Incidental Mutation 'R0511:Parp4'
| ID |
46957 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
p193, Adprtl1, E230037B21Rik, PH5P, VAULT3, VPARP, C030027K23Rik |
| MMRRC Submission |
038705-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.129)
|
| Stock # |
R0511 (G1)
|
| Quality Score |
184 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56575619-56659794 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 56635715 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161553
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (116/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610009O20Rik |
T |
C |
18: 38,254,071 (GRCm38) |
|
probably null |
Het |
| A630095E13Rik |
A |
T |
9: 36,638,577 (GRCm38) |
|
probably null |
Het |
| Abca13 |
G |
T |
11: 9,294,559 (GRCm38) |
V2141L |
probably benign |
Het |
| Adam17 |
T |
C |
12: 21,340,458 (GRCm38) |
|
probably benign |
Het |
| Adam3 |
A |
T |
8: 24,695,315 (GRCm38) |
C456S |
probably damaging |
Het |
| AI464131 |
A |
G |
4: 41,498,538 (GRCm38) |
F364S |
probably damaging |
Het |
| Aldh4a1 |
G |
T |
4: 139,642,571 (GRCm38) |
|
probably benign |
Het |
| Anapc4 |
A |
G |
5: 52,842,017 (GRCm38) |
|
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,882,368 (GRCm38) |
Q483L |
probably damaging |
Het |
| Ankle2 |
A |
G |
5: 110,242,059 (GRCm38) |
|
probably benign |
Het |
| Ankrd13b |
T |
A |
11: 77,473,288 (GRCm38) |
T150S |
possibly damaging |
Het |
| Apeh |
A |
G |
9: 108,087,055 (GRCm38) |
M524T |
probably benign |
Het |
| Arl14epl |
T |
A |
18: 46,926,417 (GRCm38) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,252,539 (GRCm38) |
F964S |
possibly damaging |
Het |
| Atg2b |
C |
T |
12: 105,617,153 (GRCm38) |
V2050M |
probably damaging |
Het |
| Atp2b4 |
A |
T |
1: 133,732,218 (GRCm38) |
|
probably benign |
Het |
| Bbof1 |
T |
A |
12: 84,430,271 (GRCm38) |
S512T |
probably benign |
Het |
| BC055324 |
T |
C |
1: 163,971,843 (GRCm38) |
|
probably null |
Het |
| C130079G13Rik |
A |
G |
3: 59,936,350 (GRCm38) |
H155R |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,075,140 (GRCm38) |
R1614L |
probably damaging |
Het |
| Car10 |
T |
C |
11: 93,490,582 (GRCm38) |
Y100H |
probably damaging |
Het |
| Ccdc81 |
T |
A |
7: 89,893,296 (GRCm38) |
E124V |
probably damaging |
Het |
| Cd84 |
A |
G |
1: 171,872,927 (GRCm38) |
T204A |
probably benign |
Het |
| Celf2 |
A |
G |
2: 6,604,176 (GRCm38) |
S178P |
probably damaging |
Het |
| Chat |
G |
A |
14: 32,409,019 (GRCm38) |
T555M |
probably damaging |
Het |
| Chd6 |
A |
G |
2: 160,992,191 (GRCm38) |
F917S |
probably damaging |
Het |
| Chrna2 |
C |
A |
14: 66,149,104 (GRCm38) |
T233N |
probably damaging |
Het |
| Cnpy2 |
T |
C |
10: 128,326,185 (GRCm38) |
V109A |
probably benign |
Het |
| Col4a1 |
T |
C |
8: 11,208,333 (GRCm38) |
|
probably null |
Het |
| Csmd1 |
C |
T |
8: 15,932,529 (GRCm38) |
V2713M |
possibly damaging |
Het |
| Cuedc1 |
G |
A |
11: 88,183,405 (GRCm38) |
R255Q |
probably damaging |
Het |
| Cxcl15 |
A |
T |
5: 90,798,038 (GRCm38) |
|
probably benign |
Het |
| Dach1 |
A |
T |
14: 97,901,329 (GRCm38) |
H559Q |
possibly damaging |
Het |
| Dennd4c |
C |
T |
4: 86,826,022 (GRCm38) |
T1367M |
probably damaging |
Het |
| Depdc5 |
T |
A |
5: 32,945,028 (GRCm38) |
Y365* |
probably null |
Het |
| Dicer1 |
T |
C |
12: 104,702,841 (GRCm38) |
Y1194C |
possibly damaging |
Het |
| Dmxl1 |
C |
G |
18: 49,891,467 (GRCm38) |
S1736* |
probably null |
Het |
| Dnah7a |
C |
T |
1: 53,497,126 (GRCm38) |
R2586K |
probably benign |
Het |
| Dnajb8 |
T |
C |
6: 88,222,485 (GRCm38) |
M1T |
probably null |
Het |
| Dync2h1 |
G |
A |
9: 7,122,692 (GRCm38) |
P2088L |
probably benign |
Het |
| Eftud2 |
T |
G |
11: 102,844,222 (GRCm38) |
H617P |
probably damaging |
Het |
| Ephb1 |
A |
G |
9: 101,995,980 (GRCm38) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,698,879 (GRCm38) |
H155Q |
probably benign |
Het |
| Ganc |
G |
T |
2: 120,448,401 (GRCm38) |
E700* |
probably null |
Het |
| Gm10912 |
A |
G |
2: 104,066,945 (GRCm38) |
|
probably benign |
Het |
| Gm9047 |
G |
T |
6: 29,478,170 (GRCm38) |
|
probably benign |
Het |
| Haus5 |
A |
T |
7: 30,659,067 (GRCm38) |
I294N |
probably damaging |
Het |
| Hmgcr |
G |
T |
13: 96,660,143 (GRCm38) |
|
probably null |
Het |
| Hr |
T |
A |
14: 70,561,912 (GRCm38) |
C641* |
probably null |
Het |
| Itga10 |
A |
G |
3: 96,658,174 (GRCm38) |
N1038S |
probably damaging |
Het |
| Itgb1bp1 |
T |
G |
12: 21,271,435 (GRCm38) |
Y172S |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,824,723 (GRCm38) |
N340S |
probably damaging |
Het |
| Kremen1 |
A |
G |
11: 5,215,447 (GRCm38) |
I41T |
probably damaging |
Het |
| Krt6b |
A |
G |
15: 101,677,607 (GRCm38) |
|
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,463,627 (GRCm38) |
R24L |
possibly damaging |
Het |
| Ldhd |
A |
G |
8: 111,629,677 (GRCm38) |
Y86H |
probably benign |
Het |
| Lilra6 |
A |
T |
7: 3,912,785 (GRCm38) |
I76N |
possibly damaging |
Het |
| Mak |
T |
C |
13: 41,046,267 (GRCm38) |
T299A |
probably benign |
Het |
| Med25 |
A |
G |
7: 44,885,078 (GRCm38) |
|
probably null |
Het |
| Mpg |
A |
T |
11: 32,230,039 (GRCm38) |
N189I |
probably damaging |
Het |
| Mroh8 |
A |
G |
2: 157,229,918 (GRCm38) |
Y556H |
probably damaging |
Het |
| Myh8 |
T |
A |
11: 67,284,507 (GRCm38) |
S294T |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,084,317 (GRCm38) |
D842E |
probably benign |
Het |
| Nat2 |
C |
T |
8: 67,501,330 (GRCm38) |
Q31* |
probably null |
Het |
| Nf1 |
T |
A |
11: 79,438,769 (GRCm38) |
M653K |
probably benign |
Het |
| Nhs |
C |
A |
X: 161,837,359 (GRCm38) |
R1467I |
probably damaging |
Het |
| Npr2 |
A |
G |
4: 43,632,801 (GRCm38) |
E206G |
probably benign |
Het |
| Nsd3 |
G |
A |
8: 25,678,716 (GRCm38) |
G629D |
possibly damaging |
Het |
| Nwd1 |
G |
A |
8: 72,682,005 (GRCm38) |
C831Y |
probably damaging |
Het |
| Olfr1094 |
A |
G |
2: 86,829,606 (GRCm38) |
I285V |
probably benign |
Het |
| Olfr584 |
T |
C |
7: 103,085,851 (GRCm38) |
I111T |
probably damaging |
Het |
| P2ry14 |
A |
G |
3: 59,116,028 (GRCm38) |
S4P |
possibly damaging |
Het |
| Pclo |
T |
C |
5: 14,679,398 (GRCm38) |
|
probably benign |
Het |
| Pclo |
A |
G |
5: 14,678,285 (GRCm38) |
|
probably benign |
Het |
| Pcnt |
A |
T |
10: 76,404,595 (GRCm38) |
S1202T |
possibly damaging |
Het |
| Pfkfb4 |
A |
G |
9: 109,027,757 (GRCm38) |
Y412C |
probably damaging |
Het |
| Pgm1 |
T |
A |
5: 64,110,555 (GRCm38) |
V449D |
probably damaging |
Het |
| Poldip3 |
T |
A |
15: 83,138,235 (GRCm38) |
D116V |
probably damaging |
Het |
| Pom121 |
G |
T |
5: 135,381,832 (GRCm38) |
Q824K |
unknown |
Het |
| Prkdc |
G |
T |
16: 15,831,282 (GRCm38) |
G3707* |
probably null |
Het |
| Prr14l |
T |
C |
5: 32,844,216 (GRCm38) |
|
probably benign |
Het |
| Ptbp2 |
T |
G |
3: 119,720,964 (GRCm38) |
I405L |
probably benign |
Het |
| Rad21l |
A |
T |
2: 151,649,069 (GRCm38) |
|
probably benign |
Het |
| Rbm6 |
G |
A |
9: 107,847,289 (GRCm38) |
Q488* |
probably null |
Het |
| Rdh1 |
T |
A |
10: 127,764,783 (GRCm38) |
M225K |
probably benign |
Het |
| Recql5 |
T |
C |
11: 115,928,383 (GRCm38) |
D119G |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,110,324 (GRCm38) |
|
probably benign |
Het |
| Robo1 |
T |
C |
16: 73,013,125 (GRCm38) |
|
probably null |
Het |
| Samd12 |
G |
A |
15: 53,860,171 (GRCm38) |
T42I |
probably benign |
Het |
| Scn10a |
A |
T |
9: 119,613,700 (GRCm38) |
M1494K |
probably damaging |
Het |
| Sec31a |
G |
A |
5: 100,375,240 (GRCm38) |
P864L |
probably benign |
Het |
| Senp2 |
T |
C |
16: 22,036,570 (GRCm38) |
V344A |
probably benign |
Het |
| Serpina5 |
G |
A |
12: 104,103,362 (GRCm38) |
D278N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,703,462 (GRCm38) |
V1017D |
probably damaging |
Het |
| Sin3a |
T |
A |
9: 57,096,895 (GRCm38) |
Y310* |
probably null |
Het |
| Slc25a32 |
T |
C |
15: 39,097,545 (GRCm38) |
T248A |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 72,492,571 (GRCm38) |
|
probably benign |
Het |
| Slc4a10 |
G |
A |
2: 62,286,862 (GRCm38) |
V722M |
probably damaging |
Het |
| Slco1a4 |
A |
G |
6: 141,830,860 (GRCm38) |
|
probably benign |
Het |
| Smg6 |
T |
A |
11: 74,929,058 (GRCm38) |
Y52N |
probably damaging |
Het |
| Sncb |
T |
G |
13: 54,765,587 (GRCm38) |
T33P |
probably damaging |
Het |
| Spef2 |
A |
G |
15: 9,583,984 (GRCm38) |
|
probably null |
Het |
| Sugp1 |
A |
G |
8: 70,059,363 (GRCm38) |
E203G |
probably damaging |
Het |
| Suv39h2 |
A |
T |
2: 3,472,579 (GRCm38) |
C105S |
probably damaging |
Het |
| Tlr1 |
A |
T |
5: 64,926,620 (GRCm38) |
F205I |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,917,873 (GRCm38) |
M496K |
probably damaging |
Het |
| Tnxb |
G |
A |
17: 34,718,245 (GRCm38) |
E2889K |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,365,803 (GRCm38) |
H126L |
possibly damaging |
Het |
| Trpm7 |
A |
T |
2: 126,826,718 (GRCm38) |
Y759* |
probably null |
Het |
| Ttc17 |
A |
G |
2: 94,323,120 (GRCm38) |
I1000T |
possibly damaging |
Het |
| Ttc27 |
A |
T |
17: 74,718,715 (GRCm38) |
N61I |
probably benign |
Het |
| Uba6 |
T |
C |
5: 86,112,750 (GRCm38) |
Y990C |
probably damaging |
Het |
| Vav3 |
A |
G |
3: 109,664,440 (GRCm38) |
|
probably benign |
Het |
| Vmn2r55 |
C |
T |
7: 12,671,018 (GRCm38) |
A153T |
possibly damaging |
Het |
| Wars2 |
A |
G |
3: 99,216,549 (GRCm38) |
D242G |
probably damaging |
Het |
| Xylt2 |
G |
A |
11: 94,669,936 (GRCm38) |
Q259* |
probably null |
Het |
| Zfp27 |
G |
A |
7: 29,894,522 (GRCm38) |
P673S |
probably damaging |
Het |
| Zgrf1 |
T |
C |
3: 127,584,660 (GRCm38) |
I1023T |
possibly damaging |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,616,460 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,647,353 (GRCm38) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,584,163 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,602,877 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,607,440 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,585,760 (GRCm38) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,622,204 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,602,326 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,610,788 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,590,502 (GRCm38) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,648,869 (GRCm38) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,648,786 (GRCm38) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,637,869 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,602,856 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,585,625 (GRCm38) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,587,808 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,602,408 (GRCm38) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,635,748 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,613,667 (GRCm38) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,629,158 (GRCm38) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,589,898 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,587,778 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,607,523 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,588,496 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,602,748 (GRCm38) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,648,843 (GRCm38) |
missense |
unknown |
|
|
R0515:Parp4
|
UTSW |
14 |
56,613,667 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,602,404 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,589,951 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,648,119 (GRCm38) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,647,882 (GRCm38) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,647,882 (GRCm38) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,590,397 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,598,406 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,589,872 (GRCm38) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,602,295 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,602,295 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,590,428 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,624,163 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,627,381 (GRCm38) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,648,132 (GRCm38) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,589,872 (GRCm38) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,648,915 (GRCm38) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,624,017 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,613,724 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,629,096 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,634,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,659,289 (GRCm38) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,613,817 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,613,724 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,595,416 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,587,778 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,620,518 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,624,140 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,592,391 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,607,494 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,629,204 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,652,304 (GRCm38) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,590,410 (GRCm38) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,647,591 (GRCm38) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,610,810 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,585,738 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,589,898 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,635,731 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,624,095 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,647,429 (GRCm38) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,614,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,624,032 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,641,283 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,629,158 (GRCm38) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,607,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,595,399 (GRCm38) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,602,300 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,627,381 (GRCm38) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,620,651 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,647,237 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,647,882 (GRCm38) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,620,490 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,613,739 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,602,404 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,620,592 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,614,759 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,589,973 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,602,799 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,648,876 (GRCm38) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,647,846 (GRCm38) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,647,681 (GRCm38) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,602,395 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,635,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,637,918 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,635,748 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,659,348 (GRCm38) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,595,251 (GRCm38) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,647,246 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,648,729 (GRCm38) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,587,814 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,629,099 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,648,616 (GRCm38) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,616,443 (GRCm38) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,627,470 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,635,817 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,614,767 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,595,333 (GRCm38) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,614,767 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,595,333 (GRCm38) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,641,318 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,629,216 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,595,371 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,648,431 (GRCm38) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,647,349 (GRCm38) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,592,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCAGCTAAGCGAGCCATCTCAAG -3'
(R):5'- ccatatctccagccccAAAGTGAC -3'
Sequencing Primer
(F):5'- gggaagttagaggcagaaaaag -3'
(R):5'- cagccccAAAGTGACTAAGTAAAAG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation