Incidental Mutation 'R5951:Cenps'
ID 470874
Institutional Source Beutler Lab
Gene Symbol Cenps
Ensembl Gene ENSMUSG00000073705
Gene Name centromere protein S
Synonyms 2610040C18Rik, Apitd1, 2810407L01Rik
MMRRC Submission 044141-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.261) question?
Stock # R5951 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 149212806-149222057 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to A at 149214658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101321 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030813] [ENSMUST00000030815] [ENSMUST00000105695] [ENSMUST00000105696] [ENSMUST00000150150] [ENSMUST00000176124] [ENSMUST00000177408]
AlphaFold Q9D084
Predicted Effect silent
Transcript: ENSMUST00000030813
SMART Domains Protein: ENSMUSP00000030813
Gene: ENSMUSG00000073705

DomainStartEndE-ValueType
Pfam:CENP-S 16 91 1.4e-36 PFAM
Pfam:CENP-T_C 18 116 2.3e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030815
SMART Domains Protein: ENSMUSP00000030815
Gene: ENSMUSG00000028971

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 65 78 N/A INTRINSIC
Pfam:Somatostatin 91 108 9.3e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105695
SMART Domains Protein: ENSMUSP00000101320
Gene: ENSMUSG00000073705

DomainStartEndE-ValueType
Pfam:CENP-S 16 75 3.4e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105696
SMART Domains Protein: ENSMUSP00000101321
Gene: ENSMUSG00000073705

DomainStartEndE-ValueType
Pfam:CENP-S 16 76 2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132672
Predicted Effect silent
Transcript: ENSMUST00000150150
SMART Domains Protein: ENSMUSP00000121878
Gene: ENSMUSG00000073705

DomainStartEndE-ValueType
Pfam:CENP-S 1 26 7.3e-14 PFAM
low complexity region 43 51 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000176124
SMART Domains Protein: ENSMUSP00000134756
Gene: ENSMUSG00000073705

DomainStartEndE-ValueType
Pfam:CENP-S 1 26 1.4e-13 PFAM
low complexity region 43 62 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000177408
AA Change: R69L
SMART Domains Protein: ENSMUSP00000135536
Gene: ENSMUSG00000073705
AA Change: R69L

DomainStartEndE-ValueType
Pfam:CENP-S 16 64 1.2e-12 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.4%
Validation Efficiency 100% (78/78)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik T A 2: 35,244,811 (GRCm39) E180D probably damaging Het
Add3 A G 19: 53,232,720 (GRCm39) probably null Het
Adgrv1 A T 13: 81,590,620 (GRCm39) I4396N probably damaging Het
Apc C T 18: 34,450,199 (GRCm39) S2331L possibly damaging Het
Apoh G T 11: 108,286,729 (GRCm39) C51F probably damaging Het
Arid4b T C 13: 14,317,648 (GRCm39) V177A possibly damaging Het
Atp13a1 T A 8: 70,249,935 (GRCm39) I343N probably damaging Het
Bcar1 T C 8: 112,440,032 (GRCm39) D654G probably benign Het
Brox T C 1: 183,064,072 (GRCm39) K245R probably damaging Het
Ccdc146 A T 5: 21,524,577 (GRCm39) S258R possibly damaging Het
Ccdc169 A C 3: 55,047,562 (GRCm39) K18Q probably damaging Het
Crot C A 5: 9,019,120 (GRCm39) E478* probably null Het
Dgkq A T 5: 108,802,236 (GRCm39) M443K probably damaging Het
Dhx32 A T 7: 133,339,057 (GRCm39) L326Q probably damaging Het
Dtwd1 A G 2: 126,000,342 (GRCm39) I93V probably benign Het
Ehmt2 C T 17: 35,118,357 (GRCm39) T44I probably benign Het
Enc1 T C 13: 97,381,765 (GRCm39) S92P probably benign Het
Epha5 T C 5: 84,479,051 (GRCm39) probably benign Het
Eya4 T A 10: 23,031,892 (GRCm39) S244C probably damaging Het
Fmnl3 G A 15: 99,223,791 (GRCm39) R302W probably damaging Het
Fscn3 A T 6: 28,436,173 (GRCm39) I490F possibly damaging Het
Galntl6 A G 8: 58,415,436 (GRCm39) V239A probably benign Het
Glg1 T C 8: 111,892,323 (GRCm39) I841V possibly damaging Het
Gm15455 T C 1: 33,876,893 (GRCm39) noncoding transcript Het
Gpd1l C T 9: 114,743,473 (GRCm39) M142I probably benign Het
Helb A G 10: 119,927,653 (GRCm39) V819A possibly damaging Het
Hnrnpul2 T G 19: 8,802,255 (GRCm39) F374C probably damaging Het
Hoxc10 G A 15: 102,875,753 (GRCm39) S154N possibly damaging Het
Ice2 A T 9: 69,319,651 (GRCm39) T367S possibly damaging Het
Iqca1 A T 1: 90,067,819 (GRCm39) probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Klhl14 T A 18: 21,784,677 (GRCm39) H250L probably damaging Het
Kmt2c A T 5: 25,535,801 (GRCm39) D1447E probably benign Het
Larp1 G T 11: 57,940,765 (GRCm39) M630I probably benign Het
Lrp2 A G 2: 69,326,667 (GRCm39) probably null Het
Map4k3 G T 17: 80,911,427 (GRCm39) Q673K probably benign Het
Mettl16 A G 11: 74,686,823 (GRCm39) N201D possibly damaging Het
Mrpl15 C A 1: 4,855,956 (GRCm39) probably benign Het
Mthfd1l T A 10: 3,998,222 (GRCm39) V655D probably damaging Het
Odf1 T C 15: 38,226,531 (GRCm39) Y144H probably damaging Het
Or2f1b G T 6: 42,739,493 (GRCm39) C169F probably damaging Het
Or5t5 G T 2: 86,616,571 (GRCm39) V166L probably benign Het
Padi1 T C 4: 140,542,140 (GRCm39) Y594C probably damaging Het
Palm3 T A 8: 84,756,049 (GRCm39) D520E probably benign Het
Paox G A 7: 139,707,567 (GRCm39) C130Y probably damaging Het
Parpbp T A 10: 87,975,769 (GRCm39) S115C probably damaging Het
Pcnx3 A G 19: 5,721,708 (GRCm39) V1438A possibly damaging Het
Pdlim2 T A 14: 70,405,229 (GRCm39) D212V probably benign Het
Pi4ka A G 16: 17,121,006 (GRCm39) F53L probably damaging Het
Pik3c2a A T 7: 115,967,419 (GRCm39) D839E probably damaging Het
Pou2f1 T C 1: 165,710,625 (GRCm39) probably benign Het
Ppl A T 16: 4,906,492 (GRCm39) Y1268N probably benign Het
Prelid3a C T 18: 67,598,011 (GRCm39) S6L probably benign Het
Ptk2 T G 15: 73,175,682 (GRCm39) D285A possibly damaging Het
Rasd2 T G 8: 75,948,811 (GRCm39) Y246D probably damaging Het
Rhbdl2 A G 4: 123,708,120 (GRCm39) T110A probably benign Het
Rhobtb1 T A 10: 69,106,085 (GRCm39) F217I probably damaging Het
Serhl T C 15: 82,987,237 (GRCm39) probably benign Het
Sh3tc2 A G 18: 62,123,078 (GRCm39) E613G probably damaging Het
Slc26a3 A G 12: 31,502,714 (GRCm39) probably benign Het
Steap4 T C 5: 8,025,769 (GRCm39) I110T probably benign Het
Syde1 C A 10: 78,425,150 (GRCm39) R287L possibly damaging Het
Tmem184c C T 8: 78,325,291 (GRCm39) probably null Het
Trmt44 C A 5: 35,730,032 (GRCm39) probably benign Het
Ttbk2 G T 2: 120,603,764 (GRCm39) S256R probably benign Het
Ttll6 A T 11: 96,036,336 (GRCm39) I322F probably damaging Het
Ubap2 A T 4: 41,205,753 (GRCm39) probably null Het
Wsb2 A T 5: 117,515,600 (GRCm39) T402S probably damaging Het
Other mutations in Cenps
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Cenps APN 4 149,213,303 (GRCm39) missense probably damaging 1.00
R5408:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5410:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5457:Cenps UTSW 4 149,216,094 (GRCm39) critical splice donor site probably null
R5939:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5952:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5953:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5954:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R5957:Cenps UTSW 4 149,214,658 (GRCm39) intron probably benign
R7601:Cenps UTSW 4 149,216,772 (GRCm39) missense possibly damaging 0.82
Predicted Primers
Posted On 2017-03-31