Mutagenetix > Incidental Mutation

Incidental Mutation 'R0511:Prkdc'

46967

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DOXNPH, DNA-PKcs, XRCC7, dxnph, DNA-PK, DNAPDcs

MMRRC Submission

038705-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.941) question?

Stock #

R0511 (G1)

Quality Score

222

Status

Validated

Chromosome

Chromosomal Location

15637866-15842235 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 15831282 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Stop codon at position 3707 (G3707*)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000023352
AA Change: G3707*

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: G3707*

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.8%

Validation Efficiency

100% (116/116)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 118 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009O20Rik	T	C	18: 38,254,071		probably null	Het
A630095E13Rik	A	T	9: 36,638,577		probably null	Het
Abca13	G	T	11: 9,294,559	V2141L	probably benign	Het
Adam17	T	C	12: 21,340,458		probably benign	Het
Adam3	A	T	8: 24,695,315	C456S	probably damaging	Het
AI464131	A	G	4: 41,498,538	F364S	probably damaging	Het
Aldh4a1	G	T	4: 139,642,571		probably benign	Het
Anapc4	A	G	5: 52,842,017		probably benign	Het
Ank3	A	T	10: 69,882,368	Q483L	probably damaging	Het
Ankle2	A	G	5: 110,242,059		probably benign	Het
Ankrd13b	T	A	11: 77,473,288	T150S	possibly damaging	Het
Apeh	A	G	9: 108,087,055	M524T	probably benign	Het
Arl14epl	T	A	18: 46,926,417		probably null	Het
Atg2a	T	C	19: 6,252,539	F964S	possibly damaging	Het
Atg2b	C	T	12: 105,617,153	V2050M	probably damaging	Het
Atp2b4	A	T	1: 133,732,218		probably benign	Het
Bbof1	T	A	12: 84,430,271	S512T	probably benign	Het
BC055324	T	C	1: 163,971,843		probably null	Het
C130079G13Rik	A	G	3: 59,936,350	H155R	possibly damaging	Het
Camta1	C	A	4: 151,075,140	R1614L	probably damaging	Het
Car10	T	C	11: 93,490,582	Y100H	probably damaging	Het
Ccdc81	T	A	7: 89,893,296	E124V	probably damaging	Het
Cd84	A	G	1: 171,872,927	T204A	probably benign	Het
Celf2	A	G	2: 6,604,176	S178P	probably damaging	Het
Chat	G	A	14: 32,409,019	T555M	probably damaging	Het
Chd6	A	G	2: 160,992,191	F917S	probably damaging	Het
Chrna2	C	A	14: 66,149,104	T233N	probably damaging	Het
Cnpy2	T	C	10: 128,326,185	V109A	probably benign	Het
Col4a1	T	C	8: 11,208,333		probably null	Het
Csmd1	C	T	8: 15,932,529	V2713M	possibly damaging	Het
Cuedc1	G	A	11: 88,183,405	R255Q	probably damaging	Het
Cxcl15	A	T	5: 90,798,038		probably benign	Het
Dach1	A	T	14: 97,901,329	H559Q	possibly damaging	Het
Dennd4c	C	T	4: 86,826,022	T1367M	probably damaging	Het
Depdc5	T	A	5: 32,945,028	Y365*	probably null	Het
Dicer1	T	C	12: 104,702,841	Y1194C	possibly damaging	Het
Dmxl1	C	G	18: 49,891,467	S1736*	probably null	Het
Dnah7a	C	T	1: 53,497,126	R2586K	probably benign	Het
Dnajb8	T	C	6: 88,222,485	M1T	probably null	Het
Dync2h1	G	A	9: 7,122,692	P2088L	probably benign	Het
Eftud2	T	G	11: 102,844,222	H617P	probably damaging	Het
Ephb1	A	G	9: 101,995,980		probably benign	Het
Fam184a	G	T	10: 53,698,879	H155Q	probably benign	Het
Ganc	G	T	2: 120,448,401	E700*	probably null	Het
Gm10912	A	G	2: 104,066,945		probably benign	Het
Gm9047	G	T	6: 29,478,170		probably benign	Het
Haus5	A	T	7: 30,659,067	I294N	probably damaging	Het
Hmgcr	G	T	13: 96,660,143		probably null	Het
Hr	T	A	14: 70,561,912	C641*	probably null	Het
Itga10	A	G	3: 96,658,174	N1038S	probably damaging	Het
Itgb1bp1	T	G	12: 21,271,435	Y172S	probably damaging	Het
Kprp	T	C	3: 92,824,723	N340S	probably damaging	Het
Kremen1	A	G	11: 5,215,447	I41T	probably damaging	Het
Krt6b	A	G	15: 101,677,607		probably benign	Het
Krt81	C	A	15: 101,463,627	R24L	possibly damaging	Het
Ldhd	A	G	8: 111,629,677	Y86H	probably benign	Het
Lilra6	A	T	7: 3,912,785	I76N	possibly damaging	Het
Mak	T	C	13: 41,046,267	T299A	probably benign	Het
Med25	A	G	7: 44,885,078		probably null	Het
Mpg	A	T	11: 32,230,039	N189I	probably damaging	Het
Mroh8	A	G	2: 157,229,918	Y556H	probably damaging	Het
Myh8	T	A	11: 67,284,507	S294T	probably benign	Het
Myom1	T	A	17: 71,084,317	D842E	probably benign	Het
Nat2	C	T	8: 67,501,330	Q31*	probably null	Het
Nf1	T	A	11: 79,438,769	M653K	probably benign	Het
Nhs	C	A	X: 161,837,359	R1467I	probably damaging	Het
Npr2	A	G	4: 43,632,801	E206G	probably benign	Het
Nsd3	G	A	8: 25,678,716	G629D	possibly damaging	Het
Nwd1	G	A	8: 72,682,005	C831Y	probably damaging	Het
Olfr1094	A	G	2: 86,829,606	I285V	probably benign	Het
Olfr584	T	C	7: 103,085,851	I111T	probably damaging	Het
P2ry14	A	G	3: 59,116,028	S4P	possibly damaging	Het
Parp4	A	G	14: 56,635,715		probably benign	Het
Pclo	A	G	5: 14,678,285		probably benign	Het
Pclo	T	C	5: 14,679,398		probably benign	Het
Pcnt	A	T	10: 76,404,595	S1202T	possibly damaging	Het
Pfkfb4	A	G	9: 109,027,757	Y412C	probably damaging	Het
Pgm1	T	A	5: 64,110,555	V449D	probably damaging	Het
Poldip3	T	A	15: 83,138,235	D116V	probably damaging	Het
Pom121	G	T	5: 135,381,832	Q824K	unknown	Het
Prr14l	T	C	5: 32,844,216		probably benign	Het
Ptbp2	T	G	3: 119,720,964	I405L	probably benign	Het
Rad21l	A	T	2: 151,649,069		probably benign	Het
Rbm6	G	A	9: 107,847,289	Q488*	probably null	Het
Rdh1	T	A	10: 127,764,783	M225K	probably benign	Het
Recql5	T	C	11: 115,928,383	D119G	probably benign	Het
Rif1	GCCACCA	GCCA	2: 52,110,324		probably benign	Het
Robo1	T	C	16: 73,013,125		probably null	Het
Samd12	G	A	15: 53,860,171	T42I	probably benign	Het
Scn10a	A	T	9: 119,613,700	M1494K	probably damaging	Het
Sec31a	G	A	5: 100,375,240	P864L	probably benign	Het
Senp2	T	C	16: 22,036,570	V344A	probably benign	Het
Serpina5	G	A	12: 104,103,362	D278N	probably benign	Het
Sh3tc1	A	T	5: 35,703,462	V1017D	probably damaging	Het
Sin3a	T	A	9: 57,096,895	Y310*	probably null	Het
Slc25a32	T	C	15: 39,097,545	T248A	probably benign	Het
Slc35e1	T	C	8: 72,492,571		probably benign	Het
Slc4a10	G	A	2: 62,286,862	V722M	probably damaging	Het
Slco1a4	A	G	6: 141,830,860		probably benign	Het
Smg6	T	A	11: 74,929,058	Y52N	probably damaging	Het
Sncb	T	G	13: 54,765,587	T33P	probably damaging	Het
Spef2	A	G	15: 9,583,984		probably null	Het
Sugp1	A	G	8: 70,059,363	E203G	probably damaging	Het
Suv39h2	A	T	2: 3,472,579	C105S	probably damaging	Het
Tlr1	A	T	5: 64,926,620	F205I	probably damaging	Het
Tnip1	A	T	11: 54,917,873	M496K	probably damaging	Het
Tnxb	G	A	17: 34,718,245	E2889K	probably damaging	Het
Trim30b	T	A	7: 104,365,803	H126L	possibly damaging	Het
Trpm7	A	T	2: 126,826,718	Y759*	probably null	Het
Ttc17	A	G	2: 94,323,120	I1000T	possibly damaging	Het
Ttc27	A	T	17: 74,718,715	N61I	probably benign	Het
Uba6	T	C	5: 86,112,750	Y990C	probably damaging	Het
Vav3	A	G	3: 109,664,440		probably benign	Het
Vmn2r55	C	T	7: 12,671,018	A153T	possibly damaging	Het
Wars2	A	G	3: 99,216,549	D242G	probably damaging	Het
Xylt2	G	A	11: 94,669,936	Q259*	probably null	Het
Zfp27	G	A	7: 29,894,522	P673S	probably damaging	Het
Zgrf1	T	C	3: 127,584,660	I1023T	possibly damaging	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15697226	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15809644	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15790466	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15775847	splice site	probably null
IGL00489:Prkdc	APN	16	15799926	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15664239	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15652358	splice site	probably benign
IGL00666:Prkdc	APN	16	15736835	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15787158	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15779426	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15816639	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15759754	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15739564	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15702115	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15669321	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15726704	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15667731	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15829692	missense	probably benign
IGL01335:Prkdc	APN	16	15816896	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15835166	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15713587	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15652302	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15667745	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15783087	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15734994	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15698887	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15708779	missense	probably benign
IGL02121:Prkdc	APN	16	15717184	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15669285	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15809759	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15785978	missense	possibly damaging	0.47
IGL02336:Prkdc	APN	16	15785979	missense	probably benign	0.01
IGL02393:Prkdc	APN	16	15816758	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15670535	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15714282	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15726542	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15670601	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15783087	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15769825	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15836043	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15752726	splice site	probably benign
IGL02803:Prkdc	APN	16	15833666	splice site	probably benign
IGL02866:Prkdc	APN	16	15831327	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15651519	nonsense	probably null
IGL02989:Prkdc	APN	16	15800016	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15834166	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15799984	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15705310	splice site	probably benign
IGL03100:Prkdc	APN	16	15713635	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15700744	splice site	probably benign
IGL03168:Prkdc	APN	16	15834166	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15769801	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15670626	nonsense	probably null
anhimid	UTSW	16	15725461	critical splice donor site	probably null
anhinga	UTSW	16	15708932	critical splice donor site	probably null
Bushtit	UTSW	16	15752764	missense	probably damaging	0.97
clover	UTSW	16	15702156	splice site	probably benign
crackle	UTSW	16	15786050	critical splice donor site	probably null
Daffy	UTSW	16	15829697	missense	possibly damaging	0.86
darter	UTSW	16	15773613	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15808058	missense	probably benign	0.01
envenomation	UTSW	16	15835227	nonsense	probably null
hobgoblin	UTSW	16	15815986	missense	probably damaging	1.00
Incubus	UTSW	16	15672327	missense	probably damaging	1.00
liming	UTSW	16	15752829	nonsense	probably null
newt	UTSW	16	15727726	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15816659	critical splice donor site	probably null
primitive	UTSW	16	15835158	frame shift	probably null
roadrunner	UTSW	16	15833887	missense	probably damaging	1.00
Schreier	UTSW	16	15670528	missense	probably benign	0.00
screamer	UTSW	16	15831282	nonsense	probably null
Screamer10	UTSW	16	15768025	missense	probably damaging	0.98
screamer2	UTSW	16	15652552	critical splice donor site	probably null
screamer3	UTSW	16	15740332	critical splice donor site	probably null
screamer4	UTSW	16	15783079	missense	probably benign	0.00
screamer5	UTSW	16	15687404	missense	probably benign
screamer6	UTSW	16	15759605	missense	probably damaging	1.00
screamer7	UTSW	16	15654817	splice site	probably null
Screamer8	UTSW	16	15719433	missense	probably benign	0.00
Screamer9	UTSW	16	15734922	missense	probably benign	0.01
Tweetie	UTSW	16	15717801	missense	probably damaging	1.00
updock	UTSW	16	15795094	missense	probably benign
ANU23:Prkdc	UTSW	16	15667731	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15708701	splice site	probably benign
R0018:Prkdc	UTSW	16	15726542	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15726542	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15726504	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15699007	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15713653	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15740332	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15736799	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15791927	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15833740	missense	probably damaging	0.97
R0538:Prkdc	UTSW	16	15833788	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15808088	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15772057	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15690407	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15810801	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15768637	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15785971	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15829716	missense	probably benign
R1027:Prkdc	UTSW	16	15650712	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15654749	splice site	probably benign
R1033:Prkdc	UTSW	16	15767951	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15752782	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15783079	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15759746	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15673997	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15690282	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15759723	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15664227	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15667700	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15731566	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15687404	missense	probably benign
R1531:Prkdc	UTSW	16	15772106	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15675328	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15734058	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15676989	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15795094	missense	probably benign
R1762:Prkdc	UTSW	16	15637961	missense	probably benign
R1789:Prkdc	UTSW	16	15739524	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15759605	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15808058	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15829635	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15725436	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15714215	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15714266	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15654817	splice site	probably null
R1939:Prkdc	UTSW	16	15835913	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15677009	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15687352	splice site	probably benign
R2056:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15727605	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15715963	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15687390	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15719433	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15705207	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15734922	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15698824	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15654817	splice site	probably null
R2271:Prkdc	UTSW	16	15654817	splice site	probably null
R2272:Prkdc	UTSW	16	15654817	splice site	probably null
R2356:Prkdc	UTSW	16	15684204	missense	probably benign
R2852:Prkdc	UTSW	16	15652552	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15664358	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15664358	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15768025	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15799967	missense	probably benign
R3834:Prkdc	UTSW	16	15791946	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15791946	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15829611	splice site	probably null
R4151:Prkdc	UTSW	16	15816773	missense	probably benign
R4233:Prkdc	UTSW	16	15835919	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15806099	splice site	probably null
R4296:Prkdc	UTSW	16	15737905	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15768022	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15773739	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15836082	missense	probably damaging	1.00
R4497:Prkdc	UTSW	16	15700653	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15736870	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15767966	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15810824	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15663074	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15816774	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15734052	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15772030	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15702112	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15810837	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15667715	missense	probably benign
R4785:Prkdc	UTSW	16	15648976	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15650712	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15702075	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15678309	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15673997	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15838018	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15772048	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15790580	missense	probably benign
R5151:Prkdc	UTSW	16	15716035	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15678272	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15772121	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15734955	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15714974	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15831312	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15805950	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15795097	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15769875	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15768637	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15678308	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15651469	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15706791	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15809612	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15829769	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15810770	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15664233	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15779388	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15717801	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15816752	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15737834	nonsense	probably null
R5826:Prkdc	UTSW	16	15734098	missense	probably benign
R5883:Prkdc	UTSW	16	15715914	missense	probably benign
R5895:Prkdc	UTSW	16	15752829	nonsense	probably null
R5998:Prkdc	UTSW	16	15783157	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15829697	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15739471	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15772073	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15790592	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15787155	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15714919	missense	probably benign
R6376:Prkdc	UTSW	16	15769885	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15698815	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15717801	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15795075	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15752764	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15786050	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15670528	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15725461	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15651538	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15777072	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15783263	critical splice donor site	probably null
R6882:Prkdc	UTSW	16	15808156	missense	probably benign	0.33
R6949:Prkdc	UTSW	16	15799989	missense	probably benign
R6950:Prkdc	UTSW	16	15815986	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15769966	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15790453	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15689343	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15698803	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15714263	missense	probably benign
R7283:Prkdc	UTSW	16	15717764	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15648738	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15672327	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15737943	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15831319	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15806096	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15689277	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15715006	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15708903	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15779451	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15816885	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15664244	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15705253	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15836082	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15714141	splice site	probably benign
R8401:Prkdc	UTSW	16	15773613	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15835158	frame shift	probably null
R8458:Prkdc	UTSW	16	15790676	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15651536	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15648924	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15664368	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15663035	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15708932	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15808204	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15783165	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15727659	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15727726	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15673760	intron	probably benign
R8971:Prkdc	UTSW	16	15675365	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15799862	splice site	probably null
R9052:Prkdc	UTSW	16	15690296	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15835227	nonsense	probably null
R9200:Prkdc	UTSW	16	15705289	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15833887	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15816659	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15708928	nonsense	probably null
R9386:Prkdc	UTSW	16	15678272	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15667601	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15839215	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15730470	missense	possibly damaging	0.96
R9608:Prkdc	UTSW	16	15730471	missense	probably damaging	1.00
R9636:Prkdc	UTSW	16	15730477	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15799954	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15715955	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15839180	nonsense	probably null
X0023:Prkdc	UTSW	16	15740278	missense	probably benign
Z1176:Prkdc	UTSW	16	15687422	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGCACTCTCATCTTTATTGACAGC -3'
(R):5'- GGGAACAAAATGCTAGTGGAATG -3'

Sequencing Primer
(F):5'- CAGGGAAGAAAAGCTGTTTC -3'
(R):5'- GACAAATACAACTTACCCGC -3'

Posted On

2013-06-11