: 105,617,153 (GRCm38) |
V2050M |
probably damaging |
Het |
| Atp2b4 |
A |
T |
1: 133,732,218 (GRCm38) |
|
probably benign |
Het |
| Bbof1 |
T |
A |
12: 84,430,271 (GRCm38) |
S512T |
probably benign |
Het |
| BC055324 |
T |
C |
1: 163,971,843 (GRCm38) |
|
probably null |
Het |
| C130079G13Rik |
A |
G |
3: 59,936,350 (GRCm38) |
H155R |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,075,140 (GRCm38) |
R1614L |
probably damaging |
Het |
| Car10 |
T |
C |
11: 93,490,582 (GRCm38) |
Y100H |
probably damaging |
Het |
| Ccdc81 |
T |
A |
7: 89,893,296 (GRCm38) |
E124V |
probably damaging |
Het |
| Cd84 |
A |
G |
1: 171,872,927 (GRCm38) |
T204A |
probably benign |
Het |
| Celf2 |
A |
G |
2: 6,604,176 (GRCm38) |
S178P |
probably damaging |
Het |
| Chat |
G |
A |
14: 32,409,019 (GRCm38) |
T555M |
probably damaging |
Het |
| Chd6 |
A |
G |
2: 160,992,191 (GRCm38) |
F917S |
probably damaging |
Het |
| Chrna2 |
C |
A |
14: 66,149,104 (GRCm38) |
T233N |
probably damaging |
Het |
| Cnpy2 |
T |
C |
10: 128,326,185 (GRCm38) |
V109A |
probably benign |
Het |
| Col4a1 |
T |
C |
8: 11,208,333 (GRCm38) |
|
probably null |
Het |
| Csmd1 |
C |
T |
8: 15,932,529 (GRCm38) |
V2713M |
possibly damaging |
Het |
| Cuedc1 |
G |
A |
11: 88,183,405 (GRCm38) |
R255Q |
probably damaging |
Het |
| Cxcl15 |
A |
T |
5: 90,798,038 (GRCm38) |
|
probably benign |
Het |
| Dach1 |
A |
T |
14: 97,901,329 (GRCm38) |
H559Q |
possibly damaging |
Het |
| Dennd4c |
C |
T |
4: 86,826,022 (GRCm38) |
T1367M |
probably damaging |
Het |
| Depdc5 |
T |
A |
5: 32,945,028 (GRCm38) |
Y365* |
probably null |
Het |
| Dicer1 |
T |
C |
12: 104,702,841 (GRCm38) |
Y1194C |
possibly damaging |
Het |
| Dmxl1 |
C |
G |
18: 49,891,467 (GRCm38) |
S1736* |
probably null |
Het |
| Dnah7a |
C |
T |
1: 53,497,126 (GRCm38) |
R2586K |
probably benign |
Het |
| Dnajb8 |
T |
C |
6: 88,222,485 (GRCm38) |
M1T |
probably null |
Het |
| Dync2h1 |
G |
A |
9: 7,122,692 (GRCm38) |
P2088L |
probably benign |
Het |
| Eftud2 |
T |
G |
11: 102,844,222 (GRCm38) |
H617P |
probably damaging |
Het |
| Ephb1 |
A |
G |
9: 101,995,980 (GRCm38) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,698,879 (GRCm38) |
H155Q |
probably benign |
Het |
| Ganc |
G |
T |
2: 120,448,401 (GRCm38) |
E700* |
probably null |
Het |
| Gm10912 |
A |
G |
2: 104,066,945 (GRCm38) |
|
probably benign |
Het |
| Gm9047 |
G |
T |
6: 29,478,170 (GRCm38) |
|
probably benign |
Het |
| Haus5 |
A |
T |
7: 30,659,067 (GRCm38) |
I294N |
probably damaging |
Het |
| Hmgcr |
G |
T |
13: 96,660,143 (GRCm38) |
|
probably null |
Het |
| Hr |
T |
A |
14: 70,561,912 (GRCm38) |
C641* |
probably null |
Het |
| Itga10 |
A |
G |
3: 96,658,174 (GRCm38) |
N1038S |
probably damaging |
Het |
| Itgb1bp1 |
T |
G |
12: 21,271,435 (GRCm38) |
Y172S |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,824,723 (GRCm38) |
N340S |
probably damaging |
Het |
| Kremen1 |
A |
G |
11: 5,215,447 (GRCm38) |
I41T |
probably damaging |
Het |
| Krt6b |
A |
G |
15: 101,677,607 (GRCm38) |
|
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,463,627 (GRCm38) |
R24L |
possibly damaging |
Het |
| Ldhd |
A |
G |
8: 111,629,677 (GRCm38) |
Y86H |
probably benign |
Het |
| Lilra6 |
A |
T |
7: 3,912,785 (GRCm38) |
I76N |
possibly damaging |
Het |
| Mak |
T |
C |
13: 41,046,267 (GRCm38) |
T299A |
probably benign |
Het |
| Med25 |
A |
G |
7: 44,885,078 (GRCm38) |
|
probably null |
Het |
| Mpg |
A |
T |
11: 32,230,039 (GRCm38) |
N189I |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,229,918 (GRCm38) |
Y556H |
probably damaging |
Het |
| Myom1 |
T |
A |
17: 71,084,317 (GRCm38) |
D842E |
probably benign |
Het |
| Nat2 |
C |
T |
8: 67,501,330 (GRCm38) |
Q31* |
probably null |
Het |
| Nf1 |
T |
A |
11: 79,438,769 (GRCm38) |
M653K |
probably benign |
Het |
| Nhs |
C |
A |
X: 161,837,359 (GRCm38) |
R1467I |
probably damaging |
Het |
| Npr2 |
A |
G |
4: 43,632,801 (GRCm38) |
E206G |
probably benign |
Het |
| Nsd3 |
G |
A |
8: 25,678,716 (GRCm38) |
G629D |
possibly damaging |
Het |
| Nwd1 |
G |
A |
8: 72,682,005 (GRCm38) |
C831Y |
probably damaging |
Het |
| Olfr1094 |
A |
G |
2: 86,829,606 (GRCm38) |
I285V |
probably benign |
Het |
| Olfr584 |
T |
C |
7: 103,085,851 (GRCm38) |
I111T |
probably damaging |
Het |
| P2ry14 |
A |
G |
3: 59,116,028 (GRCm38) |
S4P |
possibly damaging |
Het |
| Parp4 |
A |
G |
14: 56,635,715 (GRCm38) |
|
probably benign |
Het |
| Pclo |
A |
G |
5: 14,678,285 (GRCm38) |
|
probably benign |
Het |
| Pclo |
T |
C |
5: 14,679,398 (GRCm38) |
|
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,404,595 (GRCm38) |
S1202T |
possibly damaging |
Het |
| Pfkfb4 |
A |
G |
9: 109,027,757 (GRCm38) |
Y412C |
probably damaging |
Het |
| Pgm1 |
T |
A |
5: 64,110,555 (GRCm38) |
V449D |
probably damaging |
Het |
| Poldip3 |
T |
A |
15: 83,138,235 (GRCm38) |
D116V |
probably damaging |
Het |
| Pom121 |
G |
T |
5: 135,381,832 (GRCm38) |
Q824K |
unknown |
Het |
| Prkdc |
G |
T |
16: 15,831,282 (GRCm38) |
G3707* |
probably null |
Het |
| Prr14l |
T |
C |
5: 32,844,216 (GRCm38) |
|
probably benign |
Het |
| Ptbp2 |
T |
G |
3: 119,720,964 (GRCm38) |
I405L |
probably benign |
Het |
| Rad21l |
A |
T |
2: 151,649,069 (GRCm38) |
|
probably benign |
Het |
| Rbm6 |
G |
A |
9: 107,847,289 (GRCm38) |
Q488* |
probably null |
Het |
| Rdh1 |
T |
A |
10: 127,764,783 (GRCm38) |
M225K |
probably benign |
Het |
| Recql5 |
T |
C |
11: 115,928,383 (GRCm38) |
D119G |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,110,324 (GRCm38) |
|
probably benign |
Het |
| Robo1 |
T |
C |
16: 73,013,125 (GRCm38) |
|
probably null |
Het |
| Samd12 |
G |
A |
15: 53,860,171 (GRCm38) |
T42I |
probably benign |
Het |
| Scn10a |
A |
T |
9: 119,613,700 (GRCm38) |
M1494K |
probably damaging |
Het |
| Sec31a |
G |
A |
5: 100,375,240 (GRCm38) |
P864L |
probably benign |
Het |
| Senp2 |
T |
C |
16: 22,036,570 (GRCm38) |
V344A |
probably benign |
Het |
| Serpina5 |
G |
A |
12: 104,103,362 (GRCm38) |
D278N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,703,462 (GRCm38) |
V1017D |
probably damaging |
Het |
| Sin3a |
T |
A |
9: 57,096,895 (GRCm38) |
Y310* |
probably null |
Het |
| Slc25a32 |
T |
C |
15: 39,097,545 (GRCm38) |
T248A |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 72,492,571 (GRCm38) |
|
probably benign |
Het |
| Slc4a10 |
G |
A |
2: 62,286,862 (GRCm38) |
V722M |
probably damaging |
Het |
| Slco1a4 |
A |
G |
6: 141,830,860 (GRCm38) |
|
probably benign |
Het |
| Smg6 |
T |
A |
11: 74,929,058 (GRCm38) |
Y52N |
probably damaging |
Het |
| Sncb |
T |
G |
13: 54,765,587 (GRCm38) |
T33P |
probably damaging |
Het |
| Spef2 |
A |
G |
15: 9,583,984 (GRCm38) |
|
probably null |
Het |
| Sugp1 |
A |
G |
8: 70,059,363 (GRCm38) |
E203G |
probably damaging |
Het |
| Suv39h2 |
A |
T |
2: 3,472,579 (GRCm38) |
C105S |
probably damaging |
Het |
| Tlr1 |
A |
T |
5: 64,926,620 (GRCm38) |
F205I |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,917,873 (GRCm38) |
M496K |
probably damaging |
Het |
| Tnxb |
G |
A |
17: 34,718,245 (GRCm38) |
E2889K |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,365,803 (GRCm38) |
H126L |
possibly damaging |
Het |
| Trpm7 |
A |
T |
2: 126,826,718 (GRCm38) |
Y759* |
probably null |
Het |
| Ttc17 |
A |
G |
2: 94,323,120 (GRCm38) |
I1000T |
possibly damaging |
Het |
| Ttc27 |
A |
T |
17: 74,718,715 (GRCm38) |
N61I |
probably benign |
Het |
| Uba6 |
T |
C |
5: 86,112,750 (GRCm38) |
Y990C |
probably damaging |
Het |
| Vav3 |
A |
G |
3: 109,664,440 (GRCm38) |
|
probably benign |
Het |
| Vmn2r55 |
C |
T |
7: 12,671,018 (GRCm38) |
A153T |
possibly damaging |
Het |
| Wars2 |
A |
G |
3: 99,216,549 (GRCm38) |
D242G |
probably damaging |
Het |
| Xylt2 |
G |
A |
11: 94,669,936 (GRCm38) |
Q259* |
probably null |
Het |
| Zfp27 |
G |
A |
7: 29,894,522 (GRCm38) |
P673S |
probably damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,584,660 (GRCm38) |
I1023T |
possibly damaging |
Het |
|
| Other mutations in Myh8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01020:Myh8
|
APN |
11 |
67,283,403 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01348:Myh8
|
APN |
11 |
67,297,780 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01382:Myh8
|
APN |
11 |
67,301,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01454:Myh8
|
APN |
11 |
67,283,596 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01457:Myh8
|
APN |
11 |
67,292,679 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01472:Myh8
|
APN |
11 |
67,288,379 (GRCm38) |
splice site |
probably benign |
|
|
IGL01473:Myh8
|
APN |
11 |
67,301,825 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01613:Myh8
|
APN |
11 |
67,301,710 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01763:Myh8
|
APN |
11 |
67,286,419 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01828:Myh8
|
APN |
11 |
67,303,826 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL01862:Myh8
|
APN |
11 |
67,289,694 (GRCm38) |
nonsense |
probably null |
|
|
IGL01905:Myh8
|
APN |
11 |
67,284,651 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL02280:Myh8
|
APN |
11 |
67,283,372 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02386:Myh8
|
APN |
11 |
67,294,440 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02449:Myh8
|
APN |
11 |
67,294,614 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02500:Myh8
|
APN |
11 |
67,305,710 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02745:Myh8
|
APN |
11 |
67,297,501 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02799:Myh8
|
APN |
11 |
67,301,592 (GRCm38) |
splice site |
probably benign |
|
|
IGL03063:Myh8
|
APN |
11 |
67,288,205 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03223:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03336:Myh8
|
APN |
11 |
67,284,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03338:Myh8
|
APN |
11 |
67,298,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03351:Myh8
|
APN |
11 |
67,303,913 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03392:Myh8
|
APN |
11 |
67,294,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB003:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB009:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
BB013:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB019:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4354001:Myh8
|
UTSW |
11 |
67,289,630 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0012:Myh8
|
UTSW |
11 |
67,300,021 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0115:Myh8
|
UTSW |
11 |
67,306,264 (GRCm38) |
splice site |
probably benign |
|
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0132:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0393:Myh8
|
UTSW |
11 |
67,306,017 (GRCm38) |
splice site |
probably benign |
|
|
R0453:Myh8
|
UTSW |
11 |
67,292,905 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0454:Myh8
|
UTSW |
11 |
67,303,765 (GRCm38) |
nonsense |
probably null |
|
|
R0466:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0487:Myh8
|
UTSW |
11 |
67,302,011 (GRCm38) |
missense |
probably benign |
|
|
R0557:Myh8
|
UTSW |
11 |
67,301,798 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0589:Myh8
|
UTSW |
11 |
67,298,627 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0658:Myh8
|
UTSW |
11 |
67,284,532 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0782:Myh8
|
UTSW |
11 |
67,289,754 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0829:Myh8
|
UTSW |
11 |
67,283,500 (GRCm38) |
unclassified |
probably benign |
|
|
R0845:Myh8
|
UTSW |
11 |
67,286,264 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0930:Myh8
|
UTSW |
11 |
67,305,998 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0972:Myh8
|
UTSW |
11 |
67,297,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1132:Myh8
|
UTSW |
11 |
67,297,131 (GRCm38) |
nonsense |
probably null |
|
|
R1417:Myh8
|
UTSW |
11 |
67,306,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1478:Myh8
|
UTSW |
11 |
67,292,725 (GRCm38) |
missense |
probably benign |
0.23 |
|
R1497:Myh8
|
UTSW |
11 |
67,289,812 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1605:Myh8
|
UTSW |
11 |
67,301,671 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1701:Myh8
|
UTSW |
11 |
67,280,138 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1950:Myh8
|
UTSW |
11 |
67,279,004 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1989:Myh8
|
UTSW |
11 |
67,292,724 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2010:Myh8
|
UTSW |
11 |
67,297,164 (GRCm38) |
nonsense |
probably null |
|
|
R2095:Myh8
|
UTSW |
11 |
67,286,224 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2132:Myh8
|
UTSW |
11 |
67,292,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2152:Myh8
|
UTSW |
11 |
67,294,469 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2229:Myh8
|
UTSW |
11 |
67,308,348 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2302:Myh8
|
UTSW |
11 |
67,286,239 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2364:Myh8
|
UTSW |
11 |
67,294,518 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2429:Myh8
|
UTSW |
11 |
67,303,897 (GRCm38) |
missense |
probably benign |
0.21 |
|
R2880:Myh8
|
UTSW |
11 |
67,297,264 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3692:Myh8
|
UTSW |
11 |
67,301,918 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3756:Myh8
|
UTSW |
11 |
67,284,617 (GRCm38) |
unclassified |
probably benign |
|
|
R3924:Myh8
|
UTSW |
11 |
67,297,137 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4172:Myh8
|
UTSW |
11 |
67,292,421 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4255:Myh8
|
UTSW |
11 |
67,299,734 (GRCm38) |
missense |
probably benign |
|
|
R4621:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4623:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4790:Myh8
|
UTSW |
11 |
67,279,963 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4914:Myh8
|
UTSW |
11 |
67,292,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5074:Myh8
|
UTSW |
11 |
67,305,916 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5119:Myh8
|
UTSW |
11 |
67,298,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5159:Myh8
|
UTSW |
11 |
67,288,353 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5229:Myh8
|
UTSW |
11 |
67,284,484 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5320:Myh8
|
UTSW |
11 |
67,286,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5455:Myh8
|
UTSW |
11 |
67,301,418 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R5523:Myh8
|
UTSW |
11 |
67,305,962 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5540:Myh8
|
UTSW |
11 |
67,286,440 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5726:Myh8
|
UTSW |
11 |
67,294,566 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5770:Myh8
|
UTSW |
11 |
67,297,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6135:Myh8
|
UTSW |
11 |
67,297,500 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R6253:Myh8
|
UTSW |
11 |
67,301,967 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6318:Myh8
|
UTSW |
11 |
67,299,341 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6432:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6452:Myh8
|
UTSW |
11 |
67,305,739 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6452:Myh8
|
UTSW |
11 |
67,292,449 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6512:Myh8
|
UTSW |
11 |
67,289,662 (GRCm38) |
nonsense |
probably null |
|
|
R6714:Myh8
|
UTSW |
11 |
67,306,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6842:Myh8
|
UTSW |
11 |
67,284,655 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7007:Myh8
|
UTSW |
11 |
67,288,316 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7025:Myh8
|
UTSW |
11 |
67,297,539 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7086:Myh8
|
UTSW |
11 |
67,292,627 (GRCm38) |
splice site |
probably null |
|
|
R7098:Myh8
|
UTSW |
11 |
67,279,053 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7498:Myh8
|
UTSW |
11 |
67,283,437 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7716:Myh8
|
UTSW |
11 |
67,298,652 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R7765:Myh8
|
UTSW |
11 |
67,303,655 (GRCm38) |
missense |
probably benign |
0.44 |
|
R7825:Myh8
|
UTSW |
11 |
67,303,712 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7921:Myh8
|
UTSW |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7926:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7932:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8003:Myh8
|
UTSW |
11 |
67,299,760 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8028:Myh8
|
UTSW |
11 |
67,303,676 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R8121:Myh8
|
UTSW |
11 |
67,289,821 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8125:Myh8
|
UTSW |
11 |
67,299,772 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8170:Myh8
|
UTSW |
11 |
67,288,266 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8277:Myh8
|
UTSW |
11 |
67,292,909 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8304:Myh8
|
UTSW |
11 |
67,304,336 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R8431:Myh8
|
UTSW |
11 |
67,283,614 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8535:Myh8
|
UTSW |
11 |
67,278,915 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8795:Myh8
|
UTSW |
11 |
67,283,377 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R8858:Myh8
|
UTSW |
11 |
67,301,994 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R8927:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8928:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9031:Myh8
|
UTSW |
11 |
67,299,315 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R9172:Myh8
|
UTSW |
11 |
67,292,434 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9252:Myh8
|
UTSW |
11 |
67,286,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9365:Myh8
|
UTSW |
11 |
67,283,806 (GRCm38) |
missense |
probably benign |
0.42 |
|
R9468:Myh8
|
UTSW |
11 |
67,306,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9564:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9565:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
T0722:Myh8
|
UTSW |
11 |
67,304,436 (GRCm38) |
missense |
probably benign |
0.41 |
|
Z1088:Myh8
|
UTSW |
11 |
67,298,592 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh8
|
UTSW |
11 |
67,303,674 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Myh8
|
UTSW |
11 |
67,308,355 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
Z1177:Myh8
|
UTSW |
11 |
67,301,424 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1187:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1188:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1190:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1191:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCAAATGCAGTGTCCCTCAG -3'
(R):5'- GTTGCCGTCCCCATACATCATAGG -3'
Sequencing Primer
(F):5'- CAGTGTTGGCCAAAGACACTAA -3'
(R):5'- TCATCAATGCTGGGCACC -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation