Incidental Mutation 'R5952:Gm1818'
ID470965
Institutional Source Beutler Lab
Gene Symbol Gm1818
Ensembl Gene ENSMUSG00000091277
Gene Namepredicted gene 1818
SynonymsLOC217536
MMRRC Submission 044142-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.840) question?
Stock #R5952 (G1)
Quality Score225
Status Validated
Chromosome12
Chromosomal Location48555059-48559896 bp(-) (GRCm38)
Type of Mutationexon
DNA Base Change (assembly) T to G at 48555936 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s):
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169406
SMART Domains Protein: ENSMUSP00000131939
Gene: ENSMUSG00000091277

DomainStartEndE-ValueType
low complexity region 1 22 N/A INTRINSIC
Pfam:RrnaAD 78 377 4.3e-23 PFAM
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.5%
Validation Efficiency 91% (62/68)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 36,965,621 T2060A probably damaging Het
Add2 A T 6: 86,109,746 D296V probably damaging Het
Ak9 A G 10: 41,357,563 E599G possibly damaging Het
Ank3 A T 10: 69,986,463 I1604F probably benign Het
Arid4a A G 12: 71,063,206 D107G probably benign Het
Btn2a2 A T 13: 23,482,808 I209N probably benign Het
Cenps C A 4: 149,130,201 probably benign Het
Csmd3 A G 15: 47,733,505 V1979A probably damaging Het
Cyp4a12b C T 4: 115,414,517 R142* probably null Het
Ddx23 A T 15: 98,658,240 S66T unknown Het
Efcab2 A G 1: 178,475,874 K121R probably benign Het
Epb41l1 T A 2: 156,503,788 V237D probably damaging Het
Epb41l1 G T 2: 156,524,983 A579S probably benign Het
Epn1 G A 7: 5,093,912 R231H probably damaging Het
Fbrs T C 7: 127,487,752 S649P probably damaging Het
Fezf1 A G 6: 23,247,428 V216A probably benign Het
Gen1 A T 12: 11,260,896 S112T probably damaging Het
Glrx2 A G 1: 143,745,134 N84D probably benign Het
Hira C A 16: 18,935,065 T553K possibly damaging Het
Hnrnph3 A G 10: 63,015,595 probably benign Het
Ighv12-3 A T 12: 114,366,584 F97Y probably benign Het
Jcad A G 18: 4,674,554 Q772R probably damaging Het
Lamb3 A G 1: 193,332,362 T610A probably benign Het
Map3k19 T C 1: 127,822,740 D958G probably benign Het
Map4k4 G A 1: 39,999,922 probably benign Het
Mocos T C 18: 24,701,387 V827A possibly damaging Het
Ms4a10 T A 19: 10,964,122 D161V probably damaging Het
Myh9 A G 15: 77,773,332 I1071T possibly damaging Het
Myo15 A G 11: 60,479,420 E1002G possibly damaging Het
Neurod6 G A 6: 55,679,017 H212Y probably damaging Het
Olfr1448 T C 19: 12,919,830 N160D probably benign Het
Olfr56 A T 11: 49,134,572 I95F probably damaging Het
Olfr618 T A 7: 103,597,967 I217N probably damaging Het
Pcdhb17 T C 18: 37,487,080 V641A probably benign Het
Ppp3ca A T 3: 136,928,571 M431L probably benign Het
Ptprk A T 10: 28,585,675 I69F probably damaging Het
Rab34 G T 11: 78,190,268 probably benign Het
Rb1cc1 A G 1: 6,248,182 N619S probably benign Het
Rnf169 T C 7: 99,925,633 H585R probably damaging Het
Rps6kc1 A G 1: 190,885,420 V129A probably benign Het
Siglecf C T 7: 43,355,927 T437M probably benign Het
Slc25a2 T C 18: 37,638,282 N65D probably benign Het
Spire1 A G 18: 67,506,709 S245P probably benign Het
Sptb A T 12: 76,632,384 M99K probably benign Het
Tacc1 G T 8: 25,181,995 L406I possibly damaging Het
Tas2r137 T C 6: 40,491,542 I102T probably benign Het
Trappc11 A T 8: 47,496,917 probably null Het
Trbv11 A G 6: 41,107,219 noncoding transcript Het
Trmt11 A G 10: 30,560,842 Y301H probably benign Het
Tspo A G 15: 83,572,240 T75A possibly damaging Het
Ttn T C 2: 76,880,225 probably benign Het
Zfhx4 A G 3: 5,396,970 Q1210R probably damaging Het
Zhx3 A T 2: 160,782,017 Y77N probably damaging Het
Other mutations in Gm1818
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01456:Gm1818 APN 12 48555800 exon noncoding transcript
IGL01472:Gm1818 APN 12 48556289 exon noncoding transcript
IGL01634:Gm1818 APN 12 48556209 exon noncoding transcript
IGL01874:Gm1818 APN 12 48556190 exon noncoding transcript
IGL02287:Gm1818 APN 12 48555722 exon noncoding transcript
IGL02805:Gm1818 APN 12 48555735 exon noncoding transcript
R1174:Gm1818 UTSW 12 48556199 exon noncoding transcript
R1175:Gm1818 UTSW 12 48556199 exon noncoding transcript
R1636:Gm1818 UTSW 12 48555767 exon noncoding transcript
R4797:Gm1818 UTSW 12 48555610 exon noncoding transcript
R4828:Gm1818 UTSW 12 48555626 exon noncoding transcript
R4937:Gm1818 UTSW 12 48559824 exon noncoding transcript
R5022:Gm1818 UTSW 12 48555535 exon noncoding transcript
R5023:Gm1818 UTSW 12 48555535 exon noncoding transcript
R6057:Gm1818 UTSW 12 48555563 exon noncoding transcript
R6131:Gm1818 UTSW 12 48555536 exon noncoding transcript
Z1088:Gm1818 UTSW 12 48556124 exon noncoding transcript
Predicted Primers PCR Primer
(F):5'- TCCATGTGCAGGAACTTAACG -3'
(R):5'- ACATTTGGAGCCCTTACAGAG -3'

Sequencing Primer
(F):5'- TTAACGTCACAGGCCACTTG -3'
(R):5'- CTTACAGAGGAACATGGATGGAGAGC -3'
Posted On2017-03-31