Incidental Mutation 'R5970:Mical3'
ID 470798
Institutional Source Beutler Lab
Gene Symbol Mical3
Ensembl Gene ENSMUSG00000051586
Gene Name microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms C130040D16Rik, MICAL-3
MMRRC Submission 044153-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R5970 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 120908668-121107959 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 120935232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 893 (Q893*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207889]
AlphaFold Q8CJ19
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098457
SMART Domains Protein: ENSMUSP00000096056
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
low complexity region 57 80 N/A INTRINSIC
coiled coil region 114 148 N/A INTRINSIC
low complexity region 191 225 N/A INTRINSIC
coiled coil region 238 265 N/A INTRINSIC
low complexity region 317 330 N/A INTRINSIC
low complexity region 374 383 N/A INTRINSIC
low complexity region 548 562 N/A INTRINSIC
low complexity region 582 592 N/A INTRINSIC
low complexity region 625 637 N/A INTRINSIC
low complexity region 794 824 N/A INTRINSIC
low complexity region 861 882 N/A INTRINSIC
low complexity region 911 929 N/A INTRINSIC
low complexity region 950 962 N/A INTRINSIC
DUF3585 968 1110 1.39e-65 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150503
SMART Domains Protein: ENSMUSP00000115131
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
SCOP:d1bjt__ 41 141 8e-3 SMART
coiled coil region 192 219 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 328 337 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 536 546 N/A INTRINSIC
low complexity region 579 591 N/A INTRINSIC
low complexity region 748 778 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203013
Predicted Effect probably null
Transcript: ENSMUST00000207889
AA Change: Q1765*
Predicted Effect probably null
Transcript: ENSMUST00000212333
AA Change: Q893*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.4%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l1 G A 6: 90,574,028 (GRCm39) probably benign Het
Ambn T C 5: 88,615,810 (GRCm39) V413A possibly damaging Het
Amotl1 T A 9: 14,507,824 (GRCm39) D41V probably damaging Het
Arhgef26 T C 3: 62,247,468 (GRCm39) V184A probably benign Het
Birc6 G T 17: 74,925,497 (GRCm39) G936V possibly damaging Het
Ccser1 T A 6: 61,288,226 (GRCm39) S130T possibly damaging Het
Cecr2 A G 6: 120,697,868 (GRCm39) I56V probably damaging Het
Cfap52 A G 11: 67,821,570 (GRCm39) I486T probably damaging Het
Col4a3 A G 1: 82,694,050 (GRCm39) I1557V possibly damaging Het
Col6a5 T A 9: 105,823,046 (GRCm39) I104F unknown Het
Cry2 A G 2: 92,243,312 (GRCm39) S510P probably benign Het
Csmd2 G C 4: 128,439,944 (GRCm39) A3133P probably benign Het
Cyld G T 8: 89,459,621 (GRCm39) A611S probably damaging Het
Dennd4c G A 4: 86,743,749 (GRCm39) G1197E probably damaging Het
Dnah10 T C 5: 124,885,793 (GRCm39) F2969L probably benign Het
Dnai1 A G 4: 41,625,281 (GRCm39) K415R probably benign Het
Dnmbp T A 19: 43,842,610 (GRCm39) T1253S probably benign Het
Dsp T C 13: 38,379,678 (GRCm39) L1542P possibly damaging Het
Duox1 T A 2: 122,170,682 (GRCm39) L1234Q probably damaging Het
Efr3b T A 12: 4,018,590 (GRCm39) R585S possibly damaging Het
Gpt A G 15: 76,583,552 (GRCm39) probably null Het
Heatr6 G A 11: 83,644,544 (GRCm39) probably benign Het
Kcns2 A G 15: 34,839,930 (GRCm39) D431G probably benign Het
Kdm3b A G 18: 34,962,342 (GRCm39) N1543D probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Morc3 C T 16: 93,663,341 (GRCm39) H515Y possibly damaging Het
Mprip A T 11: 59,648,547 (GRCm39) R750S probably damaging Het
Mroh1 G A 15: 76,335,691 (GRCm39) V1436M probably benign Het
Muc5ac C T 7: 141,344,406 (GRCm39) R69* probably null Het
Muc5b A T 7: 141,410,449 (GRCm39) Y1274F unknown Het
Mybpc1 A G 10: 88,378,318 (GRCm39) L674P probably damaging Het
Mypn A G 10: 62,966,802 (GRCm39) V958A probably benign Het
Nipbl T C 15: 8,326,302 (GRCm39) T2436A probably benign Het
Or7g20 A G 9: 18,946,443 (GRCm39) D8G probably benign Het
Pcdhb5 T A 18: 37,454,826 (GRCm39) L402Q probably damaging Het
Pigp T A 16: 94,171,053 (GRCm39) probably null Het
Rp1 A G 1: 4,418,685 (GRCm39) L809P probably benign Het
Scn3a T A 2: 65,325,125 (GRCm39) probably benign Het
Sdf2 A T 11: 78,136,906 (GRCm39) M29L probably benign Het
Serpina3b T G 12: 104,100,350 (GRCm39) L311V possibly damaging Het
Snx31 A T 15: 36,523,634 (GRCm39) Y349* probably null Het
Spidr A C 16: 15,932,733 (GRCm39) C182W probably damaging Het
St13 A T 15: 81,261,999 (GRCm39) S146R probably damaging Het
St8sia4 A G 1: 95,581,307 (GRCm39) V145A probably damaging Het
Stradb T C 1: 59,019,175 (GRCm39) probably null Het
Tcp11l2 T A 10: 84,430,661 (GRCm39) probably benign Het
Tfdp2 C T 9: 96,199,627 (GRCm39) P74S unknown Het
Tmprss15 C T 16: 78,854,547 (GRCm39) R287H probably benign Het
Trav10d T C 14: 53,048,779 (GRCm39) Y57H probably damaging Het
Vmn2r104 A G 17: 20,249,733 (GRCm39) I846T probably benign Het
Ywhah T A 5: 33,184,292 (GRCm39) M165K possibly damaging Het
Zfp324 C A 7: 12,703,293 (GRCm39) P72T probably benign Het
Other mutations in Mical3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Mical3 APN 6 120,938,585 (GRCm39) missense possibly damaging 0.73
IGL00718:Mical3 APN 6 121,017,410 (GRCm39) missense probably damaging 0.98
IGL00940:Mical3 APN 6 120,999,371 (GRCm39) missense possibly damaging 0.55
IGL00973:Mical3 APN 6 120,911,885 (GRCm39) splice site probably benign
IGL01503:Mical3 APN 6 120,935,537 (GRCm39) missense probably benign 0.09
IGL01991:Mical3 APN 6 120,912,172 (GRCm39) missense probably damaging 0.98
IGL02794:Mical3 APN 6 120,984,270 (GRCm39) missense probably damaging 0.99
IGL02996:Mical3 APN 6 120,935,519 (GRCm39) missense probably damaging 1.00
IGL03105:Mical3 APN 6 121,019,199 (GRCm39) missense probably benign 0.01
IGL03109:Mical3 APN 6 120,986,085 (GRCm39) missense probably damaging 1.00
IGL03236:Mical3 APN 6 120,946,345 (GRCm39) missense probably benign 0.00
P0028:Mical3 UTSW 6 121,001,650 (GRCm39) missense probably benign 0.33
R0244:Mical3 UTSW 6 120,934,683 (GRCm39) missense probably benign 0.00
R0494:Mical3 UTSW 6 120,936,162 (GRCm39) missense possibly damaging 0.94
R0586:Mical3 UTSW 6 121,006,602 (GRCm39) unclassified probably benign
R1029:Mical3 UTSW 6 120,911,639 (GRCm39) missense probably benign 0.02
R1263:Mical3 UTSW 6 120,929,430 (GRCm39) missense probably damaging 0.99
R1507:Mical3 UTSW 6 121,019,199 (GRCm39) missense probably benign 0.36
R1527:Mical3 UTSW 6 121,001,740 (GRCm39) missense probably damaging 0.99
R1623:Mical3 UTSW 6 121,001,768 (GRCm39) missense probably damaging 0.99
R1680:Mical3 UTSW 6 120,936,604 (GRCm39) missense probably benign 0.09
R1697:Mical3 UTSW 6 120,984,369 (GRCm39) missense possibly damaging 0.84
R1817:Mical3 UTSW 6 121,019,196 (GRCm39) missense probably benign 0.06
R1875:Mical3 UTSW 6 121,019,025 (GRCm39) missense probably damaging 1.00
R1961:Mical3 UTSW 6 120,959,568 (GRCm39) missense possibly damaging 0.94
R2004:Mical3 UTSW 6 120,928,283 (GRCm39) missense probably damaging 1.00
R2093:Mical3 UTSW 6 121,017,347 (GRCm39) missense probably damaging 1.00
R2141:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2142:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2257:Mical3 UTSW 6 121,010,696 (GRCm39) missense possibly damaging 0.94
R2404:Mical3 UTSW 6 120,936,789 (GRCm39) missense probably benign 0.01
R2419:Mical3 UTSW 6 120,936,884 (GRCm39) missense probably benign
R2509:Mical3 UTSW 6 121,011,118 (GRCm39) missense probably damaging 1.00
R3784:Mical3 UTSW 6 120,998,298 (GRCm39) missense probably benign 0.00
R4342:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4343:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4579:Mical3 UTSW 6 120,935,660 (GRCm39) missense probably benign
R4603:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4605:Mical3 UTSW 6 121,011,041 (GRCm39) nonsense probably null
R4610:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4611:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4623:Mical3 UTSW 6 120,938,586 (GRCm39) nonsense probably null
R4669:Mical3 UTSW 6 120,934,664 (GRCm39) missense probably damaging 0.98
R4704:Mical3 UTSW 6 120,935,649 (GRCm39) missense probably benign 0.00
R4722:Mical3 UTSW 6 121,015,486 (GRCm39) missense probably benign 0.00
R4863:Mical3 UTSW 6 121,010,748 (GRCm39) missense probably damaging 0.99
R4878:Mical3 UTSW 6 120,946,348 (GRCm39) missense possibly damaging 0.51
R4885:Mical3 UTSW 6 120,912,214 (GRCm39) missense probably damaging 1.00
R4907:Mical3 UTSW 6 120,984,259 (GRCm39) missense probably benign 0.00
R5007:Mical3 UTSW 6 121,015,030 (GRCm39) missense probably damaging 0.98
R5299:Mical3 UTSW 6 120,936,473 (GRCm39) missense possibly damaging 0.71
R5303:Mical3 UTSW 6 120,936,941 (GRCm39) missense probably benign
R5368:Mical3 UTSW 6 120,936,434 (GRCm39) missense probably damaging 1.00
R5955:Mical3 UTSW 6 121,010,711 (GRCm39) missense probably damaging 0.99
R6000:Mical3 UTSW 6 120,998,281 (GRCm39) missense probably benign 0.06
R6101:Mical3 UTSW 6 121,010,671 (GRCm39) missense probably damaging 1.00
R6195:Mical3 UTSW 6 120,993,796 (GRCm39) intron probably benign
R6210:Mical3 UTSW 6 121,017,478 (GRCm39) splice site probably null
R6225:Mical3 UTSW 6 120,935,684 (GRCm39) missense probably damaging 0.98
R6258:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6260:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6349:Mical3 UTSW 6 120,936,486 (GRCm39) missense probably benign
R6352:Mical3 UTSW 6 120,929,434 (GRCm39) missense probably damaging 0.97
R6480:Mical3 UTSW 6 121,011,236 (GRCm39) missense possibly damaging 0.76
R6704:Mical3 UTSW 6 120,986,761 (GRCm39) intron probably benign
R6783:Mical3 UTSW 6 120,935,786 (GRCm39) missense possibly damaging 0.85
R6925:Mical3 UTSW 6 120,936,351 (GRCm39) missense probably benign 0.05
R6960:Mical3 UTSW 6 120,935,504 (GRCm39) missense probably damaging 1.00
R7170:Mical3 UTSW 6 120,950,694 (GRCm39) splice site probably null
R7344:Mical3 UTSW 6 121,013,505 (GRCm39) nonsense probably null
R7414:Mical3 UTSW 6 121,011,074 (GRCm39) missense probably damaging 1.00
R7455:Mical3 UTSW 6 120,935,705 (GRCm39) missense probably damaging 1.00
R7649:Mical3 UTSW 6 120,911,909 (GRCm39) missense probably damaging 1.00
R8236:Mical3 UTSW 6 120,989,504 (GRCm39) missense
R8286:Mical3 UTSW 6 120,998,149 (GRCm39) missense possibly damaging 0.68
R8316:Mical3 UTSW 6 120,911,944 (GRCm39) missense probably damaging 1.00
R8328:Mical3 UTSW 6 120,912,138 (GRCm39) missense probably damaging 0.98
R8354:Mical3 UTSW 6 120,950,381 (GRCm39) missense probably damaging 0.99
R8511:Mical3 UTSW 6 121,015,513 (GRCm39) missense possibly damaging 0.78
R8687:Mical3 UTSW 6 120,936,438 (GRCm39) missense probably benign 0.19
R8728:Mical3 UTSW 6 120,950,514 (GRCm39) missense probably damaging 0.99
R8925:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8927:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8986:Mical3 UTSW 6 120,991,822 (GRCm39) missense
R9026:Mical3 UTSW 6 120,986,848 (GRCm39) splice site probably benign
R9415:Mical3 UTSW 6 120,934,712 (GRCm39) missense probably damaging 1.00
R9515:Mical3 UTSW 6 121,001,758 (GRCm39) missense probably damaging 1.00
R9720:Mical3 UTSW 6 120,935,238 (GRCm39) missense probably damaging 0.99
R9777:Mical3 UTSW 6 120,959,529 (GRCm39) missense possibly damaging 0.91
U24488:Mical3 UTSW 6 120,978,457 (GRCm39) missense possibly damaging 0.90
Z1177:Mical3 UTSW 6 120,936,689 (GRCm39) missense possibly damaging 0.71
Z1190:Mical3 UTSW 6 120,998,319 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- CAGTGGATCAGGCTGAGTTG -3'
(R):5'- AAGAGGTCGTCGCTCTTCTC -3'

Sequencing Primer
(F):5'- GGGTGTGGCTTGTTCCCTCTC -3'
(R):5'- AACCAAAGGGGAAGCCCG -3'
Posted On 2017-03-31