Mutagenetix > Incidental Mutation

Incidental Mutation 'R4732:Dync1h1'

470521

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

042022-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4732 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 110649507 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 3030 (Q3030*)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

probably null
Transcript: ENSMUST00000018851
AA Change: Q3030*

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: Q3030*

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000167395

SMART Domains

Protein: ENSMUSP00000126117
Gene: ENSMUSG00000018707

Domain	Start	End	E-Value	Type
Pfam:MT	1	178	5.3e-18	PFAM
Pfam:AAA_9	154	252	3.6e-24	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.2%
20x: 95.1%

Validation Efficiency

99% (110/111)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 192 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700128F08Rik	T	A	9: 8,222,173		noncoding transcript	Het
3110035E14Rik	T	C	1: 9,606,976	S24P	probably benign	Het
4933409G03Rik	A	G	2: 68,614,721		probably benign	Het
Acan	T	C	7: 79,098,609	S1043P	probably damaging	Het
Ackr2	A	G	9: 121,909,183	Y208C	probably damaging	Het
Actg1	C	T	11: 120,347,479		probably benign	Het
Adam1a	T	A	5: 121,519,434	T599S	probably benign	Het
Adamts12	A	T	15: 11,270,662	S668C	probably damaging	Het
Adcy8	A	G	15: 64,754,862	V709A	possibly damaging	Het
Adgrf2	A	C	17: 42,710,754	I393S	probably damaging	Het
Ahnak	G	T	19: 9,007,301	G1983V	probably damaging	Het
AI413582	A	G	17: 27,565,270		probably benign	Het
Aim2	T	A	1: 173,463,876	D282E	possibly damaging	Het
Ak8	A	G	2: 28,760,071	Y370C	probably damaging	Het
Akap9	A	G	5: 4,013,901	D1750G	probably damaging	Het
Als2cl	T	A	9: 110,889,136	V315E	probably damaging	Het
Ankrd28	A	C	14: 31,755,741	C115G	probably benign	Het
Ap3b2	C	T	7: 81,471,932	A519T	probably damaging	Het
Apool	C	T	X: 112,372,200	T166I	probably damaging	Het
Arhgef2	A	T	3: 88,631,940	K65*	probably null	Het
Arhgef38	G	T	3: 133,132,269	Y633*	probably null	Het
Asah2	T	C	19: 31,995,358	N659S	probably benign	Het
Atf7ip2	A	G	16: 10,241,886	D430G	possibly damaging	Het
Atp8a1	G	A	5: 67,813,120	S92L	probably benign	Het
Bag4	C	T	8: 25,769,488	A228T	probably benign	Het
BC024978	T	A	7: 27,201,043	M149K	probably damaging	Het
C130073F10Rik	C	A	4: 101,890,710	S89I	probably benign	Het
Cacna1g	T	C	11: 94,443,215	T867A	probably damaging	Het
Ccdc88a	T	G	11: 29,485,906	N1276K	probably benign	Het
Cdc42bpg	T	A	19: 6,311,191	V282E	probably damaging	Het
Cdipt	T	A	7: 126,978,358	L92H	probably damaging	Het
Celsr2	T	A	3: 108,398,952	D2012V	probably damaging	Het
Cenpt	A	G	8: 105,847,136	V254A	probably benign	Het
Cep104	T	A	4: 153,988,426	D380E	probably damaging	Het
Cers5	C	T	15: 99,741,637	R123Q	probably benign	Het
Ces2h	A	G	8: 105,014,604	E76G	probably damaging	Het
Cfap77	T	A	2: 28,984,388	E143D	probably benign	Het
Chmp7	C	A	14: 69,732,296	R65L	probably damaging	Het
Cldnd2	T	A	7: 43,442,189	C65S	possibly damaging	Het
Clec2g	C	A	6: 128,981,879	Y142*	probably null	Het
Coch	A	T	12: 51,605,019	E549V	probably benign	Het
Cog7	T	C	7: 121,964,244	D215G	probably benign	Het
Col4a2	T	C	8: 11,414,779	V348A	probably benign	Het
Col4a2	A	G	8: 11,446,197	H1606R	probably benign	Het
Cpd	T	C	11: 76,811,794	N583D	probably damaging	Het
Cyp2d11	T	A	15: 82,389,227	Y481F	probably benign	Het
D130043K22Rik	T	C	13: 24,899,665	S1038P	probably damaging	Het
Deptor	C	A	15: 55,181,010	H191N	probably benign	Het
Dgkz	A	T	2: 91,938,339	I699N	probably damaging	Het
Dnah12	C	T	14: 26,781,784	T1653I	probably damaging	Het
Dnah7c	T	A	1: 46,770,173	N3550K	probably damaging	Het
Dnah8	A	G	17: 30,775,061	K3384R	probably null	Het
Dnajc11	A	G	4: 151,970,967		probably benign	Het
Dnajc13	CT	C	9: 104,186,805		probably benign	Het
Dnhd1	C	A	7: 105,673,849	N521K	probably benign	Het
Drg2	T	C	11: 60,461,396		probably null	Het
Efhb	G	A	17: 53,426,244	T533I	probably damaging	Het
Eif2d	T	C	1: 131,164,727	V374A	probably damaging	Het
Etfb	T	C	7: 43,444,200	V17A	probably damaging	Het
F5	C	T	1: 164,181,657	T332M	probably damaging	Het
Fcho1	T	C	8: 71,716,795	T156A	probably benign	Het
Fn1	A	T	1: 71,602,512		probably null	Het
Fnip2	A	T	3: 79,481,652	S561T	probably damaging	Het
Frs2	T	A	10: 117,074,093	T455S	probably benign	Het
Fry	G	A	5: 150,386,007	E639K		Het
Fto	T	A	8: 91,409,714	D205E	probably damaging	Het
Galntl6	G	A	8: 58,427,813	P147L	probably damaging	Het
Gigyf1	T	A	5: 137,524,770	D844E	probably benign	Het
Gle1	T	C	2: 29,940,232	S267P	probably damaging	Het
Glg1	G	A	8: 111,187,755	R466W	probably damaging	Het
Gm10277	T	C	11: 77,786,097		probably benign	Het
Gm20388	A	G	8: 122,270,274		probably benign	Het
Gm5724	A	T	6: 141,723,179	M509K	probably benign	Het
Gm6871	T	C	7: 41,546,749	I39V	probably benign	Het
Gm9970	A	G	5: 31,241,066		probably benign	Het
Gpr35	T	G	1: 92,983,385	I57S	probably damaging	Het
Gprin1	C	T	13: 54,739,957	G168E	possibly damaging	Het
Gtdc1	A	G	2: 44,789,055		probably benign	Het
Gtf3c2	G	T	5: 31,160,057	P586T	probably damaging	Het
Gucy1a2	A	T	9: 3,759,424	H410L	probably benign	Het
Gucy2c	A	G	6: 136,767,152	S150P	probably damaging	Het
Ifi214	T	C	1: 173,526,591	Q171R	probably benign	Het
Ifit1bl1	T	C	19: 34,594,321	I245M	probably benign	Het
Igkv4-50	T	C	6: 69,701,000	K40R	probably benign	Het
Igkv8-18	T	A	6: 70,356,296	I74N	probably damaging	Het
Il2ra	T	A	2: 11,676,920	M112K	probably benign	Het
Itpr2	A	G	6: 146,373,173	F837S	probably damaging	Het
Kbtbd7	T	C	14: 79,428,800	*691Q	probably null	Het
Kcnn2	T	A	18: 45,560,349	S331T	possibly damaging	Het
Khnyn	T	A	14: 55,886,489		probably null	Het
Kif26a	G	A	12: 112,175,573	A754T	probably benign	Het
Klra3	T	A	6: 130,327,132	Y199F	possibly damaging	Het
Lhx2	A	G	2: 38,359,991	K274R	probably damaging	Het
Lrp2	T	C	2: 69,533,555	I313V	probably benign	Het
Lrrfip1	A	T	1: 91,115,647	E591D	probably benign	Het
Lrrk2	A	C	15: 91,688,849	E200A	probably damaging	Het
Lrrk2	G	A	15: 91,765,747	E1696K	probably damaging	Het
Mast4	A	T	13: 102,772,572	M465K	probably damaging	Het
Moxd2	T	G	6: 40,878,859	I599L	probably benign	Het
Mug2	T	C	6: 122,071,872	S866P	probably damaging	Het
Ncam2	A	G	16: 81,434,884	T79A	possibly damaging	Het
Ncoa6	C	A	2: 155,421,301	Q404H	probably damaging	Het
Neb	A	G	2: 52,279,079	Y1815H	probably damaging	Het
Nell1	A	G	7: 50,856,217	D724G	probably damaging	Het
Nkx3-2	A	G	5: 41,762,144	V167A	probably benign	Het
Nsun3	C	A	16: 62,735,119	C348F	possibly damaging	Het
Obox6	A	T	7: 15,834,772	S60T	possibly damaging	Het
Olfr1	T	C	11: 73,395,695	D109G	probably benign	Het
Olfr1378	G	A	11: 50,969,266	V83M	possibly damaging	Het
Olfr138	T	A	17: 38,275,547	Y259N	probably damaging	Het
Olfr466	T	C	13: 65,152,653	V143A	possibly damaging	Het
Olfr744	T	A	14: 50,618,569	C116S	probably benign	Het
Olfr94	T	C	17: 37,197,024	T315A	probably damaging	Het
Olfr980	A	T	9: 40,006,268	I227N	probably damaging	Het
Oog2	T	A	4: 144,193,941		probably benign	Het
Pabpc1	A	T	15: 36,599,284	V389E	probably benign	Het
Pank4	A	T	4: 154,971,390	M291L	probably benign	Het
Pcf11	T	C	7: 92,658,833	D709G	probably benign	Het
Pcgf1	T	A	6: 83,079,957		probably benign	Het
Pcnx	A	G	12: 81,995,751	I2256V	probably benign	Het
Pex6	A	G	17: 46,722,288	D579G	probably benign	Het
Pex6	A	G	17: 46,724,707		probably null	Het
Piezo2	C	T	18: 63,030,401	A2149T	probably damaging	Het
Pik3c2g	A	G	6: 139,935,985	E781G	probably benign	Het
Pik3r4	G	A	9: 105,678,176	V1111I	possibly damaging	Het
Pkd1l2	T	A	8: 116,995,842		probably null	Het
Plekhg1	T	A	10: 3,957,506	S808T	probably benign	Het
Pnkp	T	A	7: 44,860,454		probably benign	Het
Polr3c	A	T	3: 96,723,661	F148I	probably damaging	Het
Ppard	A	T	17: 28,286,443	T35S	probably benign	Het
Ptov1	T	C	7: 44,867,109	D134G	probably benign	Het
Ptprz1	T	A	6: 23,002,610	S1566R	probably benign	Het
Pum1	T	C	4: 130,718,193	S158P	probably benign	Het
Qk	T	C	17: 10,216,288	H269R	probably damaging	Het
Qrsl1	T	C	10: 43,876,663	Y388C	probably damaging	Het
Rapgef1	T	G	2: 29,689,160	I182S	probably damaging	Het
Ret	T	C	6: 118,163,193	S1013G	possibly damaging	Het
Rimbp3	A	G	16: 17,210,601	R630G	possibly damaging	Het
Rnmt	A	T	18: 68,317,960		probably benign	Het
Ryr2	A	T	13: 11,577,909	M4653K	possibly damaging	Het
Sacm1l	G	A	9: 123,590,830	V553I	probably benign	Het
Sec31b	A	T	19: 44,532,677	S110T	probably damaging	Het
Serpina3k	G	A	12: 104,340,860	G117D	probably damaging	Het
Sesn2	T	C	4: 132,494,591	Y410C	probably damaging	Het
Slc24a1	G	A	9: 64,949,554	R24C	probably benign	Het
Slc35g2	A	C	9: 100,552,502	V372G	probably benign	Het
Slc7a7	T	C	14: 54,408,733	Y91C	probably damaging	Het
Slc7a9	T	A	7: 35,453,563	Y135*	probably null	Het
Slco4a1	A	G	2: 180,473,615	N662D	probably damaging	Het
Slfn4	T	A	11: 83,189,282		probably benign	Het
Slmap	T	C	14: 26,468,535	N156S	probably damaging	Het
Snx18	A	G	13: 113,617,774	S208P	probably benign	Het
Sorbs1	T	A	19: 40,314,689	R485S	probably benign	Het
Spib	A	G	7: 44,528,885	S154P	probably damaging	Het
Spty2d1	T	C	7: 46,996,110	D595G	probably damaging	Het
St7	T	A	6: 17,906,516		probably null	Het
Susd1	T	C	4: 59,428,029	T52A	possibly damaging	Het
Svs2	T	A	2: 164,237,123	D288V	possibly damaging	Het
Syt7	T	A	19: 10,442,924	I355N	probably damaging	Het
Tarm1	G	A	7: 3,496,900	Q145*	probably null	Het
Teddm2	T	A	1: 153,850,741	E76V	probably damaging	Het
Thsd7b	T	C	1: 129,613,186	S343P	probably damaging	Het
Tigd2	T	A	6: 59,211,415	H422Q	probably benign	Het
Tle1	T	C	4: 72,125,019	N538D	possibly damaging	Het
Tmc2	A	G	2: 130,261,397		probably null	Het
Tmtc1	A	C	6: 148,284,980		probably null	Het
Tns3	C	T	11: 8,450,986	R1104H	probably benign	Het
Trim6	T	C	7: 104,232,648	Y369H	probably damaging	Het
Triobp	G	A	15: 78,967,113	R489K	probably damaging	Het
Trpv4	T	C	5: 114,622,753	D732G	possibly damaging	Het
Trrap	G	A	5: 144,816,570	V1883I	probably damaging	Het
Tsc2	C	A	17: 24,603,275	V1141F	possibly damaging	Het
Ttn	A	T	2: 76,943,011	M2395K	unknown	Het
Ttn	A	G	2: 76,899,827		probably benign	Het
Tyrp1	A	T	4: 80,844,935	D353V	possibly damaging	Het
Ubd	A	C	17: 37,195,702	T160P	probably benign	Het
Ugt2b36	G	T	5: 87,081,538	Y156*	probably null	Het
Ulk4	G	A	9: 121,263,638	R178*	probably null	Het
Unc13d	A	G	11: 116,073,582	V312A	possibly damaging	Het
Urb2	G	T	8: 124,028,897	A448S	probably damaging	Het
Urod	G	A	4: 116,991,673	A92V	possibly damaging	Het
Vmn1r33	T	A	6: 66,611,819	R250S	probably benign	Het
Vmn1r87	A	T	7: 13,132,327	M11K	possibly damaging	Het
Vmn2r77	C	T	7: 86,800,987	T147I	probably benign	Het
Vstm4	A	G	14: 32,917,902	K96E	possibly damaging	Het
Washc4	A	T	10: 83,574,479	M644L	probably benign	Het
Wwp1	T	C	4: 19,661,990	D172G	probably benign	Het
Zbtb38	A	T	9: 96,687,684	V449E	probably damaging	Het
Zfhx4	T	C	3: 5,214,807		probably benign	Het
Zfp229	C	T	17: 21,745,286	H166Y	possibly damaging	Het
Zfp512b	A	G	2: 181,588,739	S453P	probably benign	Het
Zp2	C	A	7: 120,138,120	V282L	probably damaging	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110649104	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110614107	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110625607	splice site	probably benign
IGL01324:Dync1h1	APN	12	110626865	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110616692	splice site	probably benign
IGL01371:Dync1h1	APN	12	110638851	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110658128	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110614940	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110658930	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110652196	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110637124	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110632820	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110662559	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110663002	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110640888	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110640210	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110659232	nonsense	probably null
IGL02643:Dync1h1	APN	12	110659272	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110657893	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110666555	splice site	probably null
IGL03293:Dync1h1	APN	12	110628734	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110619210	missense	possibly damaging	0.49
chinashop	UTSW	12	110658134	missense	probably damaging	1.00
Gesund	UTSW	12	110616404	missense	probably benign	0.35
gymnast	UTSW	12	110618368	missense	probably damaging	1.00
Lightfoot	UTSW	12	110617920	missense	probably damaging	1.00
Lissom	UTSW	12	110632820	missense	possibly damaging	0.68
Strong	UTSW	12	110658126	missense	probably damaging	1.00
waters	UTSW	12	110629679	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110649104	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110616807	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110636446	missense	probably benign
R0110:Dync1h1	UTSW	12	110639944	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110618674	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110640980	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110640980	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110649851	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110649851	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110631692	missense	probably benign
R0450:Dync1h1	UTSW	12	110639944	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110632788	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110616496	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110651747	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110657192	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110612411	missense	probably benign
R0747:Dync1h1	UTSW	12	110629284	missense	probably damaging	0.99
R0843:Dync1h1	UTSW	12	110665213	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110665959	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110649264	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110656357	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110665662	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110626992	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110632928	splice site	probably benign
R1812:Dync1h1	UTSW	12	110662900	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110614059	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110614059	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110662625	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110624636	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110646304	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110662629	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110636509	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110625732	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110666423	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110614592	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110649588	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110629986	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110640882	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110656631	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110641220	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110643247	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110616891	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110641026	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110640586	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110643129	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110631675	missense	probably benign
R3736:Dync1h1	UTSW	12	110631675	missense	probably benign
R3882:Dync1h1	UTSW	12	110629058	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110665965	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110643190	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110618049	nonsense	probably null
R4355:Dync1h1	UTSW	12	110632899	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110657139	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110649483	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110638844	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110628767	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110662541	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110655528	missense	probably damaging	0.99
R4733:Dync1h1	UTSW	12	110649507	nonsense	probably null
R4780:Dync1h1	UTSW	12	110661196	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110639801	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110662855	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110658126	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110618010	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110626892	nonsense	probably null
R5036:Dync1h1	UTSW	12	110630535	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110640907	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110617932	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110629680	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110628830	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110615068	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110632665	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110660950	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110632820	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110641141	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110665988	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110629062	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110616404	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110646273	nonsense	probably null
R5806:Dync1h1	UTSW	12	110651653	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110614220	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110618368	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110632778	missense	probably benign
R6113:Dync1h1	UTSW	12	110620414	missense	probably benign
R6119:Dync1h1	UTSW	12	110628006	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110617993	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110646205	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110616737	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110617920	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110649848	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110658134	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110651653	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110629679	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110658547	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110652180	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110624561	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110638901	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110666087	nonsense	probably null
R7096:Dync1h1	UTSW	12	110657078	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110601739	missense	probably benign
R7224:Dync1h1	UTSW	12	110617762	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110664749	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110665162	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110635642	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110624602	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110634220	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110636453	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110636453	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110665675	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110651577	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110614107	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110630625	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110660893	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110618646	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110665766	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110655459	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110643156	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110616457	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110628734	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110616360	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110636474	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110665792	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110618142	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110616743	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110640584	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110614580	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110616827	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110635899	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110635899	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110616738	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110642043	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110658168	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110618037	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110620371	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110639963	missense	probably benign
R9036:Dync1h1	UTSW	12	110639752	missense	probably benign
R9090:Dync1h1	UTSW	12	110616876	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110656272	intron	probably benign
R9161:Dync1h1	UTSW	12	110658589	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110635503	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110616876	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110616541	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110658703	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110658371	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110649099	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110616541	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110640928	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110629917	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110637554	missense	probably damaging	1.00
Z1177:Dync1h1	UTSW	12	110641177	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110658517	nonsense	probably null

Predicted Primers

Posted On

2017-03-08