Incidental Mutation 'R5970:Or7g20'
ID 470804
Institutional Source Beutler Lab
Gene Symbol Or7g20
Ensembl Gene ENSMUSG00000045204
Gene Name olfactory receptor family 7 subfamily G member 20
Synonyms MOR150-3, GA_x6K02T2PVTD-12771995-12772930, Olfr835
MMRRC Submission 044153-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R5970 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 18946421-18947356 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18946443 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 8 (D8G)
Ref Sequence ENSEMBL: ENSMUSP00000148416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059315] [ENSMUST00000213018]
AlphaFold Q7TRG7
Predicted Effect probably benign
Transcript: ENSMUST00000059315
AA Change: D8G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000052610
Gene: ENSMUSG00000045204
AA Change: D8G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 206 2.9e-7 PFAM
Pfam:7tm_1 41 303 1.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213018
AA Change: D8G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.4%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l1 G A 6: 90,574,028 (GRCm39) probably benign Het
Ambn T C 5: 88,615,810 (GRCm39) V413A possibly damaging Het
Amotl1 T A 9: 14,507,824 (GRCm39) D41V probably damaging Het
Arhgef26 T C 3: 62,247,468 (GRCm39) V184A probably benign Het
Birc6 G T 17: 74,925,497 (GRCm39) G936V possibly damaging Het
Ccser1 T A 6: 61,288,226 (GRCm39) S130T possibly damaging Het
Cecr2 A G 6: 120,697,868 (GRCm39) I56V probably damaging Het
Cfap52 A G 11: 67,821,570 (GRCm39) I486T probably damaging Het
Col4a3 A G 1: 82,694,050 (GRCm39) I1557V possibly damaging Het
Col6a5 T A 9: 105,823,046 (GRCm39) I104F unknown Het
Cry2 A G 2: 92,243,312 (GRCm39) S510P probably benign Het
Csmd2 G C 4: 128,439,944 (GRCm39) A3133P probably benign Het
Cyld G T 8: 89,459,621 (GRCm39) A611S probably damaging Het
Dennd4c G A 4: 86,743,749 (GRCm39) G1197E probably damaging Het
Dnah10 T C 5: 124,885,793 (GRCm39) F2969L probably benign Het
Dnai1 A G 4: 41,625,281 (GRCm39) K415R probably benign Het
Dnmbp T A 19: 43,842,610 (GRCm39) T1253S probably benign Het
Dsp T C 13: 38,379,678 (GRCm39) L1542P possibly damaging Het
Duox1 T A 2: 122,170,682 (GRCm39) L1234Q probably damaging Het
Efr3b T A 12: 4,018,590 (GRCm39) R585S possibly damaging Het
Gpt A G 15: 76,583,552 (GRCm39) probably null Het
Heatr6 G A 11: 83,644,544 (GRCm39) probably benign Het
Kcns2 A G 15: 34,839,930 (GRCm39) D431G probably benign Het
Kdm3b A G 18: 34,962,342 (GRCm39) N1543D probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Mical3 G A 6: 120,935,232 (GRCm39) Q893* probably null Het
Morc3 C T 16: 93,663,341 (GRCm39) H515Y possibly damaging Het
Mprip A T 11: 59,648,547 (GRCm39) R750S probably damaging Het
Mroh1 G A 15: 76,335,691 (GRCm39) V1436M probably benign Het
Muc5ac C T 7: 141,344,406 (GRCm39) R69* probably null Het
Muc5b A T 7: 141,410,449 (GRCm39) Y1274F unknown Het
Mybpc1 A G 10: 88,378,318 (GRCm39) L674P probably damaging Het
Mypn A G 10: 62,966,802 (GRCm39) V958A probably benign Het
Nipbl T C 15: 8,326,302 (GRCm39) T2436A probably benign Het
Pcdhb5 T A 18: 37,454,826 (GRCm39) L402Q probably damaging Het
Pigp T A 16: 94,171,053 (GRCm39) probably null Het
Rp1 A G 1: 4,418,685 (GRCm39) L809P probably benign Het
Scn3a T A 2: 65,325,125 (GRCm39) probably benign Het
Sdf2 A T 11: 78,136,906 (GRCm39) M29L probably benign Het
Serpina3b T G 12: 104,100,350 (GRCm39) L311V possibly damaging Het
Snx31 A T 15: 36,523,634 (GRCm39) Y349* probably null Het
Spidr A C 16: 15,932,733 (GRCm39) C182W probably damaging Het
St13 A T 15: 81,261,999 (GRCm39) S146R probably damaging Het
St8sia4 A G 1: 95,581,307 (GRCm39) V145A probably damaging Het
Stradb T C 1: 59,019,175 (GRCm39) probably null Het
Tcp11l2 T A 10: 84,430,661 (GRCm39) probably benign Het
Tfdp2 C T 9: 96,199,627 (GRCm39) P74S unknown Het
Tmprss15 C T 16: 78,854,547 (GRCm39) R287H probably benign Het
Trav10d T C 14: 53,048,779 (GRCm39) Y57H probably damaging Het
Vmn2r104 A G 17: 20,249,733 (GRCm39) I846T probably benign Het
Ywhah T A 5: 33,184,292 (GRCm39) M165K possibly damaging Het
Zfp324 C A 7: 12,703,293 (GRCm39) P72T probably benign Het
Other mutations in Or7g20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01718:Or7g20 APN 9 18,946,584 (GRCm39) nonsense probably null
IGL02546:Or7g20 APN 9 18,946,650 (GRCm39) missense possibly damaging 0.88
R0010:Or7g20 UTSW 9 18,946,618 (GRCm39) missense probably damaging 1.00
R0107:Or7g20 UTSW 9 18,946,629 (GRCm39) missense probably damaging 1.00
R1867:Or7g20 UTSW 9 18,946,562 (GRCm39) missense probably benign 0.36
R1891:Or7g20 UTSW 9 18,947,274 (GRCm39) missense probably damaging 0.99
R1941:Or7g20 UTSW 9 18,947,162 (GRCm39) missense possibly damaging 0.93
R4152:Or7g20 UTSW 9 18,946,816 (GRCm39) nonsense probably null
R5451:Or7g20 UTSW 9 18,946,787 (GRCm39) missense probably damaging 1.00
R5677:Or7g20 UTSW 9 18,946,854 (GRCm39) missense possibly damaging 0.93
R6187:Or7g20 UTSW 9 18,946,689 (GRCm39) missense probably benign 0.12
R6805:Or7g20 UTSW 9 18,946,597 (GRCm39) missense probably damaging 1.00
R7183:Or7g20 UTSW 9 18,946,628 (GRCm39) missense probably damaging 1.00
R8029:Or7g20 UTSW 9 18,947,090 (GRCm39) missense probably damaging 1.00
R8139:Or7g20 UTSW 9 18,946,871 (GRCm39) missense probably benign 0.07
R8736:Or7g20 UTSW 9 18,946,774 (GRCm39) missense probably damaging 1.00
R8868:Or7g20 UTSW 9 18,946,778 (GRCm39) missense probably damaging 1.00
R8909:Or7g20 UTSW 9 18,946,888 (GRCm39) missense probably benign 0.08
R9116:Or7g20 UTSW 9 18,946,773 (GRCm39) missense probably damaging 1.00
R9479:Or7g20 UTSW 9 18,946,730 (GRCm39) missense probably benign 0.30
R9786:Or7g20 UTSW 9 18,947,241 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GCCTTTTAGAATATAGGCTACTGTCTC -3'
(R):5'- TTTGGAATGACAGTTGTGGATAAGC -3'

Sequencing Primer
(F):5'- ATAGGCTACTGTCTCTCATTTTTCTC -3'
(R):5'- TGACAGTTGTGGATAAGCAGATATC -3'
Posted On 2017-03-31