Mutagenetix > Incidental Mutation

Incidental Mutation 'R4732:Lrp2'

470456

Institutional Source

Beutler Lab

Gene Symbol

Lrp2

Ensembl Gene

ENSMUSG00000027070

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

Gp330, D230004K18Rik, b2b1625.2Clo, Megalin

MMRRC Submission

042022-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4732 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

69424340-69586065 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69533555 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 313 (I313V)

Ref Sequence

ENSEMBL: ENSMUSP00000097628 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080953] [ENSMUST00000092551] [ENSMUST00000100051]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000080953
AA Change: I313V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000079752
Gene: ENSMUSG00000027070
AA Change: I313V

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	4.69e-10	SMART
EGF	1353	1390	9.7e-4	SMART
EGF_CA	1391	1430	6.54e-10	SMART
LY	1457	1501	1.43e-1	SMART
LY	1502	1544	2e-14	SMART
LY	1545	1590	3.03e-14	SMART
LY	1591	1633	5.48e-12	SMART
LY	1635	1677	1.18e-2	SMART
EGF	1704	1742	5.2e-4	SMART
LY	1771	1812	1.68e1	SMART
LY	1813	1856	1.91e-2	SMART
LY	1859	1911	1.88e-10	SMART
LY	1912	1954	7.69e-7	SMART
LY	1955	1994	3e1	SMART
EGF	2022	2060	1.18e-2	SMART
LY	2088	2135	1.14e1	SMART
LY	2136	2182	2.11e-4	SMART
LY	2183	2226	2.22e-12	SMART
LY	2227	2269	1.24e-10	SMART
EGF	2346	2384	2.07e1	SMART
LY	2459	2501	9.91e-10	SMART
LY	2503	2543	1.48e-8	SMART
LY	2544	2586	6.85e-13	SMART
LY	2587	2627	8.13e-1	SMART
EGF_like	2655	2694	3.5e1	SMART
LDLa	2700	2739	2.86e-14	SMART
LDLa	2741	2778	8.09e-14	SMART
LDLa	2780	2820	3.19e-12	SMART
LDLa	2822	2862	6.94e-13	SMART
LDLa	2864	2903	9.29e-14	SMART
LDLa	2907	2947	4.79e-16	SMART
LDLa	2949	2992	8.41e-12	SMART
LDLa	2994	3031	1.08e-14	SMART
LDLa	3033	3072	1.83e-12	SMART
LDLa	3076	3113	1.16e-14	SMART
EGF	3115	3153	8.57e-5	SMART
EGF_CA	3154	3194	3.56e-11	SMART
LY	3221	3263	9.77e-9	SMART
LY	3264	3306	1.22e-9	SMART
LY	3312	3358	5.44e-7	SMART
LY	3359	3401	1.83e-13	SMART
LY	3402	3443	1.41e-5	SMART
EGF	3470	3511	8.91e-3	SMART
LDLa	3513	3552	1.79e-15	SMART
LDLa	3554	3593	9.89e-9	SMART
LDLa	3595	3634	3.07e-14	SMART
LDLa	3636	3675	3.34e-15	SMART
LDLa	3679	3718	1.39e-12	SMART
LDLa	3720	3758	3.83e-15	SMART
LDLa	3760	3797	7.15e-15	SMART
LDLa	3799	3836	2.86e-14	SMART
LDLa	3843	3882	2.38e-11	SMART
LDLa	3884	3924	3.66e-12	SMART
LDLa	3929	3966	1.93e-11	SMART
EGF	3971	4008	6.3e-3	SMART
EGF_CA	4009	4050	1.36e-7	SMART
low complexity region	4072	4084	N/A	INTRINSIC
LY	4136	4178	6.2e-11	SMART
LY	4179	4222	4.32e-10	SMART
LY	4223	4266	3.78e-15	SMART
LY	4267	4306	4.53e1	SMART
EGF	4335	4367	3.46e0	SMART
EGF	4368	4413	1.53e-1	SMART
transmembrane domain	4425	4447	N/A	INTRINSIC
low complexity region	4454	4472	N/A	INTRINSIC
low complexity region	4616	4636	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000092551
AA Change: I313V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000090212
Gene: ENSMUSG00000027070
AA Change: I313V

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000100051
AA Change: I313V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097628
Gene: ENSMUSG00000027070
AA Change: I313V

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	6.18e-10	SMART

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.2%
20x: 95.1%

Validation Efficiency

99% (110/111)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 192 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700128F08Rik	T	A	9: 8,222,173		noncoding transcript	Het
3110035E14Rik	T	C	1: 9,606,976	S24P	probably benign	Het
4933409G03Rik	A	G	2: 68,614,721		probably benign	Het
Acan	T	C	7: 79,098,609	S1043P	probably damaging	Het
Ackr2	A	G	9: 121,909,183	Y208C	probably damaging	Het
Actg1	C	T	11: 120,347,479		probably benign	Het
Adam1a	T	A	5: 121,519,434	T599S	probably benign	Het
Adamts12	A	T	15: 11,270,662	S668C	probably damaging	Het
Adcy8	A	G	15: 64,754,862	V709A	possibly damaging	Het
Adgrf2	A	C	17: 42,710,754	I393S	probably damaging	Het
Ahnak	G	T	19: 9,007,301	G1983V	probably damaging	Het
AI413582	A	G	17: 27,565,270		probably benign	Het
Aim2	T	A	1: 173,463,876	D282E	possibly damaging	Het
Ak8	A	G	2: 28,760,071	Y370C	probably damaging	Het
Akap9	A	G	5: 4,013,901	D1750G	probably damaging	Het
Als2cl	T	A	9: 110,889,136	V315E	probably damaging	Het
Ankrd28	A	C	14: 31,755,741	C115G	probably benign	Het
Ap3b2	C	T	7: 81,471,932	A519T	probably damaging	Het
Apool	C	T	X: 112,372,200	T166I	probably damaging	Het
Arhgef2	A	T	3: 88,631,940	K65*	probably null	Het
Arhgef38	G	T	3: 133,132,269	Y633*	probably null	Het
Asah2	T	C	19: 31,995,358	N659S	probably benign	Het
Atf7ip2	A	G	16: 10,241,886	D430G	possibly damaging	Het
Atp8a1	G	A	5: 67,813,120	S92L	probably benign	Het
Bag4	C	T	8: 25,769,488	A228T	probably benign	Het
BC024978	T	A	7: 27,201,043	M149K	probably damaging	Het
C130073F10Rik	C	A	4: 101,890,710	S89I	probably benign	Het
Cacna1g	T	C	11: 94,443,215	T867A	probably damaging	Het
Ccdc88a	T	G	11: 29,485,906	N1276K	probably benign	Het
Cdc42bpg	T	A	19: 6,311,191	V282E	probably damaging	Het
Cdipt	T	A	7: 126,978,358	L92H	probably damaging	Het
Celsr2	T	A	3: 108,398,952	D2012V	probably damaging	Het
Cenpt	A	G	8: 105,847,136	V254A	probably benign	Het
Cep104	T	A	4: 153,988,426	D380E	probably damaging	Het
Cers5	C	T	15: 99,741,637	R123Q	probably benign	Het
Ces2h	A	G	8: 105,014,604	E76G	probably damaging	Het
Cfap77	T	A	2: 28,984,388	E143D	probably benign	Het
Chmp7	C	A	14: 69,732,296	R65L	probably damaging	Het
Cldnd2	T	A	7: 43,442,189	C65S	possibly damaging	Het
Clec2g	C	A	6: 128,981,879	Y142*	probably null	Het
Coch	A	T	12: 51,605,019	E549V	probably benign	Het
Cog7	T	C	7: 121,964,244	D215G	probably benign	Het
Col4a2	T	C	8: 11,414,779	V348A	probably benign	Het
Col4a2	A	G	8: 11,446,197	H1606R	probably benign	Het
Cpd	T	C	11: 76,811,794	N583D	probably damaging	Het
Cyp2d11	T	A	15: 82,389,227	Y481F	probably benign	Het
D130043K22Rik	T	C	13: 24,899,665	S1038P	probably damaging	Het
Deptor	C	A	15: 55,181,010	H191N	probably benign	Het
Dgkz	A	T	2: 91,938,339	I699N	probably damaging	Het
Dnah12	C	T	14: 26,781,784	T1653I	probably damaging	Het
Dnah7c	T	A	1: 46,770,173	N3550K	probably damaging	Het
Dnah8	A	G	17: 30,775,061	K3384R	probably null	Het
Dnajc11	A	G	4: 151,970,967		probably benign	Het
Dnajc13	CT	C	9: 104,186,805		probably benign	Het
Dnhd1	C	A	7: 105,673,849	N521K	probably benign	Het
Drg2	T	C	11: 60,461,396		probably null	Het
Dync1h1	C	T	12: 110,649,507	Q3030*	probably null	Het
Efhb	G	A	17: 53,426,244	T533I	probably damaging	Het
Eif2d	T	C	1: 131,164,727	V374A	probably damaging	Het
Etfb	T	C	7: 43,444,200	V17A	probably damaging	Het
F5	C	T	1: 164,181,657	T332M	probably damaging	Het
Fcho1	T	C	8: 71,716,795	T156A	probably benign	Het
Fn1	A	T	1: 71,602,512		probably null	Het
Fnip2	A	T	3: 79,481,652	S561T	probably damaging	Het
Frs2	T	A	10: 117,074,093	T455S	probably benign	Het
Fry	G	A	5: 150,386,007	E639K		Het
Fto	T	A	8: 91,409,714	D205E	probably damaging	Het
Galntl6	G	A	8: 58,427,813	P147L	probably damaging	Het
Gigyf1	T	A	5: 137,524,770	D844E	probably benign	Het
Gle1	T	C	2: 29,940,232	S267P	probably damaging	Het
Glg1	G	A	8: 111,187,755	R466W	probably damaging	Het
Gm10277	T	C	11: 77,786,097		probably benign	Het
Gm20388	A	G	8: 122,270,274		probably benign	Het
Gm5724	A	T	6: 141,723,179	M509K	probably benign	Het
Gm6871	T	C	7: 41,546,749	I39V	probably benign	Het
Gm9970	A	G	5: 31,241,066		probably benign	Het
Gpr35	T	G	1: 92,983,385	I57S	probably damaging	Het
Gprin1	C	T	13: 54,739,957	G168E	possibly damaging	Het
Gtdc1	A	G	2: 44,789,055		probably benign	Het
Gtf3c2	G	T	5: 31,160,057	P586T	probably damaging	Het
Gucy1a2	A	T	9: 3,759,424	H410L	probably benign	Het
Gucy2c	A	G	6: 136,767,152	S150P	probably damaging	Het
Ifi214	T	C	1: 173,526,591	Q171R	probably benign	Het
Ifit1bl1	T	C	19: 34,594,321	I245M	probably benign	Het
Igkv4-50	T	C	6: 69,701,000	K40R	probably benign	Het
Igkv8-18	T	A	6: 70,356,296	I74N	probably damaging	Het
Il2ra	T	A	2: 11,676,920	M112K	probably benign	Het
Itpr2	A	G	6: 146,373,173	F837S	probably damaging	Het
Kbtbd7	T	C	14: 79,428,800	*691Q	probably null	Het
Kcnn2	T	A	18: 45,560,349	S331T	possibly damaging	Het
Khnyn	T	A	14: 55,886,489		probably null	Het
Kif26a	G	A	12: 112,175,573	A754T	probably benign	Het
Klra3	T	A	6: 130,327,132	Y199F	possibly damaging	Het
Lhx2	A	G	2: 38,359,991	K274R	probably damaging	Het
Lrrfip1	A	T	1: 91,115,647	E591D	probably benign	Het
Lrrk2	A	C	15: 91,688,849	E200A	probably damaging	Het
Lrrk2	G	A	15: 91,765,747	E1696K	probably damaging	Het
Mast4	A	T	13: 102,772,572	M465K	probably damaging	Het
Moxd2	T	G	6: 40,878,859	I599L	probably benign	Het
Mug2	T	C	6: 122,071,872	S866P	probably damaging	Het
Ncam2	A	G	16: 81,434,884	T79A	possibly damaging	Het
Ncoa6	C	A	2: 155,421,301	Q404H	probably damaging	Het
Neb	A	G	2: 52,279,079	Y1815H	probably damaging	Het
Nell1	A	G	7: 50,856,217	D724G	probably damaging	Het
Nkx3-2	A	G	5: 41,762,144	V167A	probably benign	Het
Nsun3	C	A	16: 62,735,119	C348F	possibly damaging	Het
Obox6	A	T	7: 15,834,772	S60T	possibly damaging	Het
Olfr1	T	C	11: 73,395,695	D109G	probably benign	Het
Olfr1378	G	A	11: 50,969,266	V83M	possibly damaging	Het
Olfr138	T	A	17: 38,275,547	Y259N	probably damaging	Het
Olfr466	T	C	13: 65,152,653	V143A	possibly damaging	Het
Olfr744	T	A	14: 50,618,569	C116S	probably benign	Het
Olfr94	T	C	17: 37,197,024	T315A	probably damaging	Het
Olfr980	A	T	9: 40,006,268	I227N	probably damaging	Het
Oog2	T	A	4: 144,193,941		probably benign	Het
Pabpc1	A	T	15: 36,599,284	V389E	probably benign	Het
Pank4	A	T	4: 154,971,390	M291L	probably benign	Het
Pcf11	T	C	7: 92,658,833	D709G	probably benign	Het
Pcgf1	T	A	6: 83,079,957		probably benign	Het
Pcnx	A	G	12: 81,995,751	I2256V	probably benign	Het
Pex6	A	G	17: 46,722,288	D579G	probably benign	Het
Pex6	A	G	17: 46,724,707		probably null	Het
Piezo2	C	T	18: 63,030,401	A2149T	probably damaging	Het
Pik3c2g	A	G	6: 139,935,985	E781G	probably benign	Het
Pik3r4	G	A	9: 105,678,176	V1111I	possibly damaging	Het
Pkd1l2	T	A	8: 116,995,842		probably null	Het
Plekhg1	T	A	10: 3,957,506	S808T	probably benign	Het
Pnkp	T	A	7: 44,860,454		probably benign	Het
Polr3c	A	T	3: 96,723,661	F148I	probably damaging	Het
Ppard	A	T	17: 28,286,443	T35S	probably benign	Het
Ptov1	T	C	7: 44,867,109	D134G	probably benign	Het
Ptprz1	T	A	6: 23,002,610	S1566R	probably benign	Het
Pum1	T	C	4: 130,718,193	S158P	probably benign	Het
Qk	T	C	17: 10,216,288	H269R	probably damaging	Het
Qrsl1	T	C	10: 43,876,663	Y388C	probably damaging	Het
Rapgef1	T	G	2: 29,689,160	I182S	probably damaging	Het
Ret	T	C	6: 118,163,193	S1013G	possibly damaging	Het
Rimbp3	A	G	16: 17,210,601	R630G	possibly damaging	Het
Rnmt	A	T	18: 68,317,960		probably benign	Het
Ryr2	A	T	13: 11,577,909	M4653K	possibly damaging	Het
Sacm1l	G	A	9: 123,590,830	V553I	probably benign	Het
Sec31b	A	T	19: 44,532,677	S110T	probably damaging	Het
Serpina3k	G	A	12: 104,340,860	G117D	probably damaging	Het
Sesn2	T	C	4: 132,494,591	Y410C	probably damaging	Het
Slc24a1	G	A	9: 64,949,554	R24C	probably benign	Het
Slc35g2	A	C	9: 100,552,502	V372G	probably benign	Het
Slc7a7	T	C	14: 54,408,733	Y91C	probably damaging	Het
Slc7a9	T	A	7: 35,453,563	Y135*	probably null	Het
Slco4a1	A	G	2: 180,473,615	N662D	probably damaging	Het
Slfn4	T	A	11: 83,189,282		probably benign	Het
Slmap	T	C	14: 26,468,535	N156S	probably damaging	Het
Snx18	A	G	13: 113,617,774	S208P	probably benign	Het
Sorbs1	T	A	19: 40,314,689	R485S	probably benign	Het
Spib	A	G	7: 44,528,885	S154P	probably damaging	Het
Spty2d1	T	C	7: 46,996,110	D595G	probably damaging	Het
St7	T	A	6: 17,906,516		probably null	Het
Susd1	T	C	4: 59,428,029	T52A	possibly damaging	Het
Svs2	T	A	2: 164,237,123	D288V	possibly damaging	Het
Syt7	T	A	19: 10,442,924	I355N	probably damaging	Het
Tarm1	G	A	7: 3,496,900	Q145*	probably null	Het
Teddm2	T	A	1: 153,850,741	E76V	probably damaging	Het
Thsd7b	T	C	1: 129,613,186	S343P	probably damaging	Het
Tigd2	T	A	6: 59,211,415	H422Q	probably benign	Het
Tle1	T	C	4: 72,125,019	N538D	possibly damaging	Het
Tmc2	A	G	2: 130,261,397		probably null	Het
Tmtc1	A	C	6: 148,284,980		probably null	Het
Tns3	C	T	11: 8,450,986	R1104H	probably benign	Het
Trim6	T	C	7: 104,232,648	Y369H	probably damaging	Het
Triobp	G	A	15: 78,967,113	R489K	probably damaging	Het
Trpv4	T	C	5: 114,622,753	D732G	possibly damaging	Het
Trrap	G	A	5: 144,816,570	V1883I	probably damaging	Het
Tsc2	C	A	17: 24,603,275	V1141F	possibly damaging	Het
Ttn	A	T	2: 76,943,011	M2395K	unknown	Het
Ttn	A	G	2: 76,899,827		probably benign	Het
Tyrp1	A	T	4: 80,844,935	D353V	possibly damaging	Het
Ubd	A	C	17: 37,195,702	T160P	probably benign	Het
Ugt2b36	G	T	5: 87,081,538	Y156*	probably null	Het
Ulk4	G	A	9: 121,263,638	R178*	probably null	Het
Unc13d	A	G	11: 116,073,582	V312A	possibly damaging	Het
Urb2	G	T	8: 124,028,897	A448S	probably damaging	Het
Urod	G	A	4: 116,991,673	A92V	possibly damaging	Het
Vmn1r33	T	A	6: 66,611,819	R250S	probably benign	Het
Vmn1r87	A	T	7: 13,132,327	M11K	possibly damaging	Het
Vmn2r77	C	T	7: 86,800,987	T147I	probably benign	Het
Vstm4	A	G	14: 32,917,902	K96E	possibly damaging	Het
Washc4	A	T	10: 83,574,479	M644L	probably benign	Het
Wwp1	T	C	4: 19,661,990	D172G	probably benign	Het
Zbtb38	A	T	9: 96,687,684	V449E	probably damaging	Het
Zfhx4	T	C	3: 5,214,807		probably benign	Het
Zfp229	C	T	17: 21,745,286	H166Y	possibly damaging	Het
Zfp512b	A	G	2: 181,588,739	S453P	probably benign	Het
Zp2	C	A	7: 120,138,120	V282L	probably damaging	Het

Other mutations in Lrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Lrp2	APN	2	69507779	missense	probably damaging	1.00
IGL00594:Lrp2	APN	2	69486280	missense	probably benign	0.00
IGL00782:Lrp2	APN	2	69501645	missense	probably benign	0.14
IGL00821:Lrp2	APN	2	69459516	missense	probably damaging	1.00
IGL00897:Lrp2	APN	2	69521881	missense	possibly damaging	0.86
IGL01065:Lrp2	APN	2	69469436	missense	possibly damaging	0.94
IGL01087:Lrp2	APN	2	69524073	missense	probably damaging	1.00
IGL01095:Lrp2	APN	2	69492432	nonsense	probably null
IGL01131:Lrp2	APN	2	69499239	missense	probably damaging	1.00
IGL01350:Lrp2	APN	2	69510984	missense	probably damaging	0.96
IGL01352:Lrp2	APN	2	69503526	missense	possibly damaging	0.77
IGL01358:Lrp2	APN	2	69552470	splice site	probably benign
IGL01375:Lrp2	APN	2	69478566	splice site	probably benign
IGL01384:Lrp2	APN	2	69483502	missense	probably damaging	1.00
IGL01384:Lrp2	APN	2	69453812	missense	probably null	1.00
IGL01411:Lrp2	APN	2	69482267	missense	probably damaging	1.00
IGL01418:Lrp2	APN	2	69525286	missense	probably benign
IGL01444:Lrp2	APN	2	69443716	missense	possibly damaging	0.94
IGL01464:Lrp2	APN	2	69472439	missense	probably damaging	0.98
IGL01528:Lrp2	APN	2	69492460	missense	probably damaging	1.00
IGL01663:Lrp2	APN	2	69428706	missense	probably benign
IGL01761:Lrp2	APN	2	69481235	missense	possibly damaging	0.85
IGL01780:Lrp2	APN	2	69486184	missense	possibly damaging	0.66
IGL01994:Lrp2	APN	2	69483601	missense	probably benign	0.08
IGL02015:Lrp2	APN	2	69527578	missense	probably benign	0.00
IGL02104:Lrp2	APN	2	69510418	missense	probably damaging	1.00
IGL02132:Lrp2	APN	2	69537616	missense	probably benign	0.01
IGL02134:Lrp2	APN	2	69513379	critical splice acceptor site	probably null
IGL02197:Lrp2	APN	2	69466880	missense	probably benign	0.01
IGL02212:Lrp2	APN	2	69451264	missense	probably benign	0.00
IGL02240:Lrp2	APN	2	69535046	missense	probably benign
IGL02248:Lrp2	APN	2	69482808	missense	probably damaging	1.00
IGL02369:Lrp2	APN	2	69464636	missense	probably damaging	1.00
IGL02416:Lrp2	APN	2	69469633	missense	probably damaging	1.00
IGL02417:Lrp2	APN	2	69461305	missense	probably damaging	1.00
IGL02458:Lrp2	APN	2	69521773	missense	probably damaging	0.97
IGL02479:Lrp2	APN	2	69464801	splice site	probably benign
IGL02508:Lrp2	APN	2	69503430	missense	probably benign	0.04
IGL02751:Lrp2	APN	2	69533462	missense	possibly damaging	0.56
IGL02814:Lrp2	APN	2	69506736	missense	probably damaging	1.00
IGL02867:Lrp2	APN	2	69552450	missense	possibly damaging	0.67
IGL02889:Lrp2	APN	2	69552450	missense	possibly damaging	0.67
IGL02943:Lrp2	APN	2	69455510	missense	possibly damaging	0.86
IGL02948:Lrp2	APN	2	69487837	missense	probably damaging	1.00
IGL02960:Lrp2	APN	2	69455453	splice site	probably benign
IGL02990:Lrp2	APN	2	69441396	missense	possibly damaging	0.56
IGL03027:Lrp2	APN	2	69537553	missense	probably benign	0.43
IGL03038:Lrp2	APN	2	69475464	missense	probably damaging	0.99
IGL03064:Lrp2	APN	2	69483133	missense	probably damaging	0.98
IGL03107:Lrp2	APN	2	69454833	missense	probably damaging	1.00
IGL03141:Lrp2	APN	2	69477026	missense	probably damaging	0.99
IGL03154:Lrp2	APN	2	69549042	missense	probably damaging	1.00
IGL03155:Lrp2	APN	2	69455452	splice site	probably benign
IGL03163:Lrp2	APN	2	69501526	nonsense	probably null
IGL03164:Lrp2	APN	2	69464699	missense	probably damaging	1.00
IGL03169:Lrp2	APN	2	69523194	missense	probably damaging	1.00
IGL03174:Lrp2	APN	2	69466265	missense	probably damaging	1.00
IGL03189:Lrp2	APN	2	69438478	splice site	probably benign
IGL03288:Lrp2	APN	2	69426039	missense	probably benign	0.02
IGL03350:Lrp2	APN	2	69438453	missense	probably damaging	1.00
IGL03378:Lrp2	APN	2	69431152	missense	probably damaging	1.00
casual	UTSW	2	69499263	missense	probably benign
nonchalant	UTSW	2	69489329	missense	probably damaging	1.00
Presto	UTSW	2	69459531	nonsense	probably null
relaxed	UTSW	2	69535005	missense	probably damaging	1.00
unguarded	UTSW	2	69465758	missense	probably benign	0.00
Unintended	UTSW	2	69518443	missense	probably damaging	1.00
BB009:Lrp2	UTSW	2	69426027	missense	probably benign	0.00
BB019:Lrp2	UTSW	2	69426027	missense	probably benign	0.00
IGL02835:Lrp2	UTSW	2	69505304	missense	probably damaging	1.00
IGL03055:Lrp2	UTSW	2	69458448	missense	probably damaging	1.00
PIT4362001:Lrp2	UTSW	2	69537538	missense	probably damaging	1.00
PIT4504001:Lrp2	UTSW	2	69475403	missense	probably damaging	1.00
R0008:Lrp2	UTSW	2	69516551	missense	probably benign	0.42
R0008:Lrp2	UTSW	2	69516551	missense	probably benign	0.42
R0044:Lrp2	UTSW	2	69527555	missense	probably benign	0.01
R0044:Lrp2	UTSW	2	69527555	missense	probably damaging	0.96
R0048:Lrp2	UTSW	2	69465627	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69475412	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69475412	missense	probably damaging	1.00
R0103:Lrp2	UTSW	2	69477040	missense	probably benign
R0167:Lrp2	UTSW	2	69425658	missense	possibly damaging	0.95
R0226:Lrp2	UTSW	2	69537563	missense	probably null	1.00
R0243:Lrp2	UTSW	2	69428630	missense	probably benign	0.00
R0308:Lrp2	UTSW	2	69482982	splice site	probably benign
R0323:Lrp2	UTSW	2	69469639	missense	probably damaging	1.00
R0372:Lrp2	UTSW	2	69535043	missense	probably benign	0.10
R0374:Lrp2	UTSW	2	69430307	missense	probably damaging	1.00
R0391:Lrp2	UTSW	2	69456858	missense	probably damaging	0.99
R0391:Lrp2	UTSW	2	69460337	splice site	probably benign
R0395:Lrp2	UTSW	2	69433077	missense	possibly damaging	0.89
R0401:Lrp2	UTSW	2	69479148	missense	probably damaging	0.98
R0471:Lrp2	UTSW	2	69525234	missense	probably damaging	0.97
R0483:Lrp2	UTSW	2	69507801	missense	probably damaging	0.99
R0502:Lrp2	UTSW	2	69511017	missense	probably damaging	1.00
R0542:Lrp2	UTSW	2	69428654	missense	probably benign	0.00
R0544:Lrp2	UTSW	2	69491931	missense	probably benign	0.18
R0548:Lrp2	UTSW	2	69537638	splice site	probably benign
R0593:Lrp2	UTSW	2	69467006	missense	probably benign
R0608:Lrp2	UTSW	2	69486243	missense	probably benign	0.02
R0633:Lrp2	UTSW	2	69448120	missense	probably damaging	1.00
R0691:Lrp2	UTSW	2	69451380	missense	probably benign	0.19
R0718:Lrp2	UTSW	2	69510948	missense	probably damaging	1.00
R0737:Lrp2	UTSW	2	69448169	missense	probably damaging	0.96
R0771:Lrp2	UTSW	2	69507990	missense	probably damaging	1.00
R0784:Lrp2	UTSW	2	69518365	missense	probably benign	0.32
R0885:Lrp2	UTSW	2	69482353	missense	possibly damaging	0.75
R0947:Lrp2	UTSW	2	69487838	missense	probably damaging	1.00
R1235:Lrp2	UTSW	2	69524036	missense	probably damaging	1.00
R1293:Lrp2	UTSW	2	69523302	splice site	probably null
R1301:Lrp2	UTSW	2	69428604	missense	probably damaging	0.98
R1387:Lrp2	UTSW	2	69456918	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69460477	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69483394	missense	probably damaging	0.99
R1529:Lrp2	UTSW	2	69523182	missense	probably damaging	1.00
R1543:Lrp2	UTSW	2	69500730	missense	probably damaging	1.00
R1546:Lrp2	UTSW	2	69502610	missense	probably damaging	1.00
R1550:Lrp2	UTSW	2	69502661	missense	possibly damaging	0.74
R1590:Lrp2	UTSW	2	69466763	critical splice donor site	probably null
R1689:Lrp2	UTSW	2	69503529	missense	probably benign	0.09
R1693:Lrp2	UTSW	2	69510418	missense	probably damaging	1.00
R1753:Lrp2	UTSW	2	69496489	missense	possibly damaging	0.87
R1799:Lrp2	UTSW	2	69503530	missense	probably benign	0.04
R1834:Lrp2	UTSW	2	69466880	missense	probably benign	0.01
R1921:Lrp2	UTSW	2	69523287	missense	probably damaging	1.00
R2000:Lrp2	UTSW	2	69467090	missense	probably damaging	1.00
R2077:Lrp2	UTSW	2	69507843	missense	probably damaging	1.00
R2092:Lrp2	UTSW	2	69536021	missense	probably benign	0.25
R2093:Lrp2	UTSW	2	69536021	missense	probably benign	0.25
R2108:Lrp2	UTSW	2	69506624	missense	possibly damaging	0.75
R2117:Lrp2	UTSW	2	69483385	missense	probably benign	0.05
R2122:Lrp2	UTSW	2	69483707	missense	probably damaging	1.00
R2134:Lrp2	UTSW	2	69511067	missense	probably damaging	1.00
R2207:Lrp2	UTSW	2	69467028	missense	possibly damaging	0.94
R2248:Lrp2	UTSW	2	69511010	missense	probably damaging	1.00
R2264:Lrp2	UTSW	2	69482366	missense	possibly damaging	0.88
R2316:Lrp2	UTSW	2	69491847	missense	possibly damaging	0.75
R2513:Lrp2	UTSW	2	69506374	splice site	probably null
R2984:Lrp2	UTSW	2	69425814	splice site	probably null
R3085:Lrp2	UTSW	2	69467135	missense	probably benign	0.05
R3103:Lrp2	UTSW	2	69431984	missense	probably benign	0.00
R3727:Lrp2	UTSW	2	69510429	missense	probably damaging	1.00
R3730:Lrp2	UTSW	2	69464579	missense	probably damaging	0.99
R3730:Lrp2	UTSW	2	69534907	critical splice donor site	probably null
R3731:Lrp2	UTSW	2	69464579	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69534907	critical splice donor site	probably null
R3764:Lrp2	UTSW	2	69496336	missense	probably damaging	1.00
R3768:Lrp2	UTSW	2	69505105	missense	probably benign	0.34
R3778:Lrp2	UTSW	2	69509204	missense	probably benign	0.00
R3808:Lrp2	UTSW	2	69501548	missense	probably damaging	1.00
R3809:Lrp2	UTSW	2	69501548	missense	probably damaging	1.00
R3813:Lrp2	UTSW	2	69464579	missense	probably damaging	0.99
R3828:Lrp2	UTSW	2	69426012	missense	probably benign	0.03
R3852:Lrp2	UTSW	2	69537565	missense	probably damaging	0.96
R3877:Lrp2	UTSW	2	69459472	critical splice donor site	probably null
R3877:Lrp2	UTSW	2	69549047	missense	probably damaging	1.00
R3922:Lrp2	UTSW	2	69506376	missense	probably benign
R4081:Lrp2	UTSW	2	69513273	missense	probably damaging	0.98
R4082:Lrp2	UTSW	2	69513273	missense	probably damaging	0.98
R4118:Lrp2	UTSW	2	69430262	critical splice donor site	probably null
R4193:Lrp2	UTSW	2	69467143	missense	probably damaging	1.00
R4284:Lrp2	UTSW	2	69480094	missense	possibly damaging	0.95
R4322:Lrp2	UTSW	2	69425991	nonsense	probably null
R4352:Lrp2	UTSW	2	69432182	critical splice donor site	probably null
R4407:Lrp2	UTSW	2	69502517	missense	probably damaging	1.00
R4408:Lrp2	UTSW	2	69467169	missense	probably benign	0.09
R4416:Lrp2	UTSW	2	69527231	missense	probably benign	0.18
R4426:Lrp2	UTSW	2	69506348	missense	probably benign	0.00
R4510:Lrp2	UTSW	2	69480062	missense	possibly damaging	0.58
R4511:Lrp2	UTSW	2	69480062	missense	possibly damaging	0.58
R4553:Lrp2	UTSW	2	69513285	missense	probably benign	0.13
R4591:Lrp2	UTSW	2	69536075	missense	probably damaging	1.00
R4612:Lrp2	UTSW	2	69458427	nonsense	probably null
R4622:Lrp2	UTSW	2	69460349	missense	possibly damaging	0.87
R4632:Lrp2	UTSW	2	69489129	splice site	probably null
R4633:Lrp2	UTSW	2	69461417	missense	probably benign	0.16
R4636:Lrp2	UTSW	2	69436639	missense	possibly damaging	0.93
R4657:Lrp2	UTSW	2	69466993	missense	probably damaging	1.00
R4667:Lrp2	UTSW	2	69489298	missense	probably benign	0.02
R4712:Lrp2	UTSW	2	69506551	missense	probably damaging	1.00
R4713:Lrp2	UTSW	2	69487966	missense	probably damaging	1.00
R4720:Lrp2	UTSW	2	69481173	missense	probably damaging	0.99
R4733:Lrp2	UTSW	2	69533555	missense	probably benign
R4777:Lrp2	UTSW	2	69482264	missense	probably damaging	1.00
R4779:Lrp2	UTSW	2	69459715	missense	possibly damaging	0.75
R4786:Lrp2	UTSW	2	69537956	missense	probably damaging	1.00
R4842:Lrp2	UTSW	2	69469411	missense	probably benign	0.06
R4845:Lrp2	UTSW	2	69509241	missense	possibly damaging	0.71
R4846:Lrp2	UTSW	2	69479113	missense	probably damaging	1.00
R4938:Lrp2	UTSW	2	69472368	missense	probably damaging	0.98
R4951:Lrp2	UTSW	2	69535988	missense	probably damaging	1.00
R4990:Lrp2	UTSW	2	69481388	missense	probably benign	0.01
R5075:Lrp2	UTSW	2	69465758	missense	probably benign	0.00
R5078:Lrp2	UTSW	2	69501530	missense	possibly damaging	0.93
R5102:Lrp2	UTSW	2	69489158	missense	probably damaging	0.98
R5124:Lrp2	UTSW	2	69501490	missense	probably damaging	0.97
R5131:Lrp2	UTSW	2	69430342	missense	possibly damaging	0.74
R5141:Lrp2	UTSW	2	69552349	splice site	probably null
R5223:Lrp2	UTSW	2	69524053	missense	probably damaging	0.99
R5236:Lrp2	UTSW	2	69456819	splice site	probably null
R5267:Lrp2	UTSW	2	69548978	missense	possibly damaging	0.83
R5290:Lrp2	UTSW	2	69513354	missense	probably damaging	1.00
R5333:Lrp2	UTSW	2	69525228	missense	probably benign	0.01
R5355:Lrp2	UTSW	2	69454838	nonsense	probably null
R5356:Lrp2	UTSW	2	69464708	missense	possibly damaging	0.74
R5369:Lrp2	UTSW	2	69459560	missense	probably benign	0.04
R5486:Lrp2	UTSW	2	69437465	missense	probably benign	0.04
R5554:Lrp2	UTSW	2	69552424	missense	possibly damaging	0.92
R5584:Lrp2	UTSW	2	69451288	missense	probably damaging	1.00
R5585:Lrp2	UTSW	2	69464624	missense	possibly damaging	0.77
R5587:Lrp2	UTSW	2	69499263	missense	probably benign
R5605:Lrp2	UTSW	2	69523299	missense	probably damaging	1.00
R5637:Lrp2	UTSW	2	69472418	missense	probably damaging	1.00
R5647:Lrp2	UTSW	2	69519914	missense	probably null	0.80
R5686:Lrp2	UTSW	2	69511061	missense	possibly damaging	0.88
R5691:Lrp2	UTSW	2	69502553	missense	probably damaging	1.00
R5724:Lrp2	UTSW	2	69451382	missense	probably damaging	0.99
R5726:Lrp2	UTSW	2	69509147	missense	probably damaging	1.00
R5743:Lrp2	UTSW	2	69466877	missense	probably damaging	1.00
R5777:Lrp2	UTSW	2	69455525	missense	probably damaging	1.00
R5841:Lrp2	UTSW	2	69480153	missense	probably benign	0.00
R5892:Lrp2	UTSW	2	69442776	missense	probably benign
R5951:Lrp2	UTSW	2	69496323	splice site	probably null
R5974:Lrp2	UTSW	2	69459548	missense	probably damaging	1.00
R5980:Lrp2	UTSW	2	69535005	missense	probably damaging	1.00
R6046:Lrp2	UTSW	2	69506754	missense	probably damaging	1.00
R6113:Lrp2	UTSW	2	69483557	missense	possibly damaging	0.76
R6146:Lrp2	UTSW	2	69511001	missense	probably benign	0.00
R6177:Lrp2	UTSW	2	69510419	frame shift	probably null
R6180:Lrp2	UTSW	2	69503524	missense	possibly damaging	0.85
R6219:Lrp2	UTSW	2	69469478	missense	probably damaging	1.00
R6228:Lrp2	UTSW	2	69482366	missense	possibly damaging	0.88
R6265:Lrp2	UTSW	2	69466340	missense	probably damaging	1.00
R6312:Lrp2	UTSW	2	69436681	missense	probably damaging	1.00
R6337:Lrp2	UTSW	2	69438467	missense	probably damaging	1.00
R6376:Lrp2	UTSW	2	69483443	missense	probably benign	0.02
R6385:Lrp2	UTSW	2	69495784	missense	probably benign	0.22
R6429:Lrp2	UTSW	2	69461287	missense	probably damaging	1.00
R6458:Lrp2	UTSW	2	69505156	missense	probably benign	0.00
R6524:Lrp2	UTSW	2	69436639	missense	possibly damaging	0.93
R6555:Lrp2	UTSW	2	69509303	missense	probably benign	0.00
R6594:Lrp2	UTSW	2	69439923	missense	possibly damaging	0.58
R6599:Lrp2	UTSW	2	69469405	missense	probably damaging	1.00
R6655:Lrp2	UTSW	2	69453858	missense	probably benign	0.01
R6718:Lrp2	UTSW	2	69483780	missense	probably benign	0.09
R6736:Lrp2	UTSW	2	69448211	missense	probably benign	0.02
R6738:Lrp2	UTSW	2	69458488	missense	probably damaging	0.97
R6799:Lrp2	UTSW	2	69483904	missense	probably damaging	1.00
R6846:Lrp2	UTSW	2	69518443	missense	probably damaging	1.00
R6856:Lrp2	UTSW	2	69513268	missense	probably damaging	1.00
R6861:Lrp2	UTSW	2	69513377	missense	possibly damaging	0.77
R6888:Lrp2	UTSW	2	69524141	missense	probably damaging	0.98
R6897:Lrp2	UTSW	2	69510502	missense	probably benign
R6902:Lrp2	UTSW	2	69459503	missense	probably damaging	1.00
R6908:Lrp2	UTSW	2	69472365	missense	probably damaging	1.00
R6918:Lrp2	UTSW	2	69489305	missense	probably damaging	1.00
R6989:Lrp2	UTSW	2	69472455	missense	probably damaging	1.00
R7022:Lrp2	UTSW	2	69483208	missense	probably damaging	1.00
R7025:Lrp2	UTSW	2	69483028	missense	possibly damaging	0.90
R7026:Lrp2	UTSW	2	69521787	missense	probably damaging	0.97
R7138:Lrp2	UTSW	2	69465745	missense	possibly damaging	0.94
R7145:Lrp2	UTSW	2	69454808	critical splice donor site	probably null
R7150:Lrp2	UTSW	2	69488051	missense	probably damaging	0.99
R7165:Lrp2	UTSW	2	69506573	missense	probably damaging	0.99
R7174:Lrp2	UTSW	2	69433072	missense	probably benign	0.11
R7204:Lrp2	UTSW	2	69472533	missense	probably benign	0.25
R7275:Lrp2	UTSW	2	69459531	nonsense	probably null
R7278:Lrp2	UTSW	2	69486352	missense	probably damaging	1.00
R7296:Lrp2	UTSW	2	69482381	missense	probably benign	0.04
R7315:Lrp2	UTSW	2	69491822	missense	probably damaging	0.98
R7342:Lrp2	UTSW	2	69479290	missense	possibly damaging	0.95
R7351:Lrp2	UTSW	2	69448142	missense	probably damaging	1.00
R7352:Lrp2	UTSW	2	69472397	missense	probably benign	0.04
R7366:Lrp2	UTSW	2	69483806	missense	probably damaging	1.00
R7373:Lrp2	UTSW	2	69500692	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69432213	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69459674	missense	probably damaging	0.99
R7451:Lrp2	UTSW	2	69513333	missense	probably damaging	1.00
R7492:Lrp2	UTSW	2	69537581	missense	probably damaging	0.99
R7571:Lrp2	UTSW	2	69516403	missense	probably damaging	1.00
R7638:Lrp2	UTSW	2	69477008	critical splice donor site	probably null
R7664:Lrp2	UTSW	2	69506732	missense	probably damaging	1.00
R7686:Lrp2	UTSW	2	69489237	missense	probably damaging	1.00
R7711:Lrp2	UTSW	2	69479343	critical splice acceptor site	probably null
R7737:Lrp2	UTSW	2	69496438	missense	possibly damaging	0.77
R7763:Lrp2	UTSW	2	69503388	missense	probably damaging	0.99
R7775:Lrp2	UTSW	2	69501539	missense	possibly damaging	0.74
R7824:Lrp2	UTSW	2	69501539	missense	possibly damaging	0.74
R7840:Lrp2	UTSW	2	69464784	missense	probably damaging	0.98
R7878:Lrp2	UTSW	2	69507809	missense	probably damaging	1.00
R7878:Lrp2	UTSW	2	69507810	missense	probably damaging	1.00
R7895:Lrp2	UTSW	2	69458479	missense	probably damaging	0.97
R7898:Lrp2	UTSW	2	69441366	missense	probably benign	0.00
R7912:Lrp2	UTSW	2	69428672	missense	probably benign	0.03
R7923:Lrp2	UTSW	2	69438388	missense	possibly damaging	0.75
R7932:Lrp2	UTSW	2	69426027	missense	probably benign	0.00
R7940:Lrp2	UTSW	2	69432197	missense	possibly damaging	0.91
R7954:Lrp2	UTSW	2	69503523	missense	possibly damaging	0.61
R8007:Lrp2	UTSW	2	69506505	missense	probably benign	0.02
R8084:Lrp2	UTSW	2	69509369	missense	probably damaging	0.97
R8087:Lrp2	UTSW	2	69448129	missense	probably damaging	1.00
R8090:Lrp2	UTSW	2	69464745	missense	possibly damaging	0.94
R8110:Lrp2	UTSW	2	69506453	missense	probably benign
R8129:Lrp2	UTSW	2	69430280	missense	possibly damaging	0.75
R8155:Lrp2	UTSW	2	69482998	missense	possibly damaging	0.74
R8182:Lrp2	UTSW	2	69489329	missense	probably damaging	1.00
R8239:Lrp2	UTSW	2	69481267	nonsense	probably null
R8247:Lrp2	UTSW	2	69431087	missense	possibly damaging	0.76
R8327:Lrp2	UTSW	2	69491924	missense	probably damaging	1.00
R8355:Lrp2	UTSW	2	69516484	missense	probably damaging	0.99
R8404:Lrp2	UTSW	2	69514241	nonsense	probably null
R8427:Lrp2	UTSW	2	69451297	missense	probably damaging	0.97
R8463:Lrp2	UTSW	2	69491906	missense	probably damaging	1.00
R8502:Lrp2	UTSW	2	69514241	nonsense	probably null
R8529:Lrp2	UTSW	2	69500642	missense	probably damaging	0.96
R8673:Lrp2	UTSW	2	69472460	missense	probably damaging	1.00
R8698:Lrp2	UTSW	2	69448239	missense	probably benign	0.39
R8698:Lrp2	UTSW	2	69458423	missense	probably benign	0.37
R8708:Lrp2	UTSW	2	69459613	missense	probably damaging	1.00
R8716:Lrp2	UTSW	2	69443794	missense	probably benign	0.04
R8723:Lrp2	UTSW	2	69486304	missense	probably damaging	1.00
R8787:Lrp2	UTSW	2	69552401	missense	probably damaging	1.00
R8903:Lrp2	UTSW	2	69549038	missense	possibly damaging	0.68
R8944:Lrp2	UTSW	2	69511004	missense	probably damaging	1.00
R9069:Lrp2	UTSW	2	69501652	missense	probably damaging	1.00
R9076:Lrp2	UTSW	2	69519916	missense	probably benign	0.01
R9155:Lrp2	UTSW	2	69461369	nonsense	probably null
R9173:Lrp2	UTSW	2	69469387	missense	probably damaging	1.00
R9254:Lrp2	UTSW	2	69503547	missense	probably benign	0.09
R9256:Lrp2	UTSW	2	69510959	missense	probably benign	0.03
R9291:Lrp2	UTSW	2	69480035	missense	probably damaging	1.00
R9335:Lrp2	UTSW	2	69428639	missense	probably benign	0.01
R9357:Lrp2	UTSW	2	69506573	missense	probably damaging	0.99
R9368:Lrp2	UTSW	2	69527635	missense	probably damaging	0.99
R9453:Lrp2	UTSW	2	69458488	missense	probably damaging	1.00
R9546:Lrp2	UTSW	2	69456821	critical splice donor site	probably null
R9554:Lrp2	UTSW	2	69431153	missense	probably damaging	1.00
R9597:Lrp2	UTSW	2	69430359	missense	probably benign	0.02
R9601:Lrp2	UTSW	2	69459584	missense	probably damaging	1.00
R9623:Lrp2	UTSW	2	69477079	missense	probably benign	0.09
RF016:Lrp2	UTSW	2	69509205	missense	probably benign
X0011:Lrp2	UTSW	2	69519998	missense	probably damaging	1.00
X0023:Lrp2	UTSW	2	69436600	missense	probably damaging	0.99
Z1176:Lrp2	UTSW	2	69480042	missense	possibly damaging	0.66
Z1176:Lrp2	UTSW	2	69507881	missense	possibly damaging	0.88
Z1177:Lrp2	UTSW	2	69451280	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69472453	missense	probably benign	0.03
Z1177:Lrp2	UTSW	2	69496468	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69501641	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69509289	missense	probably benign	0.00

Predicted Primers

Posted On

2017-03-08